S B Snapper

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes
    Lisa S Westerberg
    Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 207:1145-52. 2010
  2. pmc The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells
    Michel H Maillard
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Exp Med 204:381-91. 2007
  3. ncbi request reprint N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility
    S B Snapper
    Center for Blood Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Cell Biol 3:897-904. 2001
  4. ncbi request reprint A family of WASPs
    Scott B Snapper
    Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 348:350-1. 2003
  5. ncbi request reprint Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha
    D A Fruman
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Science 283:393-7. 1999
  6. ncbi request reprint Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
    S B Snapper
    Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts 02115, USA
    Immunity 9:81-91. 1998
  7. ncbi request reprint The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization
    S B Snapper
    Center for Blood Research, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 17:905-29. 1999
  8. pmc Innate immune response to encephalomyocarditis virus infection mediated by CD1d
    Mark A Exley
    Cancer Biology Program, Hematology Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Immunology 110:519-26. 2003
  9. pmc WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility
    Catherine Yan
    Center for Blood Research, 200 Longwood Avenue, Boston, MA 02115, USA
    EMBO J 22:3602-12. 2003
  10. ncbi request reprint Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells
    Vadim I Pivniouk
    Division of Immunology, Children s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int Immunol 15:1431-40. 2003

Collaborators

Detail Information

Publications29

  1. pmc Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes
    Lisa S Westerberg
    Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 207:1145-52. 2010
    ..These data indicate that there are unique requirements for the presence and activation status of WASP in B and T cells and that WASP-activating mutations interfere with lymphocyte cell survival and genomic stability...
  2. pmc The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells
    Michel H Maillard
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Exp Med 204:381-91. 2007
    ..Overall, our data reveal a critical role for WASP in nTreg cell function and implicate nTreg cell dysfunction in the autoimmunity associated with WASP deficiency...
  3. ncbi request reprint N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility
    S B Snapper
    Center for Blood Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Cell Biol 3:897-904. 2001
    ..These results imply a crucial and non-redundant role for N-WASP in murine embryogenesis and in the actin-based motility of certain pathogens but not in the general formation of actin-containing structures...
  4. ncbi request reprint A family of WASPs
    Scott B Snapper
    Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 348:350-1. 2003
  5. ncbi request reprint Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha
    D A Fruman
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Science 283:393-7. 1999
    ..In contrast, T cell development and proliferation was normal. This phenotype is similar to defects observed in mice lacking the tyrosine kinase Btk...
  6. ncbi request reprint Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
    S B Snapper
    Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts 02115, USA
    Immunity 9:81-91. 1998
    ..We discuss the implications of our findings regarding WASP function in receptor signaling and cytoskeletal reorganization in T and B cells and compare the effects of WASP deficiency in mice and humans...
  7. ncbi request reprint The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization
    S B Snapper
    Center for Blood Research, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 17:905-29. 1999
    ..WASP/N-WASP may depolymerize actin directly and/or serve as an adaptor or scaffold for these signaling molecules in a complex cascade that regulates the cytoskeleton...
  8. pmc Innate immune response to encephalomyocarditis virus infection mediated by CD1d
    Mark A Exley
    Cancer Biology Program, Hematology Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Immunology 110:519-26. 2003
    ..We propose that CD1d-reactive T cells respond to early immune signals and function in the innate immune response to a physiological viral infection by rapidly augmenting APC IL-12 production and activating NK cells...
  9. pmc WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility
    Catherine Yan
    Center for Blood Research, 200 Longwood Avenue, Boston, MA 02115, USA
    EMBO J 22:3602-12. 2003
    ..These results imply a non-redundant role for WAVE2 in murine embryogenesis and a critical role for WAVE2 in actin-based processes downstream of Rac that are essential for cell movement...
  10. ncbi request reprint Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells
    Vadim I Pivniouk
    Division of Immunology, Children s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int Immunol 15:1431-40. 2003
    ..We conclude that WASP regulates FcepsilonRI-mediated granule exocytosis, cytokine production and cytoskeletal changes in mast cells...
  11. ncbi request reprint Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice
    Christoph Klein
    Division of Molecular Medicine and Pediatric Hematology Oncology, Howard Hughes Medical Institute, The Children s Hospital, Boston, MA, USA
    Blood 101:2159-66. 2003
    ..Our results provide proof of principle that the WAS-associated T-cell signaling defects can be improved upon transplantation of retrovirally transduced HSCs without overt toxicity and may encourage clinical gene therapy trials...
  12. pmc Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development
    Vinicius Cotta-de-Almeida
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:15424-9. 2007
    ..In summary, this study suggests that, although WASP serves a unique role for peripheral T cell function, T cell development depends on the combined activity of WASP and N-WASP...
  13. ncbi request reprint Efficient uptake of Yersinia pseudotuberculosis via integrin receptors involves a Rac1-Arp 2/3 pathway that bypasses N-WASP function
    M A Alrutz
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue M and V 409, Boston, MA 02111, USA
    Mol Microbiol 42:689-703. 2001
    ..Uptake was unaffected by the absence of these proteins, indicating that beta1 integrin signalling from Rac1 to Arp 2/3 can occur in the absence of N-WASP function...
  14. pmc Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein
    Deanna D Nguyen
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 133:1188-97. 2007
    ..Wiskott-Aldrich syndrome protein (WASP) deficiency in mice results in similar clinical features. Herein, we characterized the colitis in WASP-deficient mice...
  15. pmc Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice
    Kabir S Matharu
    Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastroenterology 137:1380-90.e1-3. 2009
    ..We investigated the role of the anti-inflammatory cytokine interleukin (IL)-10 in this signaling pathway using a mouse model of colitis...
  16. ncbi request reprint WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo
    Scott B Snapper
    Gastrointestinal Unit and the Center for Inflammatory Bowel Diseases, Massachusetts General Hospital, Boston, 02114, USA
    J Leukoc Biol 77:993-8. 2005
    ..These results further delineate immunological abnormalities in WASP-deficient mice, which will be useful to assess preclinical gene therapy studies...
  17. ncbi request reprint The NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function
    Nitasha Manchanda
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:12517-22. 2005
    ..This novel function of merlin and the ERMs illustrates a mechanism by which these proteins directly exert their effects on actin reorganization and also provides new insight into N-WASP regulation...
  18. ncbi request reprint Cortactin regulates cell migration through activation of N-WASP
    Jennifer R Kowalski
    Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215, USA
    J Cell Sci 118:79-87. 2005
    ..Thus, our results suggest that cortactin has multiple mechanisms by which it can recruit and modulate the actin machinery and ultimately regulate cell migration...
  19. pmc Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival
    Emerson Liu
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, 02129, USA
    Mol Cell Biol 25:11145-55. 2005
    ..These data extend the role of ILK to immune-cell trafficking and survival via modulation of Akt- and Rac-dependent substrates, and have implications for cell recruitment in both homeostatic and pathological processes...
  20. pmc WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function
    Lisa S Westerberg
    Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, Boston, USA
    Blood 112:4139-47. 2008
    ..Our findings reveal that WASP regulates both development and function of hematopoietic cells. We demonstrate that WASP deficiency leads to an aberrant MZ that may affect responses to blood-borne pathogens and peripheral B-cell tolerance...
  21. pmc Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice
    Anna Lyubimova
    Gastrointestinal Unit and Center for Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 120:446-56. 2010
    ..We therefore propose that N-WASP acts as a positive regulator of beta-catenin-dependent transcription, modulating differentiation of HF progenitor cells...
  22. ncbi request reprint Cdc42 facilitates invasion but not the actin-based motility of Shigella
    Tomoyuki Shibata
    Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, 55 Blossom Street, Boston, MA 02114, USA
    Curr Biol 12:341-5. 2002
    ..These data further support the involvement of distinct host-encoded proteins in the steps regulating invasion and intercellular spread of Shigella...
  23. pmc Activating mutations of N-WASP alter Shigella pathogenesis
    David A Adamovich
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Biochem Biophys Res Commun 384:284-9. 2009
    ..However, plaque numbers were increased in cells expressing N-WASP L229P and L232P. These data demonstrate that N-WASP structural conformation is an important regulator of Shigella pathogenesis in distinct segments of its lifecycle...
  24. ncbi request reprint Shigella interactions with the actin cytoskeleton in the absence of Ena/VASP family proteins
    Shabeen Ally
    Infectious Disease Division, Massachusetts General Hospital, Cambridge, MA 02139, USA
    Cell Microbiol 6:355-66. 2004
    ..Thus, although VASP is recruited to the surface of intracellular Shigella, it is not essential for Shigella actin-based motility...
  25. ncbi request reprint A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome
    Catherine Lacout
    U362 Institut National de la Santé et de la Recherche Médicale INSERM, Institut Gustave Roussy, Villejuif, France
    Blood 102:1282-9. 2003
    ..Therefore, the mechanism of the skewed X-chromosomal inactivation observed in WAS carriers may be related to a migration defect of WASP-deficient HSCs...
  26. pmc A new method for rapidly generating gene-targeting vectors by engineering BACs through homologous recombination in bacteria
    Vinicius Cotta-de-Almeida
    Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Genome Res 13:2190-4. 2003
    ..This procedure avoids the need to construct or screen genomic libraries and permits the generation of most standard, conditional, or knock-in targeting vectors, often within two weeks...
  27. ncbi request reprint Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerization
    Gonzalo M Rivera
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Curr Biol 14:11-22. 2004
    ..Although several studies have implicated Nck in regulating actin polymerization, its role in living cells is not well understood...
  28. pmc Role of the WASP family proteins for Mycobacterium marinum actin tail formation
    Luisa M Stamm
    Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:14837-42. 2005
    ..Together, these data demonstrate that M. marinum subversion of host actin polymerization is most similar to distantly related Gram-negative organisms but that its mechanism for activating WASP family proteins is unique...
  29. ncbi request reprint A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis
    Samuel Solomon
    Immunology, Department of Biology, Faculty of Sciences, University of Konstanz, Konstanz, Germany
    Eur J Immunol 35:3064-73. 2005
    ....

Research Grants12

  1. The Pathogenesis Of Colitis In A Novel Th2 Model Of IBD
    Scott Snapper; Fiscal Year: 2002
    ....
  2. Exploring Regulatory T Cell Dysfunction in a Murine Model of Colitis
    Scott B Snapper; Fiscal Year: 2010
    ....
  3. Exploring Regulatory T Cell Dysfunction in a Murine Model of Colitis
    Scott Snapper; Fiscal Year: 2009
    ....
  4. Cytoskeletal-Pathogen Interactions in Shigella Infection
    Scott Snapper; Fiscal Year: 2007
    ..abstract_text> ..
  5. Cytoskeletal-Pathogen Interactions in Shigella Infection
    Scott Snapper; Fiscal Year: 2006
    ..abstract_text> ..
  6. The Pathogenesis Of Colitis In A Novel Th2 Model Of IBD
    Scott Snapper; Fiscal Year: 2004
    ....
  7. Cytoskeletal-Pathogen Interactions in Shigella Infection
    Scott Snapper; Fiscal Year: 2003
    ..abstract_text> ..
  8. The Pathogenesis Of Colitis In A Novel Th2 Model Of IBD
    Scott Snapper; Fiscal Year: 2003
    ....
  9. Exploring Regulatory T Cell Dysfunction in a Murine Model of Colitis
    Scott Snapper; Fiscal Year: 2009
    ....