David Sosnovik


Affiliation: Harvard University
Country: USA


  1. request reprint
    Sosnovik D, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, et al. Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation. 2007;115:1384-91 pubmed
    ..The techniques developed could also be used to image other existing fluorescent and magnetofluorescent probes and could significantly expand the role of fluorescence imaging in the heart. ..
  2. Sosnovik D, Wang R, Dai G, Wang T, Aikawa E, Novikov M, et al. Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium. Circ Cardiovasc Imaging. 2009;2:206-12 pubmed publisher
    ..DSI tractography thus provides a new and important readout of tissue injury after myocardial infarction. ..
  3. Sosnovik D, Garanger E, Aikawa E, Nahrendorf M, Figuiredo J, Dai G, et al. Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia. Circ Cardiovasc Imaging. 2009;2:460-7 pubmed publisher
    ..Strategies to salvage the numerous apoptotic but potentially viable cardiomyocytes in the midmyocardium in acute ischemia should be investigated. ..
  4. Panagia M, Chen H, Croteau D, Iris Chen Y, Ran C, Luptak I, et al. Multiplexed Optical Imaging of Energy Substrates Reveals That Left Ventricular Hypertrophy Is Associated With Brown Adipose Tissue Activation. Circ Cardiovasc Imaging. 2018;11:e007007 pubmed publisher
    ..The activation of brown adipose tissue occurs early in the onset of left ventricular hypertrophy, which produces tissue-specific changes in substrate uptake that may play a role in the systemic response to cardiac pressure overload. ..
  5. Goergen C, Chen H, Sakadzic S, Srinivasan V, Sosnovik D. Microstructural characterization of myocardial infarction with optical coherence tractography and two-photon microscopy. Physiol Rep. 2016;4: pubmed publisher
    ..Catheter-based approaches to segment and image myocardial microstructure in humans are feasible and could play a valuable role in guiding the development of strategies to improve infarct healing. ..
  6. Dos Santos Ferreira D, Jesus de Oliveira Pinto B, Kumar V, Cardoso V, Fernandes S, Souza C, et al. Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice. Nanomedicine. 2017;13:1693-1701 pubmed publisher
    ..Bone-targeted, pH-sensitive, doxorubicin containing liposomes represent a promising approach to selectively delivering doxorubicin to bone tumors while minimizing cardiac toxicity. ..