Akira Shimizu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Pathological features of antibody-mediated rejection
    Akira Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Bldg 149 9019, 13th Street, Boston, MA 02129, USA
    Curr Drug Targets Cardiovasc Haematol Disord 5:199-214. 2005
  2. pmc Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons
    Akira Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Am J Pathol 172:1471-81. 2008
  3. ncbi request reprint Role of the thymus in transplantation tolerance in miniature swine: V. Deficiency of the graft-to-thymus pathway of tolerance induction in recipients of cardiac transplants
    Shin Yamamoto
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Transplantation 81:607-13. 2006
  4. ncbi request reprint GalT-KO pigs: is the cup half empty or half full?
    David H Sachs
    Transplantation Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA
    Transplantation 84:12-4. 2007
  5. pmc Tolerogenicity of donor major histocompatibility complex-matched skin grafts in previously tolerant Massachusetts general hospital miniature swine
    Joshua Weiner
    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
    Transplantation 94:1192-9. 2012
  6. doi request reprint Tolerance and long-lasting peripheral chimerism after allogeneic intestinal transplantation in MGH miniature swine
    Yoshinori Ishikawa
    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA, USA
    Transplantation 89:417-26. 2010
  7. ncbi request reprint alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months
    Yau Lin Tseng
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Transplantation 80:1493-500. 2005
  8. pmc Linked suppression across an MHC-mismatched barrier in a miniature swine kidney transplantation model
    Adam D Griesemer
    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
    J Immunol 181:4027-36. 2008
  9. pmc Role of persistence of antigen and indirect recognition in the maintenance of tolerance to renal allografts
    Masayoshi Okumi
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Transplantation 85:270-80. 2008
  10. ncbi request reprint Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swine
    Shuji Nobori
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
    Transplantation 81:26-35. 2006

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Pathological features of antibody-mediated rejection
    Akira Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Bldg 149 9019, 13th Street, Boston, MA 02129, USA
    Curr Drug Targets Cardiovasc Haematol Disord 5:199-214. 2005
    ....
  2. pmc Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons
    Akira Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Am J Pathol 172:1471-81. 2008
    ....
  3. ncbi request reprint Role of the thymus in transplantation tolerance in miniature swine: V. Deficiency of the graft-to-thymus pathway of tolerance induction in recipients of cardiac transplants
    Shin Yamamoto
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Transplantation 81:607-13. 2006
    ..This study investigates the role of these pathways in cardiac transplant survival in recipients treated with a short course of tacrolimus...
  4. ncbi request reprint GalT-KO pigs: is the cup half empty or half full?
    David H Sachs
    Transplantation Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA
    Transplantation 84:12-4. 2007
  5. pmc Tolerogenicity of donor major histocompatibility complex-matched skin grafts in previously tolerant Massachusetts general hospital miniature swine
    Joshua Weiner
    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
    Transplantation 94:1192-9. 2012
    ..Here, we tested the hypothesis that skin grafts prevent rejection after simultaneous peptide administration and skin grafting...
  6. doi request reprint Tolerance and long-lasting peripheral chimerism after allogeneic intestinal transplantation in MGH miniature swine
    Yoshinori Ishikawa
    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA, USA
    Transplantation 89:417-26. 2010
    ..This study determined the ability of intestinal grafts to facilitate tolerance induction in major histocompatibility complex (MHC)-inbred miniature swine...
  7. ncbi request reprint alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months
    Yau Lin Tseng
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Transplantation 80:1493-500. 2005
    ..The recent generation of alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs has allowed investigation of the survival of GalT-KO pig organs in nonhuman primates...
  8. pmc Linked suppression across an MHC-mismatched barrier in a miniature swine kidney transplantation model
    Adam D Griesemer
    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
    J Immunol 181:4027-36. 2008
    ..To our knowledge, these data represent the first evidence of linked suppression across fully MHC-mismatched barriers in a large animal model...
  9. pmc Role of persistence of antigen and indirect recognition in the maintenance of tolerance to renal allografts
    Masayoshi Okumi
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Transplantation 85:270-80. 2008
    ..In the present study, we have examined 1) the duration of tolerance in the absence of donor antigen and 2) the pathway of antigen recognition determining maintenance or loss of tolerance...
  10. ncbi request reprint Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swine
    Shuji Nobori
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
    Transplantation 81:26-35. 2006
    ..The present study investigates cardiac allograft survival and the mechanism of long-term acceptance in recipient swine following cotransplantation of VTL and cardiac grafts from fully MHC-mismatched donors...
  11. ncbi request reprint Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience
    Kenji Kuwaki
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, MGH East, 13th Street, Boston, Massachusetts 02129, USA
    Nat Med 11:29-31. 2005
    ..There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies...
  12. ncbi request reprint alpha1,3-Galactosyltransferase gene-knockout miniature swine produce natural cytotoxic anti-Gal antibodies
    Frank J M F Dor
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Transplantation 78:15-20. 2004
    ..The expression of galactose alpha 1,3 galactose (Gal) in pigs has proved a barrier to xenotransplantation. Miniature swine lacking Gal (Gal pigs) have been produced by nuclear transfer/embryo transfer...
  13. pmc Prolonged survival of GalT-KO swine skin on baboons
    Joshua Weiner
    The Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Xenotransplantation 17:147-52. 2010
    ..As a potential alternative, we have evaluated GalT-KO swine skin, which lacks expression of the Gal epitope, to investigate the effect of eliminating this epitope on survival of pig-to-baboon skin grafts...
  14. pmc Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus grafts
    Ichiro Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Transplantation 86:601-10. 2008
    ..In this study, we assessed the diversity of the human T cell repertoire generated in porcine thymic xenografts. We also examined the ability of porcine thymus grafts to coexist with human thymus grafts...
  15. doi request reprint Hepatocyte growth factor sustains T regulatory cells and prolongs the survival of kidney allografts in major histocompatibility complex-inbred CLAWN-miniature swine
    Manei Oku
    Division of Xenotransplantation Surgery, Frontier Science Research Center, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    Transplantation 93:148-55. 2012
    ..The CLAWN swine model was therefore chosen to study the potential immunoregulatory effects of human-recombinant hepatocyte growth factor (HGF)...
  16. ncbi request reprint Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons
    Stuart L Houser
    Department of Pathology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Xenotransplantation 11:416-25. 2004
    ..Acute humoral xenograft rejection (AHXR) is an immunologic barrier in pig-to-baboon organ transplantation (Tx). We report microvascular thrombosis and myocardial necrosis in a series of cardiac xenografts...
  17. pmc Pathologic characteristics of transplanted kidney xenografts
    Akira Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    J Am Soc Nephrol 23:225-35. 2012
    ..In summary, the success of pig-to-primate xenotransplantation may necessitate immune tolerance to inhibit acute humoral and cellular xenograft rejection...
  18. pmc Upregulation of CD59: potential mechanism of accommodation in a large animal model
    Adam D Griesemer
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Transplantation 87:1308-17. 2009
    ..The development of alpha-1,3-galactosyltransferase knock-out (GalT-KO) swine that produce anti-Gal antibodies provides a large animal model capable of determining the role of complement regulatory proteins in accommodation...
  19. ncbi request reprint Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts
    Akira Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    J Am Soc Nephrol 16:2732-45. 2005
    ..Also, anti-alphaGal IgM deposition and subsequent complement activation play an important role in the mechanism of glomerular endothelial injury and activation and the formation of multiple microthrombi...
  20. ncbi request reprint Vascularized thymic lobe transplantation in a pig-to-baboon model: a novel strategy for xenogeneic tolerance induction and T-cell reconstitution
    Shin Yamamoto
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Transplantation 80:1783-90. 2005
    ..We report here our initial attempt to induce tolerance by VTL transplantation in the clinically relevant, discordant, pig-to-baboon model of xenotransplantation...
  21. ncbi request reprint Pathology of renal xenograft rejection in pig to non-human primate transplantation
    Akira Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Clin Transplant 20:46-52. 2006
    ..T-cell-mediated cellular immunity plays an important role in ACXR. Chronic humoral and cellular rejection may induce chronic xenograft rejection, and will be a major cause of graft loss in discordant xenotransplantation...
  22. ncbi request reprint Role of the thymus in transplantation tolerance in miniature Swine: IV. The thymus is required during the induction phase, but not the maintenance phase, of renal allograft tolerance
    Parsia A Vagefi
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Transplantation 77:979-85. 2004
    ..In the present study, the authors have examined the requirement for a thymus during the pretransplant, induction, and maintenance phases of tolerance...
  23. ncbi request reprint Xenogeneic thymus transplantation in a pig-to-baboon model
    Anette Wu
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Transplantation 75:282-91. 2003
    ..We have tested whether fetal porcine thymic tissue transplantation can lead to tolerance across a discordant (pig-to-baboon) xenogeneic barrier...
  24. pmc Abnormal regulatory and effector T cell function predispose to autoimmunity following xenogeneic thymic transplantation
    Yasuhiro Fudaba
    Department of Surgery, Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    J Immunol 181:7649-59. 2008
    ..Regulatory cell function is enhanced and negative selection of host-specific thymocytes may potentially also be improved by coimplantation of recipient thymic epithelial cells in the thymus xenograft...
  25. pmc Thymic rejuvenation and the induction of tolerance by adult thymic grafts
    Shuji Nobori
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 103:19081-6. 2006
    ..These findings indicate that it may be possible to manipulate thymic function in adults to induce transplantation tolerance after the age of thymic involution...
  26. ncbi request reprint Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
    Kazuhiko Yamada
    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Nat Med 11:32-4. 2005
    ..We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels...
  27. doi request reprint Pig islet xenograft rejection in a mouse model with an established human immune system
    Noriko Tonomura
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Xenotransplantation 15:129-35. 2008
    ..A better understanding of the human immune response to pig islets would help develop effective strategies for preventing graft rejection...
  28. pmc First experience with the use of a recombinant CD3 immunotoxin as induction therapy in pig-to-primate xenotransplantation: the effect of T-cell depletion on outcome
    Hiroaki Nishimura
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Transplantation 92:641-7. 2011
    ..We evaluated two induction regimens, a newly developed anti-monkey CD3 recombinant immunotoxin (anti-CD3 rIT) and an anti-human CD2 antibody (LoCD2), by assessing T-cell depletion (TCD) and graft survival...
  29. pmc Reversal of age-related thymic involution by an LHRH agonist in miniature swine
    Atsushi Hirakata
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Transpl Immunol 24:76-81. 2010
    ..In particular, we tested the impact of sex steroid blockade by Luteinizing Hormone-Releasing Hormone (LHRH)...
  30. doi request reprint Histopathology of xenografts in pig to non-human primate discordant xenotransplantation
    Akira Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Clin Transplant 24:11-5. 2010
    ..Here, we discussed the pathology of xenografts in GalT-KO pig to non-human primate kidney transplantation...
  31. ncbi request reprint Mechanisms of chronic renal allograft rejection. II. Progressive allograft glomerulopathy in miniature swine
    Akira Shimizu
    Department of Pathology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Lab Invest 82:673-86. 2002
    ..With the development of tolerance, substantial recovery of acute allograft glomerulopathy can occur after the resolution of glomerular inflammation...
  32. ncbi request reprint Composite "thymoheart" transplantation improves cardiac allograft survival
    Matthew T Menard
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 4:79-86. 2004
    ..The transfer of vascularized, functional donor thymic tissue to the host at the time of cardiac transplantation may provide a novel approach to the induction of tolerance in human heart transplant recipients...
  33. pmc Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model
    Noriko Tonomura
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, MGH East, Boston, MA 02129, USA
    Blood 111:4293-6. 2008
    ..These results confirm that a functional human immune system can be established in immunodeficient mice through cotransplantation of human fetal thymus/liver tissues and CD34(+) hematopoietic stem/progenitor cells...
  34. ncbi request reprint Despite efficient intrathymic negative selection of host-reactive T cells, autoimmune disease may develop in porcine thymus-grafted athymic mice: evidence for failure of regulatory mechanisms suppressing autoimmunity
    Yong Zhao
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Transplantation 75:1832-40. 2003
    ..Sixty percent of grafted nude mice and 10% of grafted thymectomized B6 mice develop a clinical illness resembling chronic graft-versus-host disease...
  35. pmc Establishment of transplantable porcine tumor cell lines derived from MHC-inbred miniature swine
    Patricia S Cho
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Blood 110:3996-4004. 2007
    ..These results suggest the possibility of developing a transplantable tumor model in this large-animal system...
  36. pmc Assessing the effect of immunosuppression on engraftment of pancreatic islets
    PRASHANTH VALLABHAJOSYULA
    1 Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA 2 Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 3 Department of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, MA 4 Address correspondence to Dr David H Sachs, Transplantation Biology Research Center, Massachusetts General Hospital, Building 149, 13th Street, Boston, MA 02129
    Transplantation 96:372-8. 2013
    ....
  37. ncbi request reprint Persistent rejection of peritubular capillaries and tubules is associated with progressive interstitial fibrosis
    Akira Shimizu
    Department of Pathology and Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 61:1867-79. 2002
    ..Here, we examined the differential features between both groups in the peritubular capillaries (PTCs) and tubules to clarify the pathogenesis of the progressive interstitial fibrosis in chronic rejection...
  38. ncbi request reprint Autologous graft-versus-host disease in a porcine bone marrow transplant model
    Shaun M Kunisaki
    Massachusetts General Hospital, Surgery HST, Boston, Massachusetts 02129, USA
    Transplantation 74:465-71. 2002
    ..We hypothesized that the extent of peripheral blood contamination of the bone marrow (BM) inoculum before transplant may have correlated with the incidence of such autoGvHD...
  39. ncbi request reprint Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation
    Ping Lan
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
    Blood 108:487-92. 2006
    ..Thus, the humanized NOD/SCID mice described in this paper provide a powerful model system to study human immune function...
  40. ncbi request reprint Injury and progressive loss of peritubular capillaries in the development of chronic allograft nephropathy
    Yasuo Ishii
    Department of Surgery, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Kidney Int 67:321-32. 2005
    ..However, the mechanism for graft dysfunction and the process of the development of CAN are not well understood. This study examined the role of microvascular injury in the development of CAN...
  41. pmc Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates
    Hisashi Bashuda
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Clin Invest 115:1896-902. 2005
    ..This strategy may be applicable to the design of safe clinical trials in humans...
  42. ncbi request reprint Lobular damage caused by cellular and humoral immunity in liver allograft rejection
    Tokihiko Sawada
    Second Department of Surgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Clin Transplant 19:110-4. 2005
    ..In this study, changes in the hepatic lobules were investigated retrospectively by immunohistochemistry, and compared with changes in the portal areas. Humoral immunity in ALAR was also studied by C4d-staining...
  43. ncbi request reprint Isolation and species distribution of staphylococci from animal and human skin
    Naoko Nagase
    Department of Microbiology and Immunology, Faculty of Agriculture, Kobe University, Kobe shi, Hyogo, Japan
    J Vet Med Sci 64:245-50. 2002
    ..epidermidis isolated most frequently from human skin. Strains of S. epidermidis showed the greatest genomic diversity in their fragment patterns...
  44. ncbi request reprint Genomic heterogeneity of type II CD36 deficiency
    Makoto Imai
    Third Division, Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    Clin Chim Acta 321:97-106. 2002
    ..In this study, we analyzed the genotype and frequency of type II CD36 deficiency in Japanese populations, and its hereditary pattern in three families...
  45. ncbi request reprint Spontaneous large-scale lymphoid neogenesis and balanced autoimmunity versus tolerance in the stomach of H+/K+-ATPase-reactive TCR transgenic mouse
    Tomoya Katakai
    Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Immunol 177:7858-67. 2006
    ..e., the balance of self-reactivity and tolerance, in the local environment has an impact...
  46. ncbi request reprint Isolation of the feline alpha1,3-galactosyltransferase gene, expression in transfected human cells and its phylogenetic analysis
    Bibhuti Bhusan Roy
    Department of Virology and Preventive Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    J Exp Zool B Mol Dev Evol 306:59-69. 2006
    ..Ratios of non-synonymous nucleotide changes among the primate pseudogenes as well as the primate genes are still higher than the ratios of non-primates, suggesting that the primate alpha1,3-GT genes tend to be divergent...
  47. ncbi request reprint Identification of an electron densification of the glomerular basement membrane in renal biopsy specimens
    Shigeru Sato
    Central Institute for Electron Microscopic Researches, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Med Electron Microsc 36:106-11. 2003
    ....
  48. ncbi request reprint Differential-expression and tyrosine-phosphorylation profiles of caveolin isoforms in human T cell leukemia cell lines
    Yuichiro Tsuji
    Department of Otolaryngology, Osaka Medical College, Daigakumachi, Takatsuki 569 8686, Japan
    Int J Mol Med 16:889-93. 2005
    ..This modification is likely to cause the lack of reactivity of caveolin-1alpha to the mAb, and suggests a possible close relationship to cell activation...
  49. ncbi request reprint Hepatocyte growth factor-stimulating endothelial cell growth and accelerating glomerular capillary repair in experimental progressive glomerulonephritis
    Takahiro Mori
    Department of Pathology, Nippon Medical School, Tokyo, Japan
    Nephron Exp Nephrol 94:e44-54. 2003
    ..Administering HGF is a logical and efficient strategy for treating progressive GN with severe capillary destruction...
  50. ncbi request reprint Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsin
    Reiko Inagi
    Molecular and Cellular Nephrology, Institute of Medical Sciences, Tokai University, Kanagawa, Japan
    J Am Soc Nephrol 16:1339-49. 2005
    ..This model of serpinopathy is the first to involve the kidney and the pancreas...
  51. ncbi request reprint Vascular endothelial growth factor165 resolves glomerular inflammation and accelerates glomerular capillary repair in rat anti-glomerular basement membrane glomerulonephritis
    Akira Shimizu
    Department of Pathology, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    J Am Soc Nephrol 15:2655-65. 2004
    ..The therapeutic application of VEGF may be clinically useful for severe GN accompanied by extensive glomerular inflammation and endothelial injury...
  52. ncbi request reprint [Effective measurement of coronary flow velocity reserve (CFVR) with transthoracic Doppler echocardiography (TTDE) for plasma cell leukemia with hyperviscosity syndrome]
    Satoko Oka
    First Department of Internal Medicine, Osaka Medical College
    Rinsho Ketsueki 47:16-22. 2006
    ..Noninvasive assessment of CFVR by TTDE is significantly useful for the patients who have renal failure and need chemotherapy...