Research Topics
Species | JORDAN W contact SMOLLERSummaryAffiliation: Harvard University Country: USA Publications
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Publications
The genetic basis of panic and phobic anxiety disordersJordan W Smoller
Harvard Medical School, Psychiatric Genetics Program in Mood and Anxiety Disorders, Massachusetts General Hospital, Boston, MA, USA
Am J Med Genet C Semin Med Genet 148:118-26. 2008..The identification of specific susceptibility variants will likely require much larger sample sizes and the integration of insights from genetic analyses of animal models and intermediate phenotypes...
Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHDJordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 59:460-7. 2006..Association with a single nucleotide polymorphism (SNP; G861C) has been observed, but more extensive linkage disequilibrium analyses have not been reported...- Panic attacks, daily life ischemia, and chest pain in postmenopausal womenJordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
Psychosom Med 68:824-32. 2006..Chest pain is a common symptom of panic attacks, but little is known about the relationship in older women among panic attacks, chest pain, and daily life ischemia... - Genetics of anxiety disorders: complexities and opportunitiesJordan W Smoller
Psychiatric Genetics Program in Mood and AnxietyDisorders, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
Am J Med Genet C Semin Med Genet 148:85-8. 2008 - Panic attacks and risk of incident cardiovascular events among postmenopausal women in the Women's Health Initiative Observational StudyJordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
Arch Gen Psychiatry 64:1153-60. 2007..Previous studies have documented an association of depression and phobic anxiety with cardiovascular morbidity and mortality, but little is known about the cardiovascular sequelae of panic anxiety... - Genetics of anxiety disorders: the complex road from DSM to DNAJordan W Smoller
Psychiatric Genetics Program in Mood and Anxiety Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Depress Anxiety 26:965-75. 2009..If successful, such efforts may yield novel and more effective approaches for the prevention and treatment of these common and costly disorders... - Genetics of bipolar disorderJordan W Smoller
Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Curr Psychiatry Rep 9:504-11. 2007..Genome-wide association studies have begun to appear for BPD, and more are in progress. By providing an unbiased approach, this technology may reveal novel biological mechanisms underlying BPD... - Influence of RGS2 on anxiety-related temperament, personality, and brain functionJordan W Smoller
Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Arch Gen Psychiatry 65:298-308. 2008..The gene encoding regulator of G protein signaling 2 (Rgs2) is a quantitative trait gene that influences mouse anxiety behavior, making its human ortholog (RGS2) a compelling candidate gene for human anxiety phenotypes... - Genetics of anxiety: would the genome recognize the DSM?Jordan W Smoller
Department of Psychiatry, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Depress Anxiety 25:368-77. 2008..Finally, we discuss future directions for the genetic dissection of anxiety disorders... - Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women's Health Initiative studyJordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
Arch Intern Med 169:2128-39. 2009..Antidepressants are commonly prescribed medications, but their effect on cardiovascular morbidity and mortality remains unclear... - The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorderJordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
Biol Psychiatry 57:1485-92. 2005..To evaluate this further, we genotyped additional families for this marker and a panel of markers encompassing the CRH locus... - Prevalence and correlates of panic attacks in postmenopausal women: results from an ancillary study to the Women's Health InitiativeJordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Arch Intern Med 163:2041-50. 2003..Panic attacks are known to be more common in women than in men, but the prevalence and correlates of panic in the postmenopausal period have not been well defined... - Family, twin, and adoption studies of bipolar disorderJordan W Smoller
Harvard Medical School, Boston, MA 02114, USA
Am J Med Genet C Semin Med Genet 123:48-58. 2003..Taken together, these studies indicate that bipolar disorder is phenotypically and genetically complex... - Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorderJoseph Biederman
Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
Psychiatry Res 170:199-203. 2009..94) and 5HTTLPR long allele. Our findings suggest that the DRD4 7-repeat allele is associated with a more persistent course of ADHD... - A genetic family-based association study of OLIG2 in obsessive-compulsive disorderS Evelyn Stewart
Psychiatric Neuroscience Research Division, and Obsessive Compulsive Disorder Clinic, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Arch Gen Psychiatry 64:209-14. 2007..The gene for oligodendrocyte lineage transcription factor 2 (OLIG2) is an essential regulator in the development of cells that produce white matter (myelin). The OLIG2 gene is also highly expressed in brain regions implicated in OCD... - Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibitionJordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 54:1376-81. 2003..Transgenic mice overexpressing CRH exhibit BI-like behaviors, implicating this gene in the development of the phenotype... 
Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary studyJoseph Biederman
Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008..Although our results are not fully validated yet, they should motivate further investigation of gender effects in ADHD genetic association studies...- Comparing anxiety disorders and anxiety-related traits in bipolar disorder and unipolar depressionNaomi M Simon
WACC 815, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
J Psychiatr Res 37:187-92. 2003..Further research is needed to clarify the etiologic basis of anxiety disorder/BPD comorbidity and to optimize treatment strategies for patients with these co-occurring disorders... - Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D studyRoy H Perlis
Massachusetts General Hospital, Boston, MA 02114, USA
Arch Gen Psychiatry 64:689-97. 2007.... - Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depressionJie Huang
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Psychiatric Genetics Program in Mood and Anxiety Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 167:1254-63. 2010..The purpose of this study was to apply genomewide association study (GWAS) analysis to address the specificity of genetic effects on these disorders... - Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorderS Evelyn Stewart
Psychiatric Neurodevelopmental and Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 144:1027-33. 2007..Two separate proximal haplotypes in the glutamate transporter gene, SLC1A1, were recently reported to be associated with OCD among males, but replication is required... - Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locusJinbo Fan
Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 153:29-37. 2010..Further studies in larger samples are warranted to clarify which, if any, genes in the 6q region confer risk for bipolar disorder... - Family based association analysis of statistically derived quantitative traits for drug use in ADHD and the dopamine transporter geneJessica Lasky-Su
Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, and Pediatric psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
Addict Behav 31:1088-99. 2006..A sliding window of analysis of 3 SNPs also resulted in only nominal associations. CONCLUSIONS: SNPs in DAT do not appear to be associated with the phenotypes generated from drug frequency variables among individuals with ADHD... - Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophreniaHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 11:701-10. 2009..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders... - Suggestive linkage of the child behavior checklist juvenile bipolar disorder phenotype to 1p21, 6p21, and 8q21Alysa E Doyle
Psychiatric and Neurodevelopmental Genetics Unit, Harvard Medical School, Center for Human Genetics Research at Massachusetts General Hospital, Boston MA 02114, USA
J Am Acad Child Adolesc Psychiatry 49:378-87. 2010.... - Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8qMatthew B McQueen
Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
Am J Hum Genet 77:582-95. 2005..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches... - Family based association study of pediatric bipolar disorder and the dopamine transporter gene (SLC6A3)Eric Mick
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 147:1182-5. 2008..These data provide suggestive evidence supporting a role for SLC6A3 in the etiology of pediatric bipolar disorder... - Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participantsRoy H Perlis
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Arch Gen Psychiatry 65:882-92. 2008.... - Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study IIKarestan C Koenen
Department of Society, Human Development and Health, Harvard School of Public Health, Boston, MA 02115, USA
BMC Psychiatry 9:29. 2009..Although twin studies suggest genetic influences account for substantial variance in PTSD risk, little progress has been made in identifying variants in specific genes that influence liability to this common, debilitating disorder... - The relationship of anxiety disorders, anxiety sensitivity and pulmonary dysfunction with dyspnea-related distress and avoidanceNaomi M Simon
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Nerv Ment Dis 194:951-7. 2006.... - A genomewide association study of response to lithium for prevention of recurrence in bipolar disorderRoy H Perlis
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Am J Psychiatry 166:718-25. 2009.... - Investigation of parent-of-origin effects in ADHD candidate genesJang Woo Kim
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 144:776-80. 2007..Thus, we conclude that a substantial parent-of-origin effect is unlikely for these leading ADHD candidate genes... - Time trends in mortality associated with depression: findings from the Stirling County studyJane M Murphy
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
Can J Psychiatry 55:776-83. 2010.... - Benzodiazepine use and risk of recurrence in bipolar disorder: a STEP-BD reportRoy H Perlis
Bipolar Clinic and Research Programs, 50 Staniford St, 5th Floor, Boston, MA 02114, USA
J Clin Psychiatry 71:194-200. 2010..Benzodiazepines are widely prescribed to patients with bipolar disorder, but their impact on relapse and recurrence has not been examined... - Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patientsRoy H Perlis
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Neuropsychopharmacology 34:1819-28. 2009..These hypothesis-generating analyses suggest the potential for glutamatergic treatment targets for sexual dysfunction during major depressive episodes... - Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: suggestive linkage to 3q13Alysa E Doyle
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 147:1399-411. 2008..Overall, these data support the utility of neurocognitive traits as ADHD endophenotypes, but also highlight their limited genetic overlap with the disorder... - Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D studyRoy H Perlis
Depression Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Neuropsychopharmacology 33:2810-9. 2008..More broadly, they indicate the utility of animal models in identifying genes for pharmacogenetic studies of antidepressant response... - Panic disorder and bipolar disorder: anxiety sensitivity as a potential mediator of panic during manic statesNaomi M Simon
Massachusetts General Hospital, WACC 815, 15 Parkman Street, Boston, Massachusetts 02114, United States
J Affect Disord 87:101-5. 2005..Anxiety sensitivity (AS), a risk factor for PD appears greater in bipolar disorder compared to unipolar depression, although the association of specific mood states with AS remains unknown... - Serotonin transporter polymorphisms and adverse effects with fluoxetine treatmentRoy H Perlis
Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
Biol Psychiatry 54:879-83. 2003..This study investigated a possible association with treatment-emergent insomnia or agitation... - When is pharmacogenetic testing for antidepressant response ready for the clinic? A cost-effectiveness analysis based on data from the STAR*D studyRoy H Perlis
Center for Human Genetics Research, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Neuropsychopharmacology 34:2227-36. 2009..These circumstances, particularly availability of alternative treatment strategies and test effect sizes, can be estimated and should be considered before these tests are broadly applied in clinical settings... - Assessing the impact of population stratification on genetic association studiesMatthew L Freedman
Department of Medicine and Molecular Biology, Massachusetts General Hospital, Boston, and Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
Nat Genet 36:388-93. 2004..Our results suggest that modest amounts of stratification can exist even in well designed studies... - Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorderRoy H Perlis
Center for Human Genetic Research and the Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 167:574-9. 2010..However, the prevalence of HTT CAG repeat expansions among individuals diagnosed with major depressive disorder has not been established... - The prevalence and clinical correlates of anger attacks during depressive episodes in bipolar disorderRoy H Perlis
Massachusetts General Hospital Department of Psychiatry, Boston, MA, USA
J Affect Disord 79:291-5. 2004..This study compared the prevalence and clinical significance of anger attacks in unipolar versus bipolar depression... - Cortical thickness abnormalities in cocaine addiction--a reflection of both drug use and a pre-existing disposition to drug abuse?Nikos Makris
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Neuron 60:174-88. 2008..These observations suggest that brain structure abnormalities in addicts are related in part to drug use and in part to predisposition toward addiction... - Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorderManuel A R Ferreira
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nat Genet 40:1056-8. 2008..0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder... - Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorderRoy H Perlis
Depression Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 62:536-40. 2007..Therefore, we examined the association between CREB1 polymorphisms and anger expression in MDD... - Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated agingNaomi M Simon
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Biol Psychiatry 60:432-5. 2006..We propose that chronic stress associated with mood disorders may contribute to excess vulnerability for diseases of aging such as cardiovascular disease and possibly some cancers through accelerated organismal aging... - Psychiatric genetics: a survey of psychiatrists' knowledge, opinions, and practice patternsChristine T Finn
Department of Psychiatry, the Psychiatric Genetics Program in Mood and Anxiety Disorders, Massachusetts General Hospital, Boston, Mass 02115, USA
J Clin Psychiatry 66:821-30. 2005..The goal of this study was to assess psychiatrists' familiarity with and attitudes toward genetic information... - Genetic counseling in psychiatryChristine T Finn
Harvard Medical School, Department of Psychiatry and Psychiatric Genetics Program in Mood and Anxiety Disorders, Massachusetts General Hospital, Boston, MA, USA
Harv Rev Psychiatry 14:109-21. 2006.... - Critical thinking about adverse drug effects: lessons from the psychology of risk and medical decision-making for clinical psychopharmacologyAndrew A Nierenberg
Depression and Bipolar Clinical and Research Programs, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Psychother Psychosom 77:201-8. 2008..Our purpose is to increase the awareness of how pharmaceutical companies may influence physicians by framing the risk of medication side effects to favor their products... - Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individualsJessica Lasky-Su
Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Am J Med Genet B Neuropsychiatr Genet 147:100-6. 2008..This analysis adds to previous findings by suggesting that variants at these loci may be specifically associated with inattentive symptoms... - Genetic boundary violations: phobic disorders and personalityJordan W Smoller
Am J Psychiatry 164:1631-3. 2007 - Molecular genetics of attention-deficit/hyperactivity disorderStephen V Faraone
Medical Genetics Research Center and Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
Biol Psychiatry 57:1313-23. 2005.... - Serotonin gene polymorphisms and bipolar I disorder: focus on the serotonin transporterHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, U S A
Ann Med 37:590-602. 2005..Our analyses do not support association between SLC6A4 and BDI families. Further studies using sub-groups of BDI are worthwhile... - The interface of genetics and clinical psychiatry. IntroductionEric M Morrow
Harv Rev Psychiatry 14:45-6. 2006 - Incorporating pharmacogenetics into clinical practice: reality of a new tool in psychiatry. Practical issues related to medication selectionJordan W Smoller
CNS Spectr 11:5-7. 2006 - Testing and estimating gene-environment interactions in family-based association studiesStijn Vansteelandt
Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281, S9, B 9000 Gent, Belgium
Biometrics 64:458-67. 2008..Simulation studies show that the proposed methodology is sufficiently powered for realistic sample sizes and that it provides valid tests and effect size estimators in the presence of admixture and stratification...
Research Grants
- GENETIC DISSECTION OF ANXIOUS TEMPERAMENTJordan Smoller; Fiscal Year: 2004..This integrated program of training and research in genetic methods will prepare the candidate to be an independent investigator in the rapidly evolving field of psychiatric genetics. ..
- Using Genetics to Dissect Schizhoprenia, Bipolar Disorder, and DepressionJordan W Smoller; Fiscal Year: 2010..Finally, the phenotypic and genetic database derived from these analyses will provide a valuable resource for future genetic studies by the scientific community. ..
- International Cohort Collection for Bipolar DisorderJordan Smoller; Fiscal Year: 2009..The proposed International Cohort Collection for Bipolar Disorder (ICCBD) will address the need for large-scale DNA and data resources by establishing a uniquely large collection of samples and data from individuals with BPD. ..
- Using Genetics to Dissect Schizhoprenia, Bipolar Disorder, and DepressionJordan Smoller; Fiscal Year: 2009..Finally, the phenotypic and genetic database derived from these analyses will provide a valuable resource for future genetic studies by the scientific community. ..
- Using Genetics to Dissect Schizhoprenia, Bipolar Disorder, and DepressionJordan Smoller; Fiscal Year: 2007..Finally, the phenotypic and genetic database derived from these analyses will provide a valuable resource for future genetic studies by the scientific community. ..
- Genetic Determinants of Bipolar DisorderJordan Smoller; Fiscal Year: 2007..An important dividend of this large study will be the expansion of the repository to include DNA data on relatives and on an independent sample of controls, thus facilitating future genetic studies. ..
- International Cohort Collection for Bipolar DisorderJORDAN W contact SMOLLER; Fiscal Year: 2010..The proposed International Cohort Collection for Bipolar Disorder (ICCBD) will address the need for large-scale DNA and data resources by establishing a uniquely large collection of samples and data from individuals with BPD. ..