Ramesh Shivdasani

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation
    Janghee Woo
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS ONE 6:e22493. 2011
  2. pmc Notch signaling in stomach epithelial stem cell homeostasis
    Tae Hee Kim
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Exp Med 208:677-88. 2011
  3. pmc Radiation redux: reserve intestinal stem cells miss the call to duty
    Ramesh A Shivdasani
    Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana Farber Cancer Institute, Boston, MA 02215, USA Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA Department of Medicine, Harvard Medical School, Boston, MA 02215, USA Electronic address
    Cell Stem Cell 14:135-6. 2014
  4. ncbi request reprint GEFs on the RhoAd to a colossal nucleus
    Ramesh A Shivdasani
    Dana Farber Cancer Institute, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    Dev Cell 22:471-2. 2012
  5. pmc Lonely in Paris: when one gene copy isn't enough
    Ramesh A Shivdasani
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Clin Invest 114:17-9. 2004
  6. pmc MicroRNAs: regulators of gene expression and cell differentiation
    Ramesh A Shivdasani
    Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 108:3646-53. 2006
  7. ncbi request reprint Molecular and transcriptional regulation of megakaryocyte differentiation
    R A Shivdasani
    Departments of Adult Oncology and Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Stem Cells 19:397-407. 2001
  8. ncbi request reprint Molecular regulation of vertebrate early endoderm development
    Ramesh A Shivdasani
    Department of Adult Oncology and Cancer Biology, Dana Faber Cancer Institute, Boston, MA 02115, USA
    Dev Biol 249:191-203. 2002
  9. ncbi request reprint A role for Rab27b in NF-E2-dependent pathways of platelet formation
    Sanjay Tiwari
    Dana Farber Cancer Institute, One Jimmy Fund Way, Boston, MA 02115, USA
    Blood 102:3970-9. 2003
  10. pmc Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2
    Zhao Chen
    Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 109:1451-9. 2007

Research Grants

  1. NFE2 AND BETA 1 TUBULIN IN PLATELET DIFFERENTIATION
    Ramesh Shivdasani; Fiscal Year: 2000
  2. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2010
  3. Hedgehog signaling in early development of the gastrointestinal tract
    Ramesh A Shivdasani; Fiscal Year: 2010
  4. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2009
  5. Hedgehog signaling in early development of the gastrointestinal tract
    Ramesh Shivdasani; Fiscal Year: 2009
  6. Gene expression in the mammalian intestine
    Ramesh Shivdasani; Fiscal Year: 2007
  7. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2007
  8. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2006
  9. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2005
  10. Gene expression in the mammalian intestine
    Ramesh Shivdasani; Fiscal Year: 2005

Collaborators

Detail Information

Publications41

  1. pmc Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation
    Janghee Woo
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS ONE 6:e22493. 2011
    ..Thus, as in the developing stomach, but distinct from the spleen, Barx1 control of thoracic foregut specification and tracheo-esophageal septation is tightly associated with down-regulation of adjacent Wnt pathway activity...
  2. pmc Notch signaling in stomach epithelial stem cell homeostasis
    Tae Hee Kim
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Exp Med 208:677-88. 2011
    ..These results establish a role for Notch activity in the foregut and highlight the importance of cellular context in gastric tumorigenesis...
  3. pmc Radiation redux: reserve intestinal stem cells miss the call to duty
    Ramesh A Shivdasani
    Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana Farber Cancer Institute, Boston, MA 02215, USA Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA Department of Medicine, Harvard Medical School, Boston, MA 02215, USA Electronic address
    Cell Stem Cell 14:135-6. 2014
    ..2014) demonstrate that homeostatic, proliferative Lrg5(+) cells are necessary to regenerate the epithelium after radiation, whereas quiescent Lgr5(-) reserve stem cells are surprisingly radiosensitive. ..
  4. ncbi request reprint GEFs on the RhoAd to a colossal nucleus
    Ramesh A Shivdasani
    Dana Farber Cancer Institute, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    Dev Cell 22:471-2. 2012
    ..In this issue of Developmental Cell, Gao et al. (2012) trace the basis of endomitosis to sequential downregulation of guanine nucleotide exchange factors GEF-H1 and ECT2...
  5. pmc Lonely in Paris: when one gene copy isn't enough
    Ramesh A Shivdasani
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Clin Invest 114:17-9. 2004
    ..Provocative new data suggest that FLI1 shows monoallelic expression during a brief window in megakaryocyte differentiation, which thus explains the dominant inheritance pattern of PTS despite the presence of one normal FLI1 allele...
  6. pmc MicroRNAs: regulators of gene expression and cell differentiation
    Ramesh A Shivdasani
    Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 108:3646-53. 2006
    ..This review summarizes current understanding of miRNA mechanisms, outlines some of the important outstanding questions, and describes studies that attempt to define miRNA functions in hematopoiesis...
  7. ncbi request reprint Molecular and transcriptional regulation of megakaryocyte differentiation
    R A Shivdasani
    Departments of Adult Oncology and Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Stem Cells 19:397-407. 2001
    ..Although this review focuses on transcriptional control mechanisms, it also discusses recent advances in broader consideration of the birth of platelets...
  8. ncbi request reprint Molecular regulation of vertebrate early endoderm development
    Ramesh A Shivdasani
    Department of Adult Oncology and Cancer Biology, Dana Faber Cancer Institute, Boston, MA 02115, USA
    Dev Biol 249:191-203. 2002
    ..This review synthesizes findings in three vertebrate model organisms and discusses these genetic interactions in the context of the progressive acquisition of endodermal identity early in vertebrate development...
  9. ncbi request reprint A role for Rab27b in NF-E2-dependent pathways of platelet formation
    Sanjay Tiwari
    Dana Farber Cancer Institute, One Jimmy Fund Way, Boston, MA 02115, USA
    Blood 102:3970-9. 2003
    ..These results establish a role for Rab27 in platelet synthesis and suggest that Rab27b in particular may coordinate proplatelet formation with granule transport, possibly by recruiting specific effector pathways...
  10. pmc Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2
    Zhao Chen
    Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 109:1451-9. 2007
    ..Attribution of stage-specific genes, in combination with various applications, thus constitutes a powerful way to study MK differentiation and platelet biogenesis...
  11. ncbi request reprint Characterization of a novel mammalian Groucho isoform and its role in transcriptional regulation
    Maina Lepourcelet
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 277:47732-40. 2002
    ..Taken together, these findings suggest that Grg1-S may operate in conjunction with beta-catenin and Tcf factors to regulate vertebrate gut epithelial cell differentiation...
  12. ncbi request reprint Molecular mechanisms of megakaryocyte differentiation
    Harald Schulze
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Semin Thromb Hemost 30:389-98. 2004
    ..Many of these mechanisms are unique to MKs but appear to rely both on genes that are expressed only in that lineage and others that are expressed widely...
  13. pmc Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells
    Michael P Verzi
    Dana Farber Cancer Institute and Department of Medicine, Boston, Massachusetts, USA
    Gastroenterology 135:591-600. 2008
    ..We identified stomach-restricted expression of the forkhead transcription factor FOXQ1...
  14. pmc Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2
    Michael P Verzi
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Cell 19:713-26. 2010
    ..These results reveal dynamic, context-specific functions and mechanisms of a prominent transcriptional regulator within a cell lineage...
  15. doi request reprint Culture, expansion, and differentiation of murine megakaryocytes
    Ramesh A Shivdasani
    Dana Farber Cancer Institute, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Immunol . 2005
    ....
  16. ncbi request reprint PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis
    Gang Huang
    Hematology Oncology Division, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 40:51-60. 2008
    ..1 expression rescued or partially rescued each phenotype. Thus, our data demonstrate that PU.1 is a major downstream target gene of AML1...
  17. ncbi request reprint Mechanisms and implications of platelet discoid shape
    Joseph E Italiano
    Division of Hematology and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Blood 101:4789-96. 2003
    ..Together, these findings highlight the essential requirements of the MK/platelet-restricted beta1-tubulin isoform in platelet structure and suggest that spherocytosis does not impair many aspects of platelet function...
  18. ncbi request reprint Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex
    Maina Lepourcelet
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Cell 5:91-102. 2004
    ..These compounds thus meet predicted criteria for disrupting Tcf/beta-catenin complexes and define a general standard to establish mechanism-based activity of small molecule inhibitors of this pathogenic protein-protein interaction...
  19. pmc RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules
    Harald Schulze
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Biol Chem 283:14109-19. 2008
    ..GTP may influence organization of the specialized microtubules required in thrombopoiesis and that RanBP10 might serve as a molecular link between Ran and noncentrosomal microtubules...
  20. pmc Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes
    Sunita R Patel
    Division of Hematology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Blood 106:4076-85. 2005
    ..We conclude that while continuous polymerization of microtubules is necessary to support the enlarging proplatelet mass, the sliding of overlapping microtubules is a vital component of proplatelet elongation...
  21. pmc Hic-5 regulates an epithelial program mediated by PPARgamma
    Stavit Drori
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:362-75. 2005
    ..These results indicate that Hic5 is an important component in determining an epithelial differentiation program induced by PPARgamma...
  22. pmc Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases
    Liqiang Tou
    Department of Medical Oncology and Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Mol Cell Biol 24:3132-9. 2004
    ..Thus, modulation of endogenous class I HDAC levels represents a previously unappreciated mechanism to enable onset of tissue-restricted gene expression in a developing mammalian organ...
  23. pmc Essential and redundant functions of caudal family proteins in activating adult intestinal genes
    Michael P Verzi
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell Biol 31:2026-39. 2011
    ..Integrated consideration of a transcription factor's mutant phenotype and cistrome hence reveals the continued and distinct requirement in adults of a critical developmental regulator that activates tissue-specific genes...
  24. pmc Mechanisms of organelle transport and capture along proplatelets during platelet production
    Jennifer L Richardson
    Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 106:4066-75. 2005
    ..These studies demonstrate that the components that form platelets are delivered to and assembled de novo along proplatelets...
  25. pmc Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum
    David Horst
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:35047-55. 2010
    ..These requirements parallel Spdef functions in secretory intestinal cells and suggest a common molecular mechanism for maturation of gastrointestinal secretory lineages...
  26. pmc CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity
    Ron Firestein
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 455:547-51. 2008
    ..Together these observations suggest that therapeutic interventions targeting CDK8 may confer a clinical benefit in beta-catenin-driven malignancies...
  27. pmc Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes
    Talat H Malik
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 22:8592-600. 2002
    ....
  28. pmc Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum
    Michael Y Choi
    Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell Biol 28:3208-18. 2008
    ..3 normally. These studies implicate Nkx6.3 as a selective regulator of G- and D-cell lineages, which are believed to derive from a common progenitor, and suggest that it operates in parallel with Ngn3...
  29. ncbi request reprint A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development
    Michael Y Choi
    Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Development 133:4119-29. 2006
    ..Thus, integration of developmental gene expression with biological assessment, as described here for TFs, represents a powerful tool to investigate control of tissue differentiation...
  30. ncbi request reprint Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions
    Harald Schulze
    Dana Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Blood 104:3949-57. 2004
    ..SLPI may thus have unanticipated roles in MK and platelet functions, including regulated proteolysis after activation...
  31. ncbi request reprint Dynamic visualization of thrombopoiesis within bone marrow
    Tobias Junt
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 317:1767-70. 2007
    ..These results confirm the concept of proplatelet formation in vivo and are consistent with the possibility that blood flow-induced hydrodynamic shear stress is a biophysical determinant of thrombopoiesis...
  32. ncbi request reprint Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen
    Byeong Moo Kim
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 134:3603-13. 2007
    ..These observations place Barx1 proximally within a Wt1 pathway of spleen development and reveal how a homeotic regulator employs different molecular mechanisms to mold neighboring organs...
  33. ncbi request reprint Phases of canonical Wnt signaling during the development of mouse intestinal epithelium
    Byeong Moo Kim
    Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 133:529-38. 2007
    ..Because mutations in Wnt pathway genes lead to intestinal cancer, the role of Wnt signaling in gut epithelial homeostasis is a subject of intense investigation. We studied how Wnt signaling is established during intestine development...
  34. pmc The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway
    Zhao Chen
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Blood 110:171-9. 2007
    ..The unexpected mechanism for Myh9-associated thrombocytopenia may lead to new molecular approaches to manipulate thrombopoiesis...
  35. ncbi request reprint Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF)
    Maina Lepourcelet
    Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Development 132:415-27. 2005
    ..Our findings also advance understanding of HDGF functions and implicate this developmentally regulated gene in RNA metabolic pathways that may influence malignant behaviors in colorectal cancer...
  36. pmc Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis
    Harald Schulze
    Dana Farber Cancer Institute, One Jimmy Fund Way, Boston, MA 02115, USA
    Blood 107:3868-75. 2006
    ..These observations collectively suggest a signaling pathway wherein PI-4,5-P(2) might facilitate DMS development and local assembly of actin fibers in preparation for platelet biogenesis...
  37. ncbi request reprint Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2
    Melissa A Kacena
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06520 8071, USA
    J Bone Miner Res 19:652-60. 2004
    ..Osteoblast proliferation increased up to 6-fold when cultured with megakaryocytes. A megakaryocyte-osteoblast interaction plays a role in the increased bone formation in these mice...
  38. ncbi request reprint Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons
    Frederik Van Dyck
    Department of Human Genetics, University of Leuven, B 3000 Leuven, Belgium
    Cell Metab 6:406-13. 2007
    ..PlagL2 thus regulates important aspects of dietary lipid absorption, and the PlagL2(-/-) animal model has implications for the amelioration of obesity and the metabolic syndrome...
  39. pmc Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus
    Anna Derjuga
    Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada H3T 1E2
    Mol Cell Biol 24:3286-94. 2004
    ..We hypothesize that the role of Nrf3 in vivo may become apparent only after appropriate challenge to the mice...
  40. pmc Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome
    Dobrawa Napierala
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 17:2244-54. 2008
    ..Collectively, these data suggest that skeletal dysplasia in TRPS is caused by dysregulation of chondrocyte and perichondrium development partially due to loss of Trps1 repression of Runx2...

Research Grants19

  1. NFE2 AND BETA 1 TUBULIN IN PLATELET DIFFERENTIATION
    Ramesh Shivdasani; Fiscal Year: 2000
    ..The results of these studies should substantially improve the current understanding of how MKs produce blood platelets. ..
  2. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2010
    ..Characterizing key molecular pathways of platelet formation should lead to better control of circulating platelet counts and to implementation of less toxic treatments for cancer. ..
  3. Hedgehog signaling in early development of the gastrointestinal tract
    Ramesh A Shivdasani; Fiscal Year: 2010
    ..This proposal seeks to apply genetic and cell culture tools to elucidate the precise role and mechanisms of hedgehog signaling in genesis of the mouse stomach and intestine. ..
  4. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2009
    ..Characterizing key molecular pathways of platelet formation should lead to better control of circulating platelet counts and to implementation of less toxic treatments for cancer. ..
  5. Hedgehog signaling in early development of the gastrointestinal tract
    Ramesh Shivdasani; Fiscal Year: 2009
    ..This proposal seeks to apply genetic and cell culture tools to elucidate the precise role and mechanisms of hedgehog signaling in genesis of the mouse stomach and intestine. ..
  6. Gene expression in the mammalian intestine
    Ramesh Shivdasani; Fiscal Year: 2007
    ..abstract_text> ..
  7. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2007
    ..To facilitate the Aims of this project, we also propose to adapt the method to abrogate expression of endogenous genes. We expect the collective results of our studies to advance current understanding of how MKs produce blood platelets. ..
  8. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2006
    ..To facilitate the Aims of this project, we also propose to adapt the method to abrogate expression of endogenous genes. We expect the collective results of our studies to advance current understanding of how MKs produce blood platelets. ..
  9. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2005
    ..To facilitate the Aims of this project, we also propose to adapt the method to abrogate expression of endogenous genes. We expect the collective results of our studies to advance current understanding of how MKs produce blood platelets. ..
  10. Gene expression in the mammalian intestine
    Ramesh Shivdasani; Fiscal Year: 2005
    ..abstract_text> ..
  11. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2004
    ..To facilitate the Aims of this project, we also propose to adapt the method to abrogate expression of endogenous genes. We expect the collective results of our studies to advance current understanding of how MKs produce blood platelets. ..
  12. Gene expression in the mammalian intestine
    Ramesh Shivdasani; Fiscal Year: 2004
    ..abstract_text> ..
  13. Gene expression in the mammalian intestine
    Ramesh Shivdasani; Fiscal Year: 2003
    ..abstract_text> ..
  14. NFE2 AND BETA 1 TUBULIN IN PLATELET DIFFERENTIATION
    Ramesh Shivdasani; Fiscal Year: 2003
    ..The results of these studies should substantially improve the current understanding of how MKs produce blood platelets. ..
  15. NFE2 AND BETA 1 TUBULIN IN PLATELET DIFFERENTIATION
    Ramesh Shivdasani; Fiscal Year: 2002
    ..The results of these studies should substantially improve the current understanding of how MKs produce blood platelets. ..
  16. Gene expression in the mammalian intestine
    Ramesh Shivdasani; Fiscal Year: 2002
    ..abstract_text> ..
  17. NFE2 AND BETA 1 TUBULIN IN PLATELET DIFFERENTIATION
    Ramesh Shivdasani; Fiscal Year: 2001
    ..The results of these studies should substantially improve the current understanding of how MKs produce blood platelets. ..
  18. Analysis of intestinal genes regulated by the transcription factor CDX2
    Ramesh A Shivdasani; Fiscal Year: 2010
    ..Investigation of its regulatory functions will improve understanding and, ultimately, treatment of many common GI diseases. ..