Affiliation: Harvard University
Shiromani P, Lu J, Wagner D, Thakkar J, Greco M, Basheer R, et al
. Compensatory sleep response to 12 h wakefulness in young and old rats. Am J Physiol Regul Integr Comp Physiol. 2000;278:R125-33 pubmed
..The findings also indicate that although old rats have a decline in sleep, this cannot be attributed to loss of VLPO neurons implicated in sleep...
Shiromani P, Basheer R, Thakkar J, Wagner D, Greco M, Charness M. Sleep and wakefulness in c-fos and fos B gene knockout mice. Brain Res Mol Brain Res. 2000;80:75-87 pubmed
..By demonstrating that these IEGs are involved in sleep, we suggest that the deletion of specific genes, even within a family of genes, can have a specific effect on sleep. ..
Shiromani P, Xu M, Winston E, Shiromani S, Gerashchenko D, Weaver D. Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes. Am J Physiol Regul Integr Comp Physiol. 2004;287:R47-57 pubmed
..Although mPer1 and mPer2 represent key elements of the molecular clock in the SCN, they are not required for homeostatic regulation of the daily amounts of waking, SWS, or REM sleep. ..