A J Siegel

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Exercise-associated hyponatremia: role of cytokines
    Arthur J Siegel
    Department of Internal Medicine, McLean Hospital, Belmont, Massachusetts, USA
    Am J Med 119:S74-8. 2006
  2. ncbi Cocaine-induced erythrocytosis and increase in von Willebrand factor: evidence for drug-related blood doping and prothrombotic effects
    A J Siegel
    Department of Medicine, McLean Hospital, Belmont, Mass 02478, USA
    Arch Intern Med 159:1925-9. 1999
  3. ncbi Hyponatremia in psychiatric patients: update on evaluation and management
    Arthur J Siegel
    Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Harv Rev Psychiatry 16:13-24. 2008
  4. ncbi Hypertonic (3%) sodium chloride for emergent treatment of exercise-associated hypotonic encephalopathy
    Arthur J Siegel
    Internal Medicine, McLean Hospital, Belmont, Massachusetts 02478, USA
    Sports Med 37:459-62. 2007
  5. ncbi Effect of cocaine usage on C-reactive protein, von Willebrand factor, and fibrinogen
    Arthur J Siegel
    Department of Medicine, McLean Hospital, Belmont, Massachusetts, USA
    Am J Cardiol 89:1133-5. 2002
  6. ncbi Cocaine administration induces human splenic constriction and altered hematologic parameters
    M J Kaufman
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Appl Physiol 85:1877-83. 1998
  7. ncbi Hyponatremia in marathon runners due to inappropriate arginine vasopressin secretion
    Arthur J Siegel
    Department of Medicine, McLean Hospital, Belmont, Mass, USA
    Am J Med 120:461.e11-7. 2007
  8. ncbi Testosterone gel supplementation for men with refractory depression: a randomized, placebo-controlled trial
    Harrison G Pope
    Biological Psychiatry Laboratory, McLean Hospital, 115 Mill St, Belmont, MA 02478 9106, USA
    Am J Psychiatry 160:105-11. 2003
  9. ncbi Opioid and cocaine combined effect on cocaine-induced changes in HPA and HPG axes hormones in men
    Nathalie V Goletiani
    Alcohol and Drug Abuse Research Center, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 91:526-36. 2009
  10. ncbi Cardiac biomarkers, electrolytes, and other analytes in collapsed marathon runners: implications for the evaluation of runners following competition
    Arthur J Siegel
    Department of Medicine, McLean Hospital, Belmont, MA, USA
    Am J Clin Pathol 129:948-51. 2008

Detail Information

Publications28

  1. ncbi Exercise-associated hyponatremia: role of cytokines
    Arthur J Siegel
    Department of Internal Medicine, McLean Hospital, Belmont, Massachusetts, USA
    Am J Med 119:S74-8. 2006
    ..Nonosmotic stimulation of arginine vasopressin secretion may be mediated in part by enhanced release of muscle-derived interleukin-6 during glycogen depletion, linking exertional rhabdomyolysis to the pathogenesis of EAH...
  2. ncbi Cocaine-induced erythrocytosis and increase in von Willebrand factor: evidence for drug-related blood doping and prothrombotic effects
    A J Siegel
    Department of Medicine, McLean Hospital, Belmont, Mass 02478, USA
    Arch Intern Med 159:1925-9. 1999
    ..Mechanisms that mediate cocaine-induced cardiovascular events following vasoconstriction are incompletely understood...
  3. ncbi Hyponatremia in psychiatric patients: update on evaluation and management
    Arthur J Siegel
    Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Harv Rev Psychiatry 16:13-24. 2008
    ..Hyponatremia (serum sodium concentration < 136 mEq/L) is a prevalent and potentially dangerous medical comorbidity in psychiatric patients...
  4. ncbi Hypertonic (3%) sodium chloride for emergent treatment of exercise-associated hypotonic encephalopathy
    Arthur J Siegel
    Internal Medicine, McLean Hospital, Belmont, Massachusetts 02478, USA
    Sports Med 37:459-62. 2007
    ....
  5. ncbi Effect of cocaine usage on C-reactive protein, von Willebrand factor, and fibrinogen
    Arthur J Siegel
    Department of Medicine, McLean Hospital, Belmont, Massachusetts, USA
    Am J Cardiol 89:1133-5. 2002
  6. ncbi Cocaine administration induces human splenic constriction and altered hematologic parameters
    M J Kaufman
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Appl Physiol 85:1877-83. 1998
    ..These events may help to preserve or increase tissue oxygenation in periods of high oxygen demand and/or increased vascular resistance...
  7. ncbi Hyponatremia in marathon runners due to inappropriate arginine vasopressin secretion
    Arthur J Siegel
    Department of Medicine, McLean Hospital, Belmont, Mass, USA
    Am J Med 120:461.e11-7. 2007
    ..Understanding the pathogenetic role of antidiuresis may lead to improved strategies for prevention and treatment...
  8. ncbi Testosterone gel supplementation for men with refractory depression: a randomized, placebo-controlled trial
    Harrison G Pope
    Biological Psychiatry Laboratory, McLean Hospital, 115 Mill St, Belmont, MA 02478 9106, USA
    Am J Psychiatry 160:105-11. 2003
    ..In an 8-week randomized, placebo-controlled trial, the authors administered a testosterone transdermal gel to men aged 30-65 who had refractory depression and low or borderline testosterone levels...
  9. ncbi Opioid and cocaine combined effect on cocaine-induced changes in HPA and HPG axes hormones in men
    Nathalie V Goletiani
    Alcohol and Drug Abuse Research Center, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 91:526-36. 2009
    ..These data are consistent with our earlier report that nalbuphine modestly attenuated cocaine's positive subjective effects, and that the subjective and cardiovascular effects of cocaine+nalbuphine in combination were not additive...
  10. ncbi Cardiac biomarkers, electrolytes, and other analytes in collapsed marathon runners: implications for the evaluation of runners following competition
    Arthur J Siegel
    Department of Medicine, McLean Hospital, Belmont, MA, USA
    Am J Clin Pathol 129:948-51. 2008
    ..Other metabolic abnormalities, including hypernatremia, hyponatremia, low ionized calcium and magnesium levels, and lactic acidosis may contribute to muscle fatigue and collapse...
  11. ncbi Effects of smoking successive low- and high-nicotine cigarettes on hypothalamic-pituitary-adrenal axis hormones and mood in men
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 33:749-60. 2008
    ..Tolerance to the subjective and cardiovascular effects of nicotine developed rapidly during repeated cigarette smoking, but nicotine-stimulated increases in HPA axis hormones did not change significantly...
  12. ncbi Temporal concordance of cocaine effects on mood states and neuroendocrine hormones
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, McLean Hospital, Belmont, MA 02478, USA
    Psychoneuroendocrinology 27:71-82. 2002
    ..The similarities between these hormonal profiles, the subjective effects of cocaine and the effects of "stress" are discussed...
  13. ncbi Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers
    Nathalie V Goletiani
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 86:667-77. 2007
    ..Taken together, these data suggest that nalbuphine had both mu- and kappa-like effects on PRL (PRL increase) but did not increase ACTH and cortisol...
  14. ncbi Effects of intravenous cocaine and cigarette smoking on luteinizing hormone, testosterone, and prolactin in men
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 307:339-48. 2003
    ..v. cocaine and high nicotine cigarette smoking illustrate the similarities between these drugs and suggest a possible contribution of LH to their abuse-related effects...
  15. ncbi Diminished interleukin-6 response to proinflammatory challenge in men and women after intravenous cocaine administration
    John H Halpern
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Clin Endocrinol Metab 88:1188-93. 2003
    ..Because cocaine stimulates the hypothalamic-pituitary-adrenal axis, IL-6 suppression may be a consequence of corticosteroid release. Cocaine-induced suppression of proinflammatory IL-6 may mediate impaired host defenses to infections...
  16. ncbi Effects of low- and high-nicotine cigarette smoking on mood states and the HPA axis in men
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 30:1751-63. 2005
    ..These data suggest that activation of the HPA axis may contribute to the abuse-related effects of cigarette smoking...
  17. ncbi Effects of the mixed mu/kappa opioid nalbuphine on cocaine-induced changes in subjective and cardiovascular responses in men
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 30:618-32. 2005
    ..01-0.003). Thus, there were no additive interactions between nalbuphine and cocaine on cardiovascular, subjective, or drug level measures after acute administration...
  18. ncbi Effects of cocaine on luteinizing hormone in women during the follicular and luteal phases of the menstrual cycle and in men
    J H Mendelson
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Pharmacol Exp Ther 296:972-9. 2001
    ..LH remained significantly elevated longer in men (32 min) than in women (8 and 12 min). This gender difference in cocaine's potency in stimulating LH was unexpected...
  19. ncbi Exertional dysnatremia in collapsed marathon runners: a critical role for point-of-care testing to guide appropriate therapy
    Arthur J Siegel
    McLean Hospital, Belmont, MA, USA
    Am J Clin Pathol 132:336-40. 2009
    ..Based on on-site sodium testing, dysnatremic runners were treated with appropriate intravenous fluids according to validated standards of care. Hyponatremic runners able to drink an oral hypertonic solution recovered promptly...
  20. ncbi Sodium status of collapsed marathon runners
    Alexander Kratz
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Pathol Lab Med 129:227-30. 2005
    ..These new guidelines encourage runners to drink ad libitum between 400 and 800 mL/h as opposed to the previous "as much as possible" advice...
  21. ncbi Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon
    Tomas G Neilan
    Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02115-2696, USA
    Circulation 114:2325-33. 2006
    ..001). CONCLUSIONS: Completion of a marathon is associated with correlative biochemical and echocardiographic evidence of cardiac dysfunction and injury, and this risk is increased in those participants with less training...
  22. ncbi Osmotic and nonosmotic regulation of arginine vasopressin during prolonged endurance exercise
    Tamara Hew-Butler
    Department of Human Biology, University of Cape Town, Cape Town, South Africa
    J Clin Endocrinol Metab 93:2072-8. 2008
    ....
  23. ncbi Practical management of exercise-associated hyponatremic encephalopathy: the sodium paradox of non-osmotic vasopressin secretion
    Tamara Hew-Butler
    University of Cape Town, Cape Town, South Africa
    Clin J Sport Med 18:350-4. 2008
    ....
  24. ncbi Effect of marathon running on hematologic and biochemical laboratory parameters, including cardiac markers
    Alexander Kratz
    Department of Pathology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Am J Clin Pathol 118:856-63. 2002
    ..We provide a table of modified reference ranges (or expected ranges) for basic biochemical, cardiac, and hematologic laboratory parameters for marathon runners...
  25. ncbi Measurement of a plasma stroke biomarker panel and cardiac troponin T in marathon runners before and after the 2005 Boston marathon
    Adam J Saenz
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Pathol 126:185-9. 2006
    ....
  26. ncbi Statement of the Second International Exercise-Associated Hyponatremia Consensus Development Conference, New Zealand, 2007
    Tamara Hew-Butler
    University of Cape Town, Cape Town, South Africa
    Clin J Sport Med 18:111-21. 2008
  27. ncbi Effect of marathon running on total and free serum prostate-specific antigen concentrations
    Alexander Kratz
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Arch Pathol Lab Med 127:345-8. 2003
    ..In these cases, repeat measurements should be considered at a time significantly removed from such exercise...
  28. ncbi Effects of marathon running on platelet activation markers : direct evidence for in vivo platelet activation
    Alexander Kratz
    Department of Pathology, Division of Laboratory Medicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Am J Clin Pathol 125:296-300. 2006
    ....