S P Soltoff

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation
    S P Soltoff
    Division of Signal Transduction, Harvard Institutes of Medicine, Boston, Massachusetts 02215, USA
    J Biol Chem 276:37986-92. 2001
  2. ncbi request reprint Modulation of PKCdelta tyrosine phosphorylation and activity in salivary and PC-12 cells by Src kinases
    C Benes
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Cell Physiol 280:C1498-510. 2001
  3. ncbi request reprint p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells
    S P Soltoff
    Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 271:563-7. 1996
  4. ncbi request reprint Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activation
    S P Soltoff
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Biol Chem 273:23110-7. 1998
  5. pmc The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility
    C H Benes
    Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Oncogene 31:653-63. 2012
  6. ncbi request reprint Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C
    S P Soltoff
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Biol Chem 273:2653-60. 1998
  7. pmc Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis
    V P Singh
    Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 108:1387-95. 2001
  8. ncbi request reprint P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide
    M Warny
    Gastroenterology Divison, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:26051-6. 2001
  9. pmc P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C
    Michelle D Bradford
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, MA 02215, USA
    Biochem J 366:745-55. 2002
  10. ncbi request reprint Ouabain potentiates the activation of ERK1/2 by carbachol in parotid gland epithelial cells; inhibition of ERK1/2 reduces Na(+)-K(+)-ATPase activity
    Deana Plourde
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Physiol Cell Physiol 290:C702-10. 2006

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation
    S P Soltoff
    Division of Signal Transduction, Harvard Institutes of Medicine, Boston, Massachusetts 02215, USA
    J Biol Chem 276:37986-92. 2001
    ..These results demonstrate that rottlerin directly uncouples mitochondrial respiration from oxidative phosphorylation. Previous studies using rottlerin should be evaluated cautiously...
  2. ncbi request reprint Modulation of PKCdelta tyrosine phosphorylation and activity in salivary and PC-12 cells by Src kinases
    C Benes
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Cell Physiol 280:C1498-510. 2001
    ..These results demonstrate that PKCdelta activity is positively modulated by tyrosine phosphorylation in parotid and PC-12 cells and suggest that PLC-dependent effects of secretagogues on salivary cells involve Src-related kinases...
  3. ncbi request reprint p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells
    S P Soltoff
    Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 271:563-7. 1996
    ..p120cbl was also present in A431 cells and offers an additional pathway by which EGF can activate PI 3-kinase in these cells...
  4. ncbi request reprint Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activation
    S P Soltoff
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Biol Chem 273:23110-7. 1998
    ..Although P2Y2 and EGF receptors may both activate a similar multiprotein signaling cascade immediately upstream of MAP kinase, the P2Y2 receptor appears to uniquely utilize [Ca2+]i, PKC, and, subsequently, RAFTK...
  5. pmc The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility
    C H Benes
    Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Oncogene 31:653-63. 2012
    ..Thus, signaling events that accompany the CDCP1 tyrosine phosphorylation observed in cell lines and human lung tumors may explain how the CDCP1/SFK complex regulates motility and adhesion...
  6. ncbi request reprint Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C
    S P Soltoff
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Biol Chem 273:2653-60. 1998
    ..These results suggest that the P2Y2 receptor-initiated activation of MAP kinase was dependent on the elevation of [Ca2+]i, involved the recruitment of Shc and Grb2, and was mediated by RAFTK and PKC...
  7. pmc Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis
    V P Singh
    Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 108:1387-95. 2001
    ..Our observations suggest that phosphatidylinositol 3-kinase inhibition might be of benefit in preventing acute pancreatitis...
  8. ncbi request reprint P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide
    M Warny
    Gastroenterology Divison, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:26051-6. 2001
    ..Furthermore, lipopolysaccharide mediates IL-8 production at least in part by autocrine P2Y(6) activation. These findings indicate a novel role for P2Y(6) in innate immune defenses...
  9. pmc P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C
    Michelle D Bradford
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, MA 02215, USA
    Biochem J 366:745-55. 2002
    ....
  10. ncbi request reprint Ouabain potentiates the activation of ERK1/2 by carbachol in parotid gland epithelial cells; inhibition of ERK1/2 reduces Na(+)-K(+)-ATPase activity
    Deana Plourde
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Physiol Cell Physiol 290:C702-10. 2006
    ..These results suggest that ERK1/2 and Na(+)-K(+)-ATPase may signal to each other in each direction under defined conditions in a single cell type...
  11. ncbi request reprint Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta
    Stephen P Soltoff
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, New Research Building, Room 1030 J, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Trends Pharmacol Sci 28:453-8. 2007
    ....
  12. pmc Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells
    Stephen P Soltoff
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02111, USA
    Am J Physiol Cell Physiol 295:C590-9. 2008
    ....
  13. ncbi request reprint Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling
    Stephen P Soltoff
    Beth Israel Deaconess Medical Center, Division of Signal Transduction, Boston, Massachusetts 02215, USA
    J Biol Chem 279:10910-8. 2004
    ....