Research Topics
Species | Myron SpectorSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Effects of cross-linking type II collagen-GAG scaffolds on chondrogenesis in vitro: dynamic pore reduction promotes cartilage formationScott M Vickers
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Tissue Eng 12:1345-55. 2006..This approach may provide a useful alternative to traditional means of increasing cell number density and retention of synthesized molecules that promote cartilage formation in tissue-engineered constructs...- Novel cell-scaffold interactions encountered in tissue engineering: contractile behavior of musculoskeletal connective tissue cellsM Spector
Department of Orthopedic Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Tissue Eng 8:351-7. 2002.... - Biomaterials-based tissue engineering and regenerative medicine solutions to musculoskeletal problemsMyron Spector
Tissue Engineering, VA Boston Healthcare System, and Orthopaedic Research Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Swiss Med Wkly 136:293-301. 2006.... 
The presence and distribution of lubricin in the caprine intervertebral discKristy M Shine
Tissue Engineering, VA Boston Healthcare System, 150 South Huntington Avenue, MS 151, Boston, Massachusetts 02130, USA
J Orthop Res 26:1398-406. 2008..Cells from both the annulus and nucleus were found capable of synthesizing lubricin in vitro, suggesting that these cells may be a potential source of the glycoprotein under some conditions...- Musculoskeletal connective tissue cells with muscle: expression of muscle actin in and contraction of fibroblasts, chondrocytes, and osteoblastsM Spector
Department of Orthopaedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Wound Repair Regen 9:11-8. 2001.... - Modulation of mesenchymal stem cell chondrogenesis in a tunable hyaluronic acid hydrogel microenvironmentWei Seong Toh
Tissue Engineering, VA Boston Healthcare System, Boston, MA 02130, USA
Biomaterials 33:3835-45. 2012.... - alpha-Smooth muscle actin-expressing cells and lubricin in periprosthetic tissueTadanao Funakoshi
Department of Orthopaedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biomed Mater Res A 93:515-27. 2010.... - Chondrogenic differentiation and lubricin expression of caprine infraspinatus tendon cellsTadanao Funakoshi
Tissue Engineering, VA Boston Healthcare System, Boston, Massachusetts 02130, USA
J Orthop Res 28:716-25. 2010..These data inform the use of tendon cells for rotator cuff repair, including for fibrocartilaginous zones... 
Engineering endostatin-producing cartilaginous constructs for cartilage repair using nonviral transfection of chondrocyte-seeded and mesenchymal-stem-cell-seeded collagen scaffoldsLily Jeng
Tissue Engineering Laboratories, VA Boston Healthcare System, Boston, Massachusetts 02130, USA
Tissue Eng Part A 16:3011-21. 2010..The ability to engineer endostatin-expressing cartilaginous constructs will be of value for future work exercising regulatory control of angiogenesis in cartilage repair...- Cartilaginous deposits in subchondral bone in regions of exposed bone in osteoarthritis of the human knee: histomorphometric study of PRG4 distribution in osteoarthritic cartilageDong Zhang
Tissue Engineering, VA Boston Healthcare System, Orthopaedic Research Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02130, USA
J Orthop Res 25:873-83. 2007..These cells may be able to contribute to the resurfacing of the joint in certain cartilage repair procedures... - Plasmid size influences chitosan nanoparticle mediated gene transfer to chondrocytesXiming Xu
Tissue Engineering, VA Boston Healthcare System, Boston, Massachusetts 02130, USA
J Biomed Mater Res A 84:1038-48. 2008..These results indicate that although a large plasmid can be successfully incorporated within chitosan nanoparticles, the size of the plasmid incorporated within the nanoparticles may still significantly affect gene transfer to cells... - Viscoelastic characterization of rat cerebral cortex and type I collagen scaffolds for central nervous system tissue engineeringPaul Z Elias
Tissue Engineering Laboratories, VA Boston Healthcare System, 150 South Huntington Ave, Boston, MA 02130, USA
J Mech Behav Biomed Mater 12:63-73. 2012..Similarities and differences between the mechanical behavior of the brain and collagen scaffolds of varying collagen concentration are discussed in relation to application of biomaterials for regenerative medicine... - Engineering endostatin-expressing cartilaginous constructs using injectable biopolymer hydrogelsLily Jeng
Tissue Engineering, VA Boston Healthcare System, Boston, MA 02130, USA
Acta Biomater 8:2203-12. 2012.... - Extracorporeal shockwave-induced expression of lubricin in tendons and septaDafang Zhang
Harvard Medical School, Boston, MA 02115, USA
Cell Tissue Res 346:255-62. 2011..Increased lubricin expression may contribute to the beneficial effects of ESWT in providing pain and symptom relief in musculoskeletal disorders by decreasing erosive wear... - Non-viral endostatin plasmid transfection of mesenchymal stem cells via collagen scaffoldsXiao Dan Sun
Tissue Engineering, VA Boston Healthcare System, Mail Stop 151 Research, 150 S Huntington Ave, Boston, MA 02130, USA
Biomaterials 30:1222-31. 2009..The results demonstrate the promise of the non-viral delivery of the gene for this potent anti-angiogenic protein to MSCs via a collagen scaffold... - Lubricin distribution in the torn human anterior cruciate ligament and meniscusDafang Zhang
Harvard Medical School, Boston, Massachusetts 02115, USA
J Orthop Res 29:1916-22. 2011..In all tissues, lubricin was found in the matrix and intracellularly. The surface layer of lubricin coating torn edges of ACLs and menisci may interfere with the integrative healing process needed for repair... - Lubricin in human breast tissue expander capsulesThomas Cheriyan
VA Boston Healthcare Systems, Boston, Massachusetts 02130, USA
J Biomed Mater Res B Appl Biomater 100:1961-9. 2012..Varying degrees of synovial metaplasia were seen at the tissue-implant interface. α-SMA-containing cells were also seen in all but one patient. The findings might help us better understand factors involved in capsule formation... - Contractile forces generated by articular chondrocytes in collagen-glycosaminoglycan matricesJanice M Zaleskas
Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Biomaterials 25:1299-308. 2004..Adult articular chondrocytes are capable of generating a SMA-enabled force of contraction sufficient to model extracellular matrix molecules... - Distribution of lubricin in the ruptured human rotator cuff and biceps tendon: a pilot studyTadanao Funakoshi
Department of Orthopaedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Clin Orthop Relat Res 468:1588-99. 2010..Lubricin is a lubricant for diarthrodial joint tissues and has antiadhesion properties; its presence in the (caprine) rotator cuff suggests it may have a role in intrafascicular lubrication... - Lubricin and smooth muscle α-actin-containing myofibroblasts in the pseudomembranes around loose hip and knee prosthesesThomas Cheriyan
VA Boston Healthcare Systems, Boston, MA 02130, USA
Acta Biomater 9:5751-8. 2013..There was a significant effect of location on the number of SMA-expressing cells, but not of implant type. These findings might explain why the management of loose prosthesis is so challenging... - Presence and distribution of the lubricating protein, lubricin, in the meibomian gland in rabbitsThomas Cheriyan
Tissue Engineering, VA Boston Healthcare System, Boston, MA 02130, USA
Mol Vis 17:3055-61. 2011..This study investigates the presence of lubricin in the meibomian gland, lacrimal gland and ocular surface of healthy rabbits; prompted by the hypothesis that lubricin acts as boundary lubricant and anti-adhesive protein in the eye... - Lubricin distribution in the human intervertebral discKristy M Shine
Tissue Engineering, VA Boston Healthcare System, Boston, MA 02130, USA
J Bone Joint Surg Am 91:2205-12. 2009..In this immunohistochemical study, we determined the presence and distribution of lubricin in the cells, extracellular matrix, and tissue surfaces of human nucleus pulposus and anulus fibrosus tissues... - Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilageWei Seong Toh
Tissue Engineering Laboratories, VA Boston Healthcare System, MS 151, Boston, Massachusetts 02130, USA
Mol Pharm 8:994-1001. 2011..The latest advances in cartilage tissue engineering and regeneration are critically reviewed to demonstrate an outline of challenges toward biomaterial-based approaches of cartilage regeneration... - Chemotactic recruitment of adult neural progenitor cells into multifunctional hydrogels providing sustained SDF-1α release and compatible structural supportTeck Chuan Lim
Tissue Engineering Laboratories, VA Boston Healthcare System, Mail Stop 151 Research, 150 S Huntington Ave, Boston, MA 02130, USA
FASEB J 27:1023-33. 2013..Overall, Gtn-HPA/SDF-1α-PCN hydrogels prove to be promising biomaterials for injection into cavitary brain lesions to recruit endogenous NPCs and enhance neural tissue repair/regeneration... - Development of hyaluronic acid-based scaffolds for brain tissue engineeringTzu Wei Wang
Tissue Engineering Laboratories, VA Boston Healthcare System, Mail Stop 151 Research, 150 S Huntington Ave, Boston, MA 02130, USA
Acta Biomater 5:2371-84. 2009.... - Alpha-smooth muscle actin in pathological human disc nucleus pulposus cells in vivo and in vitroDawn Hastreiter
Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Wound Repair Regen 12:430-8. 2004..008), with values decreasing through 4 weeks and then slightly rising at 6 weeks. The role of alpha-SMA in intervertebral disc pathology warrants further investigation... - Delivery of plasmid IGF-1 to chondrocytes via cationized gelatin nanoparticlesXiming Xu
Tissue Engineering, VA Boston Healthcare System, Boston, Massachusetts 02130, USA
J Biomed Mater Res A 84:73-83. 2008..A peak in the amount of released IGF-1 was detected at a gelatin:IGF-1 weight ratio of 250:1... - Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acidAndre F Steinert
Center for Molecular Orthopedics, Department of Orthopedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Tissue Eng 13:2227-37. 2007..These results indicate that TGF-beta1 cDNA delivery may affect cell-based meniscus repair approaches in vivo... - Lubricin distribution in the goat infraspinatus tendon: a basis for interfascicular lubricationTadanao Funakoshi
Tissue Engineering, VA Boston Healthcare System, 150 South Huntington Avenue, MS 151, Boston, MA 02130, USA
J Bone Joint Surg Am 90:803-14. 2008..The hypothesis was that lubricin, also known as superficial zone protein or proteoglycan 4, serves as an interfascicular lubricant... - Clinical application of extracorporeal shock wave therapy in orthopedics: focused versus unfocused shock wavesCasper Bindzus Foldager
Department of Orthopedics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Ultrasound Med Biol 38:1673-80. 2012..The aim of the present review is to investigate differences in outcome in select orthopaedic applications using focused and unfocused shock waves... - Treatment of penetrating brain injury in a rat model using collagen scaffolds incorporating soluble Nogo receptorPaul Z Elias
Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA Tissue Engineering Laboratories, VA Boston Healthcare System, Boston, MA, USA
J Tissue Eng Regen Med . 2012..Copyright © 2012 John Wiley & Sons, Ltd... - The use of extracorporeal shock wave-stimulated periosteal cells for orthotopic bone generationCathal J Kearney
Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
Tissue Eng Part A 18:1500-8. 2012..These results successfully demonstrated the efficacy of ESW-stimulated periosteum for orthotopic bone generation... - The effect of injectable gelatin-hydroxyphenylpropionic acid hydrogel matrices on the proliferation, migration, differentiation and oxidative stress resistance of adult neural stem cellsTeck Chuan Lim
Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Biomaterials 33:3446-55. 2012..Overall, Gtn-HPA hydrogels are promising injectable matrices for supporting and influencing aNSCs in ways that may be beneficial for brain tissue regeneration after injuries... - The reparative response to cross-linked collagen-based scaffolds in a rat spinal cord gap modelRahmatullah H Cholas
Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Biomaterials 33:2050-9. 2012.... - Proteoglycans synthesized by canine intervertebral disc cells grown in a type I collagen-glycosaminoglycan matrixYuan Rong
Department of Orthopedic Suergery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Tissue Eng 8:1037-47. 2002..The results provide a foundation for future investigations of collagen-glycosaminoglycan matrices for intervertebral disc tissue engineering... - Contractile actin expression in torn human menisciB Y Lin
Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Wound Repair Regen 10:259-66. 2002..This underscores the importance of providing a bridging scaffold into which such cells can migrate... - Early bone apposition in vivo on plasma-sprayed and electrochemically deposited hydroxyapatite coatings on titanium alloyHao Wang
Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, and Tissue Engineering, VA Boston Healthcare System, MA 02139, USA
Biomaterials 27:4192-203. 2006.... - A glimpse of tissue engineering in ChinaZhou Xiang
Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Tissue Eng 8:169-74. 2002..A brief summary of some of the papers may begin to suggest possibilities for collaboration between tissue engineers inside and outside of China, as well as to facilitate dissemination of important findings... - Composition of joint fluid in patients undergoing total knee replacement and revision arthroplasty: correlation with flow propertiesDan Mazzucco
Division of Health Sciences and Technology, Massachusetts Institute of Technology, and Tissue Engineering, VA Boston Healthcare System, USA
Biomaterials 25:4433-45. 2004..The variation in composition and lower HA concentration in joints necessitating revision may relate to variation in arthroplasty lubrication leading to highly variable wear rates and clinical outcomes... - Rheology of joint fluid in total knee arthroplasty patientsDan Mazzucco
Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Orthop Res 20:1157-63. 2002..Both groups exhibited degenerate flow properties when compared to synovial fluid from healthy individuals. Further examination of the connection between flow properties and the tribology of joint replacement prostheses is warranted... - Cell outgrowth from the human ACL in vitro: regional variation and response to TGF-beta1Martha Meaney Murray
Department of Orthopedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Orthop Res 20:875-80. 2002..However, this study is only a first step, and additional experiments are needed to further optimize tissue engineering parameters for enhancement of the repair of the ACL... - Collagen-GAG scaffolds grafted onto myocardial infarcts in a rat model: a delivery vehicle for mesenchymal stem cellsZhou Xiang
Department of Orthopaedic Surgery, Huaxi Hospital, Sichuan University, Chengdu, China
Tissue Eng 12:2467-78. 2006..BrdU-positive cells appeared both in the degraded scaffold and the infarct region. DHT cross-linked collagen-GAG scaffolds warrant continued investigation as delivery vehicles for implantation of cells into infarcted cardiac tissue... - Formation of lung alveolar-like structures in collagen-glycosaminoglycan scaffolds in vitroPatty Chen
Division of Health Sciences and Technology, Harvard-Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Tissue Eng 11:1436-48. 2005..This culture system may be of value in facilitating exploration of strategies for preparing such scaffolds for the regeneration of lung tissue in vivo... - Bone bonding to hydroxyapatite and titanium surfaces on femoral stems retrieved from human subjects at autopsyAlexandra E Porter
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge MA 02139, USA
Biomaterials 25:5199-208. 2004..Many ultrastructural features of the bone bonded to the HA coatings on these implants from human subjects were comparable to those found on HA-coated devices implanted in a canine model... - Fabrication and characterization of porous hyaluronic acid-collagen composite scaffoldsShunqing Tang
Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China
J Biomed Mater Res A 82:323-35. 2007..The demonstration that these scaffolds can be populated by chondrocytes and support in vitro formation of cartilaginous tissue warrants further investigation of this material system for tissue engineering... - Scaffold-based articular cartilage repairRamille M Capito
Department of Material Science and Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
IEEE Eng Med Biol Mag 22:42-50. 2003 - Periosteum stimulates subchondral bone densification in autologous chondrocyte transplantation in a sheep modelMartin Russlies
Department of Orthopaedic Surgery, University Hospital Lubeck, 23538 Lubeck, Germany
Cell Tissue Res 319:133-42. 2005..These findings warrant evaluation of subchondral bone changes in patients treated by ACT and the correlation of these changes with clinical outcome... - Quantitation of osteoblast-like cell mineralization on tissue culture polystyrene and Ti-6Al-4V alloy disks by Tc-99m-MDP labeling and imaging in vitroHao Wang
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Bone 36:84-92. 2005..The results warrant implementation of this scintigraphic method for quantitative studies of osteoblast-mediated mineralization in vitro... - Biomanufacturing: a US-China National Science Foundation-sponsored workshopWei Sun
Mechanical Engineering and Mechanics, Drexel University, Philadelphia, Pennsylvania, USA
Tissue Eng 12:1169-81. 2006..In formulating the questions that remain to be answered and discussing the knowledge required to further advance the field, the Workshop provided a basis for recommendations for future work... - Translation from research to applicationsErnst Hunziker
ITI Research Institute for Dental and Skeletal Biology, University of Bern, Bern, Switzerland
Tissue Eng 12:3341-64. 2006..b>Myron Spector discussed collagen-glycosaminoglycan (GAG) scaffolds for musculoskeletal tissue engineering... - Incorporation of hyaluronic acid into collagen scaffolds for the control of chondrocyte-mediated contraction and chondrogenesisShunqing Tang
Department of Biomedical Engineering, Jinan University, Guangzhou 510632, People s Republic of China
Biomed Mater 2:S135-41. 2007..HA can play a useful role in adjusting the mechanical behavior of tissue engineering scaffolds and chondrogenesis in chondrocyte-seeded scaffolds... - Collagen-based matrices with axially oriented poresMarta Madaghiele
Department of Engineering for Innovation, University of Lecce, Lecce, 73100 Italy
J Biomed Mater Res A 85:757-67. 2008..In particular the definition of an orientation index (OI) was employed as a means to quantify the orientation of the pore channels inside the scaffolds...