ALMA GREGORY contact SORENSEN

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion
    A Gregory Sorensen
    AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cancer Res 72:402-7. 2012
  2. pmc Stability of large diffusion/perfusion mismatch in anterior circulation strokes for 4 or more hours
    R Gilberto Gonzalez
    Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Boston, Harvard Medical School, Boston, MA 02114, USA
    BMC Neurol 10:13. 2010
  3. ncbi request reprint Human acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imaging
    A G Sorensen
    Department of Radiology, Massachusetts General Hospital, Boston, USA
    Radiology 212:785-92. 1999
  4. ncbi request reprint Future prospects for fMRI in the clinic
    A Gregory Sorensen
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School Massachusetts Institute of Technology, Boston, Massachusetts, USA
    J Magn Reson Imaging 23:941-4. 2006
  5. doi request reprint Response criteria for glioma
    A Gregory Sorensen
    Harvard Medical School, Boston, MA, USA
    Nat Clin Pract Oncol 5:634-44. 2008
  6. doi request reprint Advances in imaging 2007
    A Gregory Sorensen
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Stroke 39:276-8. 2008
  7. pmc A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients
    A Gregory Sorensen
    A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Res 69:5296-300. 2009
  8. doi request reprint Advances in imaging 2009
    A Gregory Sorensen
    Department of Neuroradiology, Massachusetts General Hospital, Boston, Mass, USA
    Stroke 41:e91-2. 2010
  9. ncbi request reprint Magnetic resonance as a cancer imaging biomarker
    A Gregory Sorensen
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    J Clin Oncol 24:3274-81. 2006
  10. ncbi request reprint Comparison of diameter and perimeter methods for tumor volume calculation
    A G Sorensen
    MGH NMR Center and Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Clin Oncol 19:551-7. 2001

Research Grants

  1. Silicon Graphics Prism Extreme 128P/1TB
    ALMA SORENSEN; Fiscal Year: 2006
  2. 7T Translational MRI System
    ALMA SORENSEN; Fiscal Year: 2007
  3. MRI DIFFUSION/PERFUSION MISMATCH IN HUMAN ACUTE STROKE
    ALMA SORENSEN; Fiscal Year: 2007
  4. Toward Multi-Center MR Brain Perfusion
    ALMA GREGORY SORENSEN; Fiscal Year: 2010
  5. Quantitative MR-PET for Therapy Assessment in Glioma Patients
    ALMA GREGORY contact SORENSEN; Fiscal Year: 2010
  6. Nuclear Magnetic Resonance
    ALMA SORENSEN; Fiscal Year: 2006
  7. High Resolution PET Camera for Brain Imaging
    ALMA SORENSEN; Fiscal Year: 2006
  8. MRI DIFFUSION/PERFUSION MISMATCH IN HUMAN ACUTE STROKE
    ALMA SORENSEN; Fiscal Year: 2003
  9. A 3.0 Tesla MRI System in a Neuroscience ICU
    ALMA SORENSEN; Fiscal Year: 2004
  10. Imaging Biomarkers for Cancer Drug Development
    ALMA SORENSEN; Fiscal Year: 2004

Collaborators

Detail Information

Publications69

  1. pmc Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion
    A Gregory Sorensen
    AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cancer Res 72:402-7. 2012
    ..Together, our findings offer direct clinical evidence in support of the hypothesis that vascular normalization can increase tumor perfusion and help improve patient survival...
  2. pmc Stability of large diffusion/perfusion mismatch in anterior circulation strokes for 4 or more hours
    R Gilberto Gonzalez
    Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Boston, Harvard Medical School, Boston, MA 02114, USA
    BMC Neurol 10:13. 2010
    ..The purpose of this study was to determine the persistence of a diffusion/perfusion mismatch in patients with ICA or proximal MCA occlusions...
  3. ncbi request reprint Human acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imaging
    A G Sorensen
    Department of Radiology, Massachusetts General Hospital, Boston, USA
    Radiology 212:785-92. 1999
    ..To (a) determine the optimal choice of a scalar metric of anisotropy and (b) determine by means of magnetic resonance imaging if changes in diffusion anisotropy occurred in acute human ischemic stroke...
  4. ncbi request reprint Future prospects for fMRI in the clinic
    A Gregory Sorensen
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School Massachusetts Institute of Technology, Boston, Massachusetts, USA
    J Magn Reson Imaging 23:941-4. 2006
    ..Diagnostic imaging will always be linked in the clinic to therapeutic choices, and therefore the most powerful approach to link fMRI more directly to the clinic will be to tie fMRI to therapy development and implementation...
  5. doi request reprint Response criteria for glioma
    A Gregory Sorensen
    Harvard Medical School, Boston, MA, USA
    Nat Clin Pract Oncol 5:634-44. 2008
    ....
  6. doi request reprint Advances in imaging 2007
    A Gregory Sorensen
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Stroke 39:276-8. 2008
  7. pmc A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients
    A Gregory Sorensen
    A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Res 69:5296-300. 2009
    ..54; P = 0.004) and progression-free survival (rho = 0.6; P = 0.001). The vascular normalization index described here should be validated in randomized clinical trials...
  8. doi request reprint Advances in imaging 2009
    A Gregory Sorensen
    Department of Neuroradiology, Massachusetts General Hospital, Boston, Mass, USA
    Stroke 41:e91-2. 2010
    ..We will briefly cover each of these in turn...
  9. ncbi request reprint Magnetic resonance as a cancer imaging biomarker
    A Gregory Sorensen
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    J Clin Oncol 24:3274-81. 2006
    ....
  10. ncbi request reprint Comparison of diameter and perimeter methods for tumor volume calculation
    A G Sorensen
    MGH NMR Center and Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Clin Oncol 19:551-7. 2001
    ..We sought to compare the common method of using orthogonal diameters to estimate lesion volume (the diameter method) with a computer-assisted planimetric technique (the perimeter method)...
  11. ncbi request reprint Strategies for improving the detection of fMRI activation in trigeminal pathways with cardiac gating
    Wei Ting Zhang
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, and Harvard Medical School, Bldg 149 2301, 13th Street, Charlestown, MA 02129, USA
    Neuroimage 31:1506-12. 2006
    ..Activation in the brainstem and the thalamus was best detected by cardiac-gated dual-echo EPI...
  12. ncbi request reprint Real-time RF pulse adjustment for B0 drift correction
    Thomas Benner
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 56:204-9. 2006
    ..The proposed method corrects for apparent image shift and ensures continuously effective fat saturation over the duration of an acquisition...
  13. ncbi request reprint Comparison of manual and automatic section positioning of brain MR images
    Thomas Benner
    Department of Radiology and General Clinical Research Center, Massachusetts General Hospital, Athinoula A Martinos Center, Harvard Medical School, 149 13th St, Rm 2301, Charlestown, MA 02129, USA
    Radiology 239:246-54. 2006
    ..001). Automatic section prescription leads to improved reproducibility of imaging orientations for intra- and intersubject series in clinical practice...
  14. ncbi request reprint Intraoperative visualization of the pyramidal tract by diffusion-tensor-imaging-based fiber tracking
    Christopher Nimsky
    Department of Neurosurgery, University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neuroimage 30:1219-29. 2006
    ..Intraoperative visualization of major white matter tracts allows save resection of gliomas near eloquent brain areas. A possible shifting of the pyramidal tract has to be taken into account after major tumor parts are resected...
  15. ncbi request reprint Technical aspects of perfusion-weighted imaging
    Ona Wu
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimaging Clin N Am 15:623-37, xi. 2005
    ..Understanding the technical aspects of PWI may improve comprehension of the capabilities and limitations of this technique...
  16. ncbi request reprint Imaging biomarkers predictive of disease/therapy outcome: ischemic stroke and drug development
    Janet C Miller
    MGH HST Center for Biomarkers in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    Prog Drug Res 62:319-56. 2005
  17. doi request reprint Relaxation-compensated fast multislice amide proton transfer (APT) imaging of acute ischemic stroke
    Phillip Zhe Sun
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Magn Reson Med 59:1175-82. 2008
    ..In summary, our study has established a fast volumetric pH-weighted APT imaging technique, allowing further investigation to fully evaluate its diagnostic power...
  18. ncbi request reprint On-line automatic slice positioning for brain MR imaging
    Andre J W van der Kouwe
    Department of Radiology, MGH, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 27:222-30. 2005
    ..Translations and rotations relative to the atlas can be set so that planning can be done in anatomical space, rather than scanner coordinates, and stored as part of the protocol allowing standardization of slice orientations...
  19. ncbi request reprint Automated perfusion-weighted MRI using localized arterial input functions
    Cory Lorenz
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Division of Health Sciences and Technology, Harvard MIT, Charlestown, Massachusetts 08129, USA
    J Magn Reson Imaging 24:1133-9. 2006
    ....
  20. pmc AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    Tracy T Batchelor
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cancer Cell 11:83-95. 2007
    ..Our study provides insight into different mechanisms of action of this class of drugs in recurrent glioblastoma patients and suggests that the timing of combination therapy may be critical for optimizing activity against this tumor...
  21. ncbi request reprint Magnetic resonance spectroscopy study of oxygen therapy in ischemic stroke
    Aneesh B Singhal
    Stroke 38:2851-4. 2007
    ..Recent studies suggest that normobaric oxygen therapy (NBO) is neuroprotective in acute ischemic stroke...
  22. doi request reprint Perfusion MR imaging: moving forward
    A Gregory Sorensen
    Radiology 249:416-7. 2008
  23. doi request reprint Imaging pH using the chemical exchange saturation transfer (CEST) MRI: Correction of concomitant RF irradiation effects to quantify CEST MRI for chemical exchange rate and pH
    Phillip Zhe Sun
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 60:390-7. 2008
    ....
  24. doi request reprint Physiological noise in MR images: an indicator of the tissue response to ischemia?
    Harris H Wang
    Medical Engineering Medical Physics Program, Division of Health Sciences and Technology, Harvard University Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Magn Reson Imaging 27:866-71. 2008
    ..To determine whether measuring signal intensity (SI) fluctuations in MRI time series data from acute stroke patients would identify ischemic tissue...
  25. doi request reprint Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke
    Hakan Ay
    A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Stroke 39:1409-13. 2008
    ..We hypothesized that the volume of LA correlated with the proportion of initially ischemic but eventually infarcted tissue in acute human stroke...
  26. doi request reprint Interexaminer difference in infarct volume measurements on MRI: a source of variance in stroke research
    Hakan Ay
    Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown MA 02129, USA
    Stroke 39:1171-6. 2008
    ..We sought to quantify the variance imposed by measurement error in DWI and PWI lesion volume measurements in ischemic stroke...
  27. ncbi request reprint Correction for artifacts induced by B(0) and B(1) field inhomogeneities in pH-sensitive chemical exchange saturation transfer (CEST) imaging
    Phillip Zhe Sun
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Magn Reson Med 58:1207-15. 2007
    ..In addition, the proposed algorithm was verified with both numerical simulation and experimental measurements, and showed nearly complete correction of CEST imaging measurement errors caused by moderate field inhomogeneity...
  28. ncbi request reprint Angiogenesis in brain tumours
    Rakesh K Jain
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Rev Neurosci 8:610-22. 2007
    ..This creates a window of opportunity for optimally combining chemotherapeutics and radiation...
  29. ncbi request reprint Using the wild bootstrap to quantify uncertainty in diffusion tensor imaging
    Brandon Whitcher
    Clinical Imaging Centre, GlaxoSmithKline, Hammersmith Hospital, London, UK
    Hum Brain Mapp 29:346-62. 2008
    ..The wild bootstrap method can provide empirical distributions for tensor-derived quantities, such as fractional anisotropy and principal eigenvector direction, even when the exact distributions are not easily derived...
  30. pmc Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI
    Caterina Mainero
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 35:1201-10. 2007
    ..These results indicate that the pain modulatory system is involved to a different extent during primary versus secondary mechanical allodynia...
  31. ncbi request reprint Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation
    Juliette Selb
    Massachusetts General Hospital, Athinoula A Martinos Center, Photon Migration Imaging Laboratory, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 10:11013. 2005
    ..Finally, we use the time-gated measurements to resolve in depth the brain activation during the motor stimulus...
  32. ncbi request reprint Applying instance-based techniques to prediction of final outcome in acute stroke
    Christian Gottrup
    DIMAC A S, Højbjerg, Denmark
    Artif Intell Med 33:223-36. 2005
    ..This requires an accurate prediction of the extent of infarction if untreated. In this study, we investigate the applicability of highly flexible instance-based (IB) methods for such predictions...
  33. ncbi request reprint Effects of tracer arrival time on flow estimates in MR perfusion-weighted imaging
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology Harvard Medical School, Boston, 02129, USA
    Magn Reson Med 50:856-64. 2003
    ..These conditions may occur in practice due to the application of a user-selected AIF that is not the "true AIF" and therefore caution must be taken in interpreting CBF and MTT estimates...
  34. ncbi request reprint Perfusion-weighted magnetic resonance imaging of the brain: techniques and application in children
    Thierry A G M Huisman
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Eur Radiol 14:59-72. 2004
    ..The normal developmental changes of the cerebral haemodynamics in children as measured by PWI are presented as well as the application of PWI in cerebral ischaemia, primary and secondary cerebral vasculopathies and in cerebral tumours...
  35. ncbi request reprint Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathy
    Kei Yamada
    Massachusetts General Hospital NMR Center, Harvard Medical School, Boston, USA
    Stroke 33:87-94. 2002
    ..Steno-occlusive disease in the parent vessels is another factor that may affect the results of the PWI. The purpose of this study was to elucidate the effect of the calculation methods and underlying vasculopathy on PWI...
  36. ncbi request reprint Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Boston, Massachusetts 02129, USA
    Magn Reson Med 50:164-74. 2003
    ..Shift maps can continue to provide a sensitive reflection of disturbed hemodynamics...
  37. ncbi request reprint Guidelines and recommendations for perfusion imaging in cerebral ischemia: A scientific statement for healthcare professionals by the writing group on perfusion imaging, from the Council on Cardiovascular Radiology of the American Heart Association
    Richard E Latchaw
    Stroke 34:1084-104. 2003
  38. ncbi request reprint Biomarkers in imaging: realizing radiology's future
    John J Smith
    Department of Radiology and MGH Center for Biomarkers in Imaging, Massachusetts General Hospital, 15 Parkman St, WACC 515, Boston, MA 02114, USA
    Radiology 227:633-8. 2003
    ..By applying this paradigm to the array of imaging modalities, the radiology community is poised to become a major force in preclinical and clinical evaluations of new medical treatments...
  39. ncbi request reprint Assessing tissue viability with MR diffusion and perfusion imaging
    Pamela W Schaefer
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 24:436-43. 2003
    ..We sought to determine parameters that distinguish regions of brain destined for infarction from those that will survive despite hypoperfusion...
  40. ncbi request reprint Diffusion-weighted imaging for the evaluation of diffuse axonal injury in closed head injury
    Thierry A G M Huisman
    Department of Radiology, Neuroradiology Section, and MGH NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown Boston, USA
    J Comput Assist Tomogr 27:5-11. 2003
    ..The purpose of this work was to compare diffusion-weighted imaging (DWI) with conventional MRI in the detection of shearing injuries in acute closed head injuries...
  41. ncbi request reprint Predicting cerebral ischemic infarct volume with diffusion and perfusion MR imaging
    Pamela W Schaefer
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 23:1785-94. 2002
    ..Diffusion and perfusion MR imaging have proved useful in the assessment of acute stroke. We evaluated the utility of these techniques in detecting acute ischemic infarction and in predicting final infarct size...
  42. ncbi request reprint Iron-induced susceptibility effect at the globus pallidus causes underestimation of flow and volume on dynamic susceptibility contrast-enhanced MR perfusion images
    Kei Yamada
    Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto City, Japan
    AJNR Am J Neuroradiol 23:1022-9. 2002
    ..The purpose of this study was to assess the effect of iron-induced susceptibility on the calculated perfusion parameters. The difference of this effect between gradient-echo and spin-echo sequences was also assessed...
  43. ncbi request reprint The potential of proton magnetic resonance spectroscopy ((1)H-MRS) in the diagnosis and management of patients with brain tumors
    Xavier Leclerc
    NMR Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    Curr Opin Oncol 14:292-8. 2002
    ..Some persistent drawbacks, including measurement time and spectral resolution, will probably be overcome in the near future...
  44. ncbi request reprint Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imaging
    James M Provenzale
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    AJR Am J Roentgenol 178:711-6. 2002
    ..Our hypothesis was that permeability measurements using a T2(*)-weighted technique would show permeability in high-grade neoplasms to be higher than that in low-grade neoplasms...
  45. ncbi request reprint Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury
    Thierry A G M Huisman
    MGH NMR Center, Division of Neuroradiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    AJNR Am J Neuroradiol 25:370-6. 2004
    ..Our objective was to determine if changes in anisotropic diffusion in TBI correlate with acute Glasgow coma scale (GCS) and/or Rankin scores at discharge...
  46. ncbi request reprint Imaging angiogenesis: applications and potential for drug development
    Janet C Miller
    Department of Radiology, Massachusetts General Hospital, 100 Charles River Plaza, Boston, MA 02114, USA
    J Natl Cancer Inst 97:172-87. 2005
    ..Finally, we discuss which imaging methods are most likely to have the sensitivity and reliability required for monitoring responses to cancer therapy and describe ways in which imaging has been used in clinical trials to date...
  47. ncbi request reprint Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Cereb Cortex 15:854-69. 2005
    ..Since DT-MRI allows the precise definition of only the stem portion of each fiber pathway, the origin and termination of the subdivisions of SLF are extrapolated from the available data in experimental material from non-human primates...
  48. ncbi request reprint Using imaging biomarkers to accelerate drug development and clinical trials
    Homer H Pien
    Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Drug Discov Today 10:259-66. 2005
    ..We conclude with some remarks concerning new developments that will be required to significantly advance the field of pharmaco-imaging...
  49. ncbi request reprint Diffusion tensor magnetic resonance imaging of brain tumors
    L Celso Hygino Cruz Júnior
    Clinica de Diagnostico por Imagem, Multi Imagem Ressonância Magnética, Av das Ameréricas 4666, Centro Médico BarraShopping, Rio de Janeiro, Brazil
    Neurosurg Clin N Am 16:115-34. 2005
    ..Furthermore, evaluation of the response to treatment with chemotherapy and radiation therapy might also be possible. Although DTI has some limitations, its active investigation and further study are clearly warranted...
  50. ncbi request reprint Diffusion-weighted MR imaging in closed head injury: high correlation with initial glasgow coma scale score and score on modified Rankin scale at discharge
    Pamela W Schaefer
    Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Gray B285, Boston, MA 02114, USA
    Radiology 233:58-66. 2004
    ..To determine whether diffusion-weighted magnetic resonance (MR) imaging findings and conventional MR imaging findings correlate with initial Glasgow Coma Scale score and score on modified Rankin scale at discharge...
  51. ncbi request reprint MRI measurements of water diffusion: impact of region of interest selection on ischemic quantification
    Yelda Ozsunar
    Department of Radiology, School of Medicine, Adnan Menderes University, Aydin 09100, Turkey
    Eur J Radiol 51:195-201. 2004
    ..To investigate the effect of ADC heterogeneity on region of interest (ROI) measurement of isotropic and anisotropic water diffusion in acute (< 12 h) cerebral infarctions...
  52. ncbi request reprint Characterization and evolution of diffusion MR imaging abnormalities in stroke patients undergoing intra-arterial thrombolysis
    Pamela W Schaefer
    Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 25:951-7. 2004
    ..We evaluated the evolution of abnormal DWI findings in patients with acute stroke who underwent thrombolysis...
  53. ncbi request reprint A pilot study of normobaric oxygen therapy in acute ischemic stroke
    Aneesh B Singhal
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 36:797-802. 2005
    ..Therapies that transiently prevent ischemic neuronal death can potentially extend therapeutic time windows for stroke thrombolysis. We conducted a pilot study to investigate the effects of high-flow oxygen in acute ischemic stroke...
  54. ncbi request reprint An evidence-based causative classification system for acute ischemic stroke
    Hakan Ay
    A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Ann Neurol 58:688-97. 2005
    ..The SSS-TOAST is a dynamic algorithm that can accommodate modifications as new epidemiological data accumulate and diagnostic techniques advance...
  55. doi request reprint Summary statement novel agents in the treatment of lung cancer: Fifth Cambridge Conference assessing opportunities for combination therapy
    Thomas J Lynch
    Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA
    J Thorac Oncol 3:S107-12. 2008
    ..A CME activity based on this summary is also available at www.informedicalcme.com/cme...
  56. ncbi request reprint Transient ischemic attack with infarction: a unique syndrome?
    Hakan Ay
    Department of A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Radiology, Boston, MA 02129, USA
    Ann Neurol 57:679-86. 2005
    ..3% in those with ischemic stroke. TIA with infarction appears to have unique features separate from TIA without infarction and ischemic stroke. We propose identifying TSI as a separate clinical syndrome with distinct prognostic features...
  57. ncbi request reprint Conversion of ischemic brain tissue into infarction increases with age
    Hakan Ay
    The AA Martinos Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Stroke 36:2632-6. 2005
    ..We hypothesize that age is a marker for tissue susceptibility to ischemia and thus plays a role in determining tissue outcome in human stroke...
  58. ncbi request reprint Diffusion magnetic resonance imaging of acute ischemic stroke
    Pamela W Schaefer
    Neuroradiology Division, Stroke Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Semin Roentgenol 37:219-29. 2002
  59. ncbi request reprint CT and conventional and diffusion-weighted MR imaging in acute stroke: study in 691 patients at presentation to the emergency department
    Mark E Mullins
    Neuroradiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, GRB285, Boston, MA 02114, USA
    Radiology 224:353-60. 2002
    ..To compare the diagnostic accuracy of computed tomography (CT) and magnetic resonance (MR) imaging in a consecutive series of patients at presentation to the emergency department with symptoms of acute stroke...
  60. ncbi request reprint Evolution of water diffusion and anisotropy in hyperacute stroke: significant correlation between fractional anisotropy and T2
    Yelda Ozsunar
    Department of Radiology, School of Medicine, Adnan Menderes University, Aydin, Turkey
    AJNR Am J Neuroradiol 25:699-705. 2004
    ..Our purpose was to correlate fractional anisotropy (FA) measurements with the clinical time of stroke onset, apparent diffusion coefficients (ADC), and T2 signal intensity...
  61. ncbi request reprint Do highly concentrated gadolinium chelates improve MR brain perfusion imaging? Intraindividually controlled randomized crossover concentration comparison study of 0.5 versus 1.0 mol/L gadobutrol
    Bernd Tombach
    Dept of Clinical Radiology, Univ of Münster, Albert Schweitzer Strasse 33, D 48129 Munster, Germany
    Radiology 226:880-8. 2003
    ..To assess the potential advantages of using a 1.0 mol/L versus 0.5 mol/L gadobutrol formulation for magnetic resonance (MR) brain perfusion imaging...
  62. ncbi request reprint Preoperative and intraoperative diffusion tensor imaging-based fiber tracking in glioma surgery
    Christopher Nimsky
    Department of Neurosurgery, University Erlangen Nurnberg, Erlangen, Germany
    Neurosurgery 56:130-7; discussion 138. 2005
    ..To investigate the intraoperative displacement of major white matter tracts during glioma resection by comparing preoperative and intraoperative diffusion tensor imaging-based fiber tracking...
  63. doi request reprint Middle cerebral artery infarcts encompassing the insula are more prone to growth
    Hakan Ay
    Department of Neurology, A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Stroke 39:373-8. 2008
    ....
  64. ncbi request reprint Intraoperative diffusion-tensor MR imaging: shifting of white matter tracts during neurosurgical procedures--initial experience
    Christopher Nimsky
    Department of Neurosurgery, University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Radiology 234:218-25. 2005
    ..To prospectively evaluate the location of white matter tracts with diffusion-tensor imaging (DTI) during neurosurgical procedures...
  65. ncbi request reprint A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System
    Hakan Ay
    AA Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Stroke 38:2979-84. 2007
    ..In this article, we present an automated version of the SSS-TOAST, the Causative Classification System (CCS), to facilitate its utility in multicenter settings...
  66. ncbi request reprint Robust inference of baseline optical properties of the human head with three-dimensional segmentation from magnetic resonance imaging
    Alex H Bamett
    Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Appl Opt 42:3095-108. 2003
    ..We sample from the exact posterior and show robustness to numerical model error. This opens up the possibility of simultaneous DOT and MR for quantitative cortically constrained functional neuroimaging...
  67. ncbi request reprint Effect of using local arterial input functions on cerebral blood flow estimation
    Cory Lorenz
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Magn Reson Imaging 24:57-65. 2006
    ....
  68. ncbi request reprint The real estate factor: quantifying the impact of infarct location on stroke severity
    Nina M Menezes
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and the Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Boston, MA, USA
    Stroke 38:194-7. 2007
    ..In the current study, we sought to quantify the impact of location on neurological deficit severity and to delineate this impact from that of volume...
  69. pmc Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRI
    Jonathan J Wisco
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149 13th Street, Room 2301, Charlestown, MA 02129, United States
    Schizophr Res 94:317-27. 2007
    ..0352). We discuss these findings in relation to the neurodevelopmental hypothesis and language dysfunction in schizophrenia...

Research Grants25

  1. Silicon Graphics Prism Extreme 128P/1TB
    ALMA SORENSEN; Fiscal Year: 2006
    ....
  2. 7T Translational MRI System
    ALMA SORENSEN; Fiscal Year: 2007
    ..We list 24 funded projects in support of this additional instrumentation. ..
  3. MRI DIFFUSION/PERFUSION MISMATCH IN HUMAN ACUTE STROKE
    ALMA SORENSEN; Fiscal Year: 2007
    ....
  4. Toward Multi-Center MR Brain Perfusion
    ALMA GREGORY SORENSEN; Fiscal Year: 2010
    ..This will enable this technique to become more widely available and more appropriately establish its benefit to patients. ..
  5. Quantitative MR-PET for Therapy Assessment in Glioma Patients
    ALMA GREGORY contact SORENSEN; Fiscal Year: 2010
    ..In this work we validate this new technology and explore its potential utility for the quantitative assessment of therapy response in glioma patients. ..
  6. Nuclear Magnetic Resonance
    ALMA SORENSEN; Fiscal Year: 2006
    ..D. and Ph.D. scientists for the biomedical NMR research community. ..
  7. High Resolution PET Camera for Brain Imaging
    ALMA SORENSEN; Fiscal Year: 2006
    ..Placement of the HRRT in the proposed environment will provide a unique facility to advance brain imaging research that in turn will provide insights for a variety of illnesses and biomedical questions. ..
  8. MRI DIFFUSION/PERFUSION MISMATCH IN HUMAN ACUTE STROKE
    ALMA SORENSEN; Fiscal Year: 2003
    ..Our long-term goal is the development of a tool that can be used to guide clinical practice and to quantitatively evaluate novel therapies. ..
  9. A 3.0 Tesla MRI System in a Neuroscience ICU
    ALMA SORENSEN; Fiscal Year: 2004
    ..Since these subjects are difficult to bring to the instrumentation, we seek to gain these insights by bringing the instrumentation to them. The proposed instrument will bring state-of-the-art performance to a unique setting. ..
  10. Imaging Biomarkers for Cancer Drug Development
    ALMA SORENSEN; Fiscal Year: 2004
    ..The planning grant revolves around three aims: to confer a multidisciplinary partnership to work towards this goal; to select a set of demonstration projects, and to develop an operating plan for the partnership. ..
  11. Imaging Archive for Magnetic Resonance Imaging Systems
    ALMA SORENSEN; Fiscal Year: 2005
    ..Overall, this needed resource will greatly facilitate many NIH-funded investigators and investigations for years to come. ..
  12. MRI DIFFUSION/PERFUSION MISMATCH IN HUMAN ACUTE STROKE
    ALMA SORENSEN; Fiscal Year: 2005
    ..Incorporating genetic and imaging information together could greatly strengthen the relevance and immediacy of each. ..
  13. Sharing canonical human stroke data
    Ona Wu; Fiscal Year: 2010
    ..Linking our existing portals with BIRN resources has the potential to greatly facilitate data sharing which will benefit the understanding of stroke and speed discovery of new therapeutic interventions. ..