ROY SOBERMAN

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The expanding network of redox signaling: new observations, complexities, and perspectives
    Roy J Soberman
    Renal Unit and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Clin Invest 111:571-4. 2003
  2. pmc The organization and consequences of eicosanoid signaling
    Roy J Soberman
    Renal Unit and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 Navy Yard, Charlestown, MA 02129, USA
    J Clin Invest 111:1107-13. 2003
  3. pmc CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2
    Roy J Soberman
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    PLoS ONE 7:e47740. 2012
  4. ncbi request reprint Membrane localization and topology of leukotriene C4 synthase
    Peter Christmas
    Renal Unit and Program in Membrane Biology, Department of Medicine, Harvard Medical School and Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:28902-8. 2002
  5. ncbi request reprint Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter
    Peter Christmas
    Renal Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    J Biol Chem 278:25133-42. 2003
  6. ncbi request reprint Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4
    Peter Christmas
    Renal Unit and Department of Medicine, Massachusetts General Hospital East, Navy Yard Bldg 149, 13th Street, Charlestown, MA 02129, USA
    J Biol Chem 281:7189-96. 2006
  7. pmc The membrane organization of leukotriene synthesis
    Asim K Mandal
    Department of Medicine, Massachusetts General Hospital, 149 The Navy Yard, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:6587-92. 2004

Research Grants

  1. Leukotrienes and Lung Inflammation
    ROY SOBERMAN; Fiscal Year: 2010
  2. Leukotrienes and Lung Inflammation
    ROY SOBERMAN; Fiscal Year: 2009
  3. Leukotrienes and Lung Inflammation
    ROY SOBERMAN; Fiscal Year: 2007
  4. Pharmacology of 4F Cytochrome P450's (Supplement)
    ROY SOBERMAN; Fiscal Year: 2003
  5. Leukotrienes and Lung Inflammation
    ROY SOBERMAN; Fiscal Year: 2010

Collaborators

Detail Information

Publications7

  1. pmc The expanding network of redox signaling: new observations, complexities, and perspectives
    Roy J Soberman
    Renal Unit and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Clin Invest 111:571-4. 2003
  2. pmc The organization and consequences of eicosanoid signaling
    Roy J Soberman
    Renal Unit and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 Navy Yard, Charlestown, MA 02129, USA
    J Clin Invest 111:1107-13. 2003
  3. pmc CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2
    Roy J Soberman
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    PLoS ONE 7:e47740. 2012
    ..In summary, our data demonstrate an unanticipated and novel requirement for CD200R1 in "licensing" pro-inflammatory functions of TLR2 and in limiting viral replication that are supported by ex vivo and in vivo evidence...
  4. ncbi request reprint Membrane localization and topology of leukotriene C4 synthase
    Peter Christmas
    Renal Unit and Program in Membrane Biology, Department of Medicine, Harvard Medical School and Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:28902-8. 2002
    ..The differential localization of two very similar integral membrane proteins suggests that mechanisms other than size-dependent exclusion regulate their passage to the inner nuclear membrane...
  5. ncbi request reprint Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter
    Peter Christmas
    Renal Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    J Biol Chem 278:25133-42. 2003
    ..ZEB-2 interacts with C-terminal binding protein and Smads, and this would provide opportunities for integrating environmental signals in myelopoiesis and inflammation...
  6. ncbi request reprint Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4
    Peter Christmas
    Renal Unit and Department of Medicine, Massachusetts General Hospital East, Navy Yard Bldg 149, 13th Street, Charlestown, MA 02129, USA
    J Biol Chem 281:7189-96. 2006
    ..The results identify CYP4F18 as a critical protein in the regulation of LTB(4) metabolism and functional responses in mouse PMN and identify it as the functional orthologue of human PMN CYP4F3A...
  7. pmc The membrane organization of leukotriene synthesis
    Asim K Mandal
    Department of Medicine, Massachusetts General Hospital, 149 The Navy Yard, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:6587-92. 2004
    ..The results indicate that the formation of LTC(4) and LTB(4) may be determined by the compartmentalization of biosynthetic enzymes in discrete molecular complexes...

Research Grants12

  1. Leukotrienes and Lung Inflammation
    ROY SOBERMAN; Fiscal Year: 2010
    ..The completion of these aims will allow the identification of novel mechanisms and, potentially, therapeutic approaches, to inflammatory pulmonary diseases. ..
  2. Leukotrienes and Lung Inflammation
    ROY SOBERMAN; Fiscal Year: 2009
    ..The completion of these aims will allow the identification of novel mechanisms and, potentially, therapeutic approaches, to inflammatory pulmonary diseases. ..
  3. Leukotrienes and Lung Inflammation
    ROY SOBERMAN; Fiscal Year: 2007
    ..The completion of these aims will allow the identification of novel mechanisms and, potentially, therapeutic approaches, to inflammatory pulmonary diseases. ..
  4. Pharmacology of 4F Cytochrome P450's (Supplement)
    ROY SOBERMAN; Fiscal Year: 2003
    ..Luciferase reporter constructs, DNase I footprinting, EMSA, and mutagenesis will identify promoter elements determining the expression of CYP4F3 in hematopoetic and liver cells. ..
  5. Leukotrienes and Lung Inflammation
    ROY SOBERMAN; Fiscal Year: 2010
    ..The completion of these aims will allow the identification of novel mechanisms and, potentially, therapeutic approaches, to inflammatory pulmonary diseases. ..