Research Topics
Genomes and Genes | D I SimonSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Increased neointima formation in cysteine-rich protein 2-deficient mice in response to vascular injuryJiao Wei
Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Circ Res 97:1323-31. 2005..Our data demonstrate that CRP2 is not required for vascular development. However, an absence of CRP2 enhanced VSMC migration and increased neointima formation following arterial injury...- A comparative study of light transmission aggregometry and automated bedside platelet function assays in patients undergoing percutaneous coronary intervention and receiving abciximab, eptifibatide, or tirofibanD I Simon
Cardiac Catheterization Laboratory, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Catheter Cardiovasc Interv 52:425-32. 2001..These findings may have implications for the results of trials comparing the efficacy of these agents in patients undergoing PCI... 
Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)D I Simon
Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Exp Med 192:193-204. 2000..These observations provide a molecular target for disrupting leukocyte-platelet complexes that promote vascular inflammation in thrombosis, atherosclerosis, and angioplasty-related restenosis...- Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplastyD I Simon
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 105:293-300. 2000..These data establish a role for inflammation in neointimal thickening and suggest that leukocyte recruitment to mechanically injured arteries may prevent restenosis... - A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbitsC Rogers
Department of Medicine, Cardiac Catheterization Laboratory and Coronary Care Unit, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 95:10134-9. 1998..02). Mac-1 blockade reduces experimental neointimal thickening, suggesting that leukocyte recruitment to and infiltration of injured arteries may be a valid target for preventing intimal hyperplasia... - Regulation of integrin function by the urokinase receptorY Wei
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Science 273:1551-5. 1996..These data provide a paradigm for regulation of integrins in which a nonintegrin membrane receptor interacts with and modifies the function of activated integrins... - Neutrophil, not macrophage, infiltration precedes neointimal thickening in balloon-injured arteriesF G Welt
Department of Medicine Cardiac Catheterization Laboratory and Coronary Care Unit, Cardiovascular Division, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
Arterioscler Thromb Vasc Biol 20:2553-8. 2000..These data suggest a central role for neutrophils in restenosis and help to explain prior reports of an inhibitory effect of anti-inflammatory therapies on neointimal growth after balloon injury... - 7E3 monoclonal antibody directed against the platelet glycoprotein IIb/IIIa cross-reacts with the leukocyte integrin Mac-1 and blocks adhesion to fibrinogen and ICAM-1D I Simon
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Arterioscler Thromb Vasc Biol 17:528-35. 1997.... - Leukocyte integrin Mac-1 recruits toll/interleukin-1 receptor superfamily signaling intermediates to modulate NF-kappaB activityC Shi
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Circ Res 89:859-65. 2001..Taken together, these observations indicate that Mac-1 recruits a Toll/IL-1 receptor family-like cascade to modulate NF-kappaB activity. This represents a new pathway for integrin-dependent modulation of gene expression... - Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin functionD I Simon
Cardiovascular, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 275:10228-34. 2000.... - Role of urokinase receptor and caveolin in regulation of integrin signalingH A Chapman
Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Thromb Haemost 82:291-7. 1999..Interruption of u-PAR/integrin interactions may be a strategy to regulate cellular migration in these settings... - Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cellsG K Sukhova
Brigham and Women s Hospital, Vascular Medicine and Atherosclerosis Unit and Cardiovascular and Respiratory Divisions, Department of Medicine, Boston, Massachusetts 02115, USA
J Clin Invest 102:576-83. 1998.... - Photodynamic therapy with motexafin lutetium induces redox-sensitive apoptosis of vascular cellsZ Chen
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Arterioscler Thromb Vasc Biol 21:759-64. 2001..Reducing plaque cellularity by the induction of apoptosis may be one mechanism by which PDT reduces plaque burden, possibly modulates plaque vulnerability, and inhibits restenosis in vivo... - Simplified risk score models accurately predict the risk of major in-hospital complications following percutaneous coronary interventionF S Resnic
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Cardiol 88:5-9. 2001..Their discriminatory power is comparable to those of logistic models and neural network models. Accurate bedside risk stratification may be achieved with these simple models... - Vitamin E and vascular homeostasis: implications for atherosclerosisJ F Keaney
Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, 02118, USA
FASEB J 13:965-75. 1999..In the setting of atherosclerosis, inhibition of protein kinase C by vitamin E would be expected to maintain normal vascular homeostasis and thus reduce the clinical incidence of cardiovascular disease... - Leukocyte engagement of platelet glycoprotein Ibalpha via the integrin Mac-1 is critical for the biological response to vascular injuryYunmei Wang
Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 112:2993-3000. 2005.... - Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular eventsAileen M Healy
Millennium Pharmaceuticals, Inc, Cambridge, MA, USA
Circulation 113:2278-84. 2006..Because platelets lack nuclear DNA but retain megakaryocyte-derived mRNAs, the platelet transcriptome provides a novel window on gene expression preceding acute coronary events... - Hemizygous deficiency of Krüppel-like factor 2 augments experimental atherosclerosisG Brandon Atkins
University Hospitals Harrington McLaughlin Heart and Vascular Institute, Cleveland, Ohio, USA
Circ Res 103:690-3. 2008..These novel observations establish that KLF2 is an atheroprotective factor... - Far-fetched benefit of inflammationDaniel I Simon
Circulation 115:548-9. 2007 - The importance of the interaction between leukocyte integrin Mac-1 and platelet glycoprotein Ib-a for leukocyte recruitment by platelets and for the inflammatory response to vascular injuryAlexandre C Zago
Instituto do Coracao, Universidade de Sao Paulo
Arq Bras Cardiol 90:54-63. 2008.... - Cooperative regulation in development by SMRT and FOXP1Kristen Jepsen
Department of Medicine, Howard Hughes Medical Institute, University of California at San Diego, School of Medicine, La Jolla, California 92093, USA
Genes Dev 22:740-5. 2008..Our studies demonstrate that SMRT and FOXP1 define a functional biological unit required to orchestrate specific programs critical for mammalian organogenesis, linking developmental roles of FOX to a specific corepressor... - Leukocyte integrin Mac-1 promotes acute cardiac allograft rejectionKoichi Shimizu
Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 117:1997-2008. 2008.... - Expression, activation, and function of integrin alphaMbeta2 (Mac-1) on neutrophil-derived microparticlesElzbieta Pluskota
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic, OH 44195, USA
Blood 112:2327-35. 2008..Thus, cooperation of these 2 receptor/counterreceptor systems regulates the prothrombotic properties of PMN-derived MPs... - Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitroYasuhiko Sakata
Vascular Medicine Research, Brigham and Women s Hospital, Cambridge, Mass 02139, USA
Arterioscler Thromb Vasc Biol 24:2069-74. 2004..To determine the role of the cardiovascular-restricted, hairy-related bHLH transcription factor, CHF1/Hey2, in the biological response to vascular injury... - Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1Can Shi
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 114:408-18. 2004..This represents a new pathway for integrin-dependent modulation of gene expression and control of cellular differentiation... - Biomechanically induced gene iex-1 inhibits vascular smooth muscle cell proliferation and neointima formationP Christian Schulze
Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02139, USA
Circ Res 93:1210-7. 2003..These findings suggest that the induction of iex-1 represents a novel negative biomechanical feedback mechanism limiting the vascular response to injury... - Essential role for Smad3 in regulating MCP-1 expression and vascular inflammationMark W Feinberg
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Circ Res 94:601-8. 2004.... - KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activationSucharita SenBanerjee
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
J Exp Med 199:1305-15. 2004..These data implicate KLF2 as a novel regulator of endothelial activation in response to proinflammatory stimuli... - Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trialDavid A Morrow
Thrombolysis in Myocardial Infarction Study Group, Brigham and Women s Hospital, Boston, MA 02115, USA
Am Heart J 155:49-55. 2008..Elevated concentrations of MRP-8/14 are associated with a higher risk for future cardiovascular events in apparently healthy individuals but have not been assessed with respect to prognosis in patients with acute coronary syndrome... - Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein IbalphaRaila Ehlers
Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Tower 3, Boston, MA 02115, USA
J Exp Med 198:1077-88. 2003..These observations provide a molecular target for disrupting leukocyte-platelet complexes that promote vascular inflammation in thrombosis, atherosclerosis, and angioplasty-related restenosis... - Simvastatin reduces neointimal thickening in low-density lipoprotein receptor-deficient mice after experimental angioplasty without changing plasma lipidsZhiping Chen
Cardiovascular Division, Brigham and Women's Hospital, Boston, Mass 02115, USA
Circulation 106:20-3. 2002..Although the mechanisms are not yet established, additional research may lead to new understanding of the actions of statins and novel therapeutic interventions for preventing restenosis... - Increased thrombosis after arterial injury in human C-reactive protein-transgenic miceHaim D Danenberg
Harvard MIT Division of Health Sciences and Technology, Cambridge, Mass 02139, USA
Circulation 108:512-5. 2003..To determine whether CRP directly modulates vascular cell function in vivo, we subjected wild-type mice, which do not express CRP, and human CRP-transgenic (CRPtg) mice to 2 models of arterial injury... - Clopidogrel inhibits shear-induced platelet functionJames L Orford
Cardiac Catheterization Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA
Platelets 13:187-9. 2002..This study suggests that the Xylum Clot Signature Analyzer can measure changes in platelet function in response to a modest platelet inhibitor, and may be a useful clinical tool for the monitoring of antiplatelet therapies in patients... - Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient miceJie Hong Pan
Department of Medicine, University of California San Francisco, Calif, USA
Circulation 109:3149-53. 2004..Therefore, we investigated whether deficiency of MIF modulates atherosclerotic lesion formation and composition in low-density lipoprotein receptor-deficient (LDLr-/-) mice... - Sweet and sticky: diabetic platelets, enhanced reactivity, and cardiovascular riskDaniel I Simon
J Am Coll Cardiol 50:1548-50. 2007 - Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injuryZhiping Chen
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:13014-9. 2004..In addition, Nox2 deficiency led to reduced cellular proliferation and leukocyte accumulation. These data indicate that Nox2-mediated oxidant production has a requisite role in the response to tissue injury... - Recombinant nematode anticoagulant protein c2 in patients with non-ST-segment elevation acute coronary syndrome: the ANTHEM-TIMI-32 trialRobert P Giugliano
TIMI Study Group, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 49:2398-407. 2007..We sought to evaluate the safety and efficacy of recombinant nematode anticoagulant protein c2 (rNAPc2) in patients with non-ST-segment elevation acute coronary syndrome (nSTE-ACS)... - Aspirin resistance or variable response or both?Xi Cheng
Division of Cardiology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
Am J Cardiol 98:11N-17N. 2006.... - Incidence of aspirin nonresponsiveness using the Ultegra Rapid Platelet Function Assay-ASAJohn C Wang
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Cardiol 92:1492-4. 2003..01, 95% confidence interval 1.189 to 3.411, p=0.009). Further prospective studies are needed to correlate aspirin nonresponsiveness to adverse clinical events... - Molecular basis of restenosis and drug-eluting stentsMarco A Costa
Division of Cardiology and Cardiovascular Imaging Core Laboratories, University of Florida, Shands-Jacksonville, Jacksonville, Fla, USA
Circulation 111:2257-73. 2005 - Inflammation as a mechanism and therapeutic target for in-stent restenosisDouglas E Drachman
Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA
Curr Atheroscler Rep 7:44-9. 2005..By examining the specific mechanisms governing the inflammatory response to percutaneous coronary intervention, we may gain insight into potential therapeutic targets and strategies to prevent restenosis in clinical practice... - Comparison of the risk of vascular complications associated with femoral and radial access coronary catheterization procedures in obese versus nonobese patientsNicholas Cox
Cardiovascular Division (Cardiac Catheterization Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Cardiol 94:1174-7. 2004..quot; The use of transradial access and arterial access closure devices was associated with reduced vascular complications in the population of obese patients... - Platelet disaggregation: putting time on your side in acute myocardial infarctionDaniel I Simon
J Am Coll Cardiol 44:324-6. 2004 - Integrin signals, transcription factors, and monocyte differentiationCan Shi
Cardiovascular Division and Center for Excellence in Vascular Biology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Trends Cardiovasc Med 16:146-52. 2006..This represents a new pathway for integrin-dependent modulation of gene expression and control of cellular differentiation...