Kiersten S Smith
Affiliation: Harvard University
- Behavioral responses during the initial exposures to a low dose of cocaine in late preweanling and adult ratsKiersten S Smith
Center for Molecular and Behavioral Neuroscience, Rutgers University, USA
Neurotoxicol Teratol 30:202-12. 2008..The behavioral patterns of this age group offer a preclinical model of the early effects of drugs of abuse...
- Reduction of fear-potentiated startle by benzodiazepines in C57BL/6J miceKiersten S Smith
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 213:697-706. 2011..Recent surges in the diagnosis of posttraumatic stress disorder (PTSD) from combat-exposed veterans have prompted an urgent need to understand the pathophysiology underlying this debilitating condition...
- Behavioral differences between late preweanling and adult female Sprague-Dawley rat exploration of animate and inanimate stimuli and foodKiersten S Smith
Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
Behav Brain Res 217:326-36. 2011..These data provide a basis for the use of the preweanling as a preclinical model for understanding and medicating human disorders during development that are characterized by dysfunctional interactions with specific stimuli...
- Benzodiazepine-induced anxiolysis and reduction of conditioned fear are mediated by distinct GABAA receptor subtypes in miceKiersten S Smith
Laboratory of Genetic Neuropharmacology, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Neuropharmacology 63:250-8. 2012..This raises the possibility that GABAergic pharmacological interventions for specific anxiety disorders can be differentially tailored...
- Comparison of infant and adult rats in exploratory activity, diurnal patterns, and responses to novel and anxiety-provoking environmentsKiersten S Smith
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, US
Behav Neurosci 121:449-61. 2007..Such differences may allow enhanced gathering of environmental information by the infant and are important to consider in the design of experiments using infants...
- Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypesKiersten S Smith
Laboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA, USA
Neuropharmacology 62:54-62. 2012..This article is part of a Special Issue entitled 'Anxiety and Depression'...
- Antidepressant-like properties of α2-containing GABA(A) receptorsIsabel Vollenweider
Laboratory of Genetic Neuropharmacology, McLean Hospital, and Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
Behav Brain Res 217:77-80. 2011..2-containing GABA(A) receptors may therefore represent a novel target for the development of more effective antidepressants...