- Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2J A Sloane
Department of Neurology, Center for Life Sciences, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 107:11555-60. 2010..We thus have defined a mechanism controlling remyelination failure in MS where hyaluronan is degraded by hyaluronidases into hyaluronan oligomers that block OPC maturation and remyelination through TLR2-MyD88 signaling...
- Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkeyJ A Sloane
Department of Pathology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurochem 84:157-68. 2003..The overexpression of CNPase and MOSP suggests new formation of myelin by oligodendrocytes, which may occur in response to myelin degradation and injury caused by proteolytic enzymes such as calpain...