David Skurnik

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection
    David Skurnik
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Infect Dis 205:1709-18. 2012
  2. doi request reprint Is exposure to mercury a driving force for the carriage of antibiotic resistance genes?
    David Skurnik
    EA3964 Résistance Bactérienne in Vivo, Faculte de Medecine, Université Paris Diderot and Hôpital Bichat Claude Bernard, CNR Résistance Bactérienne dans les Flores Commensales, APHP, 75018 Paris, France
    J Med Microbiol 59:804-7. 2010
  3. pmc Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens
    Colette Cywes-Bentley
    Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:E2209-18. 2013
  4. pmc Natural antibodies in normal human serum inhibit Staphylococcus aureus capsular polysaccharide vaccine efficacy
    David Skurnik
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Infect Dis 55:1188-97. 2012
  5. pmc Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes
    Tami D Lieberman
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 43:1275-80. 2011
  6. ncbi request reprint Effect of human vicinity on antimicrobial resistance and integrons in animal faecal Escherichia coli
    David Skurnik
    Laboratoire de Bacteriologie, Hopital Bichat Claude Bernard, AP HP and EA3964, Universite Paris 7 Denis Diderot, 46 rue Henri Huchard, 75018 Paris, France
    J Antimicrob Chemother 57:1215-9. 2006
  7. doi request reprint Organic and conventional fruits and vegetables contain equivalent counts of Gram-negative bacteria expressing resistance to antibacterial agents
    Raymond Ruimy
    EA 6934 lt lt Résistance Bactérienne in vivo gt gt Université Paris Diderot, and Centre National de Référence sur la Résistance aux Antibiotiques, Hopital Bichat Claude Bernard, APHP, Paris, France
    Environ Microbiol 12:608-15. 2010
  8. doi request reprint Characteristics of human intestinal Escherichia coli with changing environments
    David Skurnik
    EA3964 lt lt Résistance bactérienne in vivo gt gt Faculté de Médecine, Université Paris 7 and Hôpital Bichat APHP, 75018 Paris, France
    Environ Microbiol 10:2132-7. 2008
  9. pmc A comprehensive analysis of in vitro and in vivo genetic fitness of Pseudomonas aeruginosa using high-throughput sequencing of transposon libraries
    David Skurnik
    Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 9:e1003582. 2013
  10. pmc Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing
    David Skurnik
    Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 110:20747-52. 2013

Collaborators

Detail Information

Publications12

  1. pmc Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection
    David Skurnik
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Infect Dis 205:1709-18. 2012
    ....
  2. doi request reprint Is exposure to mercury a driving force for the carriage of antibiotic resistance genes?
    David Skurnik
    EA3964 Résistance Bactérienne in Vivo, Faculte de Medecine, Université Paris Diderot and Hôpital Bichat Claude Bernard, CNR Résistance Bactérienne dans les Flores Commensales, APHP, 75018 Paris, France
    J Med Microbiol 59:804-7. 2010
    ..Exposure to mercury might be a specific driving force for the acquisition and maintenance of mobile antibiotic resistance gene carriage in the absence of antibiotic selective pressure...
  3. pmc Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens
    Colette Cywes-Bentley
    Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:E2209-18. 2013
    ..Vaccination targeting PNAG could contribute to immunity against serious and diverse prokaryotic and eukaryotic pathogens, and the conserved production of PNAG suggests that it is a critical factor in microbial biology...
  4. pmc Natural antibodies in normal human serum inhibit Staphylococcus aureus capsular polysaccharide vaccine efficacy
    David Skurnik
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Infect Dis 55:1188-97. 2012
    ..aureus cell surface polysaccharide, poly-N-acetyl glucosamine (PNAG). Here we evaluated whether natural antibody to PNAG in normal human serum (NHS) had a similar deleterious effect...
  5. pmc Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes
    Tami D Lieberman
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 43:1275-80. 2011
    ..The identification of parallel molecular evolution as a pathogen spreads among multiple individuals points to the key selection forces it experiences within human hosts...
  6. ncbi request reprint Effect of human vicinity on antimicrobial resistance and integrons in animal faecal Escherichia coli
    David Skurnik
    Laboratoire de Bacteriologie, Hopital Bichat Claude Bernard, AP HP and EA3964, Universite Paris 7 Denis Diderot, 46 rue Henri Huchard, 75018 Paris, France
    J Antimicrob Chemother 57:1215-9. 2006
    ..To determine the level of antimicrobial resistance and the occurrence of class 1, 2 and 3 integrons in faecal Escherichia coli from several animal populations variously exposed to human contact...
  7. doi request reprint Organic and conventional fruits and vegetables contain equivalent counts of Gram-negative bacteria expressing resistance to antibacterial agents
    Raymond Ruimy
    EA 6934 lt lt Résistance Bactérienne in vivo gt gt Université Paris Diderot, and Centre National de Référence sur la Résistance aux Antibiotiques, Hopital Bichat Claude Bernard, APHP, Paris, France
    Environ Microbiol 12:608-15. 2010
    ..which grouped into two phylotypes and all carrying the bla(RAHN) gene. Thus, both organic and conventional fruits and vegetables may constitute significant sources of resistant bacteria and of resistance genes...
  8. doi request reprint Characteristics of human intestinal Escherichia coli with changing environments
    David Skurnik
    EA3964 lt lt Résistance bactérienne in vivo gt gt Faculté de Médecine, Université Paris 7 and Hôpital Bichat APHP, 75018 Paris, France
    Environ Microbiol 10:2132-7. 2008
    ..03). Our results suggest that the composition of the commensal intestinal flora of humans is not static but changes dynamically in response to new environmental conditions...
  9. pmc A comprehensive analysis of in vitro and in vivo genetic fitness of Pseudomonas aeruginosa using high-throughput sequencing of transposon libraries
    David Skurnik
    Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 9:e1003582. 2013
    ..These experiments resulted in the identification of the P. aeruginosa strain PA14 genes necessary for optimal survival in the mucosal and systemic environments of a mammalian host. ..
  10. pmc Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing
    David Skurnik
    Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 110:20747-52. 2013
    ..aeruginosa in infected murine hosts suggests that either drug resistance or host colonization can cause the emergence of more pathogenic, drug-resistant P. aeruginosa clones in a single genetic event. ..
  11. pmc Magic bullets for the 21st century: the reemergence of immunotherapy for multi- and pan-resistant microbes
    Damien Roux
    Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Antimicrob Chemother 67:2785-7. 2012
    ..These discoveries could lead to utilization of antibodies to PNAG for either therapeutic use in patients infected by PNAG-producing MDR bacteria or prophylactic use in patients at risk of developing MDR infections...
  12. pmc Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice
    David Skurnik
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 120:3220-33. 2010
    ..aureus infections in humans could be due, in part, to interference in OPK when antibodies to CP and PNAG antigens are both present. This information could be used to better design S. aureus vaccine components...