Research Topics
Genomes and Genes | S B SnapperSummaryAffiliation: Harvard University Country: USA Publications
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Publications
N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motilityS B Snapper
Center for Blood Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Cell Biol 3:897-904. 2001..These results imply a crucial and non-redundant role for N-WASP in murine embryogenesis and in the actin-based motility of certain pathogens but not in the general formation of actin-containing structures...- A family of WASPsScott B Snapper
Massachusetts General Hospital, Boston, MA 02114, USA
N Engl J Med 348:350-1. 2003 - Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alphaD A Fruman
Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Science 283:393-7. 1999..In contrast, T cell development and proliferation was normal. This phenotype is similar to defects observed in mice lacking the tyrosine kinase Btk... - The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organizationS B Snapper
Center for Blood Research, Boston, Massachusetts 02115, USA
Annu Rev Immunol 17:905-29. 1999..WASP/N-WASP may depolymerize actin directly and/or serve as an adaptor or scaffold for these signaling molecules in a complex cascade that regulates the cytoskeleton... 
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motilityCatherine Yan
Center for Blood Research, 200 Longwood Avenue, Boston, MA 02115, USA
EMBO J 22:3602-12. 2003..These results imply a non-redundant role for WAVE2 in murine embryogenesis and a critical role for WAVE2 in actin-based processes downstream of Rac that are essential for cell movement...- Innate immune response to encephalomyocarditis virus infection mediated by CD1dMark A Exley
Cancer Biology Program, Hematology Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Immunology 110:519-26. 2003..We propose that CD1d-reactive T cells respond to early immune signals and function in the innate immune response to a physiological viral infection by rapidly augmenting APC IL-12 production and activating NK cells... - Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activationS B Snapper
Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts 02115, USA
Immunity 9:81-91. 1998..We discuss the implications of our findings regarding WASP function in receptor signaling and cytoskeletal reorganization in T and B cells and compare the effects of WASP deficiency in mice and humans... - Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cellsVadim I Pivniouk
Division of Immunology, Children s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
Int Immunol 15:1431-40. 2003..We conclude that WASP regulates FcepsilonRI-mediated granule exocytosis, cytokine production and cytoskeletal changes in mast cells... - Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell developmentVinicius Cotta-de-Almeida
Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 104:15424-9. 2007..In summary, this study suggests that, although WASP serves a unique role for peripheral T cell function, T cell development depends on the combined activity of WASP and N-WASP... - Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytesLisa S Westerberg
Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
J Exp Med 207:1145-52. 2010..These data indicate that there are unique requirements for the presence and activation status of WASP in B and T cells and that WASP-activating mutations interfere with lymphocyte cell survival and genomic stability... - Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in miceChristoph Klein
Division of Molecular Medicine and Pediatric Hematology/Oncology, Howard Hughes Medical Institute, The Children's Hospital, Boston, MA, USA
Blood 101:2159-66. 2003..Our results provide proof of principle that the WAS-associated T-cell signaling defects can be improved upon transplantation of retrovirally transduced HSCs without overt toxicity and may encourage clinical gene therapy trials... - Efficient uptake of Yersinia pseudotuberculosis via integrin receptors involves a Rac1-Arp 2/3 pathway that bypasses N-WASP functionM A Alrutz
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue M and V 409, Boston, MA 02111, USA
Mol Microbiol 42:689-703. 2001..Uptake was unaffected by the absence of these proteins, indicating that beta1 integrin signalling from Rac1 to Arp 2/3 can occur in the absence of N-WASP function... - WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivoScott B Snapper
Gastrointestinal Unit and the Center for Inflammatory Bowel Diseases, Massachusetts General Hospital, Boston, 02114, USA
J Leukoc Biol 77:993-8. 2005..These results further delineate immunological abnormalities in WASP-deficient mice, which will be useful to assess preclinical gene therapy studies... - Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome proteinDeanna D Nguyen
Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Gastroenterology 133:1188-97. 2007..Wiskott-Aldrich syndrome protein (WASP) deficiency in mice results in similar clinical features. Herein, we characterized the colitis in WASP-deficient mice... - The NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization functionNitasha Manchanda
Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Biol Chem 280:12517-22. 2005..This novel function of merlin and the ERMs illustrates a mechanism by which these proteins directly exert their effects on actin reorganization and also provides new insight into N-WASP regulation... - Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient miceKabir S Matharu
Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
Gastroenterology 137:1380-90.e1-3. 2009..We investigated the role of the anti-inflammatory cytokine interleukin (IL)-10 in this signaling pathway using a mouse model of colitis... 
The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cellsMichel H Maillard
Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
J Exp Med 204:381-91. 2007..Overall, our data reveal a critical role for WASP in nTreg cell function and implicate nTreg cell dysfunction in the autoimmunity associated with WASP deficiency...- Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survivalEmerson Liu
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, 02129, USA
Mol Cell Biol 25:11145-55. 2005..These data extend the role of ILK to immune-cell trafficking and survival via modulation of Akt- and Rac-dependent substrates, and have implications for cell recruitment in both homeostatic and pathological processes... - WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and functionLisa S Westerberg
Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, Boston, USA
Blood 112:4139-47. 2008..Our findings reveal that WASP regulates both development and function of hematopoietic cells. We demonstrate that WASP deficiency leads to an aberrant MZ that may affect responses to blood-borne pathogens and peripheral B-cell tolerance... - Cortactin regulates cell migration through activation of N-WASPJennifer R Kowalski
Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215, USA
J Cell Sci 118:79-87. 2005..Thus, our results suggest that cortactin has multiple mechanisms by which it can recruit and modulate the actin machinery and ultimately regulate cell migration... - Activating mutations of N-WASP alter Shigella pathogenesisDavid A Adamovich
Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Biochem Biophys Res Commun 384:284-9. 2009..However, plaque numbers were increased in cells expressing N-WASP L229P and L232P. These data demonstrate that N-WASP structural conformation is an important regulator of Shigella pathogenesis in distinct segments of its lifecycle... - Cdc42 facilitates invasion but not the actin-based motility of ShigellaTomoyuki Shibata
Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, 55 Blossom Street, Boston, MA 02114, USA
Curr Biol 12:341-5. 2002..These data further support the involvement of distinct host-encoded proteins in the steps regulating invasion and intercellular spread of Shigella... - Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in miceAnna Lyubimova
Gastrointestinal Unit and Center for Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Invest 120:446-56. 2010..We therefore propose that N-WASP acts as a positive regulator of beta-catenin-dependent transcription, modulating differentiation of HF progenitor cells... - Shigella interactions with the actin cytoskeleton in the absence of Ena/VASP family proteinsShabeen Ally
Infectious Disease Division, Massachusetts General Hospital, Cambridge, MA 02139, USA
Cell Microbiol 6:355-66. 2004..Thus, although VASP is recruited to the surface of intracellular Shigella, it is not essential for Shigella actin-based motility... - A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndromeCatherine Lacout
U362 Institut National de la Santé et de la Recherche Médicale INSERM, Institut Gustave Roussy, Villejuif, France
Blood 102:1282-9. 2003..Therefore, the mechanism of the skewed X-chromosomal inactivation observed in WAS carriers may be related to a migration defect of WASP-deficient HSCs... - Role of the WASP family proteins for Mycobacterium marinum actin tail formationLuisa M Stamm
Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 102:14837-42. 2005..Together, these data demonstrate that M. marinum subversion of host actin polymerization is most similar to distantly related Gram-negative organisms but that its mechanism for activating WASP family proteins is unique... - A crucial role for macrophages in the pathology of K/B x N serum-induced arthritisSamuel Solomon
Immunology, Department of Biology, Faculty of Sciences, University of Konstanz, Konstanz, Germany
Eur J Immunol 35:3064-73. 2005.... - Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerizationGonzalo M Rivera
Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Curr Biol 14:11-22. 2004.... - A new method for rapidly generating gene-targeting vectors by engineering BACs through homologous recombination in bacteriaVinicius Cotta-de-Almeida
Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Genome Res 13:2190-4. 2003..This procedure avoids the need to construct or screen genomic libraries and permits the generation of most standard, conditional, or knock-in targeting vectors, often within two weeks...
Research Grants
- Exploring Regulatory T Cell Dysfunction in a Murine Model of ColitisScott B Snapper; Fiscal Year: 2010....
- Cytoskeletal-Pathogen Interactions in Shigella InfectionScott Snapper; Fiscal Year: 2007..abstract_text> ..
- Cytoskeletal-Pathogen Interactions in Shigella InfectionScott Snapper; Fiscal Year: 2006..abstract_text> ..
- The Pathogenesis Of Colitis In A Novel Th2 Model Of IBDScott Snapper; Fiscal Year: 2004....
- Exploring Regulatory T Cell Dysfunction in a Murine Model of ColitisScott Snapper; Fiscal Year: 2009....