Joseph G Sodroski


Affiliation: Harvard University
Country: USA


  1. Pacheco B, Alsahafi N, Debbeche O, Prévost J, Ding S, Chapleau J, et al. Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors. J Virol. 2017;91: pubmed publisher
    ..Here we identify residues in the HIV-1 transmembrane envelope glycoprotein that stabilize the unliganded state by modulating the transitions from the unliganded state to the CD4-bound state. ..
  2. Nguyen H, Alsahafi N, Finzi A, Sodroski J. Effects of the SOS (A501C/T605C) and DS (I201C/A433C) Disulfide Bonds on HIV-1 Membrane Envelope Glycoprotein Conformation and Function. J Virol. 2019;: pubmed publisher
    ..Awareness of these effects can assist efforts to create stable HIV-1 Env complexes that more closely resemble the State-1 conformation. ..
  3. Lu M, Ma X, Castillo Menendez L, Gorman J, Alsahafi N, Ermel U, et al. Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET. Nature. 2019;568:415-419 pubmed publisher
  4. Castillo Menendez L, Nguyen H, Sodroski J. Conformational Differences between Functional Human Immunodeficiency Virus Envelope Glycoprotein Trimers and Stabilized Soluble Trimers. J Virol. 2019;93: pubmed publisher
  5. Ukah O, Puray Chavez M, Tedbury P, Herschhorn A, Sodroski J, Sarafianos S. Visualization of HIV-1 RNA Transcription from Integrated HIV-1 DNA in Reactivated Latently Infected Cells. Viruses. 2018;10: pubmed publisher
    ..Hence, these approaches are shown to be suitable for qualitative and quantitative studies of HIV-1 latency and reactivation. ..
  6. Madani N, Princiotto A, Mach L, Ding S, Prévost J, Richard J, et al. A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge. Nat Commun. 2018;9:2363 pubmed publisher
    ..The protective immune response persists for at least six months after vaccination. CD4mc should increase the protective efficacy of any HIV-1 Env vaccine that elicits antibodies against CD4-induced conformations of Env. ..
  7. Castillo Menendez L, Witt K, Espy N, Princiotto A, Madani N, Pacheco B, et al. Comparison of Uncleaved and Mature Human Immunodeficiency Virus Membrane Envelope Glycoprotein Trimers. J Virol. 2018;92: pubmed publisher
    ..Stabilized soluble Envs exhibit more compact shapes but expose some Env elements differently than the natural Env. ..
  8. Madani N, Princiotto A, Easterhoff D, Bradley T, Luo K, Williams W, et al. Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds. J Virol. 2016;90:5031-5046 pubmed publisher
    ..These results suggest an approach to prevent HIV-1 sexual transmission in which a virus-sensitizing microbicide is combined with a vaccine. ..
  9. Espy N, Pacheco B, Sodroski J. Adaptation of HIV-1 to cells with low expression of the CCR5 coreceptor. Virology. 2017;508:90-107 pubmed publisher
    ..The adapted Envs exhibited a greater propensity to undergo conformational changes, as evidenced by increased exposure of conserved regions near the CD4- and CCR5-binding sites. ..

More Information


  1. Kar A, Mao Y, Bird G, WALENSKY L, Sodroski J. Characterization of a core fragment of the rhesus monkey TRIM5α protein. BMC Biochem. 2011;12:1 pubmed publisher
    ..These results indicate that the B-box 2, coiled-coil and linker 2 regions of TRIM5α form a core dimerization motif that exhibits a high level of alpha-helical content. ..
  2. Madani N, Princiotto A, Zhao C, Jahanbakhshsefidi F, Mertens M, Herschhorn A, et al. Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds. J Virol. 2017;91: pubmed publisher
    ..Understanding the mechanistic factors that influence the activity of CD4-mimetic compounds can help to improve their potency and coverage of diverse HIV-1 strains. ..
  3. Nguyen H, Madani N, Ding H, Elder E, Princiotto A, Gu C, et al. Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein. Virol J. 2017;14:33 pubmed publisher
    ..However, for HIV-1 Env ectodomains that are minimally modified, membrane-anchored Envs exhibit the most native structures and can be stabilized by appropriately positioned FT domains. ..
  4. Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith A, et al. The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions. Nat Commun. 2017;8:1049 pubmed publisher
    ..These HIV-1 mutants require less CD4 to infect cells and are relatively resistant to State 1-preferring broadly neutralizing antibodies. These data provide insights into the molecular mechanism and vulnerability of HIV-1 entry. ..
  5. Tipper C, Sodroski J. Contribution of glutamine residues in the helix 4-5 loop to capsid-capsid interactions in simian immunodeficiency virus of macaques. J Virol. 2014;88:10289-302 pubmed publisher
    ..This strategy may allow these viruses to forego the use of capsid-stabilizing factors from the host cell, some of which have antiviral activity. ..
  6. Zhang S, Sodroski J. Efficient human immunodeficiency virus (HIV-1) infection of cells lacking PDZD8. Virology. 2015;481:73-8 pubmed publisher
    ..These results indicate that PDZD8 is not absolutely necessary for HIV-1 infection and diminishes its attractiveness as a potential target for intervention. ..