Genomes and Genes
J W Smoller
Affiliation: Harvard University
- Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccoloP F Sullivan
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
Mol Psychiatry 14:359-75. 2009..With the integrated replication effort, we present a specific hypothesis for further studies...
- Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study IIKarestan C Koenen
Department of Society, Human Development and Health, Harvard School of Public Health, Boston, MA 02115, USA
BMC Psychiatry 9:29. 2009..Although twin studies suggest genetic influences account for substantial variance in PTSD risk, little progress has been made in identifying variants in specific genes that influence liability to this common, debilitating disorder...
- Genetic association analysis of behavioral inhibition using candidate loci from mouse modelsJ W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Med Genet 105:226-35. 2001..This study illustrates the potential utility of using candidate genes derived from mouse models to dissect the genetic basis of BI, a possible intermediate phenotype for panic and phobic disorders...
- Implications of comorbidity and ascertainment bias for identifying disease genesJ W Smoller
Harvard School of Public Health, Boston, Massachusetts, USA
Am J Med Genet 96:817-22. 2000..We conclude that ascertainment bias may contribute to the frequent difficulty in replicating candidate gene study findings in psychiatry. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:817-822, 2000...
- Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regionsJ W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
Am J Med Genet 105:195-206. 2001..05, P = 0.035). While these linkage results are merely suggestive, this study illustrates the potential advantages of using mouse gene-mapping results and exploring alternative phenotype definitions in linkage studies of anxiety disorder...
- Further evidence of association between two NET single-nucleotide polymorphisms with ADHDJ W Kim
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Mol Psychiatry 13:624-30. 2008..This is the first time that identical alleles of NET from different studies were implicated, and thus our report provides further evidence that the NET gene is involved in the etiology of ADHD...
- Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorderJ Lasky-Su
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Ann Hum Genet 71:648-59. 2007..Although definitive conclusions await independent replication, these results suggest that a variant in DRD5 may affect age at onset for ADHD...
- On the validity of the TDT test in the presence of comorbidity and ascertainment biasJ M Robins
Department of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Genet Epidemiol 21:326-36. 2001..We derive conditions under which the presence of true and/or spurious comorbidity will result in an artificial correlation between the target phenotype and the candidate gene...
- Panic and phobic anxiety: defining phenotypes for genetic studiesJ W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
Am J Psychiatry 155:1152-62. 1998..The authors' aim is to begin to apply this analysis to the anxiety disorders, focusing on panic and phobic disorders...
- Personality and bipolar disorder: dissecting state and trait associations between mood and personalityJ H Barnett
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Psychiatric Genetics Program in Mood and Anxiety Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Psychol Med 41:1593-604. 2011..This study aimed to determine whether there is a characteristic personality profile in BD, and whether associations between BD and personality are best explained by state or trait effects...
- Childhood history of anxiety disorders among adults with social phobia: rates, correlates, and comparisons with patients with panic disorderM W Otto
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Depress Anxiety 14:209-13. 2001....
- Whole-genome association study of bipolar disorderP Sklar
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Psychiatry 13:558-69. 2008..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
- Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a modelR H Perlis
Depression Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Psychol Med 42:41-50. 2012..Electronic medical records (EMR) provide a unique opportunity for efficient, large-scale clinical investigation in psychiatry. However, such studies will require development of tools to define treatment outcome...
- Investigation of variation in SNAP-25 and ADHD and relationship to co-morbid major depressive disorderJ W Kim
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 144:781-90. 2007..We further suggest that co-morbidity with MDD may enhance detection of the association between SNAP-25 and ADHD...
- The genetics of panic disorderC T Finn
Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
Curr Psychiatry Rep 3:131-7. 2001..We review the genetic epidemiology of PD as well as recent molecular genetic studies of the disorder, and conclude with a discussion of promising strategies that attempt to uncover specific genetic loci involved in the etiology of PD...
- BDNF, relative preference, and reward circuitry responses to emotional communicationG P Gasic
Motivation and Emotion Neuroscience Collaboration MENC, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 150:762-81. 2009..This study demonstrates that functional allelic variation in BDNF modulates human brain circuits processing reward/aversion information and relative preference transactions...
- How do clinicians respond to patients who miss appointments?J W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 59:330-8; quiz 339-40. 1998..quot; In an effort to determine how clinicians customarily handle missed appointments, we surveyed mental health clinicians and internists at 2 academic hospitals: a private psychiatric hospital and an urban general hospital...
- The genetics of bipolar disorderJ H Barnett
Center for Human Genetic Research, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Neuroscience 164:331-43. 2009..Detailed genetic dissection of the disorder may provide novel targets (both pharmacologic and psychosocial) for intervention...
- Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorderP H Lee
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
Transl Psychiatry 2:e184. 2012..This result is consistent with previous studies that support a role of the glutamatergic system in synaptic plasticity and MDD and support the potential utility of targeting glutamatergic neurotransmission in the treatment of MDD...
- Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile ratsJ B Levine
Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Neuroscience 151:589-603. 2008..Implications of the findings for understanding, assessing, and treating the maladaptive effects of psychosocial deprivation on physical healing during childhood are discussed...
- A study of how socioeconomic status moderates the relationship between SNPs encompassing BDNF and ADHD symptom counts in ADHD familiesJ Lasky-Su
Medical Genetics Research Program, Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
Behav Genet 37:487-97. 2007..The two exons within BDNF represent potential functional variants that may be causing the observed associations...
- Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured childrenK C Koenen
Mol Psychiatry 10:1058-9. 2005
- Genetic map of rat chromosome 5 including the fatty (fa) locusG E Truett
Laboratory of Human Behavior and Metabolism, Rockefeller University, New York, New York 10021
Mamm Genome 6:25-30. 1995..One locus, D1S85h, was found to lie only 0.4 cM from fa, close enough to serve as a reliable marker for the prediction of phenotype from genotype, and will be useful also for studies on the development of obesity in the fatty rat...