D I Simon

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Increased neointima formation in cysteine-rich protein 2-deficient mice in response to vascular injury
    Jiao Wei
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circ Res 97:1323-31. 2005
  2. pmc Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha
    Raila Ehlers
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Tower 3, Boston, MA 02115, USA
    J Exp Med 198:1077-88. 2003
  3. ncbi A comparative study of light transmission aggregometry and automated bedside platelet function assays in patients undergoing percutaneous coronary intervention and receiving abciximab, eptifibatide, or tirofiban
    D I Simon
    Cardiac Catheterization Laboratory, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Catheter Cardiovasc Interv 52:425-32. 2001
  4. pmc Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)
    D I Simon
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Exp Med 192:193-204. 2000
  5. pmc Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty
    D I Simon
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 105:293-300. 2000
  6. pmc A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits
    C Rogers
    Department of Medicine, Cardiac Catheterization Laboratory and Coronary Care Unit, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:10134-9. 1998
  7. ncbi Regulation of integrin function by the urokinase receptor
    Y Wei
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 273:1551-5. 1996
  8. ncbi Neutrophil, not macrophage, infiltration precedes neointimal thickening in balloon-injured arteries
    F G Welt
    Department of Medicine Cardiac Catheterization Laboratory and Coronary Care Unit, Cardiovascular Division, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 20:2553-8. 2000
  9. ncbi 7E3 monoclonal antibody directed against the platelet glycoprotein IIb/IIIa cross-reacts with the leukocyte integrin Mac-1 and blocks adhesion to fibrinogen and ICAM-1
    D I Simon
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 17:528-35. 1997
  10. ncbi Leukocyte integrin Mac-1 recruits toll/interleukin-1 receptor superfamily signaling intermediates to modulate NF-kappaB activity
    C Shi
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 89:859-65. 2001

Collaborators

Detail Information

Publications44

  1. ncbi Increased neointima formation in cysteine-rich protein 2-deficient mice in response to vascular injury
    Jiao Wei
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circ Res 97:1323-31. 2005
    ..Our data demonstrate that CRP2 is not required for vascular development. However, an absence of CRP2 enhanced VSMC migration and increased neointima formation following arterial injury...
  2. pmc Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha
    Raila Ehlers
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Tower 3, Boston, MA 02115, USA
    J Exp Med 198:1077-88. 2003
    ..These observations provide a molecular target for disrupting leukocyte-platelet complexes that promote vascular inflammation in thrombosis, atherosclerosis, and angioplasty-related restenosis...
  3. ncbi A comparative study of light transmission aggregometry and automated bedside platelet function assays in patients undergoing percutaneous coronary intervention and receiving abciximab, eptifibatide, or tirofiban
    D I Simon
    Cardiac Catheterization Laboratory, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Catheter Cardiovasc Interv 52:425-32. 2001
    ..These findings may have implications for the results of trials comparing the efficacy of these agents in patients undergoing PCI...
  4. pmc Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)
    D I Simon
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Exp Med 192:193-204. 2000
    ..These observations provide a molecular target for disrupting leukocyte-platelet complexes that promote vascular inflammation in thrombosis, atherosclerosis, and angioplasty-related restenosis...
  5. pmc Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty
    D I Simon
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 105:293-300. 2000
    ..These data establish a role for inflammation in neointimal thickening and suggest that leukocyte recruitment to mechanically injured arteries may prevent restenosis...
  6. pmc A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits
    C Rogers
    Department of Medicine, Cardiac Catheterization Laboratory and Coronary Care Unit, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:10134-9. 1998
    ..02). Mac-1 blockade reduces experimental neointimal thickening, suggesting that leukocyte recruitment to and infiltration of injured arteries may be a valid target for preventing intimal hyperplasia...
  7. ncbi Regulation of integrin function by the urokinase receptor
    Y Wei
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 273:1551-5. 1996
    ..These data provide a paradigm for regulation of integrins in which a nonintegrin membrane receptor interacts with and modifies the function of activated integrins...
  8. ncbi Neutrophil, not macrophage, infiltration precedes neointimal thickening in balloon-injured arteries
    F G Welt
    Department of Medicine Cardiac Catheterization Laboratory and Coronary Care Unit, Cardiovascular Division, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 20:2553-8. 2000
    ..These data suggest a central role for neutrophils in restenosis and help to explain prior reports of an inhibitory effect of anti-inflammatory therapies on neointimal growth after balloon injury...
  9. ncbi 7E3 monoclonal antibody directed against the platelet glycoprotein IIb/IIIa cross-reacts with the leukocyte integrin Mac-1 and blocks adhesion to fibrinogen and ICAM-1
    D I Simon
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 17:528-35. 1997
    ....
  10. ncbi Leukocyte integrin Mac-1 recruits toll/interleukin-1 receptor superfamily signaling intermediates to modulate NF-kappaB activity
    C Shi
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 89:859-65. 2001
    ..Taken together, these observations indicate that Mac-1 recruits a Toll/IL-1 receptor family-like cascade to modulate NF-kappaB activity. This represents a new pathway for integrin-dependent modulation of gene expression...
  11. ncbi Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function
    D I Simon
    Cardiovascular, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:10228-34. 2000
    ....
  12. ncbi Role of urokinase receptor and caveolin in regulation of integrin signaling
    H A Chapman
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Thromb Haemost 82:291-7. 1999
    ..Interruption of u-PAR/integrin interactions may be a strategy to regulate cellular migration in these settings...
  13. pmc Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells
    G K Sukhova
    Brigham and Women s Hospital, Vascular Medicine and Atherosclerosis Unit and Cardiovascular and Respiratory Divisions, Department of Medicine, Boston, Massachusetts 02115, USA
    J Clin Invest 102:576-83. 1998
    ....
  14. ncbi Photodynamic therapy with motexafin lutetium induces redox-sensitive apoptosis of vascular cells
    Z Chen
    Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 21:759-64. 2001
    ..Reducing plaque cellularity by the induction of apoptosis may be one mechanism by which PDT reduces plaque burden, possibly modulates plaque vulnerability, and inhibits restenosis in vivo...
  15. ncbi Simplified risk score models accurately predict the risk of major in-hospital complications following percutaneous coronary intervention
    F S Resnic
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Cardiol 88:5-9. 2001
    ..Their discriminatory power is comparable to those of logistic models and neural network models. Accurate bedside risk stratification may be achieved with these simple models...
  16. ncbi Vitamin E and vascular homeostasis: implications for atherosclerosis
    J F Keaney
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, 02118, USA
    FASEB J 13:965-75. 1999
    ..In the setting of atherosclerosis, inhibition of protein kinase C by vitamin E would be expected to maintain normal vascular homeostasis and thus reduce the clinical incidence of cardiovascular disease...
  17. ncbi Leukocyte engagement of platelet glycoprotein Ibalpha via the integrin Mac-1 is critical for the biological response to vascular injury
    Yunmei Wang
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 112:2993-3000. 2005
    ....
  18. ncbi Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events
    Aileen M Healy
    Millennium Pharmaceuticals, Inc, Cambridge, MA, USA
    Circulation 113:2278-84. 2006
    ..Because platelets lack nuclear DNA but retain megakaryocyte-derived mRNAs, the platelet transcriptome provides a novel window on gene expression preceding acute coronary events...
  19. pmc Hemizygous deficiency of Kr├╝ppel-like factor 2 augments experimental atherosclerosis
    G Brandon Atkins
    University Hospitals Harrington McLaughlin Heart and Vascular Institute, Cleveland, Ohio, USA
    Circ Res 103:690-3. 2008
    ..These novel observations establish that KLF2 is an atheroprotective factor...
  20. ncbi Far-fetched benefit of inflammation
    Daniel I Simon
    Circulation 115:548-9. 2007
  21. ncbi The importance of the interaction between leukocyte integrin Mac-1 and platelet glycoprotein Ib-a for leukocyte recruitment by platelets and for the inflammatory response to vascular injury
    Alexandre C Zago
    Instituto do Coracao, Universidade de Sao Paulo
    Arq Bras Cardiol 90:54-63. 2008
    ....
  22. pmc Cooperative regulation in development by SMRT and FOXP1
    Kristen Jepsen
    Department of Medicine, Howard Hughes Medical Institute, University of California at San Diego, School of Medicine, La Jolla, California 92093, USA
    Genes Dev 22:740-5. 2008
    ..Our studies demonstrate that SMRT and FOXP1 define a functional biological unit required to orchestrate specific programs critical for mammalian organogenesis, linking developmental roles of FOX to a specific corepressor...
  23. pmc Leukocyte integrin Mac-1 promotes acute cardiac allograft rejection
    Koichi Shimizu
    Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 117:1997-2008. 2008
    ....
  24. pmc Expression, activation, and function of integrin alphaMbeta2 (Mac-1) on neutrophil-derived microparticles
    Elzbieta Pluskota
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic, OH 44195, USA
    Blood 112:2327-35. 2008
    ..Thus, cooperation of these 2 receptor/counterreceptor systems regulates the prothrombotic properties of PMN-derived MPs...
  25. ncbi Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro
    Yasuhiko Sakata
    Vascular Medicine Research, Brigham and Women s Hospital, Cambridge, Mass 02139, USA
    Arterioscler Thromb Vasc Biol 24:2069-74. 2004
    ..To determine the role of the cardiovascular-restricted, hairy-related bHLH transcription factor, CHF1/Hey2, in the biological response to vascular injury...
  26. ncbi Biomechanically induced gene iex-1 inhibits vascular smooth muscle cell proliferation and neointima formation
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02139, USA
    Circ Res 93:1210-7. 2003
    ..These findings suggest that the induction of iex-1 represents a novel negative biomechanical feedback mechanism limiting the vascular response to injury...
  27. pmc Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1
    Can Shi
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 114:408-18. 2004
    ..This represents a new pathway for integrin-dependent modulation of gene expression and control of cellular differentiation...
  28. ncbi Simvastatin reduces neointimal thickening in low-density lipoprotein receptor-deficient mice after experimental angioplasty without changing plasma lipids
    Zhiping Chen
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 106:20-3. 2002
    ....
  29. ncbi Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation
    Mark W Feinberg
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Res 94:601-8. 2004
    ....
  30. pmc KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation
    Sucharita SenBanerjee
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Exp Med 199:1305-15. 2004
    ..These data implicate KLF2 as a novel regulator of endothelial activation in response to proinflammatory stimuli...
  31. pmc Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial
    David A Morrow
    Thrombolysis in Myocardial Infarction Study Group, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am Heart J 155:49-55. 2008
    ..Elevated concentrations of MRP-8/14 are associated with a higher risk for future cardiovascular events in apparently healthy individuals but have not been assessed with respect to prognosis in patients with acute coronary syndrome...
  32. ncbi Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice
    Jie Hong Pan
    Department of Medicine, University of California San Francisco, Calif, USA
    Circulation 109:3149-53. 2004
    ..Therefore, we investigated whether deficiency of MIF modulates atherosclerotic lesion formation and composition in low-density lipoprotein receptor-deficient (LDLr-/-) mice...
  33. pmc Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury
    Zhiping Chen
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:13014-9. 2004
    ..In addition, Nox2 deficiency led to reduced cellular proliferation and leukocyte accumulation. These data indicate that Nox2-mediated oxidant production has a requisite role in the response to tissue injury...
  34. ncbi Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice
    Haim D Danenberg
    Harvard MIT Division of Health Sciences and Technology, Cambridge, Mass 02139, USA
    Circulation 108:512-5. 2003
    ..To determine whether CRP directly modulates vascular cell function in vivo, we subjected wild-type mice, which do not express CRP, and human CRP-transgenic (CRPtg) mice to 2 models of arterial injury...
  35. ncbi Clopidogrel inhibits shear-induced platelet function
    James L Orford
    Cardiac Catheterization Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Platelets 13:187-9. 2002
    ..This study suggests that the Xylum Clot Signature Analyzer can measure changes in platelet function in response to a modest platelet inhibitor, and may be a useful clinical tool for the monitoring of antiplatelet therapies in patients...
  36. ncbi Sweet and sticky: diabetic platelets, enhanced reactivity, and cardiovascular risk
    Daniel I Simon
    J Am Coll Cardiol 50:1548-50. 2007
  37. ncbi Recombinant nematode anticoagulant protein c2 in patients with non-ST-segment elevation acute coronary syndrome: the ANTHEM-TIMI-32 trial
    Robert P Giugliano
    TIMI Study Group, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 49:2398-407. 2007
    ..We sought to evaluate the safety and efficacy of recombinant nematode anticoagulant protein c2 (rNAPc2) in patients with non-ST-segment elevation acute coronary syndrome (nSTE-ACS)...
  38. ncbi Incidence of aspirin nonresponsiveness using the Ultegra Rapid Platelet Function Assay-ASA
    John C Wang
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Cardiol 92:1492-4. 2003
    ..01, 95% confidence interval 1.189 to 3.411, p=0.009). Further prospective studies are needed to correlate aspirin nonresponsiveness to adverse clinical events...
  39. ncbi Aspirin resistance or variable response or both?
    Xi Cheng
    Division of Cardiology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Am J Cardiol 98:11N-17N. 2006
    ....
  40. ncbi Platelet disaggregation: putting time on your side in acute myocardial infarction
    Daniel I Simon
    J Am Coll Cardiol 44:324-6. 2004
  41. ncbi Molecular basis of restenosis and drug-eluting stents
    Marco A Costa
    Division of Cardiology and Cardiovascular Imaging Core Laboratories, University of Florida, Shands Jacksonville, Jacksonville, Fla, USA
    Circulation 111:2257-73. 2005
  42. ncbi Inflammation as a mechanism and therapeutic target for in-stent restenosis
    Douglas E Drachman
    Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Atheroscler Rep 7:44-9. 2005
    ..By examining the specific mechanisms governing the inflammatory response to percutaneous coronary intervention, we may gain insight into potential therapeutic targets and strategies to prevent restenosis in clinical practice...
  43. ncbi Comparison of the risk of vascular complications associated with femoral and radial access coronary catheterization procedures in obese versus nonobese patients
    Nicholas Cox
    Cardiovascular Division Cardiac Catheterization Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Cardiol 94:1174-7. 2004
    ..quot; The use of transradial access and arterial access closure devices was associated with reduced vascular complications in the population of obese patients...
  44. ncbi Integrin signals, transcription factors, and monocyte differentiation
    Can Shi
    Cardiovascular Division and Center for Excellence in Vascular Biology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Trends Cardiovasc Med 16:146-52. 2006
    ..This represents a new pathway for integrin-dependent modulation of gene expression and control of cellular differentiation...