Research Topics
Genomes and Genes
| Eric S SilvermanSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Immunostimulatory DNA for asthma: better than eating dirtEric S Silverman
Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachussetts, USA
Am J Respir Cell Mol Biol 28:645-7. 2003- Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsivenessJosephine Hjoberg
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115-6021, USA
J Appl Physiol 97:249-59. 2004..These data suggest that increased nitric oxide in the airways has no proinflammatory effects per se and may have beneficial effects on pulmonary function... - Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthmaEric S Silverman
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 169:214-9. 2004..We conclude that the T allele of C-509T is associated with the diagnosis of asthma and may enhance TGF-beta1 gene transcription... - Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthmaEric S Silverman
Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115 6021, USA
J Allergy Clin Immunol 114:747-54. 2004..Abnormal regulation of CRH and endogenous glucocorticoids has been implicated in the pathogenesis of asthma... - Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lungEric S Silverman
Division of Pulmonary and Critical Care Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston 02115, USA
Am J Respir Cell Mol Biol 27:697-704. 2002..Overexpression of ESE-3 protein in 3T3 cells and human bronchial smooth muscle cells inhibits MMP-1 promoter activity, suggesting that ESE-3 may function as a transcriptional repressor... - Oncostatin M causes eotaxin-1 release from airway smooth muscle: synergy with IL-4 and IL-13Debora S Faffe
Physiology Program, Harvard School of Public Health, Boston, Mass 02115, USA
J Allergy Clin Immunol 115:514-20. 2005..Eotaxin is implicated in asthmatic eosinophilia. Oncostatin M (OSM) causes eotaxin release from fibroblasts... - Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscleJosephine Hjoberg
Physiology Program, Dept of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
Am J Physiol Lung Cell Mol Physiol 286:L817-25. 2004..Although EGR-1 is induced by PDGF in human airway smooth muscle cells in cell culture, the role of EGR-1 in airway remodeling and asthma remains to be established... - DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthmaRebecca M Baron
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Respir Crit Care Med 166:927-32. 2002..This study suggests that epithelium-specific ETS-2 and ETS-3 genes are unlikely to contain polymorphic loci that have a major impact on asthma susceptibility in our population... - Oncostatin M causes VEGF release from human airway smooth muscle: synergy with IL-1betaDebora S Faffe
Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Am J Physiol Lung Cell Mol Physiol 288:L1040-8. 2005..This is the first description of a role for OSM on IL-1R1 expression in any cell type. OSM may contribute to airway remodeling observed in chronic airway disease... 
TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroidsKelan G Tantisira
Channing Laboratory and Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:18099-104. 2004..TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids...- FCER2: a pharmacogenetic basis for severe exacerbations in children with asthmaKelan G Tantisira
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
J Allergy Clin Immunol 120:1285-91. 2007..Although inhaled corticosteroids (ICSs) generally protect against severe exacerbations in asthma, they may result in elevated IgE levels, which are associated with exacerbations... 
Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthmaAugusto A Litonjua
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Respir Res 6:52. 2005..Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lung development and asthma pathogenesis...- Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responsesScott T Weiss
Respiratory, Genetic, and Environmental Epidemiology, Channing Laboratory, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115
Proc Am Thorac Soc 1:364-7. 2004..The approach of a test and multiple replication populations is a valuable strategy in asthma pharmacogenetics, which can insure valid association findings... - The IL12B gene is associated with asthmaAdrienne G Randolph
Channing Laboratory, Brigham and Women s Hospital, Department of Anesthesia, Children s Hospital, and Harvard Medical School, Boston, MA, USA
Am J Hum Genet 75:709-15. 2004..IL12B may be an important asthma gene... - PU.1 regulates cathepsin S expression in professional APCsYing Wang
Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 176:275-83. 2006..1 alone. These data indicate that PU.1 participates in the regulation of CTSS transcription in APCs. Thus, manipulation of PU.1 expression may directly alter the endosomal proteolytic environment in these cells... - Pharmacogenetics of asthmaLyle J Palmer
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 165:861-6. 2002 - IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expressionKarin Storm van's Gravesande
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 168:4488-94. 2002..Thus, IRF-1 is the critical transcriptional mediator of IFN-gamma-dependent cathepsin S activation. These data elucidate a new pathway by which IRF-1 may affect MHC class II processing and presentation... - Cloning and functional analysis of the mouse 5-lipoxygenase promoterEric S Silverman
Pulmonary and Critical Care Division and Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Cell Mol Biol 26:475-83. 2002..We show that Sp1/Sp3 is essential for constitutive promoter-reporter activity... - Association of a missense mutation in the NOS3 gene with exhaled nitric oxide levelsKarin Storm van's Gravesande
Division of Pulmonary and Critical Care Medicine, Tower 4B, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Crit Care Med 168:228-31. 2003.... - Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroidsKelan G Tantisira
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Hum Mol Genet 13:1353-9. 2004.... - Sequence variants in the FcepsilonRI alpha chain geneToshiki Shikanai
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Appl Physiol 93:37-41. 2002..We conclude that homozygosity for the C allele of FcepsilonRI alpha chain variant is associated with lower IgE levels... - Interleukin-9 influences chemokine release in airway smooth muscle: role of ERKSimonetta Baraldo
Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Am J Physiol Lung Cell Mol Physiol 284:L1093-102. 2003..Our results indicate that airway smooth muscle is a target for IL-9 and that IL-9 amplifies the potential for these cells to recruit eosinophils and neutrophils into the airways by a mechanism involving ERK... - Monocyte chemoattractant protein-4 core promoter genetic variants: influence on YY-1 affinity and plasma levelsOmer Kalayci
Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, PBB 3rd Floor Clinics Building, Boston, MA 02115, USA
Am J Respir Cell Mol Biol 29:750-6. 2003.... - Roles for early response cytokines during Escherichia coli pneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1Joseph P Mizgerd
Physiology Program, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
Am J Physiol Lung Cell Mol Physiol 286:L1302-10. 2004..Thus during E. coli pneumonia in mice, the lack of signaling from TNF-alpha and IL-1 decreases inflammation and preserves lung compliance... - Diminished lipoxin biosynthesis in severe asthmaBruce D Levy
Pulmonary and Critical Care Medicine and Partners Asthma Center, Department of Internal Medicine, PBB Clinics 3, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Crit Care Med 172:824-30. 2005..Although arachidonic acid metabolism is well appreciated to regulate airway inflammation and reactivity, alterations in the biosynthetic capacity for both pro- and antiinflammatory eicosanoids in severe asthma have not been determined... - Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expressionDaniel J Tschumperlin
Physiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Lung Cell Mol Physiol 282:L904-11. 2002..These results demonstrate that compressive stress is a selective and potent activator of signal transduction and gene expression in bronchial epithelial cells... - Effect of dexamethasone on beta2-adrenergic desensitization in airway smooth muscle: role of the ARG19 polymorphismPaul E Moore
Departments of Pediatrics and Pharmacology (Dr. Moore and Mr. Calder, Vanderbilt University School of Medicine, Nashville, TN 37232-2586, USA
Chest 123:368S-9S. 2003 - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 36-2002. A 32-year-old man with hemoptysis of nearly three decades' durationEric S Silverman
N Engl J Med 347:1693-701. 2002