J A Sloane

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2
    J A Sloane
    Department of Neurology, Center for Life Sciences, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 107:11555-60. 2010
  2. ncbi request reprint Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey
    J A Sloane
    Department of Pathology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurochem 84:157-68. 2003

Detail Information

Publications2

  1. pmc Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2
    J A Sloane
    Department of Neurology, Center for Life Sciences, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 107:11555-60. 2010
    ..We thus have defined a mechanism controlling remyelination failure in MS where hyaluronan is degraded by hyaluronidases into hyaluronan oligomers that block OPC maturation and remyelination through TLR2-MyD88 signaling...
  2. ncbi request reprint Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey
    J A Sloane
    Department of Pathology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurochem 84:157-68. 2003
    ..The overexpression of CNPase and MOSP suggests new formation of myelin by oligodendrocytes, which may occur in response to myelin degradation and injury caused by proteolytic enzymes such as calpain...