Kiersten S Smith
Affiliation: Harvard University
- Behavioral responses during the initial exposures to a low dose of cocaine in late preweanling and adult ratsKiersten S Smith
Center for Molecular and Behavioral Neuroscience, Rutgers University, USA
Neurotoxicol Teratol 30:202-12. 2008..The behavioral patterns of this age group offer a preclinical model of the early effects of drugs of abuse...
- Reduction of fear-potentiated startle by benzodiazepines in C57BL/6J miceKiersten S Smith
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 213:697-706. 2011..Recent surges in the diagnosis of posttraumatic stress disorder (PTSD) from combat-exposed veterans have prompted an urgent need to understand the pathophysiology underlying this debilitating condition...
- Behavioral differences between late preweanling and adult female Sprague-Dawley rat exploration of animate and inanimate stimuli and foodKiersten S Smith
Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
Behav Brain Res 217:326-36. 2011..These data provide a basis for the use of the preweanling as a preclinical model for understanding and medicating human disorders during development that are characterized by dysfunctional interactions with specific stimuli...
- Benzodiazepine-induced anxiolysis and reduction of conditioned fear are mediated by distinct GABAA receptor subtypes in miceKiersten S Smith
Laboratory of Genetic Neuropharmacology, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Neuropharmacology 63:250-8. 2012..This raises the possibility that GABAergic pharmacological interventions for specific anxiety disorders can be differentially tailored...
- Comparison of infant and adult rats in exploratory activity, diurnal patterns, and responses to novel and anxiety-provoking environmentsKiersten S Smith
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, US
Behav Neurosci 121:449-61. 2007..Such differences may allow enhanced gathering of environmental information by the infant and are important to consider in the design of experiments using infants...
- Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channelsAntonio Riccio
Howard Hughes Medical Institute, Department of Cardiology, Boston Children s Hospital, Boston, Massachusetts 02115, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, and Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg 194223, Russia
J Neurosci 34:3653-67. 2014..Thus, TRPC4 and the structurally and functionally related subunit, TRPC5, may both contribute to the mechanisms underlying regulation of innate fear responses. ..
- Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypesKiersten S Smith
Laboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA, USA
Neuropharmacology 62:54-62. 2012..This article is part of a Special Issue entitled 'Anxiety and Depression'...
- Neural Basis of Benzodiazepine Reward: Requirement for α2 Containing GABAA Receptors in the Nucleus AccumbensElif Engin
1 Laboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA, USA 2 Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Neuropsychopharmacology 39:1805-15. 2014..Findings imply that α2GABAARs in the NAc are involved in at least some reward-related properties of benzodiazepines, which might partially underlie repeated drug-taking behavior. ..
- Antidepressant-like properties of α2-containing GABA(A) receptorsIsabel Vollenweider
Laboratory of Genetic Neuropharmacology, McLean Hospital, and Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
Behav Brain Res 217:77-80. 2011..2-containing GABA(A) receptors may therefore represent a novel target for the development of more effective antidepressants...