Stephanie Shore

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Direct effects of Th2 cytokines on airway smooth muscle
    Stephanie A Shore
    Physiology Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Curr Opin Pharmacol 4:235-40. 2004
  2. pmc Role of the adiponectin binding protein, T-cadherin (Cdh13), in allergic airways responses in mice
    Alison S Williams
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e41088. 2012
  3. pmc Augmented pulmonary responses to acute ozone exposure in obese mice: roles of TNFR2 and IL-13
    Alison Suzanne Williams
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 121:551-7. 2013
  4. pmc Role of the adiponectin binding protein, T-cadherin (cdh13), in pulmonary responses to subacute ozone
    David I Kasahara
    Department of Environmental Health, Harvard School of Public Health HSPH, Boston, Massachusetts, United States of America
    PLoS ONE 8:e65829. 2013
  5. pmc Environmental perturbations: Obesity
    Stephanie A Shore
    Dept of Env Health, Harvard School of Public Health, USA
    Compr Physiol 1:263-82. 2011
  6. ncbi request reprint Effect of leptin on allergic airway responses in mice
    Stephanie A Shore
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115 6021, USA
    J Allergy Clin Immunol 115:103-9. 2005
  7. pmc Beta-agonists and asthma: too much of a good thing?
    Stephanie A Shore
    Physiology Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    J Clin Invest 112:495-7. 2003
  8. ncbi request reprint IL-13 and IL-4 promote TARC release in human airway smooth muscle cells: role of IL-4 receptor genotype
    Debora S Faffe
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 285:L907-14. 2003
  9. ncbi request reprint Responses to ozone are increased in obese mice
    S A Shore
    Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
    J Appl Physiol (1985) 95:938-45. 2003
  10. doi request reprint Obesity and asthma: possible mechanisms
    Stephanie A Shore
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Allergy Clin Immunol 121:1087-93; quiz 1094-5. 2008

Research Grants

  1. Impact of obesity on airway responses to air pollution
    Stephanie Shore; Fiscal Year: 2005
  2. OBESITY AND AIRWAY RESPONSIVENESS
    Stephanie A Shore; Fiscal Year: 2010
  3. Impact of obesity on airway responses to air pollution
    Stephanie Shore; Fiscal Year: 2007
  4. Impact of obesity on airway responses to air pollution
    Stephanie Shore; Fiscal Year: 2006
  5. Impact of obesity on airway responses to air pollution
    Stephanie A Shore; Fiscal Year: 2010
  6. OBESITY AND AIRWAY RESPONSIVENESS
    Stephanie Shore; Fiscal Year: 2007
  7. OBESITY AND AIRWAY RESPONSIVENESS
    Stephanie Shore; Fiscal Year: 2009
  8. Impact of obesity on airway responses to air pollution
    Stephanie Shore; Fiscal Year: 2009
  9. Rho Kinase and Airway Hyperresponsiveness
    Stephanie A Shore; Fiscal Year: 2010

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Direct effects of Th2 cytokines on airway smooth muscle
    Stephanie A Shore
    Physiology Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Curr Opin Pharmacol 4:235-40. 2004
    ..Understanding the mechanistic basis for the interactions between these cytokines and airway smooth muscle might suggest new avenues for therapeutic intervention in asthma...
  2. pmc Role of the adiponectin binding protein, T-cadherin (Cdh13), in allergic airways responses in mice
    Alison S Williams
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e41088. 2012
    ..In conclusion, T-cad does not mediate the protective effects of adiponectin. Instead, mice lacking T-cad have reduced allergic airways disease, likely because elevated serum adiponectin levels act on other adiponectin signaling pathways...
  3. pmc Augmented pulmonary responses to acute ozone exposure in obese mice: roles of TNFR2 and IL-13
    Alison Suzanne Williams
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 121:551-7. 2013
    ..Acute ozone (O(3)) exposure results in greater inflammation and airway hyperresponsiveness (AHR) in obese versus lean mice...
  4. pmc Role of the adiponectin binding protein, T-cadherin (cdh13), in pulmonary responses to subacute ozone
    David I Kasahara
    Department of Environmental Health, Harvard School of Public Health HSPH, Boston, Massachusetts, United States of America
    PLoS ONE 8:e65829. 2013
    ..Our results indicate that T-cadherin is required for the ability of adiponectin to suppress some but not all aspects of ozone-induced pulmonary inflammation...
  5. pmc Environmental perturbations: Obesity
    Stephanie A Shore
    Dept of Env Health, Harvard School of Public Health, USA
    Compr Physiol 1:263-82. 2011
    ..Weight reduction should be encouraged in any symptomatic obese individual, since virtually all of the respiratory complications of obesity improve with even moderate weight loss...
  6. ncbi request reprint Effect of leptin on allergic airway responses in mice
    Stephanie A Shore
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115 6021, USA
    J Allergy Clin Immunol 115:103-9. 2005
    ..Epidemiologic data indicate that the incidence of asthma is increased in obese patients...
  7. pmc Beta-agonists and asthma: too much of a good thing?
    Stephanie A Shore
    Physiology Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    J Clin Invest 112:495-7. 2003
    ..A new study describes one possible mechanism and reveals a potential new therapeutic target in the treatment of asthma...
  8. ncbi request reprint IL-13 and IL-4 promote TARC release in human airway smooth muscle cells: role of IL-4 receptor genotype
    Debora S Faffe
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 285:L907-14. 2003
    ....
  9. ncbi request reprint Responses to ozone are increased in obese mice
    S A Shore
    Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
    J Appl Physiol (1985) 95:938-45. 2003
    ..Our results also indicate that the hormone leptin, which is increased in the obese, has the capacity to increase airway inflammation...
  10. doi request reprint Obesity and asthma: possible mechanisms
    Stephanie A Shore
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Allergy Clin Immunol 121:1087-93; quiz 1094-5. 2008
    ..Novel therapeutic strategies for treatment of the obese patient with asthma may result from an increased understanding of the mechanisms underlying this relationship...
  11. ncbi request reprint Regulation of beta-adrenergic responses in airway smooth muscle
    Stephanie A Shore
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Respir Physiol Neurobiol 137:179-95. 2003
    ..Understanding the regulation of beta-adrenergic responses in airway smooth muscle cells may prove to be an important step in improving the efficacy of beta-agonists for the treatment of asthma...
  12. ncbi request reprint Obesity and asthma
    Stephanie A Shore
    Physiology Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Pharmacol Ther 110:83-102. 2006
    ..Understanding the mechanistic basis for the relationship between obesity and asthma may lead to new therapeutic strategies for treatment of this susceptible population...
  13. ncbi request reprint Obesity and asthma: implications for treatment
    Stephanie A Shore
    Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Curr Opin Pulm Med 13:56-62. 2007
    ..The purpose of this review is to evaluate recent data addressing this relationship and its biological basis, and to evaluate the implications of these data for treatment...
  14. ncbi request reprint Obesity and asthma: lessons from animal models
    Stephanie A Shore
    Program in Molecular and Integrative Physiological Sciences, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 102:516-28. 2007
    ..Understanding the mechanistic basis for the relationship between obesity and asthma may lead to novel therapeutic strategies for treatment of the obese asthmatic subject...
  15. ncbi request reprint Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice
    Stephanie A Shore
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Allergy Clin Immunol 118:389-95. 2006
    ..Epidemiologic data indicate an increased incidence of asthma in the obese...
  16. ncbi request reprint Obesity and asthma: cause for concern
    Stephanie A Shore
    Physiology Program, Harvard School of Public Health, 665 Huntington Avenue, Boston MA 02115, USA
    Curr Opin Pharmacol 6:230-6. 2006
    ..Understanding the mechanistic basis for the relationship between obesity and asthma could lead to new therapeutic strategies for treatment of this susceptible population...
  17. pmc No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice
    Stephanie A Shore
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 105:1127-33. 2008
    ..Metformin did not affect ozone-induced inflammation in mice of either genotype. The results indicate that hyperglycemia is unlikely to account for the pulmonary phenotype of obese mice...
  18. pmc Pulmonary responses to subacute ozone exposure in obese vs. lean mice
    Stephanie A Shore
    Molecular and Integrative Physiological Sciences Program, Dept of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    J Appl Physiol (1985) 107:1445-52. 2009
    ..In summary, the neutrophilic inflammation induced by prolonged low level ozone exposure was attenuated in obese mice and appeared to result from an absence of IL-6-dependent neutrophil recruitment in the obese mice...
  19. ncbi request reprint Ventilatory responses to ozone are reduced in immature rats
    S A Shore
    Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
    J Appl Physiol (1985) 88:2023-30. 2000
    ..The results indicate that the ventilatory response to O(3) is absent in 2-wk-old rats and that lack of this response, in conjunction with a greater specific ventilation, leads to greater lung injury...
  20. pmc Obesity, airway hyperresponsiveness, and inflammation
    Stephanie A Shore
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 108:735-43. 2010
    ..Determining how obesity promotes asthma may uncover novel therapeutic strategies that are effective in the obese asthmatic subject...
  21. ncbi request reprint Tumor necrosis factor receptor 2 contributes to ozone-induced airway hyperresponsiveness in mice
    S A Shore
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 164:602-7. 2001
    ..Our results indicate that TNF contributes to the AHR but not the PMN emigration induced by acute O(3) exposure...
  22. ncbi request reprint Ozone-induced airway hyperresponsiveness is reduced in immature mice
    S A Shore
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 92:1019-28. 2002
    ..The results suggest that immature mice are less sensitive than adult mice to O(3), at least in terms of the ability of O(3) to induce airway hyperresponsiveness and promote release of certain cytokines...
  23. ncbi request reprint Effects of cytokines on contractile and dilator responses of airway smooth muscle
    Stephanie A Shore
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Clin Exp Pharmacol Physiol 29:859-66. 2002
    ..3. Understanding the mechanistic basis for the effects of these cytokines may prove to be an important step in improving the efficacy of beta-adrenoceptor agonists for the treatment of asthma...
  24. pmc Impact of aging on pulmonary responses to acute ozone exposure in mice: role of TNFR1
    Stephanie A Shore
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Inhal Toxicol 23:878-88. 2011
    ..Chamber studies in adult humans indicate reduced responses to acute ozone with increasing age. Age-related changes in TNFα have been observed. TNFα induced inflammation is predominantly mediated through TNFR1...
  25. ncbi request reprint Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness
    Josephine Hjoberg
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115 6021, USA
    J Appl Physiol 97:249-59. 2004
    ..These data suggest that increased nitric oxide in the airways has no proinflammatory effects per se and may have beneficial effects on pulmonary function...
  26. ncbi request reprint Role of tachykinins in airway responses to ozone in rats
    T Takebayashi
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 85:442-50. 1998
    ..The results also indicate that the more pronounced effect of O3 on BAL neutrophils in Cap-treated rats is not the result of a greater inhaled dose of O3 resulting from greater VE...
  27. ncbi request reprint Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung
    Eric S Silverman
    Division of Pulmonary and Critical Care Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston 02115, USA
    Am J Respir Cell Mol Biol 27:697-704. 2002
    ..Overexpression of ESE-3 protein in 3T3 cells and human bronchial smooth muscle cells inhibits MMP-1 promoter activity, suggesting that ESE-3 may function as a transcriptional repressor...
  28. ncbi request reprint Friction in airway smooth muscle: mechanism, latch, and implications in asthma
    J J Fredberg
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachsetts 02115, USA
    J Appl Physiol (1985) 81:2703-12. 1996
    ..This last finding may account for the unique inability of asthmatic patients to reverse spontaneous airways obstruction with a deep inspiration...
  29. ncbi request reprint Differential effects of ozone on airway and tissue mechanics in obese mice
    Y M Rivera-Sanchez
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Appl Physiol 96:2200-6. 2004
    ..Our results also demonstrate that changes in the lung tissue rather than the airways account for the amplification of O(3)-induced hyperresponsiveness observed in obese mice...
  30. ncbi request reprint Interleukin-6 family cytokines: signaling and effects in human airway smooth muscle cells
    T Lahiri
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1225-32. 2001
    ..Our results indicate that IL-6 and OSM are capable of inducing signaling in HASM cells. In addition, OSM and IL-1beta synergistically cause COX-2 expression and PGE(2) release...
  31. ncbi request reprint Selected contribution: time course and heterogeneity of contractile responses in cultured human airway smooth muscle cells
    B Fabry
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 91:986-94. 2001
    ....
  32. ncbi request reprint Chemical regulation of pulmonary airway tone
    J M Drazen
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Physiol 57:151-70. 1995
    ..The next major challenge is to understand how they function in an integrated fashion...
  33. ncbi request reprint Methacholine-induced bronchoconstriction in dogs: effects of lung volume and O3 exposure
    S T Kariya
    Department of Environmental Sciences and Physiology, Harvard School of Public Health, Boston, Massachusetts
    J Appl Physiol (1985) 65:2679-86. 1988
    ..These data suggest O3 exposure does not affect MCh responses in conducting airways; rather, it affects responses of peripheral contractile elements to MCh, without changing their maximal response...
  34. ncbi request reprint Selected contribution: synergism between TNF-alpha and IL-1 beta in airway smooth muscle cells: implications for beta-adrenergic responsiveness
    P E Moore
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Appl Physiol 91:1467-74. 2001
    ..The data suggest that the simultaneous release in the airway, of even very small amounts of cytokines, can have important functional consequences...
  35. ncbi request reprint Obesity and asthma: directions for research
    Scott T Weiss
    Channing Laboratory, Brigham and Women s Hospital, and Harvard School of Public Health, 181 Longwood Avenue, Boston, MA 02110, USA
    Am J Respir Crit Care Med 169:963-8. 2004
  36. ncbi request reprint Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells
    J C Laporte
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 164:141-8. 2001
    ..We propose that these direct effect of IL-13 on HASM cells may contribute at least in part to the airway narrowing observed in patients with asthma...
  37. pmc Role of Rho kinase isoforms in murine allergic airway responses
    M Zhu
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115 6021, USA
    Eur Respir J 38:841-50. 2011
    ..Ovalbumin-induced changes in lavage interleukin-13, interleukin-5 and lymphocytes were also reduced in ROCK1(+/-) mice. In conclusion, both ROCK1 and ROCK2 are important in regulating allergic airway responses...
  38. pmc Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells
    Ming Zhu
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    Am J Respir Cell Mol Biol 45:111-9. 2011
    ....
  39. ncbi request reprint Repeated exposure to isoprene oxidation products causes enhanced respiratory tract effects in multiple murine strains
    Annette C Rohr
    Electric Power Research Institute, Palo Alto, California 94304 1395, USA
    Inhal Toxicol 15:1191-207. 2003
    ....
  40. ncbi request reprint Effect of obesity on pulmonary inflammation induced by acute ozone exposure: role of interleukin-6
    Jason E Lang
    Molecular and Integrative Physiological Sciences Program, Dept of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1013-20. 2008
    ..Moreover, obesity-related differences in activation of STAT proteins may contribute to some of the differences in the response of obese vs. lean mice...
  41. doi request reprint Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation
    Richard A Johnston
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    J Appl Physiol (1985) 104:1727-35. 2008
    ..However, mice with DIO must remain obese for an extended period of time before this pulmonary phenotype is observed...
  42. ncbi request reprint Airway smooth muscle proliferation and mechanics: effects of AMP kinase agonists
    Anat Ratnovsky
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Mol Cell Biomech 4:143-57. 2007
    ..Taken together, these findings suggest that metformin, probably through activation of AMPK, reduces the rate of ongoing reorganization of the CSK and inhibits ASM cell proliferation...
  43. ncbi request reprint Macrophage inflammatory protein-2 levels are associated with changes in serum leptin concentrations following ozone-induced airway inflammation
    Richard A Johnston
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115 6021, USA
    Chest 123:369S-70S. 2003
  44. ncbi request reprint CXCR2 is essential for maximal neutrophil recruitment and methacholine responsiveness after ozone exposure
    Richard A Johnston
    Physiology Program, Dept of Environmental Health, Harvard School of Public Health, Boston, MA 02115 6021, USA
    Am J Physiol Lung Cell Mol Physiol 288:L61-7. 2005
    ..These results indicate CXCR2 is essential for maximal neutrophil recruitment, epithelial cell sloughing, and persistent increases in MCh responsiveness after an acute O(3) exposure...
  45. ncbi request reprint Role of interleukin-6 in murine airway responses to ozone
    Richard A Johnston
    Bldg 1, Rm 1304A, Physiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    Am J Physiol Lung Cell Mol Physiol 288:L390-7. 2005
    ..Our results indicate that IL-6 deficiency reduces airway neutrophilia, as well as the levels of BALF sTNFR1 and sTNFR2 following acute high dose and/or subacute low-dose O(3) exposure, but has no effect on O(3)-induced AHR...
  46. ncbi request reprint Interleukin-9 influences chemokine release in airway smooth muscle: role of ERK
    Simonetta Baraldo
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1093-102. 2003
    ..Our results indicate that airway smooth muscle is a target for IL-9 and that IL-9 amplifies the potential for these cells to recruit eosinophils and neutrophils into the airways by a mechanism involving ERK...
  47. ncbi request reprint Cytokine regulation of beta-adrenergic responses in airway smooth muscle
    Stephanie A Shore
    Physiology Program, Harvard School of Public Health, Boston, Mass 02115, USA
    J Allergy Clin Immunol 110:S255-60. 2002
    ..Understanding the mechanistic basis for the effects of these cytokines may prove to be an important step in improving the efficacy of beta-agonists for the treatment of asthma...
  48. ncbi request reprint Effect of IL-1beta on CRE-dependent gene expression in human airway smooth muscle cells
    Thomas Lahiri
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1239-46. 2002
    ....
  49. ncbi request reprint IL-13 and IL-4 cause eotaxin release in human airway smooth muscle cells: a role for ERK
    Paul E Moore
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Bldg 1 Rm 311, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 282:L847-53. 2002
    ....
  50. pmc Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17
    Muriel Pichavant
    Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:385-93. 2008
    ....
  51. ncbi request reprint Modeling airway remodeling: the winner by a nose?
    Stephanie A Shore
    Am J Respir Crit Care Med 168:910-1. 2003
  52. ncbi request reprint Oncostatin M causes VEGF release from human airway smooth muscle: synergy with IL-1beta
    Debora S Faffe
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1040-8. 2005
    ..This is the first description of a role for OSM on IL-1R1 expression in any cell type. OSM may contribute to airway remodeling observed in chronic airway disease...
  53. ncbi request reprint Oncostatin M causes eotaxin-1 release from airway smooth muscle: synergy with IL-4 and IL-13
    Debora S Faffe
    Physiology Program, Harvard School of Public Health, Boston, Mass 02115, USA
    J Allergy Clin Immunol 115:514-20. 2005
    ..Eotaxin is implicated in asthmatic eosinophilia. Oncostatin M (OSM) causes eotaxin release from fibroblasts...
  54. ncbi request reprint Obesity, smooth muscle, and airway hyperresponsiveness
    Stephanie A Shore
    Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:925-7. 2005
    ....
  55. ncbi request reprint Augmented responses to ozone in obese carboxypeptidase E-deficient mice
    Richard A Johnston
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    Am J Physiol Regul Integr Comp Physiol 290:R126-33. 2006
    ..These results also suggest that chronic systemic inflammation may enhance airway responses to O3 in obese mice...
  56. pmc Interleukin-13 and interleukin-4 induce vascular endothelial growth factor release from airway smooth muscle cells: role of vascular endothelial growth factor genotype
    Debora S Faffe
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 34:213-8. 2006
    ..Our data suggest that IL-4 and IL-13 mediate their effects on VEGF expression post-transcriptionally and indicate that polymorphisms in the VEGF, but not the IL-4R alpha, gene affect VEGF release from smooth muscle cells...
  57. ncbi request reprint Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma
    Eric S Silverman
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 169:214-9. 2004
    ..We conclude that the T allele of C-509T is associated with the diagnosis of asthma and may enhance TGF-beta1 gene transcription...
  58. ncbi request reprint Increased pulmonary responses to acute ozone exposure in obese db/db mice
    Frank L Lu
    Physiology Program, Dept of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115 6021, USA
    Am J Physiol Lung Cell Mol Physiol 290:L856-65. 2006
    ..Differences between ob/ob mice, which lack leptin, and db/db mice, which lack Ob-R(b) but not Ob-R(a), suggest leptin, acting through Ob-R(a), can modify some pulmonary responses to O(3)...
  59. ncbi request reprint Airway smooth muscle in asthma--not just more of the same
    Stephanie A Shore
    Physiology Program, Harvard School of Public Health, Boston, USA
    N Engl J Med 351:531-2. 2004
  60. ncbi request reprint Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscle
    Josephine Hjoberg
    Physiology Program, Dept of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    Am J Physiol Lung Cell Mol Physiol 286:L817-25. 2004
    ..Although EGR-1 is induced by PDGF in human airway smooth muscle cells in cell culture, the role of EGR-1 in airway remodeling and asthma remains to be established...
  61. ncbi request reprint Pulmonary responses to acute ozone exposure in fasted mice: effect of leptin administration
    Richard A Johnston
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    J Appl Physiol 102:149-56. 2007
    ..These effects of fasting are the result of declines in serum leptin. The mechanistic basis for this protective effect of leptin in fasted mice remains to be determined but is not related to effects on ozone-induced inflammation...
  62. ncbi request reprint Role of heat shock protein 27 in cytoskeletal remodeling of the airway smooth muscle cell
    Steven S An
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115
    J Appl Physiol (1985) 96:1701-13. 2004
    ..Taken together, these results show that phosphorylated HSP27 favors reduced bead motions that are probably due to stabilization of the actin cytoskeleton...
  63. pmc Type I interleukin-1 receptor is required for pulmonary responses to subacute ozone exposure in mice
    Richard A Johnston
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Am J Respir Cell Mol Biol 37:477-84. 2007
    ..In addition, these results suggest that the induction of IL-6 via IL-1RI may be important in mediating the effects of O(3) during subacute exposure...
  64. pmc Allergic airway responses in obese mice
    Richard A Johnston
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 176:650-8. 2007
    ..Epidemiologic data indicate an increased incidence of asthma in the obese...
  65. ncbi request reprint Effect of dexamethasone on beta2-adrenergic desensitization in airway smooth muscle: role of the ARG19 polymorphism
    Paul E Moore
    Departments of Pediatrics and Pharmacology Dr Moore and Mr Calder, Vanderbilt University School of Medicine, Nashville, TN 37232 2586, USA
    Chest 123:368S-9S. 2003
  66. pmc Symposium on obesity and asthma - November 2, 2006
    Louis Philippe Boulet
    Centre de Pneumologie, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Hopital Laval, Quebec
    Can Respir J 14:201-8. 2007
    ....

Research Grants11

  1. Impact of obesity on airway responses to air pollution
    Stephanie Shore; Fiscal Year: 2005
    ..Understanding the mechanistic basis for the augmented pulmonary responses to air pollution may lead to therapeutic strategies for reductions in responses to air pollution in this at risk population. ..
  2. OBESITY AND AIRWAY RESPONSIVENESS
    Stephanie A Shore; Fiscal Year: 2010
    ..The focus of our research is a hormone produced by fat cells. Understanding the relationship between obesity and asthma could lead to new strategies for treating asthma, particularly in patients who are overweight or obese. ..
  3. Impact of obesity on airway responses to air pollution
    Stephanie Shore; Fiscal Year: 2007
    ..Understanding the mechanistic basis for the augmented pulmonary responses to air pollution may lead to therapeutic strategies for reductions in responses to air pollution in this at risk population. ..
  4. Impact of obesity on airway responses to air pollution
    Stephanie Shore; Fiscal Year: 2006
    ..Understanding the mechanistic basis for the augmented pulmonary responses to air pollution may lead to therapeutic strategies for reductions in responses to air pollution in this at risk population. ..
  5. Impact of obesity on airway responses to air pollution
    Stephanie A Shore; Fiscal Year: 2010
    ..Understanding the mechanistic basis for the augmented pulmonary responses to air pollution may lead to new therapeutic strategies for this increasingly at risk population. ..
  6. OBESITY AND AIRWAY RESPONSIVENESS
    Stephanie Shore; Fiscal Year: 2007
    ..The focus of our research is a hormone produced by fat cells. Understanding the relationship between obesity and asthma could lead to new strategies for treating asthma, particularly in patients who are overweight or obese. ..
  7. OBESITY AND AIRWAY RESPONSIVENESS
    Stephanie Shore; Fiscal Year: 2009
    ..The focus of our research is a hormone produced by fat cells. Understanding the relationship between obesity and asthma could lead to new strategies for treating asthma, particularly in patients who are overweight or obese. ..
  8. Impact of obesity on airway responses to air pollution
    Stephanie Shore; Fiscal Year: 2009
    ..Understanding the mechanistic basis for the augmented pulmonary responses to air pollution may lead to therapeutic strategies for reductions in responses to air pollution in this at risk population. ..
  9. Rho Kinase and Airway Hyperresponsiveness
    Stephanie A Shore; Fiscal Year: 2010
    ..Thus, the ROCK pathway may be an important and still relatively unexplored therapeutic target in asthma. Understanding the role of ROCKs in mouse models of asthma could lead to new strategies for preventing this disease. ..