S Y Sokol

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Analysis of Dishevelled signalling pathways during Xenopus development
    S Y Sokol
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Curr Biol 6:1456-67. 1996
  2. ncbi request reprint A positive role for the PP2A catalytic subunit in Wnt signal transduction
    M J Ratcliffe
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Molecular Medicine Unit, Beth Israel Deaconess Medical Center, Boston, Massachessetts 02215, USA
    J Biol Chem 275:35680-3. 2000
  3. pmc Axis determination by inhibition of Wnt signaling in Xenopus
    K Itoh
    Department of Microbiology and Molecular Genetics, Harvard Medical School and Molecular Medicine Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215 USA
    Genes Dev 13:2328-36. 1999
  4. ncbi request reprint A role for Siamois in Spemann organizer formation
    M J Fan
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Development 124:2581-9. 1997
  5. pmc Wnt signaling and transcriptional control of Siamois in Xenopus embryos
    M J Fan
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 95:5626-31. 1998
  6. ncbi request reprint Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled
    S Y Sokol
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA, USA
    Development 121:1637-47. 1995
  7. ncbi request reprint Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy
    G Abu-Jawdeh
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Lab Invest 79:439-47. 1999
  8. ncbi request reprint The effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42
    S Y Sokol
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:48425-30. 2001
  9. ncbi request reprint The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development
    T L Tang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215
    Cell 80:473-83. 1995
  10. ncbi request reprint Functional and structural diversity of the human Dickkopf gene family
    V E Krupnik
    Department of Microbiology and Molecular Genetics, Harvard Medical School and Division of Molecular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Gene 238:301-13. 1999

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Analysis of Dishevelled signalling pathways during Xenopus development
    S Y Sokol
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Curr Biol 6:1456-67. 1996
    ..Using the ability of a mutant form of the Xenopus homologue of Dsh (Xdsh) to block Wnt and Dsh signalling in a model system, this work attempts to clarify the role of the endogenous Xdsh during the early stages of vertebrate development...
  2. ncbi request reprint A positive role for the PP2A catalytic subunit in Wnt signal transduction
    M J Ratcliffe
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Molecular Medicine Unit, Beth Israel Deaconess Medical Center, Boston, Massachessetts 02215, USA
    J Biol Chem 275:35680-3. 2000
    ..Because previous work has suggested that PP2A can act upstream of beta-catenin, we propose that PP2A regulates the Wnt pathway at multiple levels...
  3. pmc Axis determination by inhibition of Wnt signaling in Xenopus
    K Itoh
    Department of Microbiology and Molecular Genetics, Harvard Medical School and Molecular Medicine Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215 USA
    Genes Dev 13:2328-36. 1999
    ..These results suggest that Wnt signaling is required to maintain ventral cell fates and has to be suppressed for dorsal development to occur...
  4. ncbi request reprint A role for Siamois in Spemann organizer formation
    M J Fan
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Development 124:2581-9. 1997
    ..These results suggest that Siamois function is essential for beta-catenin-mediated formation of the Spemann organizer, and that Siamois acts prior to noggin in specifying dorsal development...
  5. pmc Wnt signaling and transcriptional control of Siamois in Xenopus embryos
    M J Fan
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 95:5626-31. 1998
    ..We also present evidence for autoregulation of Siamois transcription. Furthermore, the Siamois promoter was activated by Wnt signaling in 293T tissue culture cells, demonstrating that regulation of the promoter is functionally conserved...
  6. ncbi request reprint Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled
    S Y Sokol
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA, USA
    Development 121:1637-47. 1995
    ..These studies suggest that Wnt signal transduction pathway is conserved between Drosophila and vertebrates and point to a role for maternal Xdsh product in dorsal axis formation and in neural induction...
  7. ncbi request reprint Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy
    G Abu-Jawdeh
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Lab Invest 79:439-47. 1999
    ..These results indicate that frpHE functions as a regulator of the Wnt-frizzled signaling pathway and is involved in endometrial physiology and carcinogenesis...
  8. ncbi request reprint The effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42
    S Y Sokol
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:48425-30. 2001
    ..Together these data indicate that the activity of IQGAP1 in embryonic ectoderm requires Cdc42 function...
  9. ncbi request reprint The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development
    T L Tang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215
    Cell 80:473-83. 1995
    ..Our results indicate that SH-PTP2 is required for early vertebrate development, acting as a positive component in FGF signaling downstream of the FGF receptor and upstream of MAP kinase...
  10. ncbi request reprint Functional and structural diversity of the human Dickkopf gene family
    V E Krupnik
    Department of Microbiology and Molecular Genetics, Harvard Medical School and Division of Molecular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Gene 238:301-13. 1999
    ..Thus, hDkks 1 and 4 may inhibit Wnt activity by a mechanism upstream of Frizzled. Our findings highlight the structural and functional heterogeneity of human Dkk-related proteins...
  11. ncbi request reprint Xwnt-2b is a novel axis-inducing Xenopus Wnt, which is expressed in embryonic brain
    Y Landesman
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215, USA
    Mech Dev 63:199-209. 1997
    ..These results suggest that Xwnt-2b is a member of the axis-inducing Wnts and that it is involved in brain development and in later organogenesis...
  12. pmc Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos
    I Dominguez
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 92:8498-502. 1995
    ..These results strongly suggest that XGSK-3 beta functions to inhibit dorsoventral axis formation in the embryo and provide evidence for conservation of the Wnt signaling pathway in Drosophila and vertebrates...
  13. ncbi request reprint Wnt signaling and dorso-ventral axis specification in vertebrates
    S Y Sokol
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Molecular Medicine Unit, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, Massachusetts 02215, USA
    Curr Opin Genet Dev 9:405-10. 1999
    ..Recent discoveries of new players in this signaling pathway have narrowed down the search for the initial cues for axis specification in vertebrate embryos...