Eric S Silverman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Immunostimulatory DNA for asthma: better than eating dirt
    Eric S Silverman
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachussetts, USA
    Am J Respir Cell Mol Biol 28:645-7. 2003
  2. ncbi Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness
    Josephine Hjoberg
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115 6021, USA
    J Appl Physiol 97:249-59. 2004
  3. ncbi Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma
    Eric S Silverman
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 169:214-9. 2004
  4. ncbi Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma
    Eric S Silverman
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115 6021, USA
    J Allergy Clin Immunol 114:747-54. 2004
  5. ncbi Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung
    Eric S Silverman
    Division of Pulmonary and Critical Care Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston 02115, USA
    Am J Respir Cell Mol Biol 27:697-704. 2002
  6. ncbi Oncostatin M causes eotaxin-1 release from airway smooth muscle: synergy with IL-4 and IL-13
    Debora S Faffe
    Physiology Program, Harvard School of Public Health, Boston, Mass 02115, USA
    J Allergy Clin Immunol 115:514-20. 2005
  7. ncbi Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscle
    Josephine Hjoberg
    Physiology Program, Dept of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    Am J Physiol Lung Cell Mol Physiol 286:L817-25. 2004
  8. ncbi DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma
    Rebecca M Baron
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 166:927-32. 2002
  9. ncbi Oncostatin M causes VEGF release from human airway smooth muscle: synergy with IL-1beta
    Debora S Faffe
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1040-8. 2005
  10. pmc TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids
    Kelan G Tantisira
    Channing Laboratory and Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18099-104. 2004

Collaborators

Detail Information

Publications28

  1. ncbi Immunostimulatory DNA for asthma: better than eating dirt
    Eric S Silverman
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachussetts, USA
    Am J Respir Cell Mol Biol 28:645-7. 2003
  2. ncbi Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness
    Josephine Hjoberg
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115 6021, USA
    J Appl Physiol 97:249-59. 2004
    ..These data suggest that increased nitric oxide in the airways has no proinflammatory effects per se and may have beneficial effects on pulmonary function...
  3. ncbi Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma
    Eric S Silverman
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 169:214-9. 2004
    ..We conclude that the T allele of C-509T is associated with the diagnosis of asthma and may enhance TGF-beta1 gene transcription...
  4. ncbi Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma
    Eric S Silverman
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115 6021, USA
    J Allergy Clin Immunol 114:747-54. 2004
    ..Abnormal regulation of CRH and endogenous glucocorticoids has been implicated in the pathogenesis of asthma...
  5. ncbi Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung
    Eric S Silverman
    Division of Pulmonary and Critical Care Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston 02115, USA
    Am J Respir Cell Mol Biol 27:697-704. 2002
    ..Overexpression of ESE-3 protein in 3T3 cells and human bronchial smooth muscle cells inhibits MMP-1 promoter activity, suggesting that ESE-3 may function as a transcriptional repressor...
  6. ncbi Oncostatin M causes eotaxin-1 release from airway smooth muscle: synergy with IL-4 and IL-13
    Debora S Faffe
    Physiology Program, Harvard School of Public Health, Boston, Mass 02115, USA
    J Allergy Clin Immunol 115:514-20. 2005
    ..Eotaxin is implicated in asthmatic eosinophilia. Oncostatin M (OSM) causes eotaxin release from fibroblasts...
  7. ncbi Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscle
    Josephine Hjoberg
    Physiology Program, Dept of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    Am J Physiol Lung Cell Mol Physiol 286:L817-25. 2004
    ..Although EGR-1 is induced by PDGF in human airway smooth muscle cells in cell culture, the role of EGR-1 in airway remodeling and asthma remains to be established...
  8. ncbi DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma
    Rebecca M Baron
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 166:927-32. 2002
    ..This study suggests that epithelium-specific ETS-2 and ETS-3 genes are unlikely to contain polymorphic loci that have a major impact on asthma susceptibility in our population...
  9. ncbi Oncostatin M causes VEGF release from human airway smooth muscle: synergy with IL-1beta
    Debora S Faffe
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1040-8. 2005
    ..This is the first description of a role for OSM on IL-1R1 expression in any cell type. OSM may contribute to airway remodeling observed in chronic airway disease...
  10. pmc TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids
    Kelan G Tantisira
    Channing Laboratory and Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18099-104. 2004
    ..TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids...
  11. ncbi FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:1285-91. 2007
    ..Although inhaled corticosteroids (ICSs) generally protect against severe exacerbations in asthma, they may result in elevated IgE levels, which are associated with exacerbations...
  12. pmc Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
    ..Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lung development and asthma pathogenesis...
  13. ncbi Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses
    Scott T Weiss
    Respiratory, Genetic, and Environmental Epidemiology, Channing Laboratory, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115
    Proc Am Thorac Soc 1:364-7. 2004
    ..The approach of a test and multiple replication populations is a valuable strategy in asthma pharmacogenetics, which can insure valid association findings...
  14. pmc The IL12B gene is associated with asthma
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Department of Anesthesia, Children s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 75:709-15. 2004
    ..IL12B may be an important asthma gene...
  15. ncbi PU.1 regulates cathepsin S expression in professional APCs
    Ying Wang
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:275-83. 2006
    ..1 alone. These data indicate that PU.1 participates in the regulation of CTSS transcription in APCs. Thus, manipulation of PU.1 expression may directly alter the endosomal proteolytic environment in these cells...
  16. ncbi Pharmacogenetics of asthma
    Lyle J Palmer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 165:861-6. 2002
  17. ncbi IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression
    Karin Storm van's Gravesande
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:4488-94. 2002
    ..Thus, IRF-1 is the critical transcriptional mediator of IFN-gamma-dependent cathepsin S activation. These data elucidate a new pathway by which IRF-1 may affect MHC class II processing and presentation...
  18. ncbi Cloning and functional analysis of the mouse 5-lipoxygenase promoter
    Eric S Silverman
    Pulmonary and Critical Care Division and Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 26:475-83. 2002
    ..We show that Sp1/Sp3 is essential for constitutive promoter-reporter activity...
  19. ncbi Association of a missense mutation in the NOS3 gene with exhaled nitric oxide levels
    Karin Storm van's Gravesande
    Division of Pulmonary and Critical Care Medicine, Tower 4B, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 168:228-31. 2003
    ....
  20. ncbi Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 13:1353-9. 2004
    ....
  21. ncbi Sequence variants in the FcepsilonRI alpha chain gene
    Toshiki Shikanai
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 93:37-41. 2002
    ..We conclude that homozygosity for the C allele of FcepsilonRI alpha chain variant is associated with lower IgE levels...
  22. ncbi Interleukin-9 influences chemokine release in airway smooth muscle: role of ERK
    Simonetta Baraldo
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1093-102. 2003
    ..Our results indicate that airway smooth muscle is a target for IL-9 and that IL-9 amplifies the potential for these cells to recruit eosinophils and neutrophils into the airways by a mechanism involving ERK...
  23. ncbi Monocyte chemoattractant protein-4 core promoter genetic variants: influence on YY-1 affinity and plasma levels
    Omer Kalayci
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, PBB 3rd Floor Clinics Building, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 29:750-6. 2003
    ....
  24. ncbi Roles for early response cytokines during Escherichia coli pneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1
    Joseph P Mizgerd
    Physiology Program, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1302-10. 2004
    ..Thus during E. coli pneumonia in mice, the lack of signaling from TNF-alpha and IL-1 decreases inflammation and preserves lung compliance...
  25. pmc Diminished lipoxin biosynthesis in severe asthma
    Bruce D Levy
    Pulmonary and Critical Care Medicine and Partners Asthma Center, Department of Internal Medicine, PBB Clinics 3, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:824-30. 2005
    ..Although arachidonic acid metabolism is well appreciated to regulate airway inflammation and reactivity, alterations in the biosynthetic capacity for both pro- and antiinflammatory eicosanoids in severe asthma have not been determined...
  26. ncbi Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression
    Daniel J Tschumperlin
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 282:L904-11. 2002
    ..These results demonstrate that compressive stress is a selective and potent activator of signal transduction and gene expression in bronchial epithelial cells...
  27. ncbi Effect of dexamethasone on beta2-adrenergic desensitization in airway smooth muscle: role of the ARG19 polymorphism
    Paul E Moore
    Departments of Pediatrics and Pharmacology Dr Moore and Mr Calder, Vanderbilt University School of Medicine, Nashville, TN 37232 2586, USA
    Chest 123:368S-9S. 2003
  28. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 36-2002. A 32-year-old man with hemoptysis of nearly three decades' duration
    Eric S Silverman
    N Engl J Med 347:1693-701. 2002