Research Topics
| ALMA GREGORY contact SORENSENSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusionA Gregory Sorensen
AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
Cancer Res 72:402-7. 2012..Together, our findings offer direct clinical evidence in support of the hypothesis that vascular normalization can increase tumor perfusion and help improve patient survival...- Stability of large diffusion/perfusion mismatch in anterior circulation strokes for 4 or more hoursR Gilberto Gonzalez
Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Boston, Harvard Medical School, Boston, MA 02114, USA
BMC Neurol 10:13. 2010..The purpose of this study was to determine the persistence of a diffusion/perfusion mismatch in patients with ICA or proximal MCA occlusions... 
Human acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imagingA G Sorensen
Department of Radiology, Massachusetts General Hospital, Boston, USA
Radiology 212:785-92. 1999..To (a) determine the optimal choice of a scalar metric of anisotropy and (b) determine by means of magnetic resonance imaging if changes in diffusion anisotropy occurred in acute human ischemic stroke...- Future prospects for fMRI in the clinicA Gregory Sorensen
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School Massachusetts Institute of Technology, Boston, Massachusetts, USA
J Magn Reson Imaging 23:941-4. 2006..Diagnostic imaging will always be linked in the clinic to therapeutic choices, and therefore the most powerful approach to link fMRI more directly to the clinic will be to tie fMRI to therapy development and implementation... 
Response criteria for gliomaA Gregory Sorensen
Harvard Medical School, Boston, MA, USA
Nat Clin Pract Oncol 5:634-44. 2008....- Advances in imaging 2007A Gregory Sorensen
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Stroke 39:276-8. 2008 - A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patientsA Gregory Sorensen
A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02114, USA
Cancer Res 69:5296-300. 2009..54; P = 0.004) and progression-free survival (rho = 0.6; P = 0.001). The vascular normalization index described here should be validated in randomized clinical trials... - Advances in imaging 2009A Gregory Sorensen
Department of Neuroradiology, Massachusetts General Hospital, Boston, Mass, USA
Stroke 41:e91-2. 2010..We will briefly cover each of these in turn... - Magnetic resonance as a cancer imaging biomarkerA Gregory Sorensen
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
J Clin Oncol 24:3274-81. 2006.... - Comparison of diameter and perimeter methods for tumor volume calculationA G Sorensen
MGH NMR Center and Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Clin Oncol 19:551-7. 2001..We sought to compare the common method of using orthogonal diameters to estimate lesion volume (the diameter method) with a computer-assisted planimetric technique (the perimeter method)... - Strategies for improving the detection of fMRI activation in trigeminal pathways with cardiac gatingWei Ting Zhang
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, and Harvard Medical School, Bldg 149 2301, 13th Street, Charlestown, MA 02129, USA
Neuroimage 31:1506-12. 2006..Activation in the brainstem and the thalamus was best detected by cardiac-gated dual-echo EPI... - Real-time RF pulse adjustment for B0 drift correctionThomas Benner
Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
Magn Reson Med 56:204-9. 2006..The proposed method corrects for apparent image shift and ensures continuously effective fat saturation over the duration of an acquisition... - Comparison of manual and automatic section positioning of brain MR imagesThomas Benner
Department of Radiology and General Clinical Research Center, Massachusetts General Hospital, Athinoula A Martinos Center, Harvard Medical School, 149 13th St, Rm 2301, Charlestown, MA 02129, USA
Radiology 239:246-54. 2006..001). Automatic section prescription leads to improved reproducibility of imaging orientations for intra- and intersubject series in clinical practice... - Intraoperative visualization of the pyramidal tract by diffusion-tensor-imaging-based fiber trackingChristopher Nimsky
Department of Neurosurgery, University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
Neuroimage 30:1219-29. 2006..Intraoperative visualization of major white matter tracts allows save resection of gliomas near eloquent brain areas. A possible shifting of the pyramidal tract has to be taken into account after major tumor parts are resected... - Technical aspects of perfusion-weighted imagingOna Wu
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Neuroimaging Clin N Am 15:623-37, xi. 2005..Understanding the technical aspects of PWI may improve comprehension of the capabilities and limitations of this technique... - Imaging biomarkers predictive of disease/therapy outcome: ischemic stroke and drug developmentJanet C Miller
MGH-HST Center for Biomarkers in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
Prog Drug Res 62:319-56. 2005 - Relaxation-compensated fast multislice amide proton transfer (APT) imaging of acute ischemic strokePhillip Zhe Sun
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Magn Reson Med 59:1175-82. 2008..In summary, our study has established a fast volumetric pH-weighted APT imaging technique, allowing further investigation to fully evaluate its diagnostic power... - On-line automatic slice positioning for brain MR imagingAndre J W van der Kouwe
Department of Radiology, MGH, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Neuroimage 27:222-30. 2005..Translations and rotations relative to the atlas can be set so that planning can be done in anatomical space, rather than scanner coordinates, and stored as part of the protocol allowing standardization of slice orientations... - Automated perfusion-weighted MRI using localized arterial input functionsCory Lorenz
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Division of Health Sciences and Technology, Harvard/MIT, Charlestown, Massachusetts 08129, USA
J Magn Reson Imaging 24:1133-9. 2006..Similarly, the local MTT lesion volumes had the least mean squared error (MSE). CONCLUSION: Automated CBF calculation using local AIFs is feasible and appears to produce more useful CBF maps... - AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patientsTracy T Batchelor
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Cancer Cell 11:83-95. 2007..Our study provides insight into different mechanisms of action of this class of drugs in recurrent glioblastoma patients and suggests that the timing of combination therapy may be critical for optimizing activity against this tumor... - Magnetic resonance spectroscopy study of oxygen therapy in ischemic strokeAneesh B Singhal
Stroke 38:2851-4. 2007..N-acetyl-aspartate decreased in patients receiving room air but not in NBO-treated patients. CONCLUSIONS: These data suggest that NBO improves aerobic metabolism and preserves neuronal integrity in the ischemic brain... - Perfusion MR imaging: moving forwardA Gregory Sorensen
Radiology 249:416-7. 2008 - Imaging pH using the chemical exchange saturation transfer (CEST) MRI: Correction of concomitant RF irradiation effects to quantify CEST MRI for chemical exchange rate and pHPhillip Zhe Sun
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Magn Reson Med 60:390-7. 2008.... - Physiological noise in MR images: an indicator of the tissue response to ischemia?Harris H Wang
Medical Engineering Medical Physics Program, Division of Health Sciences and Technology, Harvard University Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
J Magn Reson Imaging 27:866-71. 2008..To determine whether measuring signal intensity (SI) fluctuations in MRI time series data from acute stroke patients would identify ischemic tissue... - Severity of leukoaraiosis and susceptibility to infarct growth in acute strokeHakan Ay
A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Stroke 39:1409-13. 2008..We hypothesized that the volume of LA correlated with the proportion of initially ischemic but eventually infarcted tissue in acute human stroke... - Interexaminer difference in infarct volume measurements on MRI: a source of variance in stroke researchHakan Ay
Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown MA 02129, USA
Stroke 39:1171-6. 2008..We sought to quantify the variance imposed by measurement error in DWI and PWI lesion volume measurements in ischemic stroke... - Correction for artifacts induced by B(0) and B(1) field inhomogeneities in pH-sensitive chemical exchange saturation transfer (CEST) imagingPhillip Zhe Sun
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
Magn Reson Med 58:1207-15. 2007..In addition, the proposed algorithm was verified with both numerical simulation and experimental measurements, and showed nearly complete correction of CEST imaging measurement errors caused by moderate field inhomogeneity... - Angiogenesis in brain tumoursRakesh K Jain
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA
Nat Rev Neurosci 8:610-22. 2007..This creates a window of opportunity for optimally combining chemotherapeutics and radiation... - Using the wild bootstrap to quantify uncertainty in diffusion tensor imagingBrandon Whitcher
Clinical Imaging Centre, GlaxoSmithKline, Hammersmith Hospital, London, UK
Hum Brain Mapp 29:346-62. 2008..The wild bootstrap method can provide empirical distributions for tensor-derived quantities, such as fractional anisotropy and principal eigenvector direction, even when the exact distributions are not easily derived... - Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRICaterina Mainero
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 35:1201-10. 2007..These results indicate that the pain modulatory system is involved to a different extent during primary versus secondary mechanical allodynia... - Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validationJuliette Selb
Massachusetts General Hospital, Athinoula A Martinos Center, Photon Migration Imaging Laboratory, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
J Biomed Opt 10:11013. 2005..Finally, we use the time-gated measurements to resolve in depth the brain activation during the motor stimulus... - Applying instance-based techniques to prediction of final outcome in acute strokeChristian Gottrup
DIMAC A S, Højbjerg, Denmark
Artif Intell Med 33:223-36. 2005..This requires an accurate prediction of the extent of infarction if untreated. In this study, we investigate the applicability of highly flexible instance-based (IB) methods for such predictions... - Effects of tracer arrival time on flow estimates in MR perfusion-weighted imagingOna Wu
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology Harvard Medical School, Boston, 02129, USA
Magn Reson Med 50:856-64. 2003..These conditions may occur in practice due to the application of a user-selected AIF that is not the "true AIF" and therefore caution must be taken in interpreting CBF and MTT estimates... - Perfusion-weighted magnetic resonance imaging of the brain: techniques and application in childrenThierry A G M Huisman
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Eur Radiol 14:59-72. 2004..The normal developmental changes of the cerebral haemodynamics in children as measured by PWI are presented as well as the application of PWI in cerebral ischaemia, primary and secondary cerebral vasculopathies and in cerebral tumours... - Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathyKei Yamada
Massachusetts General Hospital NMR Center, Harvard Medical School, Boston, USA
Stroke 33:87-94. 2002..Steno-occlusive disease in the parent vessels is another factor that may affect the results of the PWI. The purpose of this study was to elucidate the effect of the calculation methods and underlying vasculopathy on PWI... - Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrixOna Wu
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Boston, Massachusetts 02129, USA
Magn Reson Med 50:164-74. 2003..Shift maps can continue to provide a sensitive reflection of disturbed hemodynamics... - Guidelines and recommendations for perfusion imaging in cerebral ischemia: A scientific statement for healthcare professionals by the writing group on perfusion imaging, from the Council on Cardiovascular Radiology of the American Heart AssociationRichard E Latchaw
Stroke 34:1084-104. 2003 - Biomarkers in imaging: realizing radiology's futureJohn J Smith
Department of Radiology and MGH Center for Biomarkers in Imaging, Massachusetts General Hospital, 15 Parkman St, WACC 515, Boston, MA 02114, USA
Radiology 227:633-8. 2003..By applying this paradigm to the array of imaging modalities, the radiology community is poised to become a major force in preclinical and clinical evaluations of new medical treatments... - Assessing tissue viability with MR diffusion and perfusion imagingPamela W Schaefer
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
AJNR Am J Neuroradiol 24:436-43. 2003..ADC, DW intensity, FA, and rCBV ratios may provide adjunctive information... - Diffusion-weighted imaging for the evaluation of diffuse axonal injury in closed head injuryThierry A G M Huisman
Department of Radiology, Neuroradiology Section, and MGH NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown Boston, USA
J Comput Assist Tomogr 27:5-11. 2003..The purpose of this work was to compare diffusion-weighted imaging (DWI) with conventional MRI in the detection of shearing injuries in acute closed head injuries... - Predicting cerebral ischemic infarct volume with diffusion and perfusion MR imagingPamela W Schaefer
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
AJNR Am J Neuroradiol 23:1785-94. 2002..Diffusion and perfusion MR imaging have proved useful in the assessment of acute stroke. We evaluated the utility of these techniques in detecting acute ischemic infarction and in predicting final infarct size... - Iron-induced susceptibility effect at the globus pallidus causes underestimation of flow and volume on dynamic susceptibility contrast-enhanced MR perfusion imagesKei Yamada
Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto City, Japan
AJNR Am J Neuroradiol 23:1022-9. 2002..Little variance in the measured mean transit time was noted. CONCLUSION: Iron-induced susceptibility effect may lead to underestimation of relative cerebral blood flow and relative cerebral blood volume in the basal ganglia... - The potential of proton magnetic resonance spectroscopy ((1)H-MRS) in the diagnosis and management of patients with brain tumorsXavier Leclerc
NMR Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
Curr Opin Oncol 14:292-8. 2002..Some persistent drawbacks, including measurement time and spectral resolution, will probably be overcome in the near future... - Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imagingJames M Provenzale
Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
AJR Am J Roentgenol 178:711-6. 2002..CONCLUSION: Permeability values for high-grade tumors obtained using a T2(*)-weighted method were significantly greater than those for low-grade tumors and are consistent with previous studies reporting results using T1-weighted methods... - Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injuryThierry A G M Huisman
MGH-NMR Center, Division of Neuroradiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
AJNR Am J Neuroradiol 25:370-6. 2004..CONCLUSION: DTI reveals changes in the white matter that are correlated with both acute GCS and Rankin scores at discharge. DTI may be a valuable biomarker for the severity of tissue injury and a predictor for outcome... - Imaging angiogenesis: applications and potential for drug developmentJanet C Miller
Department of Radiology, Massachusetts General Hospital, 100 Charles River Plaza, Boston, MA 02114, USA
J Natl Cancer Inst 97:172-87. 2005..Finally, we discuss which imaging methods are most likely to have the sensitivity and reliability required for monitoring responses to cancer therapy and describe ways in which imaging has been used in clinical trials to date... - Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI studyNikos Makris
Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
Cereb Cortex 15:854-69. 2005..Since DT-MRI allows the precise definition of only the stem portion of each fiber pathway, the origin and termination of the subdivisions of SLF are extrapolated from the available data in experimental material from non-human primates... - Using imaging biomarkers to accelerate drug development and clinical trialsHomer H Pien
Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Drug Discov Today 10:259-66. 2005..We conclude with some remarks concerning new developments that will be required to significantly advance the field of pharmaco-imaging... - Diffusion tensor magnetic resonance imaging of brain tumorsL Celso Hygino Cruz Júnior
Clinica de Diagnostico por Imagem, Multi Imagem Ressonância Magnética, Av das Ameréricas 4666, Centro Médico BarraShopping, Rio de Janeiro, Brazil
Neurosurg Clin N Am 16:115-34. 2005..Furthermore, evaluation of the response to treatment with chemotherapy and radiation therapy might also be possible. Although DTI has some limitations, its active investigation and further study are clearly warranted... - Diffusion-weighted MR imaging in closed head injury: high correlation with initial glasgow coma scale score and score on modified Rankin scale at dischargePamela W Schaefer
Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Gray B285, Boston, MA 02114, USA
Radiology 233:58-66. 2004..To determine whether diffusion-weighted magnetic resonance (MR) imaging findings and conventional MR imaging findings correlate with initial Glasgow Coma Scale score and score on modified Rankin scale at discharge... - MRI measurements of water diffusion: impact of region of interest selection on ischemic quantificationYelda Ozsunar
Department of Radiology, School of Medicine, Adnan Menderes University, Aydin 09100, Turkey
Eur J Radiol 51:195-201. 2004..To investigate the effect of ADC heterogeneity on region of interest (ROI) measurement of isotropic and anisotropic water diffusion in acute (< 12 h) cerebral infarctions... - Characterization and evolution of diffusion MR imaging abnormalities in stroke patients undergoing intra-arterial thrombolysisPamela W Schaefer
Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
AJNR Am J Neuroradiol 25:951-7. 2004..ADC values, ADC ratios, and DWI ratios may be useful in identifying the portion of abnormal tissue that is potentially salvageable after reperfusion therapy... - A pilot study of normobaric oxygen therapy in acute ischemic strokeAneesh B Singhal
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Stroke 36:797-802. 2005..Therapies that transiently prevent ischemic neuronal death can potentially extend therapeutic time windows for stroke thrombolysis. We conducted a pilot study to investigate the effects of high-flow oxygen in acute ischemic stroke... - An evidence-based causative classification system for acute ischemic strokeHakan Ay
A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Ann Neurol 58:688-97. 2005..The SSS-TOAST is a dynamic algorithm that can accommodate modifications as new epidemiological data accumulate and diagnostic techniques advance... - Summary statement novel agents in the treatment of lung cancer: Fifth Cambridge Conference assessing opportunities for combination therapyThomas J Lynch
Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA
J Thorac Oncol 3:S107-12. 2008..A CME activity based on this summary is also available at www.informedicalcme.com/cme... - Transient ischemic attack with infarction: a unique syndrome?Hakan Ay
Department of A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Radiology, Boston, MA 02129, USA
Ann Neurol 57:679-86. 2005..3% in those with ischemic stroke. TIA with infarction appears to have unique features separate from TIA without infarction and ischemic stroke. We propose identifying TSI as a separate clinical syndrome with distinct prognostic features... - Conversion of ischemic brain tissue into infarction increases with ageHakan Ay
The AA Martinos Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Stroke 36:2632-6. 2005..We hypothesize that age is a marker for tissue susceptibility to ischemia and thus plays a role in determining tissue outcome in human stroke... - Diffusion magnetic resonance imaging of acute ischemic strokePamela W Schaefer
Neuroradiology Division, Stroke Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Semin Roentgenol 37:219-29. 2002 - CT and conventional and diffusion-weighted MR imaging in acute stroke: study in 691 patients at presentation to the emergency departmentMark E Mullins
Neuroradiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, GRB285, Boston, MA 02114, USA
Radiology 224:353-60. 2002..After 12 hours, accuracy was equivalent. CONCLUSION: In the diagnosis of stroke in the early period (<12 hours after presentation), DW MR imaging is superior to conventional MR imaging and CT... - Evolution of water diffusion and anisotropy in hyperacute stroke: significant correlation between fractional anisotropy and T2Yelda Ozsunar
Department of Radiology, School of Medicine, Adnan Menderes University, Aydin, Turkey
AJNR Am J Neuroradiol 25:699-705. 2004..CONCLUSION: Change in FA is inversely correlated with T2 signal intensity and, to a lesser extent, the time of onset, but it is not well correlated with ADC values in the acute stage... - Do highly concentrated gadolinium chelates improve MR brain perfusion imaging? Intraindividually controlled randomized crossover concentration comparison study of 0.5 versus 1.0 mol/L gadobutrolBernd Tombach
Dept of Clinical Radiology, Univ of Münster, Albert Schweitzer Strasse 33, D 48129 Munster, Germany
Radiology 226:880-8. 2003..To assess the potential advantages of using a 1.0 mol/L versus 0.5 mol/L gadobutrol formulation for magnetic resonance (MR) brain perfusion imaging... - Preoperative and intraoperative diffusion tensor imaging-based fiber tracking in glioma surgeryChristopher Nimsky
Department of Neurosurgery, University Erlangen Nurnberg, Erlangen, Germany
Neurosurgery 56:130-7; discussion 138. 2005..To investigate the intraoperative displacement of major white matter tracts during glioma resection by comparing preoperative and intraoperative diffusion tensor imaging-based fiber tracking... - Middle cerebral artery infarcts encompassing the insula are more prone to growthHakan Ay
Department of Neurology, A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Stroke 39:373-8. 2008.... - Intraoperative diffusion-tensor MR imaging: shifting of white matter tracts during neurosurgical procedures--initial experienceChristopher Nimsky
Department of Neurosurgery, University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
Radiology 234:218-25. 2005..To prospectively evaluate the location of white matter tracts with diffusion-tensor imaging (DTI) during neurosurgical procedures... - A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke SystemHakan Ay
AA Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Stroke 38:2979-84. 2007..In this article, we present an automated version of the SSS-TOAST, the Causative Classification System (CCS), to facilitate its utility in multicenter settings... - Robust inference of baseline optical properties of the human head with three-dimensional segmentation from magnetic resonance imagingAlex H Bamett
Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Appl Opt 42:3095-108. 2003..We sample from the exact posterior and show robustness to numerical model error. This opens up the possibility of simultaneous DOT and MR for quantitative cortically constrained functional neuroimaging... - Effect of using local arterial input functions on cerebral blood flow estimationCory Lorenz
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA
J Magn Reson Imaging 24:57-65. 2006..CONCLUSION: The local-AIF technique results in an increase in the calculated CBF values for tissues with D/D, consistent with a reduction in the errors associated with D/D... - The real estate factor: quantifying the impact of infarct location on stroke severityNina M Menezes
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and the Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Boston, MA, USA
Stroke 38:194-7. 2007..In the current study, we sought to quantify the impact of location on neurological deficit severity and to delineate this impact from that of volume... - Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRIJonathan J Wisco
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149 13th Street, Room 2301, Charlestown, MA 02129, United States
Schizophr Res 94:317-27. 2007..0352). We discuss these findings in relation to the neurodevelopmental hypothesis and language dysfunction in schizophrenia...
Research Grants
- Silicon Graphics Prism Extreme 128P/1TBALMA SORENSEN; Fiscal Year: 2006....
- 7T Translational MRI SystemALMA SORENSEN; Fiscal Year: 2007..We list 24 funded projects in support of this additional instrumentation. ..
- MRI DIFFUSION/PERFUSION MISMATCH IN HUMAN ACUTE STROKEALMA SORENSEN; Fiscal Year: 2007....
- Toward Multi-Center MR Brain PerfusionALMA GREGORY SORENSEN; Fiscal Year: 2010..This will enable this technique to become more widely available and more appropriately establish its benefit to patients. ..
- Quantitative MR-PET for Therapy Assessment in Glioma PatientsALMA GREGORY contact SORENSEN; Fiscal Year: 2010..In this work we validate this new technology and explore its potential utility for the quantitative assessment of therapy response in glioma patients. ..
- Nuclear Magnetic ResonanceALMA SORENSEN; Fiscal Year: 2006..D. and Ph.D. scientists for the biomedical NMR research community. ..
- High Resolution PET Camera for Brain ImagingALMA SORENSEN; Fiscal Year: 2006..Placement of the HRRT in the proposed environment will provide a unique facility to advance brain imaging research that in turn will provide insights for a variety of illnesses and biomedical questions. ..
- MRI DIFFUSION/PERFUSION MISMATCH IN HUMAN ACUTE STROKEALMA SORENSEN; Fiscal Year: 2003..Our long-term goal is the development of a tool that can be used to guide clinical practice and to quantitatively evaluate novel therapies. ..
- A 3.0 Tesla MRI System in a Neuroscience ICUALMA SORENSEN; Fiscal Year: 2004..Since these subjects are difficult to bring to the instrumentation, we seek to gain these insights by bringing the instrumentation to them. The proposed instrument will bring state-of-the-art performance to a unique setting. ..
- Imaging Biomarkers for Cancer Drug DevelopmentALMA SORENSEN; Fiscal Year: 2004..The planning grant revolves around three aims: to confer a multidisciplinary partnership to work towards this goal; to select a set of demonstration projects, and to develop an operating plan for the partnership. ..
- Imaging Archive for Magnetic Resonance Imaging SystemsALMA SORENSEN; Fiscal Year: 2005..Overall, this needed resource will greatly facilitate many NIH-funded investigators and investigations for years to come. ..
- MRI DIFFUSION/PERFUSION MISMATCH IN HUMAN ACUTE STROKEALMA SORENSEN; Fiscal Year: 2005..Incorporating genetic and imaging information together could greatly strengthen the relevance and immediacy of each. ..
- Sharing canonical human stroke dataOna Wu; Fiscal Year: 2010..Linking our existing portals with BIRN resources has the potential to greatly facilitate data sharing which will benefit the understanding of stroke and speed discovery of new therapeutic interventions. ..