Lucia Sobrin

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe)
    Lucia Sobrin
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:7593-602. 2011
  2. pmc Intravitreal triamcinolone for cancer-associated retinopathy refractory to systemic therapy
    Nancy Huynh
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA
    J Ophthalmic Inflamm Infect 2:169-71. 2012
  3. pmc Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes
    Lucia Sobrin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 119:1874-85. 2012
  4. pmc Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration
    Yi Yu
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, 800 WashingtonStreet, No 450, Boston, MA 02111, USA
    Hum Mol Genet 20:3699-709. 2011
  5. pmc Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis
    Jun Suzuki
    Retina Service, Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 53:4158-69. 2012
  6. pmc ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration
    Lucia Sobrin
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Am J Ophthalmol 151:345-52.e3. 2011
  7. doi Long-term Follow-up and Outcomes in Traumatic Macular Holes
    John B Miller
    Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School Department of Ophthalmology, Boston, Massachusetts
    Am J Ophthalmol 160:1255-1258.e1. 2015
  8. doi Ocular inflammatory disease in patients with polymyalgia rheumatica: A case series and review of the literature
    Sepideh Faez
    Ocular Immunology and Uveitis Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA
    Clin Rheumatol 35:251-8. 2016
  9. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
  10. doi Conversion to aflibercept for chronic refractory or recurrent neovascular age-related macular degeneration
    Yoshihiro Yonekawa
    Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Am J Ophthalmol 156:29-35.e2. 2013

Detail Information

Publications27

  1. pmc Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe)
    Lucia Sobrin
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:7593-602. 2011
    ....
  2. pmc Intravitreal triamcinolone for cancer-associated retinopathy refractory to systemic therapy
    Nancy Huynh
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA
    J Ophthalmic Inflamm Infect 2:169-71. 2012
    ..The purpose of this study is to report the use of intravitreal triamcinolone for treatment of cancer-associated retinopathy (CAR) refractory to systemic therapy...
  3. pmc Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes
    Lucia Sobrin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 119:1874-85. 2012
    ....
  4. pmc Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration
    Yi Yu
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, 800 WashingtonStreet, No 450, Boston, MA 02111, USA
    Hum Mol Genet 20:3699-709. 2011
    ..The novel variants identified in this study suggest that angiogenesis (VEGFA) and extracellular collagen matrix (FRK/COL10A1) pathways contribute to the development of advanced AMD...
  5. pmc Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis
    Jun Suzuki
    Retina Service, Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 53:4158-69. 2012
    ..To investigate the anti-inflammatory effect of an adenosine monophosphate (AMP) analog, aminoimidazole carboxamide ribonucleotide (AICAR), in experimental autoimmune uveoretinitis (EAU)...
  6. pmc ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration
    Lucia Sobrin
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Am J Ophthalmol 151:345-52.e3. 2011
    ..To determine if genetic variants that have been associated with age-related macular degeneration (AMD) have a differential effect on the risk of choroidal neovascularization (CNV) and geographic atrophy...
  7. doi Long-term Follow-up and Outcomes in Traumatic Macular Holes
    John B Miller
    Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School Department of Ophthalmology, Boston, Massachusetts
    Am J Ophthalmol 160:1255-1258.e1. 2015
    ..To review presenting characteristics, clinical course, and long-term visual and anatomic outcomes of patients with traumatic macular holes at a tertiary referral center...
  8. doi Ocular inflammatory disease in patients with polymyalgia rheumatica: A case series and review of the literature
    Sepideh Faez
    Ocular Immunology and Uveitis Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA
    Clin Rheumatol 35:251-8. 2016
    ..Four of the five patients who had relapsing PMR had recurrent or persistent uveitis over the course of follow-up. PMR may be associated with both scleritis and uveitis and should be considered as a possible underlying cause of OID. ..
  9. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
    ..Results implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD...
  10. doi Conversion to aflibercept for chronic refractory or recurrent neovascular age-related macular degeneration
    Yoshihiro Yonekawa
    Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Am J Ophthalmol 156:29-35.e2. 2013
    ..To explore the visual and anatomic outcomes of patients with refractory or recurrent neovascular age-related macular degeneration (AMD) who were converted from bevacizumab and/or ranibizumab to aflibercept...
  11. doi SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN CONVALESCENT PHASE OF TREATED SARCOID CHOROIDAL GRANULOMAS
    Evangelia Papavasileiou
    Uveitis and Retina Divisions, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts
    Retin Cases Brief Rep 10:32-6. 2016
    ..To report swept-source optical coherence tomography findings of sarcoid choroidal granulomas in the posttreatment convalescent stage of disease...
  12. doi Side-effects of anti-inflammatory therapy in uveitis
    Eduardo Uchiyama
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA and
    Semin Ophthalmol 29:456-67. 2014
    ..In this article, we review the most common agents utilized in the treatment of uveitis and their side-effect profiles...
  13. doi Accuracy of the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) as a research tool for identification of patients with uveitis and scleritis
    Eduardo Uchiyama
    Uveitis and Ocular Immunology Division, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Ophthalmic Epidemiol 22:139-41. 2015
    ....
  14. doi A Man with Paraneoplastic Retinopathy plus Small Fiber Polyneuropathy Associated with Waldenström Macroglobulinemia (Lymphoplasmacytic Lymphoma): Insights into Mechanisms
    Yingna Liu
    A Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Ocul Immunol Inflamm 23:405-9. 2015
    ..To report a well-characterized Waldenström's macroglobulinemia (WM) case that provides insight into the mechanisms of two paraneoplastic complications -- cancer-associated retinopathy (CAR) and small fiber polyneuropathy (SFPN)...
  15. doi Ocular ischemic syndrome presenting as retinal vasculitis in a patient with moyamoya syndrome
    Evangelia Papavasileiou
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
    Retin Cases Brief Rep 9:170-2. 2015
    ..To report a case of ocular ischemic syndrome presenting as retinal vasculitis in a patient with Moyamoya syndrome...
  16. doi Choroiditis and choroidal neovascularization in acute disseminated encephalomyelitis
    Nikol Panou
    Department of Ophthalmology, Zoodochos Pigi Wing, Amalia Fleming Prefectoral General Hospital, Athens, Greece Retina Uveitis Services, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts
    Retin Cases Brief Rep 7:89-90. 2013
    ..To present a case with bilateral choroidal neovascularization (CNV) secondary to acute disseminated encephalomyelitis-associated choroiditis requiring immunomodulatory therapy for prevention of recurrence...
  17. doi Blau syndrome-associated uveitis and the NOD2 gene
    Parvathy Pillai
    Uveitis Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Semin Ophthalmol 28:327-32. 2013
    ..Clinical and genetic aspects of BS will be discussed, as well as recent advances in treatment protocols...
  18. doi Nature and nurture- genes and environment- predict onset and progression of macular degeneration
    Lucia Sobrin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Prog Retin Eye Res 40:1-15. 2014
    ..Personalized medicine and individualized prevention and treatment strategies may become a reality in the near future. ..
  19. doi The use of biologic agents in the treatment of ocular manifestations of Behcet's disease
    Nicole R Benitah
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Semin Ophthalmol 26:295-303. 2011
    ....
  20. doi Role of OCT in the diagnosis and management of macular edema from uveitis
    Rebecca S Hunter
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Semin Ophthalmol 27:236-41. 2012
    ..In this review, we evaluate the role of OCT in the diagnosis and management of uveitic macular edema...
  21. doi Drug delivery options for the treatment of ocular inflammation
    Ann Marie Lobo
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Semin Ophthalmol 25:283-8. 2010
    ..Their design was inspired by the ganciclovir implant, which prevented the progression of CMV retinitis in AIDS patients. Technological advances in drug delivery have supplied new treatments for patients with ocular inflammatory disease...
  22. doi Optic nerve involvement with panuveitis in Sweet syndrome
    Ann Marie Lobo
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ocul Immunol Inflamm 19:167-70. 2011
    ..To report a case of a patient with optic nerve involvement in neuro-Sweet syndrome and review the literature on this systemic disease...
  23. doi Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats
    Jun Suzuki
    Retina Service, Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA
    Invest Ophthalmol Vis Sci 52:6565-71. 2011
    ..CONCLUSIONS. AICAR reduces systemic LPS susceptibility and attenuates intraocular inflammation in a rat EIU model by limiting infiltration of leukocytes, suppressing inflammatory mediators, and inhibiting the NF-κB pathway...
  24. pmc Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy after bevacizumab
    Sophia I Pachydaki
    Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA
    J Ophthalmic Inflamm Infect 2:29-37. 2012
    ..This study aims to describe surgical management results and the pathologic features of choroidal neovascularization (CNV) secondary to punctate inner choroidopathy (PIC) following anti-vascular endothelial growth factor treatment...
  25. doi Cancer-associated retinopathy: update on pathogenesis and therapy
    Yevgeniy Shildkrot
    Massachusetts Eye and Ear Infirmary, Retina Service, Harvard Medical School, Boston, MA 02114, USA
    Semin Ophthalmol 26:321-8. 2011
    ..The goal of this review is to analyze the clinical features of diagnosis and management of retinopathy in the context of recent advances in the elucidation of CAR pathogenesis...
  26. pmc Genetic profile for five common variants associated with age-related macular degeneration in densely affected families: a novel analytic approach
    Lucia Sobrin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Eur J Hum Genet 18:496-501. 2010
    ..Given that these densely affected families may harbor rare, more penetrant variants for AMD, linkage analyses and resequencing targeting these families may be an effective approach to finding additional implicated genes...