Lucia Sobrin

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe)
    Lucia Sobrin
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:7593-602. 2011
  2. pmc Intravitreal triamcinolone for cancer-associated retinopathy refractory to systemic therapy
    Nancy Huynh
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA
    J Ophthalmic Inflamm Infect 2:169-71. 2012
  3. doi Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes
    Lucia Sobrin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 119:1874-85. 2012
  4. pmc Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration
    Yi Yu
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, 800 WashingtonStreet, No 450, Boston, MA 02111, USA
    Hum Mol Genet 20:3699-709. 2011
  5. pmc Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis
    Jun Suzuki
    Retina Service, Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 53:4158-69. 2012
  6. pmc ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration
    Lucia Sobrin
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Am J Ophthalmol 151:345-52.e3. 2011
  7. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
  8. doi Conversion to aflibercept for chronic refractory or recurrent neovascular age-related macular degeneration
    Yoshihiro Yonekawa
    Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Am J Ophthalmol 156:29-35.e2. 2013
  9. doi Blau syndrome-associated uveitis and the NOD2 gene
    Parvathy Pillai
    Uveitis Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Semin Ophthalmol 28:327-32. 2013
  10. ncbi Nature and nurture- genes and environment- predict onset and progression of macular degeneration
    Lucia Sobrin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Prog Retin Eye Res 40:1-15. 2014

Collaborators

Detail Information

Publications19

  1. pmc Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe)
    Lucia Sobrin
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:7593-602. 2011
    ....
  2. pmc Intravitreal triamcinolone for cancer-associated retinopathy refractory to systemic therapy
    Nancy Huynh
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA
    J Ophthalmic Inflamm Infect 2:169-71. 2012
    ..The purpose of this study is to report the use of intravitreal triamcinolone for treatment of cancer-associated retinopathy (CAR) refractory to systemic therapy...
  3. doi Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes
    Lucia Sobrin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 119:1874-85. 2012
    ....
  4. pmc Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration
    Yi Yu
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, 800 WashingtonStreet, No 450, Boston, MA 02111, USA
    Hum Mol Genet 20:3699-709. 2011
    ..The novel variants identified in this study suggest that angiogenesis (VEGFA) and extracellular collagen matrix (FRK/COL10A1) pathways contribute to the development of advanced AMD...
  5. pmc Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis
    Jun Suzuki
    Retina Service, Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 53:4158-69. 2012
    ..To investigate the anti-inflammatory effect of an adenosine monophosphate (AMP) analog, aminoimidazole carboxamide ribonucleotide (AICAR), in experimental autoimmune uveoretinitis (EAU)...
  6. pmc ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration
    Lucia Sobrin
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Am J Ophthalmol 151:345-52.e3. 2011
    ..To determine if genetic variants that have been associated with age-related macular degeneration (AMD) have a differential effect on the risk of choroidal neovascularization (CNV) and geographic atrophy...
  7. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
    ..Results implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD...
  8. doi Conversion to aflibercept for chronic refractory or recurrent neovascular age-related macular degeneration
    Yoshihiro Yonekawa
    Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Am J Ophthalmol 156:29-35.e2. 2013
    ..To explore the visual and anatomic outcomes of patients with refractory or recurrent neovascular age-related macular degeneration (AMD) who were converted from bevacizumab and/or ranibizumab to aflibercept...
  9. doi Blau syndrome-associated uveitis and the NOD2 gene
    Parvathy Pillai
    Uveitis Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Semin Ophthalmol 28:327-32. 2013
    ..Clinical and genetic aspects of BS will be discussed, as well as recent advances in treatment protocols...
  10. ncbi Nature and nurture- genes and environment- predict onset and progression of macular degeneration
    Lucia Sobrin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Prog Retin Eye Res 40:1-15. 2014
    ..Personalized medicine and individualized prevention and treatment strategies may become a reality in the near future. ..
  11. doi Role of OCT in the diagnosis and management of macular edema from uveitis
    Rebecca S Hunter
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Semin Ophthalmol 27:236-41. 2012
    ..In this review, we evaluate the role of OCT in the diagnosis and management of uveitic macular edema...
  12. pmc Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy after bevacizumab
    Sophia I Pachydaki
    Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA
    J Ophthalmic Inflamm Infect 2:29-37. 2012
    ..This study aims to describe surgical management results and the pathologic features of choroidal neovascularization (CNV) secondary to punctate inner choroidopathy (PIC) following anti-vascular endothelial growth factor treatment...
  13. doi Cancer-associated retinopathy: update on pathogenesis and therapy
    Yevgeniy Shildkrot
    Massachusetts Eye and Ear Infirmary, Retina Service, Harvard Medical School, Boston, MA 02114, USA
    Semin Ophthalmol 26:321-8. 2011
    ..The goal of this review is to analyze the clinical features of diagnosis and management of retinopathy in the context of recent advances in the elucidation of CAR pathogenesis...
  14. doi The use of biologic agents in the treatment of ocular manifestations of Behcet's disease
    Nicole R Benitah
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Semin Ophthalmol 26:295-303. 2011
    ....
  15. doi Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats
    Jun Suzuki
    Retina Service, Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA
    Invest Ophthalmol Vis Sci 52:6565-71. 2011
    ..CONCLUSIONS. AICAR reduces systemic LPS susceptibility and attenuates intraocular inflammation in a rat EIU model by limiting infiltration of leukocytes, suppressing inflammatory mediators, and inhibiting the NF-κB pathway...
  16. doi Optic nerve involvement with panuveitis in Sweet syndrome
    Ann Marie Lobo
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ocul Immunol Inflamm 19:167-70. 2011
    ..To report a case of a patient with optic nerve involvement in neuro-Sweet syndrome and review the literature on this systemic disease...
  17. doi Drug delivery options for the treatment of ocular inflammation
    Ann Marie Lobo
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Semin Ophthalmol 25:283-8. 2010
    ..Their design was inspired by the ganciclovir implant, which prevented the progression of CMV retinitis in AIDS patients. Technological advances in drug delivery have supplied new treatments for patients with ocular inflammatory disease...
  18. pmc Genetic profile for five common variants associated with age-related macular degeneration in densely affected families: a novel analytic approach
    Lucia Sobrin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Eur J Hum Genet 18:496-501. 2010
    ..Given that these densely affected families may harbor rare, more penetrant variants for AMD, linkage analyses and resequencing targeting these families may be an effective approach to finding additional implicated genes...