Research Topics
Genomes and Genes
| K Claire SimonSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Epstein-Barr virus neutralizing antibody levels and risk of multiple sclerosisKelly Claire Simon
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Mult Scler 18:1185-7. 2012..2, 95% confidence interval [CI] 0.97-5.1). This association was attenuated after adjustment for anti-EBNA1 IgG Ab titers (RR = 1.4, 95% CI 0.5-3.5). This preliminary finding warrants further study in a larger population...
XVI European Charcot Foundation lecture: nutrition and environment: can MS be prevented?Kelly Claire Simon
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
J Neurol Sci 311:1-8. 2011..Epidemiologic observation has provided key insights into environmental and nutritional factors that may alter one's susceptibility to MS, however, there are still many questions in unraveling the etiology of this complex disease...
Genetic predictors of 25-hydroxyvitamin D levels and risk of multiple sclerosisKelly Claire Simon
Department of Nutrition, Harvard School of Public Health, 677 Huntington Ave, Building 2, 3rd Floor, Boston, MA 02115, USA
J Neurol 258:1676-82. 2011..91, 95% CI: 0.80, 1.04). This preliminary finding suggests the possibility that the putative beneficial effect of vitamin D on MS risk maybe attenuated in individuals carrying the HLA-DR15 MS risk allele...
Calcium channel blocker use and risk of Parkinson's diseaseKelly Claire Simon
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Mov Disord 25:1818-22. 2010..18, 95% CI: 0.73-1.92), frequency of use or duration of use of CCBs and PD risk was observed (P > 0.2 for all). These findings do not support a role for CCBs in providing neuroprotection against development of PD...
EBNA1 and LMP1 variants in multiple sclerosis cases and controlsK C Simon
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
Acta Neurol Scand 124:53-8. 2011..Some findings from observational studies, including possible epidemics and differences in prevalence, may be explained if different strains of EBV conferred different MS risk...
Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosisK Claire Simon
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Mult Scler 16:133-8. 2010..The finding of a marginally significant gene-environment interaction requires replication in larger datasets, but suggests future genetic studies may benefit from considering relevant environmental context...
Reproductive factors, exogenous estrogen use, and risk of Parkinson's diseaseKelly Claire Simon
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Mov Disord 24:1359-65. 2009..The use of postmenopausal hormone use may interact with other risk factors, but findings are preliminary and need confirmation in other populations...
Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson diseaseKelly Claire Simon
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Neurology 69:1688-95. 2007..To determine whether history of hypertension, hypercholesterolemia, or diabetes is associated with risk of Parkinson disease (PD)...
Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk scorePhilip L De Jager
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
Lancet Neurol 8:1111-9. 2009..We investigated the usefulness of an aggregate measure of risk of MS that is based on genetic susceptibility loci. We also assessed the added effect of environmental risk factors that are associated with susceptibility for MS...
Vitamin D and multiple sclerosisAlberto Ascherio
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Lancet Neurol 9:599-612. 2010....
