David Sosnovik

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Diffusion MRI tractography of the developing human fetal heart
    Choukri Mekkaoui
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e72795. 2013
  2. pmc Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival
    Howard H Chen
    1 Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA
    Theranostics 2:148-55. 2012
  3. pmc Reproducibility of in-vivo diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy
    Laura Ann McGill
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United Kingdom
    J Cardiovasc Magn Reson 14:86. 2012
  4. pmc Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation
    Choukri Mekkaoui
    Athinoula A, Martinos Center for Biomedical Imaging, Boston, MA, USA
    J Cardiovasc Magn Reson 14:70. 2012
  5. ncbi request reprint Molecular magnetic resonance imaging in cardiovascular medicine
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Circulation 115:2076-86. 2007
  6. ncbi request reprint Cardiac MRI in mice at 9.4 Tesla with a transmit-receive surface coil and a cardiac-tailored intensity-correction algorithm
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Magn Reson Imaging 26:279-87. 2007
  7. pmc Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA
    Basic Res Cardiol 103:122-30. 2008
  8. pmc Molecular imaging in cardiovascular magnetic resonance imaging: current perspective and future potential
    David E Sosnovik
    Department of Cardiology, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Top Magn Reson Imaging 19:59-68. 2008
  9. doi request reprint Will molecular MR imaging play a role in identification and treatment of patients with vulnerable atherosclerotic plaques?
    David E Sosnovik
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Charlestown, MA 02129, USA
    Radiology 251:309-10. 2009
  10. pmc Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    Circ Cardiovasc Imaging 2:206-12. 2009

Collaborators

Detail Information

Publications39

  1. pmc Diffusion MRI tractography of the developing human fetal heart
    Choukri Mekkaoui
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e72795. 2013
    ..We aimed here to use diffusion tensor MRI (DTI) tractography to characterize the evolution of fiber architecture in the developing human fetal heart...
  2. pmc Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival
    Howard H Chen
    1 Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA
    Theranostics 2:148-55. 2012
    ..We focus in particular on approaches that include the possibility of modulating the activity of these kinases and proteases in a theranostic approach...
  3. pmc Reproducibility of in-vivo diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy
    Laura Ann McGill
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United Kingdom
    J Cardiovasc Magn Reson 14:86. 2012
    ..Recent technical advances have improved in-vivo cDTI, and the aim of this study was to assess the interstudy reproducibility of quantitative in-vivo cDTI in patients with HCM...
  4. pmc Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation
    Choukri Mekkaoui
    Athinoula A, Martinos Center for Biomedical Imaging, Boston, MA, USA
    J Cardiovasc Magn Reson 14:70. 2012
    ..The aim of this study was therefore to develop a technique for quantitative 3D diffusion CMR tractography of the heart, and to apply this method to quantify fiber architecture in the remote zone of remodeled hearts...
  5. ncbi request reprint Molecular magnetic resonance imaging in cardiovascular medicine
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Circulation 115:2076-86. 2007
  6. ncbi request reprint Cardiac MRI in mice at 9.4 Tesla with a transmit-receive surface coil and a cardiac-tailored intensity-correction algorithm
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Magn Reson Imaging 26:279-87. 2007
    ..To evaluate the use of a transmit-receive surface (TRS) coil and a cardiac-tailored intensity-correction algorithm for cardiac MRI in mice at 9.4 Tesla (9.4T)...
  7. pmc Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA
    Basic Res Cardiol 103:122-30. 2008
    ..First generation MNP are already in clinical use and second generation agents, with longer blood half lives, are likely to be approved for routine clinical use in the near future...
  8. pmc Molecular imaging in cardiovascular magnetic resonance imaging: current perspective and future potential
    David E Sosnovik
    Department of Cardiology, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Top Magn Reson Imaging 19:59-68. 2008
    ..The application of molecular MRI in diseases of the vasculature and myocardium is then reviewed. The clinical experience to date, as well as the promise and potential impact of molecular MRI, is extensively discussed...
  9. doi request reprint Will molecular MR imaging play a role in identification and treatment of patients with vulnerable atherosclerotic plaques?
    David E Sosnovik
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Charlestown, MA 02129, USA
    Radiology 251:309-10. 2009
    ..The well-conducted and valuable study reported by Amirbekian et al in this issue of Radiology adds further momentum to this important endeavor...
  10. pmc Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    Circ Cardiovasc Imaging 2:206-12. 2009
    ..Unlike diffusion tensor imaging, DSI tractography resolves multiple myofiber populations per voxel, thus generating accurate 3D tractograms, which we present in the myocardium for the first time...
  11. pmc Diffusion MR tractography of the heart
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA
    J Cardiovasc Magn Reson 11:47. 2009
    ..The application of DSI in ischemic heart disease is reviewed, and the requisites for widespread clinical translation of diffusion MR tractography in the heart are discussed...
  12. ncbi request reprint Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 115:1384-91. 2007
    ....
  13. pmc Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia
    David E Sosnovik
    Center for Molecular Imaging Research, The Cardiology Division, Martinos Center for Biomedical Imaging, and the Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston Mass, USA
    Circ Cardiovasc Imaging 2:460-7. 2009
    ..The technique uses the annexin-based nanoparticle AnxCLIO-Cy5.5 (apoptosis) and simultaneous delayed-enhancement imaging with a novel gadolinium chelate, Gd-DTPA-NBD (necrosis)...
  14. ncbi request reprint Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Magn Reson Med 54:718-24. 2005
    ..1 versus 1.1, P<0.01). This study thus demonstrates the feasibility of obtaining high-resolution MR images of cardiomyocyte apoptosis in vivo with the novel nanoparticle, AnxCLIO-Cy5.5...
  15. ncbi request reprint Emerging concepts in molecular MRI
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Curr Opin Biotechnol 18:4-10. 2007
    ..These and other advances in molecular MRI offer great promise for the future and have significant potential for clinical translation...
  16. ncbi request reprint Magnetic resonance and fluorescence based molecular imaging technologies
    David Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Fruit Street, Boston, MA 02114, USA
    Prog Drug Res 62:83-115. 2005
  17. ncbi request reprint Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
    Circulation 115:377-86. 2007
    ..Visualizing early changes in valvular cell functions in vivo may predict the future risk and identify therapeutic targets for prevention of aortic valve stenosis...
  18. ncbi request reprint Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials
    Farouc A Jaffer
    Harvard Medical School, Charlestown, MA 02129, USA
    Mol Imaging 5:85-92. 2006
    ..To better understand their cellular targeting and imaging capabilities in atherosclerosis, we investigated prototypical dextran-coated near-infrared fluorescent MFNPs in the apolipoprotein E-deficient (apo E-/-) mouse model...
  19. pmc Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Circulation 117:1153-60. 2008
    ..We hypothesized that MPO imaging could be used to measure inflammatory responses after myocardial ischemia locally and noninvasively in a murine model...
  20. ncbi request reprint Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circ Res 100:1218-25. 2007
    ..Spectrally resolved imaging agents allow for simultaneous assesment of key processes of in vivo cellular functions. Specifically, we show that in vivo FMT detects impaired healing in FXIII-/- mice...
  21. ncbi request reprint Magneto/optical annexin V, a multimodal protein
    Eyk A Schellenberger
    Center for Molecular Imaging Research, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Bioconjug Chem 15:1062-7. 2004
    ..4 nM). Our conjugation strategy preserves the strength of the interaction between annexin V and apoptotic cells, while yielding a probe, Anx-CLIO-Cy5.5, that is readily detectable by standard MR imaging or NIRF optical methods...
  22. pmc A 128-channel receive-only cardiac coil for highly accelerated cardiac MRI at 3 Tesla
    Melanie Schmitt
    Department of Radiology, A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 59:1431-9. 2008
    ..The ability of the 128-channel coil to facilitate highly accelerated cardiac imaging was demonstrated in four volunteers using acceleration factors up to seven-fold (R=7) in a single spatial dimension...
  23. pmc High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA
    Am J Physiol Heart Circ Physiol 292:H3172-8. 2007
    ..This efficient imaging tool is a valuable addition to the current phenotyping armamentarium and will allow rapid testing of novel drugs and cell-based interventions in murine models...
  24. ncbi request reprint Multiparameter magnetic relaxation switch assays
    Sonia Taktak
    Center for Molecular Imaging Research and Department of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Anal Chem 79:8863-9. 2007
    ..The T1/T2 and T2 replication interrogation methods illustrate how MRSw assays can employ multiple parameters, instead of relying only on T2, to obtain information about the reaction of NPs with molecular targets...
  25. doi request reprint Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 5406, Charlestown, MA 02129, USA
    Eur Heart J 29:445-54. 2008
    ..Here we assess the impact of transglutaminase-modulating therapies on healing and evolution of heart failure using a novel, non-invasive molecular imaging technique...
  26. ncbi request reprint Molecular imaging of myocardial infarction
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Mol Cell Cardiol 41:921-33. 2006
    ....
  27. pmc Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure
    David E Sosnovik
    Center for Molecular Imaging Research, The Cardiology Division, and Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Masss, USA
    Circ Cardiovasc Imaging 2:468-75. 2009
    ..The myocardium in heart failure, however, is characterized by very low levels of CM apoptosis and normal vascular permeability, factors thought to preclude the use of molecular MRI...
  28. pmc Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging
    Christian T Farrar
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    NMR Biomed 21:453-63. 2008
    ..The optimal performance of ORI will thus likely be seen at low fields, with moderate MION concentrations and with sequences containing very short TEs...
  29. pmc Targeted imaging of myocardial damage
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, MA 02129, USA
    Nat Clin Pract Cardiovasc Med 5:S63-70. 2008
    ..The use of targeted imaging agents in the myocardium has the potential to provide valuable insights into the pathophysiology of myocardial injury and to facilitate the development of novel therapeutic strategies...
  30. pmc MR-optical imaging of cardiovascular molecular targets
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA
    Basic Res Cardiol 103:87-94. 2008
    ..We discuss strengths and limitations of respective imaging technologies, and comment on the potential of multi-modality imaging approaches...
  31. ncbi request reprint Acute myocardial infarction: contrast-enhanced multi-detector row CT in a porcine model
    Udo Hoffmann
    Department of Radiology, Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, 100 Charles River Plaza, Suite 400, Boston, MA 02114, USA
    Radiology 231:697-701. 2004
    ....
  32. pmc Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction
    Florian Leuschner
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, USA
    Circ Res 107:1364-73. 2010
    ..Monocytes recruited to ischemic myocardium originate from a reservoir in the spleen, and the release from their splenic niche relies on angiotensin (Ang) II signaling...
  33. ncbi request reprint Measurement of radial artery contrast intensity to assess cardiac microbubble behavior
    David E Sosnovik
    Cardiac Ultrasound Laboratory, Massachusetts Genral Hospital, Harvard Medical School, Boston, 02114, USA
    J Am Soc Echocardiogr 16:1267-73. 2003
    ..We sought to determine whether analysis of the contrast signal from the radial artery is better able to reflect changes in left ventricular (LV) microbubble dynamics than the signal from the LV itself...
  34. pmc Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Circulation 117:379-87. 2008
    ....
  35. ncbi request reprint Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circulation 114:1504-11. 2006
    ....
  36. ncbi request reprint Non-invasive imaging of plaque vulnerability: an important tool for the assessment of agents to stabilise atherosclerotic plaques
    David E Sosnovik
    Division of Cardiology, CIMIT Massachusetts General Hospital, Boston, MA 02114, USA
    Expert Opin Investig Drugs 11:693-704. 2002
    ..This knowledge will be extremely important for physicians and scientists involved in the clinical evaluation of novel agents to stabilise the vulnerable plaque...
  37. pmc Off-resonance angiography: a new method to depict vessels--phantom and rabbit studies
    Grigorios Korosoglou
    Russell H Morgan Department of Radiology and Radiological Science, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Radiology 249:501-9. 2008
    ..0-T imager. Signal-to-noise and contrast-to-noise ratios were measured in the aorta of rabbits in vivo. Venous blood was obtained from the rabbits before and after MION-47 injection for use in phantom studies...
  38. pmc Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using "positive contrast" magnetic resonance imaging
    Grigorios Korosoglou
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Am Coll Cardiol 52:483-91. 2008
    ....
  39. ncbi request reprint Effects of region-of-interest length on estimates of myocardial ultrasonic attenuation and backscatter
    Steven L Baldwin
    Washington University, St Louis, Missouri 63130, USA
    Med Phys 32:418-26. 2005
    ..Statistically significant differences were observed for measurements utilizing the ROI lengths as short as 0.4 cm with corresponding progressively increasing areas under the ROC curves for increasing ROI lengths. [NIH R37 HL40302]..

Research Grants5

  1. Magnetic Resonance Imaging of Cardiomyocyte Apoptosis
    David Sosnovik; Fiscal Year: 2007
    ..The proposed research also has the potential to facilitate a greater understanding of cardiomyocyte apoptosis and accelerate the development of novel cardioprotective strategies. ..
  2. Molecular and Microstructural Imaging of Cardiomyocyte Apoptosis and Autophagy
    David E Sosnovik; Fiscal Year: 2010
    ..The development of such strategies has the potential to significantly reduce the rapidly rising number of patients with heart failure, and is thus of major clinical and public health significance. ..
  3. Molecular and Microstructural Imaging of Cardiomyocyte Apoptosis and Autophagy
    David Sosnovik; Fiscal Year: 2009
    ..The development of such strategies has the potential to significantly reduce the rapidly rising number of patients with heart failure, and is thus of major clinical and public health significance. ..