Research Topics
| Uwe SiebertSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Efficacy, routine effectiveness, and safety of horsechestnut seed extract in the treatment of chronic venous insufficiency. A meta-analysis of randomized controlled trials and large observational studiesU Siebert
Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians University of Munich, Germany
Int Angiol 21:305-15. 2002....- Cost-effectiveness of using N-terminal pro-brain natriuretic peptide to guide the diagnostic assessment and management of dyspneic patients in the emergency departmentUwe Siebert
Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 98:800-5. 2006.... - Effectiveness and cost-effectiveness of initial combination therapy with interferon/peginterferon plus ribavirin in patients with chronic hepatitis C in Germany: a health technology assessment commissioned by the German Federal Ministry of Health and SociUwe Siebert
Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig Maximilians University, Munich, Germany
Int J Technol Assess Health Care 21:55-65. 2005.... - Using competence network collaboration and decision-analytic modeling to assess the cost-effectiveness of interferon alpha-2b plus ribavirin as initial treatment of chronic hepatitis C in GermanyUwe Siebert
Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
Eur J Health Econ 6:112-23. 2005..Competence network collaboration and decision modeling provide a useful and efficient approach to combine evidence from international studies with country-specific parameters... - Three-year clinical follow-up after strontium-90/yttrium-90 beta-irradiation for the treatment of in-stent coronary restenosisVerena Baierl
Division of Cardiology, Department of Medicine, Medizinische Klinik und Poliklinik, University Hospital Campus Innenstadt, Munich, Germany
Am J Cardiol 96:1399-403. 2005..083), and 35.8% (p = 0.003), respectively. In conclusion, these results indicate a delayed and, even in the third year after the index procedure, continued restenotic process after beta irradiation of in-stent restenotic lesions... - Sirolimus-eluting stent implantation and beta-irradiation for the treatment of in-stent restenotic lesions: comparison of underlying mechanisms of acute gain and late loss as assessed by volumetric intravascular ultrasoundThomas M Schiele
Cardiology Division, Hospital of the Ludwig Maximilians University of Munich, Munich, Germany
Am Heart J 150:351-7. 2005.... 
Decision-analytic evaluation of the clinical effectiveness and cost-effectiveness of management programmes in chronic heart failureAlexander Göhler
Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 4724, USA
Eur J Heart Fail 10:1026-32. 2008..While management programmes (MPs) for chronic heart failure (CHF) are clinically effective, their cost-effectiveness remains uncertain. Thus, this study sought to determine the cost-effectiveness of MPs...- Assessment and characterization of time-related differences in plaque composition by intravascular ultrasound-derived radiofrequency analysis in heart transplant recipientsAndreas König
Department of Medicine, Division of Cardiology, Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat, Munich, Germany
J Heart Lung Transplant 27:302-9. 2008..Intravascular ultrasound (IVUS) and IVUS-derived radiofrequency plaque composition analysis (IVUS-RF) provide further information about the process of coronary atherosclerosis... - Randomized comparison of dexamethasone-eluting stents with bare metal stent implantation in patients with acute coronary syndrome: serial angiographic and sonographic analysisAndreas König
Department of Medicine, Division of Cardiology, Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat, Munich, Germany
Am Heart J 153:979.e1-8. 2007.... - Utility estimates for decision-analytic modeling in chronic heart failure--health states based on New York Heart Association classes and number of rehospitalizationsAlexander Göhler
Institute for Technology Assessment, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Value Health 12:185-7. 2009..Our objective was to estimate utilities for New York Heart Association (NYHA) classification and number of cardiovascular rehospitalizations... - Cardiac CT in emergency department patients with acute chest painUdo Hoffmann
Department of Radiology, Massachusetts General Hospital, 165 Charles River Plaza, Suite 400, Boston, MA 02114, USA
Radiographics 26:963-78; discussion 979-80. 2006.... - A validated clinical and biochemical score for the diagnosis of acute heart failure: the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Acute Heart Failure ScoreAaron L Baggish
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Am Heart J 151:48-54. 2006..CONCLUSION: We report a simple and accurate scoring system combining NT-proBNP testing and clinical assessment for the diagnosis or exclusion of acute HF in patients with dyspnea... - Decision-analytic models to simulate health outcomes and costs in heart failure: a systematic reviewAlexander Goehler
Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02214, USA
Pharmacoeconomics 29:753-69. 2011..As the diagnostics and biomarkers evolve, there is the hope for better intermediate endpoints for modelling disease progression as those that are currently in use all have limitations... - The Munich score: a clinical index to predict survival in ambulatory patients with chronic heart failure in the era of new medical therapiesHans Ulrich Stempfle
Department of Internal Medicine, Asklepios Stadtklinik Bad Tölz, Munich, Germany
J Heart Lung Transplant 27:222-8. 2008..In this study we assessed the prognostic value of 55 variables at baseline and 9 variables representing changes of hemodynamic parameters over time... - Comparison of acute and long-term results and underlying mechanisms from sirolimus-eluting stent implantation for the treatment of in-stent restenosis and recurrent in-stent restenosis in patients in whom intracoronary radiation failed as assessed by intrThomas M Schiele
Cardiology Division, Medizinische Poliklinik Innenstadt, University of Munich, Munich, Germany
Am J Cardiol 94:917-21. 2004..The efficacy of sirolimus-eluting stent implantation for the treatment of patients with their first episodes of ISR and with recurrent ISR due to the failure of vascular brachytherapy was compared using intravascular ultrasound imaging... 
Comparing the clinical effectiveness of different new-born hearing screening strategies. A decision analysisEva Grill
Department of Physical Medicine and Rehabilitation, University of Munich, Munich, Germany
BMC Public Health 5:12. 2005..The objective was to systematically compare two screening strategies for the early detection of new-born hearing disorders, UNHS and risk factor screening, with no systematic screening regarding their influence on early diagnosis...- A systematic meta-analysis of the efficacy and heterogeneity of disease management programs in congestive heart failureAlexander Göhler
Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 4724, USA
J Card Fail 12:554-67. 2006.... - Cost-effectiveness analysis in the assessment of diagnostic imaging technologiesG Scott Gazelle
Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 101 Merrimac St, 10th Floor, Boston, MA 02114 4724, USA
Radiology 235:361-70. 2005..The article will then conclude with a consideration of the limits of medical technology assessment... - Intravascular optical coherence tomography: comparison with histopathology in atherosclerotic peripheral artery specimensOliver A Meissner
Institute for Clinical Radiology, Institute of Pathology, Ludwig Maximilians University, Munich
J Vasc Interv Radiol 17:343-9. 2006.... - The role of decision-analytic models in the prevention, diagnosis and treatment of coronary heart diseaseUwe Siebert
Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians University of Munich, Marchioninistr 15 81377 Munich, Germany
Z Kardiol 91:144-51. 2002..In addition, the cost-effectiveness of alternative choices must be considered to optimize resource allocations from a societal perspective, further complicating the decision making process... - Endovascular optical coherence tomography ex vivo: venous wall anatomy and tissue alterations after endovenous therapyOliver A Meissner
Institute for Clinical Radiology, Ludwig Maximilians University, Ziemssenstr 1, 80336 Munich, Germany
Eur Radiol 17:2384-93. 2007..90 and 0.88, respectively). OCT allows for reproducible evaluation of normal venous wall and alterations after endovenous therapy. OCT could prove to be valuable for optimizing endovenous therapy in vivo... - Deterministic sensitivity analysis for first-order Monte Carlo simulations: a technical noteBenjamin P Geisler
Institute for Technology Assessment, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Value Health 12:96-7. 2009..Our purpose was to facilitate one-way deterministic sensitivity analysis of TreeAge Markov state-transition models requiring first-order Monte Carlo simulations... - Progression-free survival as a surrogate endpoint in advanced breast cancerRebecca A Miksad
Department of Medicine, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Int J Technol Assess Health Care 24:371-83. 2008..Using trial-level, meta-analytic approaches, we evaluated PFS as a surrogate endpoint... - A systematic review on diagnostic accuracy of CT-based detection of significant coronary artery diseaseBertrand Janne d'Othée
Beth Israel Deaconess Medical Center, Department of Radiology, Harvard Medical School, 330 Brookline Avenue, W CC 385, Boston, MA 02215 5400, United States
Eur J Radiol 65:449-61. 2008..Systematic review of diagnostic accuracy of contrast enhanced coronary computed tomography (CE-CCT)... - Systematic assessment of decision models in Parkinson's diseaseUwe Siebert
Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Value Health 7:610-26. 2004..We believe that structural bias could be avoided if underlying disease progression and treatment effects on symptoms are modeled separately... - Critical limb ischemia: hybrid MR angiography compared with DSAOliver A Meissner
Institute for Clinical Radiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Radiology 235:308-18. 2005..To compare a hybrid magnetic resonance (MR) angiography protocol with selective digital subtraction angiography (DSA) in patients with critical limb ischemia... - Are high doses of intracoronary adenosine an alternative to standard intravenous adenosine for the assessment of fractional flow reserve?Gianni Casella
Department of Cardiology, Medizinische Poliklinik Klinikum Innenstadt, Ludwig Maximilians University, Munich, Germany
Am Heart J 148:590-5. 2004..Therefore, this study compared different high, intracoronary doses of adenosine for the potential to achieve a maximal hyperemia equivalent to the standard intravenous route... - Evidence for lower variability of coronary artery calcium mineral mass measurements by multi-detector computed tomography in a community-based cohort--consequences for progression studiesUdo Hoffmann
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 100 Charles River Plaza Suite 400, Boston, MA 02114, USA
Eur J Radiol 57:396-402. 2006.... - Cabergoline versus levodopa monotherapy: a decision analysisAntje M Smala
Medical Economics Research Group (MERG, Munich, Germany
Mov Disord 18:898-905. 2003..Although costs were higher in patients on cabergoline, the corresponding cost-effectiveness ratio for cabergoline was at least as favourable as the ratios for many commonly accepted therapies... - Decision-analytic modeling to evaluate benefits and harms of medical tests: uses and limitationsThomas A Trikalinos
Tufts Evidence Based Practice Center and Center for Clinical Evidence Synthesis, Tufts Medical Center, Boston, Massachusetts, USA
Med Decis Making 29:E22-9. 2009.... - Postoperative troponin-T predicts prolonged intensive care unit length of stay following cardiac surgeryAaron L Baggish
Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
Crit Care Med 32:1866-71. 2004..0 ng/mL increase in cTnT measured at 18-24 hrs postprocedure. CONCLUSIONS: Elevated postoperative cTnT concentrations can prospectively identify patients requiring prolonged intensive care unit length of stay after cardiac surgery... - Magnetic resonance angiography in the follow-up of distal lower-extremity bypass surgery: comparison with duplex ultrasound and digital subtraction angiographyOliver A Meissner
Institute for Clinical Radiology, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
J Vasc Interv Radiol 15:1269-77. 2004..In cases of discrepancy, digital subtraction angiography (DSA) served as the reference standard... - Evolution of angiographic restenosis rate and late lumen loss after intracoronary beta radiation for in-stent restenotic lesionsThomas M Schiele
Cardiology Division, Department of Medicine, Medizinische Klinik und Poliklinik Innenstadt, University Hospital, Munich, Germany
Am J Cardiol 93:836-42. 2004..17 +/- 0.29 mm; 12 to 24 months: 0.11 +/- 0.20 mm). Restenosis after angioplasty and beta-irradiation of in-stent restenotic lesions is not complete within 6 months but is sustained with a gradual decrease over 24 months... - Cost-effectiveness of primarily human papillomavirus-based cervical cancer screening in settings with currently established Pap screening: a systematic review commissioned by the German Federal Ministry of HealthNikolai Mühlberger
University for Health Sciences, Medical Informatics and Technology, Austria
Int J Technol Assess Health Care 24:184-92. 2008..Emphasis was placed on the German situation with annual Pap screening... - Cost effectiveness of combination therapy with pioglitazone for type 2 diabetes mellitus from a german statutory healthcare perspectiveKurt Neeser
Institute for Medical Informatics and Biostatistics, Basel, Switzerland
Pharmacoeconomics 22:321-41. 2004..However, the drug acquisition cost for pioglitazone is greater than standard medications for type 2 diabetes. Long-term data regarding the cost effectiveness of pioglitazone-based combination therapy are not available... - Case finding for hepatitis C in primary care: a cost utility analysisJoanna Thompson Coon
Peninsula Technology Assessment Group, Peninsula Medical School, University of Exeter, Noy Scott House, Barrack Road, Exeter, EX2 5DW, UK
Fam Pract 23:393-406. 2006..Hepatitis C is an important public health problem. The need for more intensified action to identify those infected with the virus has been recognized. Primary care is an important setting for case finding... - The German cervical cancer screening model: development and validation of a decision-analytic model for cervical cancer screening in GermanyUwe Siebert
Department of Public Health, Medical Decision Making and Health Technology Assessment, UMIT University of Health Sciences, Medical Informatics and Technology, Hall i T, Austria
Eur J Public Health 16:185-92. 2006..We sought to develop and validate a decision-analytic model for the natural history of cervical cancer for the German health care context and to apply it to cervical cancer screening... - Safety of FFR-based treatment strategies: the Munich experienceJohannes Rieber
Medizinische Klinik der Universität München Innenstadt Ziemssenstr 1 80336 München, Germany
Z Kardiol 91:115-9. 2002..75... - Cost effectiveness analysis of routine use of genotypic antiretroviral resistance testing after failure of antiretroviral treatment for HIVMichael Corzillius
2nd Department of Internal Medicine, Christian-Albrechts-University, Kiel, Germany
Antivir Ther 9:27-36. 2004..CONCLUSION: Routine use of GART after treatment failures is cost effective. GART prior to the first HAART would be equally cost effective if it could lower the probability of first HAART failure by approximately a third... - Impact of intravascular ultrasound-guided stenting on long-term clinical outcome: a meta-analysis of available studies comparing intravascular ultrasound-guided and angiographically guided stentingGianni Casella
Catheterization Laboratory, Ospedale Maggiore, Bologna, Italy
Catheter Cardiovasc Interv 59:314-21. 2003..Whether these benefits could be very helpful when dealing with lesions at high risk for restenosis is still an issue... - Response to highly active antiretroviral therapy strongly predicts outcome in patients with AIDS-related lymphomaChristian Hoffmann
University Hospital Kiel, Germany
AIDS 17:1521-9. 2003..We analyzed the outcome of patients with ARL with respect to the use and efficacy of highly active antiretroviral therapy (HAART) and to potential prognostic factors... - Fractional flow reserve predicts major adverse cardiac events after coronary stent implantationJohannes Rieber
Dept. of Cardiology, Medizinische Klinik-Innenstadt, University of Munich, Ziemssenstr. 1 80336 Munich, Germany
Z Kardiol 91:132-6. 2002..Further studies have to investigate whether outcome after stenting might be improved by guiding the procedure with a pressure guide wire... - Dopamine transporter imaging and SPECT in diagnostic work-up of Parkinson's disease: a decision-analytic approachRichard C Dodel
Department of Neurology, Friedrich Wilhelms University, Bonn, Germany
Mov Disord 18:S52-62. 2003..These results should be adjusted to the specific setting and individual patient preferences... - Rationale and design of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) studyWilliam F Fearon
Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
Am Heart J 154:632-6. 2007..However, some have suggested that invasive physiologic guidance may improve decision making... - [Impact of vaccination against oncogenic human papillomavirus on the incidence and mortality of cervical cancer in Germany]Achim Schneider
Klinik für Gynäkologie und gynäkologische Onkologie, Charite, Berlin
Med Klin (Munich) 102:515-23. 2007..The study aims to evaluate the achievable long-term impact of HPV vaccination on invasive cervical cancer (ICC) incidence and mortality in Germany, a country with an opportunistic Pap screening program and suboptimal participation... - Cost effectiveness of haemophilia treatment: a cross-national assessmentBarbara Lippert
Department of Haemostasis and Transfusion Medicine, University Hospital of Munich, Germany
Blood Coagul Fibrinolysis 16:477-85. 2005..7 million Euro dollars per quality-adjusted life year. Based on our decision analysis, the use of prophylactic treatment was overall more effective than on-demand therapy in young haemophiliacs, but at extremely high cost... - Resource utilization and costs of stroke unit care in GermanyRichard C Dodel
Department of Neurology and Institute of Medical Biometry and Epidemiology, Philipps University, Marburg, Marburg, Germany
Value Health 7:144-52. 2004..Recently, the concept of an integrated stroke unit has been established in several countries to improve the outcome of patients. This study evaluates the costs of acute care of the different cerebrovascular insults in a stroke unit... - Diagnostic performance of stress perfusion and delayed-enhancement MR imaging in patients with coronary artery diseaseRicardo C Cury
Department of Radiology, Beneficencia Portuguesa Hospital, Sao Paulo, Brazil
Radiology 240:39-45. 2006.... - Cardiac magnetic resonance perfusion imaging for the functional assessment of coronary artery disease: a comparison with coronary angiography and fractional flow reserveJohannes Rieber
Department of Cardiology, Division of Internal Medicine, University of Munich Germany
Eur Heart J 27:1465-71. 2006.... - Cost of illness and its predictors for Parkinson's disease in GermanyAnnika E Spottke
Department of Neurology, Friedrich-Wilhelms-University, Bonn, Germany
Pharmacoeconomics 23:817-36. 2005..Total indirect costs amounted to 3180 euro +/-6480 euro. CONCLUSION: According to our study, PD puts a high financial burden on society and underscores the need for further economic and medical research to optimise treatment for PD... - Application, feasibility, and efficacy of a combined intravascular ultrasound and stent delivery system: results from a prospective multicenter trialJohannes Rieber
Department of Cardiology, Division of Internal Medicine, University of Munich, Germany
J Interv Cardiol 18:367-74. 2005..The concept of combining IVUS information and a stent delivery system may be increasingly attractive with evolving imaging modalities like virtual histology or a combination with drug-eluting stents... - Key principles for the improved conduct of health technology assessments for resource allocation decisionsMichael F Drummond
Centre for Health Economics, University of York, Heslington, York, UK
Int J Technol Assess Health Care 24:244-58; discussion 362-8. 2008..The principles are organized into four sections: (i) "Structure" of HTA programs; (ii) "Methods" of HTA; (iii) "Processes for Conduct" of HTA; and (iv) "Use of HTAs in Decision Making."..