Richard L Sidman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Unique glycerophospholipid signature in retinal stem cells correlates with enzymatic functions of diverse long-chain acyl-CoA synthetases
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Stem Cells 25:2864-73. 2007
  2. ncbi request reprint Injection of mouse and human neural stem cells into neonatal Niemann-Pick A model mice
    Richard L Sidman
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Brain Res 1140:195-204. 2007
  3. pmc Temporal neuropathologic and behavioral phenotype of 6neo/6neo Pompe disease mice
    Richard L Sidman
    Department of Neurology RLS, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Neuropathol Exp Neurol 67:803-18. 2008
  4. doi request reprint Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Neuron 68:45-60. 2010
  5. ncbi request reprint Neural stem cells rescue nervous purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:7839-48. 2006
  6. pmc Tissue plasminogen activator regulates Purkinje neuron development and survival
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 110:E2410-9. 2013
  7. pmc Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18117-22. 2004
  8. ncbi request reprint Expression profile of an operationally-defined neural stem cell clone
    Mark A Parker
    Department of Otolaryngology, EN41, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Exp Neurol 194:320-32. 2005
  9. ncbi request reprint Physical activity-mediated functional recovery after spinal cord injury: potential roles of neural stem cells
    Yang D Teng
    Department of Neurosurgery, Harvard Medical School, Brigham and Women s Hospital and Children s Hospital Boston, Boston, MA 02115, USA
    Regen Med 1:763-76. 2006
  10. pmc Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:7847-52. 2006

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Unique glycerophospholipid signature in retinal stem cells correlates with enzymatic functions of diverse long-chain acyl-CoA synthetases
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Stem Cells 25:2864-73. 2007
    ..These novel findings suggest that LACS-associated GPL signature and cell membrane fluidity may participate in regulating proliferation versus differentiation in RSCs and, perhaps, other types of stem cells...
  2. ncbi request reprint Injection of mouse and human neural stem cells into neonatal Niemann-Pick A model mice
    Richard L Sidman
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Brain Res 1140:195-204. 2007
    ..However, though Purkinje cell rescue has been achieved with NSCs in some other disease models, loss of Purkinje neurons and decline in rotorod performance were still present in injected ASMKO mice...
  3. pmc Temporal neuropathologic and behavioral phenotype of 6neo/6neo Pompe disease mice
    Richard L Sidman
    Department of Neurology RLS, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Neuropathol Exp Neurol 67:803-18. 2008
    ..A better understanding of the basis for clinical manifestations is needed to correlate CNS pathology with Pompe disease manifestations...
  4. doi request reprint Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Neuron 68:45-60. 2010
    ..These findings provide insight into Nna1's role in neuronal development and why its absence renders Purkinje cells more vulnerable...
  5. ncbi request reprint Neural stem cells rescue nervous purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:7839-48. 2006
    ..This report demonstrates for the first time that NSCs can rescue imperiled host neurons by rectifying their gene expression, elevating somatic stem cell therapeutic potential beyond solely cell replacement strategy...
  6. pmc Tissue plasminogen activator regulates Purkinje neuron development and survival
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 110:E2410-9. 2013
    ..In sum, excess tPA/plasmin, through separate downstream molecular mechanisms, regulates postnatal PN dendritogenesis, synaptogenesis, mitochondrial structure and function, and selective PN viability. ..
  7. pmc Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18117-22. 2004
    ..CXCR4 expression within germinal zones suggests that NSC homing after injury and migration during development may invoke similar mechanisms...
  8. ncbi request reprint Expression profile of an operationally-defined neural stem cell clone
    Mark A Parker
    Department of Otolaryngology, EN41, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Exp Neurol 194:320-32. 2005
    ..Furthermore, when operational definitions are employed, a common set of stem-like genes does emerge across both embryonic and somatic stem cells of various organ systems, including the nervous system...
  9. ncbi request reprint Physical activity-mediated functional recovery after spinal cord injury: potential roles of neural stem cells
    Yang D Teng
    Department of Neurosurgery, Harvard Medical School, Brigham and Women s Hospital and Children s Hospital Boston, Boston, MA 02115, USA
    Regen Med 1:763-76. 2006
    ....
  10. pmc Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:7847-52. 2006
    ..We thus propose a molecular pathway by which the excessive tPA in nr cerebellum mediates PN degeneration...
  11. pmc Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis
    Yinghua Ma
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Cell Biol 175:209-15. 2006
    ..These findings reveal novel functions for TLR8 in the mammalian nervous system that are distinct from the classical role of TLRs in immunity...
  12. ncbi request reprint Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development
    Alexander J R Bishop
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 63:5335-43. 2003
    ..This temporal resolution suggests that Atm and p53 can act to maintain genomic integrity by different mechanisms in certain in vivo contexts...
  13. doi request reprint Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis
    Yang D Teng
    Departments of Neurosurgery and PM and R, Brigham and Women s Hospital, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 4:165ra164. 2012
    ..We conclude that the widespread, pleiotropic, modulatory actions exerted by transplanted NSCs may represent an accessible therapeutic application of stem cells for treating ALS and other untreatable degenerative diseases...
  14. pmc Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A
    Dou Yu
    Department of Neurosurgery, Harvard Medical School Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:E746-55. 2013
    ..Therefore, HUP-A may provide safe and effective management for chronic postneurotrauma pain by reestablishing homeostasis of sensory circuits...
  15. pmc Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice
    Jaime Imitola
    Brigham and Women s Hospital, Center for Neurologic Diseases, Partner Multiple Sclerosis Center, Harvard Medical School, Department of Neurology, Boston, Massachusetts 02115, USA
    J Biomed Opt 16:021109. 2011
    ....
  16. ncbi request reprint TLR8: an innate immune receptor in brain, neurons and axons
    Yinghua Ma
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Cell Cycle 6:2859-68. 2007
    ....
  17. pmc Functional multipotency of stem cells: a conceptual review of neurotrophic factor-based evidence and its role in translational research
    Yang D Teng
    Division of SCI Research, Veterans Affairs Boston Healthcare System, Boston, MA, USA
    Curr Neuropharmacol 9:574-85. 2011
    ..We suggest that embracing this view of the "multipotency" of the SCs is pivotal for correctly, efficiently, and optimally exploiting stem cell biology for therapeutic applications, including reconstitution of a dysfunctional CNS...
  18. pmc Stem cells: cross-talk and developmental programs
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Boston, MA4 02115, USA
    Philos Trans R Soc Lond B Biol Sci 359:823-37. 2004
    ..Understanding the relevant molecular pathways of stem cell repair phenotype should be a priority, in our view, for the entire stem cell field...
  19. pmc Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination
    Soo Jin Chun
    Department of Neurology, Beth Israel Deaconess Medical Center, Center for Neurodegeneration and Repair and the Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 163:397-408. 2003
    ..A dominant negative ILK inhibits LN-2-induced myelinlike membrane formation. A critical component of the myelination signaling cascade includes LN-2 and integrin signals through ILK...
  20. pmc Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:12175-80. 2007
    ..We propose that multiple modes of reciprocal interaction between exogenous hNSCs and the pathological host milieu underlie the functional improvement observed in this model of PD...
  21. ncbi request reprint Treatment of hypoxia-induced retinopathy with targeted proapoptotic peptidomimetic in a mouse model of disease
    Johanna Lahdenranta
    The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    FASEB J 21:3272-8. 2007
    ..Targeted proapoptotic peptides may prove useful in the management of angiogenic retinal diseases...
  22. ncbi request reprint A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration
    David E Sleat
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 24:9117-26. 2004
    ..In addition, the CLN2-targeted mouse also represents a valuable model for the evaluation of different therapeutic strategies...
  23. ncbi request reprint Intrinsic resistance of neural stem cells to toxic metabolites may make them well suited for cell non-autonomous disorders: evidence from a mouse model of Krabbe leukodystrophy
    Roseanne M Taylor
    Department of Animal Science, Faculty of Veterinary Science, University of Sydney and New South Wales, Australia
    J Neurochem 97:1585-99. 2006
    ..Most neurological disease are complex in this way and will likely require multifaceted approaches, perhaps with NSCs serving as the 'glue'...
  24. ncbi request reprint Acute injury directs the migration, proliferation, and differentiation of solid organ stem cells: evidence from the effect of hypoxia-ischemia in the CNS on clonal "reporter" neural stem cells
    Kook In Park
    Department of Pediatrics and The Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea
    Exp Neurol 199:156-78. 2006
    ....
  25. ncbi request reprint Neural stem cells as novel cancer therapeutic vehicles
    Stephen Yip
    Department of Pathology and Laboratory Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada
    Eur J Cancer 42:1298-308. 2006
    ..These aspects are reviewed and discussed here...
  26. ncbi request reprint Purkinje cell degeneration (pcd) phenotypes caused by mutations in the axotomy-induced gene, Nna1
    Angeles Fernandez-Gonzalez
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Science 295:1904-6. 2002
    ..The present study suggests an unexpected molecular link between neuronal degeneration and regeneration, and its results have potential implications for neurodegenerative diseases and male infertility...
  27. pmc Impaired angiogenesis in aminopeptidase N-null mice
    Roberto Rangel
    Department of Genitourinary Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:4588-93. 2007
    ..Finally, in addition to vascular biology research, APN-null mice may be useful reagents in other medical fields such as malignant, cardiovascular, immunological, or infectious diseases...
  28. ncbi request reprint Aminopeptidase A is a functional target in angiogenic blood vessels
    Serena Marchio
    The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 5:151-62. 2004
    ..Finally, we successfully treated tumor-bearing mice with APA binding peptides or anti-APA blocking monoclonal antibodies. These data show that APA is a regulator of blood vessel formation, and can serve as a functional vascular target...