M Simons

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Clinical trials in coronary angiogenesis: issues, problems, consensus: An expert panel summary
    M Simons
    Angiogenesis Research Center, BIDMC, Harvard Medical School, Boston, MA, USA
    Circulation 102:E73-86. 2000
  2. ncbi request reprint Therapeutic angiogenesis with basic fibroblast growth factor: technique and early results
    F W Sellke
    Angiogenesis Research Center, Department of Surgery at Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Ann Thorac Surg 65:1540-4. 1998
  3. ncbi request reprint Therapeutic angiogenesis in cardiology using protein formulations
    M J Post
    Angiogenesis Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cardiovasc Res 49:522-31. 2001
  4. ncbi request reprint Expression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial ischemia
    X Xu
    Harvard Medical School and the Division of Cardiothoracic Surgery and Angiogenesis Research Center, Beth Israel Deaconess Medical Center, 110 Francis St, Boston, MA 02215, USA
    J Thorac Cardiovasc Surg 121:735-42. 2001
  5. ncbi request reprint Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia
    R J Laham
    Angiogenesis Research Center, Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Pharmacol Exp Ther 292:795-802. 2000
  6. ncbi request reprint Intracoronary and intravenous administration of basic fibroblast growth factor: myocardial and tissue distribution
    R J Laham
    Angiogenesis Research Center, Department of Medicine, Harvard Medical School, and Beth Israel Deaconess Medical, Boston, MA 02215, USA
    Drug Metab Dispos 27:821-6. 1999
  7. ncbi request reprint Therapeutic angiogenesis with recombinant fibroblast growth factor-2 improves stress and rest myocardial perfusion abnormalities in patients with severe symptomatic chronic coronary artery disease
    J E Udelson
    Cardiac Imaging Core Laboratory, Division of Cardiology, New England Medical Center Hospitals Tufts University School of Medicine, Boston, MA 02111, USA
    Circulation 102:1605-10. 2000
  8. ncbi request reprint Coronary angiogenesis: detection in vivo with MR imaging sensitive to collateral neocirculation--preliminary study in pigs
    J D Pearlman
    Department of Medicine, Cardiovascular Angiogenesis Research Center, Beth Israel Deaconess Medical Center East, Boston, MA 02215, USA
    Radiology 214:801-7. 2000
  9. ncbi request reprint Angiogenesis in cardiovascular disease: current status and therapeutic potential
    F W Sellke
    Beth Israel Deaconess Medical Center, Division of Cardiothoracic Surgery, Harvard Medical School, Boston, Massachusetts 02215, USA
    Drugs 58:391-6. 1999
  10. ncbi request reprint Attenuation of endothelium-dependent dilation of pig pulmonary arterioles after cardiopulmonary bypass is prevented by monoclonal antibody to complement C5a
    K W Park
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Center for Experimental Therapeutics and Reperfusion Injury, Harvard Medical School, Boston, Massachusetts 02215, USA
    Anesth Analg 89:42-8. 1999

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Clinical trials in coronary angiogenesis: issues, problems, consensus: An expert panel summary
    M Simons
    Angiogenesis Research Center, BIDMC, Harvard Medical School, Boston, MA, USA
    Circulation 102:E73-86. 2000
    ....
  2. ncbi request reprint Therapeutic angiogenesis with basic fibroblast growth factor: technique and early results
    F W Sellke
    Angiogenesis Research Center, Department of Surgery at Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Ann Thorac Surg 65:1540-4. 1998
    ....
  3. ncbi request reprint Therapeutic angiogenesis in cardiology using protein formulations
    M J Post
    Angiogenesis Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cardiovasc Res 49:522-31. 2001
    ....
  4. ncbi request reprint Expression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial ischemia
    X Xu
    Harvard Medical School and the Division of Cardiothoracic Surgery and Angiogenesis Research Center, Beth Israel Deaconess Medical Center, 110 Francis St, Boston, MA 02215, USA
    J Thorac Cardiovasc Surg 121:735-42. 2001
    ....
  5. ncbi request reprint Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia
    R J Laham
    Angiogenesis Research Center, Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Pharmacol Exp Ther 292:795-802. 2000
    ..This mode of FGF-2 administration may prove to be a useful therapeutic strategy for the treatment of patients with ischemic heart disease...
  6. ncbi request reprint Intracoronary and intravenous administration of basic fibroblast growth factor: myocardial and tissue distribution
    R J Laham
    Angiogenesis Research Center, Department of Medicine, Harvard Medical School, and Beth Israel Deaconess Medical, Boston, MA 02215, USA
    Drug Metab Dispos 27:821-6. 1999
    ..The less invasive nature of i.v. delivery, its potential for repeat administration, and its applicability to a larger population may offset its resultant reduced myocardial deposition. Efficacy studies are ongoing...
  7. ncbi request reprint Therapeutic angiogenesis with recombinant fibroblast growth factor-2 improves stress and rest myocardial perfusion abnormalities in patients with severe symptomatic chronic coronary artery disease
    J E Udelson
    Cardiac Imaging Core Laboratory, Division of Cardiology, New England Medical Center Hospitals Tufts University School of Medicine, Boston, MA 02111, USA
    Circulation 102:1605-10. 2000
    ..We report the effects of the administration of recombinant fibroblast growth factor-2 (rFGF-2) protein on myocardial perfusion using single photon emission computed tomography imaging in humans with advanced coronary disease...
  8. ncbi request reprint Coronary angiogenesis: detection in vivo with MR imaging sensitive to collateral neocirculation--preliminary study in pigs
    J D Pearlman
    Department of Medicine, Cardiovascular Angiogenesis Research Center, Beth Israel Deaconess Medical Center East, Boston, MA 02215, USA
    Radiology 214:801-7. 2000
    ..To assess the ability to track neovascularization over time with a magnetic resonance (MR) imaging technique sensitized to new intramyocardial collateral development as a means of evaluating therapeutic angiogenesis...
  9. ncbi request reprint Angiogenesis in cardiovascular disease: current status and therapeutic potential
    F W Sellke
    Beth Israel Deaconess Medical Center, Division of Cardiothoracic Surgery, Harvard Medical School, Boston, Massachusetts 02215, USA
    Drugs 58:391-6. 1999
    ..Thus, therapeutic angiogenesis has the potential to extend treatment options to patients who are not optimal candidates for conventional methods of myocardial revascularisation...
  10. ncbi request reprint Attenuation of endothelium-dependent dilation of pig pulmonary arterioles after cardiopulmonary bypass is prevented by monoclonal antibody to complement C5a
    K W Park
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Center for Experimental Therapeutics and Reperfusion Injury, Harvard Medical School, Boston, Massachusetts 02215, USA
    Anesth Analg 89:42-8. 1999
    ..We conclude that pig pulmonary endothelial dysfunction associated with CPB may be mediated by C5a. The mechanism may involve changes in NOS translation...
  11. ncbi request reprint Serial motion assessment by reference tracking (SMART): application to detection of local functional impact of chronic myocardial ischemia
    J D Pearlman
    Angiogenesis Research Center, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Comput Assist Tomogr 25:558-62. 2001
    ..To compare measurements of wall motion and thickening with and without correcting for cardiac twisting and shortening...
  12. ncbi request reprint Intramyocardial delivery of FGF2 in combination with radio frequency transmyocardial revascularization
    J Bao
    Angiogenesis Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Catheter Cardiovasc Interv 53:429-34. 2001
    ..In conclusion, the combination of RF ablation and growth factor delivery using the RF-PMR system is feasible and efficient. Cathet Cardiovasc Intervent 2001;53:429-434...
  13. ncbi request reprint Gene transfer for angiogenesis in coronary artery disease
    R J Laham
    Angiogenesis Research Center, Interventional Cardiology Section, Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Annu Rev Med 52:485-502. 2001
    ..Finally, we discuss the promises and pitfalls of clinical angiogenesis and gene transfer studies, stressing the importance of proper design of clinical trials and adequate protection of research subjects...
  14. ncbi request reprint Comparison of transendocardial and retrograde coronary venous intramyocardial catheter delivery systems in healthy and infarcted pigs
    D V Baklanov
    Angiogenesis Research Center, Dartmouth Medical School, Hanover, NH, USA
    Catheter Cardiovasc Interv 68:416-23. 2006
    ....
  15. ncbi request reprint Basic FGF reduces stunning via a NOS2-dependent pathway in coronary-perfused mouse hearts
    T G Hampton
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Physiol Heart Circ Physiol 279:H260-8. 2000
    ..We conclude that basic FGF attenuates myocardial stunning independent of alterations in Ca(i)(2+) by stimulating NO production via an NOS2-dependent pathway...
  16. ncbi request reprint Re-evaluating therapeutic neovascularization
    E D de Muinck
    Section of Cardiology, Department of Medicine, Angiogenesis Research Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Mol Cell Cardiol 36:25-32. 2004
    ..Attention should also be focused on the way in which arteriogenesis is stimulated and the endpoints of clinical trials should be redefined...
  17. ncbi request reprint Antisense oligonucleotide inhibition of PDGFR-beta receptor subunit expression directs suppression of intimal thickening
    M G Sirois
    Harvard MIT Division of Health Sciences and Technology, Cambridge, Brigham and Women s Hospital E R E, Boston, Mass, USA
    Circulation 95:669-76. 1997
    ..Platelet-derived growth factor-BB (PDGF-BB) released from activated platelets adherent to subendothelial connective tissue is a principal smooth muscle cell chemotactic factor...