Peter J Siekmeier

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Development of antipsychotic medications with novel mechanisms of action based on computational modeling of hippocampal neuropathology
    Peter J Siekmeier
    Laboratory for Computational Neuroscience, McLean Hospital, Belmont, Massachusetts, United States of America
    PLoS ONE 8:e58607. 2013
  2. ncbi request reprint Modeling of context-dependent retrieval in hippocampal region CA1: implications for cognitive function in schizophrenia
    Peter J Siekmeier
    Department of Psychiatry, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Schizophr Res 89:177-90. 2007
  3. pmc Evidence of multistability in a realistic computer simulation of hippocampus subfield CA1
    Peter J Siekmeier
    Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Behav Brain Res 200:220-31. 2009
  4. pmc Patterns of spontaneous magnetoencephalographic activity in patients with schizophrenia
    Peter J Siekmeier
    Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    J Clin Neurophysiol 27:179-90. 2010
  5. ncbi request reprint Enhanced semantic priming in schizophrenia: a computer model based on excessive pruning of local connections in association cortex
    Peter J Siekmeier
    Department of Psychiatry, McLean Hospital, Belmont, Massachusetts, USA
    Br J Psychiatry 180:345-50. 2002
  6. ncbi request reprint Dopaminergic contributions to hippocampal pathophysiology in schizophrenia: a computational study
    Peter J Siekmeier
    1 Laboratory for Computational Neuroscience, McLean Hospital, Belmont, MA, USA 2 Harvard Medical School, Boston, MA, USA
    Neuropsychopharmacology 39:1713-21. 2014

Research Grants

Detail Information

Publications6

  1. pmc Development of antipsychotic medications with novel mechanisms of action based on computational modeling of hippocampal neuropathology
    Peter J Siekmeier
    Laboratory for Computational Neuroscience, McLean Hospital, Belmont, Massachusetts, United States of America
    PLoS ONE 8:e58607. 2013
    ..As such, they generate specific falsifiable hypotheses, which can guide postmortem and other laboratory research. Significantly, this work also suggests specific non-obvious targets for potential pharmacologic agents...
  2. ncbi request reprint Modeling of context-dependent retrieval in hippocampal region CA1: implications for cognitive function in schizophrenia
    Peter J Siekmeier
    Department of Psychiatry, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Schizophr Res 89:177-90. 2007
    ..As such, it can shed light on the etiology of schizophrenia in a fundamental way, and also holds the promise of pointing the way to more effective treatments...
  3. pmc Evidence of multistability in a realistic computer simulation of hippocampus subfield CA1
    Peter J Siekmeier
    Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Behav Brain Res 200:220-31. 2009
    ..Ways that this methodology could shed light on the etiology of mental illness, such as schizophrenia, are discussed...
  4. pmc Patterns of spontaneous magnetoencephalographic activity in patients with schizophrenia
    Peter J Siekmeier
    Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    J Clin Neurophysiol 27:179-90. 2010
    ....
  5. ncbi request reprint Enhanced semantic priming in schizophrenia: a computer model based on excessive pruning of local connections in association cortex
    Peter J Siekmeier
    Department of Psychiatry, McLean Hospital, Belmont, Massachusetts, USA
    Br J Psychiatry 180:345-50. 2002
    ..Many studies have found that people with schizophrenia exhibit abnormally high levels of semantic priming. Post-mortem and neuroimaging studies of schizophrenia suggest a reduction of neuritic processes (dendrites and synapses)...
  6. ncbi request reprint Dopaminergic contributions to hippocampal pathophysiology in schizophrenia: a computational study
    Peter J Siekmeier
    1 Laboratory for Computational Neuroscience, McLean Hospital, Belmont, MA, USA 2 Harvard Medical School, Boston, MA, USA
    Neuropsychopharmacology 39:1713-21. 2014
    ....

Research Grants2

  1. Computational Modeling of Hippocampus in Schizophrenia
    Peter Siekmeier; Fiscal Year: 2007
    ....