Lois E H Smith


Affiliation: Harvard University
Country: USA


  1. Sun Y, Smith L. Retinal Vasculature in Development and Diseases. Annu Rev Vis Sci. 2018;4:101-122 pubmed publisher
    ..We also review animal models currently used for studying retinal vascular development. ..
  2. Smith L, Hard A, Hellstrom A. The biology of retinopathy of prematurity: how knowledge of pathogenesis guides treatment. Clin Perinatol. 2013;40:201-14 pubmed publisher
    ..Risk factors determined from many clinical studies and animal studies fall into 2 categories: prenatal factors and postnatal factors. ..
  3. Fu Z, Wang Z, Liu C, Gong Y, Cakir B, Liegl R, et al. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018;67:974-985 pubmed publisher
  4. Sun Y, Ju M, Lin Z, Fredrick T, Evans L, Tian K, et al. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015;8:ra94 pubmed publisher
    ..These results suggest that neuronal and glial cell SOCS3 limits pathological retinal angiogenesis by suppressing VEGF signaling. ..
  5. Fu Z, Gong Y, Lofqvist C, Hellstrom A, Smith L. Review: adiponectin in retinopathy. Biochim Biophys Acta. 2016;1862:1392-400 pubmed publisher
    ..Further investigations in this field are likely to lead to new preventative approaches for these diseases. ..
  6. Gong Y, Fu Z, Edin M, Liu C, Wang Z, Shao Z, et al. Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arterioscler Thromb Vasc Biol. 2016;36:1919-27 pubmed publisher
    ..Inhibition of CYP2C activity adds to the protective effects of ?-3 LCPUFA on pathological retinal neovascularization and CNV. ..
  7. Gong Y, Shao Z, Fu Z, Edin M, Sun Y, Liegl R, et al. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016;13:201-211 pubmed publisher
    ..Fenofibrate augmented the overall protective effects of ?-3 LCPUFAs on neovascular eye diseases. ..
  8. Gong Y, Fu Z, Liegl R, Chen J, Hellstrom A, Smith L. ?-3 and ?-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases. Am J Clin Nutr. 2017;106:16-26 pubmed publisher
    ..This review summarizes our current understanding of the roles of ?-3 and ?-6 LC-PUFAs and their enzymatic metabolites in neovascular eye diseases. ..
  9. Fu Z, Gong Y, Liegl R, Wang Z, Liu C, Meng S, et al. FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice. Cell Rep. 2017;18:1606-1613 pubmed publisher
    ..These data suggest that FGF21 may be a therapeutic target for pathologic vessel growth in patients with neovascular eye diseases, including retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration. ..

More Information


  1. Sun Y, Lin Z, Liu C, Gong Y, Liegl R, Fredrick T, et al. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017;214:1753-1767 pubmed publisher
    ..These findings suggested that the photoreceptor c-Fos controls blood vessel growth into the normally avascular photoreceptor layer through the inflammatory signal-induced STAT3/VEGFA pathway. ..
  2. Fu Z, Lofqvist C, Liegl R, Wang Z, Sun Y, Gong Y, et al. Photoreceptor glucose metabolism determines normal retinal vascular growth. EMBO Mol Med. 2018;10:76-90 pubmed publisher
    ..Photoreceptor knockdown of Pdgfb delayed retinal vascular formation. Stimulation of the APN pathway might prevent hyperglycemia-associated retinal abnormalities and suppress phase I ROP in premature infants. ..