Research Topics
| Akira ShimizuSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Pathological features of antibody-mediated rejectionAkira Shimizu
Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Bldg 149 9019, 13th Street, Boston, MA 02129, USA
Curr Drug Targets Cardiovasc Haematol Disord 5:199-214. 2005....
Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboonsAkira Shimizu
Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
Am J Pathol 172:1471-81. 2008....- GalT-KO pigs: is the cup half empty or half full?David H Sachs
Transplantation Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA
Transplantation 84:12-4. 2007 - Tolerogenicity of donor major histocompatibility complex-matched skin grafts in previously tolerant Massachusetts general hospital miniature swineJoshua Weiner
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
Transplantation 94:1192-9. 2012..Here, we tested the hypothesis that skin grafts prevent rejection after simultaneous peptide administration and skin grafting... 
Tolerance and long-lasting peripheral chimerism after allogeneic intestinal transplantation in MGH miniature swineYoshinori Ishikawa
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA, USA
Transplantation 89:417-26. 2010..This study determined the ability of intestinal grafts to facilitate tolerance induction in major histocompatibility complex (MHC)-inbred miniature swine...- Linked suppression across an MHC-mismatched barrier in a miniature swine kidney transplantation modelAdam D Griesemer
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
J Immunol 181:4027-36. 2008..To our knowledge, these data represent the first evidence of linked suppression across fully MHC-mismatched barriers in a large animal model... - alpha1,3-Galactosyltransferase gene-knockout miniature swine produce natural cytotoxic anti-Gal antibodiesFrank J M F Dor
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
Transplantation 78:15-20. 2004..The model of Gal organ transplantation into a Gal SLA-matched recipient would be a valuable large animal model in the study of accommodation or B-cell tolerance... - alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 monthsYau-Lin Tseng
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
Transplantation 80:1493-500. 2005..However, function of a pig organ in a baboon for a period approaching six months, which has not been reported previously, lends encouragement that the barriers to xenotransplantation will eventually be overcome... - Role of the thymus in transplantation tolerance in miniature swine: V. Deficiency of the graft-to-thymus pathway of tolerance induction in recipients of cardiac transplantsShin Yamamoto
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
Transplantation 81:607-13. 2006..Strategies to increase donor antigen migration to the host thymus might therefore assist in tolerance induction to cardiac allografts... - Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swineShuji Nobori
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
Transplantation 81:26-35. 2006..CONCLUSION: This is the first demonstration of the long-term acceptance of fully MHC-mismatched cardiac allografts in large animals... - Vascularized thymic lobe transplantation in a pig-to-baboon model: a novel strategy for xenogeneic tolerance induction and T-cell reconstitutionShin Yamamoto
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
Transplantation 80:1783-90. 2005..When coupled with additional strategies aimed at silencing humoral rejection, VTL transplantation may significantly prolong xenograft survival and result in long-term tolerance... - Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experienceKenji Kuwaki
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, MGH-East, 13th Street, Boston, Massachusetts 02129, USA
Nat Med 11:29-31. 2005..There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies... - Role of persistence of antigen and indirect recognition in the maintenance of tolerance to renal allograftsMasayoshi Okumi
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Transplantation 85:270-80. 2008..In the present study, we have examined 1) the duration of tolerance in the absence of donor antigen and 2) the pathway of antigen recognition determining maintenance or loss of tolerance... - Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus graftsIchiro Shimizu
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Transplantation 86:601-10. 2008..In this study, we assessed the diversity of the human T cell repertoire generated in porcine thymic xenografts. We also examined the ability of porcine thymus grafts to coexist with human thymus grafts... - Prolonged survival of GalT-KO swine skin on baboonsJoshua Weiner
The Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Xenotransplantation 17:147-52. 2010..As a potential alternative, we have evaluated GalT-KO swine skin, which lacks expression of the Gal epitope, to investigate the effect of eliminating this epitope on survival of pig-to-baboon skin grafts... - Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissueKazuhiko Yamada
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
Nat Med 11:32-4. 2005..We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels... - Hepatocyte growth factor sustains T regulatory cells and prolongs the survival of kidney allografts in major histocompatibility complex-inbred CLAWN-miniature swineManei Oku
Division of Xenotransplantation Surgery, Frontier Science Research Center, Kagoshima University, Sakuragaoka, Kagoshima, Japan
Transplantation 93:148-55. 2012..The CLAWN swine model was therefore chosen to study the potential immunoregulatory effects of human-recombinant hepatocyte growth factor (HGF)... - Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboonsStuart L Houser
Department of Pathology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Xenotransplantation 11:416-25. 2004..Acute humoral xenograft rejection (AHXR) is an immunologic barrier in pig-to-baboon organ transplantation (Tx). We report microvascular thrombosis and myocardial necrosis in a series of cardiac xenografts... - Pathologic characteristics of transplanted kidney xenograftsAkira Shimizu
Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
J Am Soc Nephrol 23:225-35. 2012..In summary, the success of pig-to-primate xenotransplantation may necessitate immune tolerance to inhibit acute humoral and cellular xenograft rejection... - Upregulation of CD59: potential mechanism of accommodation in a large animal modelAdam D Griesemer
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Transplantation 87:1308-17. 2009..The development of alpha-1,3-galactosyltransferase knock-out (GalT-KO) swine that produce anti-Gal antibodies provides a large animal model capable of determining the role of complement regulatory proteins in accommodation... - Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenograftsAkira Shimizu
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA
J Am Soc Nephrol 16:2732-45. 2005..Also, anti-alphaGal IgM deposition and subsequent complement activation play an important role in the mechanism of glomerular endothelial injury and activation and the formation of multiple microthrombi... - Abnormal regulatory and effector T cell function predispose to autoimmunity following xenogeneic thymic transplantationYasuhiro Fudaba
Department of Surgery, Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
J Immunol 181:7649-59. 2008..Regulatory cell function is enhanced and negative selection of host-specific thymocytes may potentially also be improved by coimplantation of recipient thymic epithelial cells in the thymus xenograft... - Pathology of renal xenograft rejection in pig to non-human primate transplantationAkira Shimizu
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
Clin Transplant 20:46-52. 2006..T-cell-mediated cellular immunity plays an important role in ACXR. Chronic humoral and cellular rejection may induce chronic xenograft rejection, and will be a major cause of graft loss in discordant xenotransplantation... - Role of the thymus in transplantation tolerance in miniature Swine: IV. The thymus is required during the induction phase, but not the maintenance phase, of renal allograft toleranceParsia A Vagefi
Transplantation Biology Research Center, Massachusetts General Hospital-Harvard Medical School, Boston, MA 02129, USA
Transplantation 77:979-85. 2004..Understanding the role of the thymus in establishing tolerance may permit the development of tolerance induction strategies, especially for pediatric transplant recipients... - Xenogeneic thymus transplantation in a pig-to-baboon modelAnette Wu
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
Transplantation 75:282-91. 2003..CONCLUSIONS: Porcine thymic tissue is able to induce xenogeneic hyporesponsiveness. More efficient thymic engraftment may allow this approach to induce xenograft tolerance... - Pig islet xenograft rejection in a mouse model with an established human immune systemNoriko Tonomura
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Xenotransplantation 15:129-35. 2008..A better understanding of the human immune response to pig islets would help develop effective strategies for preventing graft rejection... - First experience with the use of a recombinant CD3 immunotoxin as induction therapy in pig-to-primate xenotransplantation: the effect of T-cell depletion on outcomeHiroaki Nishimura
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Transplantation 92:641-7. 2011..We evaluated two induction regimens, a newly developed anti-monkey CD3 recombinant immunotoxin (anti-CD3 rIT) and an anti-human CD2 antibody (LoCD2), by assessing T-cell depletion (TCD) and graft survival... - Reversal of age-related thymic involution by an LHRH agonist in miniature swineAtsushi Hirakata
Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
Transpl Immunol 24:76-81. 2010..In particular, we tested the impact of sex steroid blockade by Luteinizing Hormone-Releasing Hormone (LHRH)... - Histopathology of xenografts in pig to non-human primate discordant xenotransplantationAkira Shimizu
Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
Clin Transplant 24:11-5. 2010..Here, we discussed the pathology of xenografts in GalT-KO pig to non-human primate kidney transplantation... - Mechanisms of chronic renal allograft rejection. II. Progressive allograft glomerulopathy in miniature swineAkira Shimizu
Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, USA
Lab Invest 82:673-86. 2002..With the development of tolerance, substantial recovery of acute allograft glomerulopathy can occur after the resolution of glomerular inflammation... - Thymic rejuvenation and the induction of tolerance by adult thymic graftsShuji Nobori
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
Proc Natl Acad Sci U S A 103:19081-6. 2006..These findings indicate that it may be possible to manipulate thymic function in adults to induce transplantation tolerance after the age of thymic involution... - Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse modelNoriko Tonomura
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, MGH East, Boston, MA 02129, USA
Blood 111:4293-6. 2008..These results confirm that a functional human immune system can be established in immunodeficient mice through cotransplantation of human fetal thymus/liver tissues and CD34(+) hematopoietic stem/progenitor cells... - Composite "thymoheart" transplantation improves cardiac allograft survivalMatthew T Menard
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Am J Transplant 4:79-86. 2004..The transfer of vascularized, functional donor thymic tissue to the host at the time of cardiac transplantation may provide a novel approach to the induction of tolerance in human heart transplant recipients... - Despite efficient intrathymic negative selection of host-reactive T cells, autoimmune disease may develop in porcine thymus-grafted athymic mice: evidence for failure of regulatory mechanisms suppressing autoimmunityYong Zhao
Bone Marrow Transplantation Section, Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
Transplantation 75:1832-40. 2003.... - Establishment of transplantable porcine tumor cell lines derived from MHC-inbred miniature swinePatricia S Cho
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Blood 110:3996-4004. 2007..These results suggest the possibility of developing a transplantable tumor model in this large-animal system... - Autologous graft-versus-host disease in a porcine bone marrow transplant modelShaun M Kunisaki
Massachusetts General Hospital, Surgery-HST, Boston, Massachusetts 02129, USA
Transplantation 74:465-71. 2002..The role of autologous T cells needs further delineation but may help to explain the occasional occurrences of autoGvHD that have been reported in humans after autoBMT... - Persistent rejection of peritubular capillaries and tubules is associated with progressive interstitial fibrosisAkira Shimizu
Department of Pathology and Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, USA
Kidney Int 61:1867-79. 2002..CONCLUSIONS: Persistent rejection directed at PTCs and tubules, and proliferation of myofibroblasts are prominent features in the progressive interstitial fibrosis in chronic rejection, and are probably key events in its pathogenesis... - Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantationPing Lan
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
Blood 108:487-92. 2006..Thus, the humanized NOD/SCID mice described in this paper provide a powerful model system to study human immune function... - Injury and progressive loss of peritubular capillaries in the development of chronic allograft nephropathyYasuo Ishii
Department of Surgery, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan
Kidney Int 67:321-32. 2005..In particular, injury, angioregression and progressive loss of the PTC network strongly contributed to the development of interstitial fibrosis and graft dysfunction in CAN, and might play a crucial role in the development of CAN... - Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primatesHisashi Bashuda
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
J Clin Invest 115:1896-902. 2005..This strategy may be applicable to the design of safe clinical trials in humans... - Identification of an electron densification of the glomerular basement membrane in renal biopsy specimensShigeru Sato
Central Institute for Electron Microscopic Researches, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Med Electron Microsc 36:106-11. 2003.... - Hepatocyte growth factor-stimulating endothelial cell growth and accelerating glomerular capillary repair in experimental progressive glomerulonephritisTakahiro Mori
Department of Pathology, Nippon Medical School, Tokyo, Japan
Nephron Exp Nephrol 94:e44-54. 2003..Administering HGF is a logical and efficient strategy for treating progressive GN with severe capillary destruction... - Genomic heterogeneity of type II CD36 deficiencyMakoto Imai
Third Division, Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
Clin Chim Acta 321:97-106. 2002..In this study, we analyzed the genotype and frequency of type II CD36 deficiency in Japanese populations, and its hereditary pattern in three families... - Vascular endothelial growth factor165 resolves glomerular inflammation and accelerates glomerular capillary repair in rat anti-glomerular basement membrane glomerulonephritisAkira Shimizu
Department of Pathology, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
J Am Soc Nephrol 15:2655-65. 2004..The therapeutic application of VEGF may be clinically useful for severe GN accompanied by extensive glomerular inflammation and endothelial injury... - Spontaneous large-scale lymphoid neogenesis and balanced autoimmunity versus tolerance in the stomach of H+/K+-ATPase-reactive TCR transgenic mouseTomoya Katakai
Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
J Immunol 177:7858-67. 2006..e., the balance of self-reactivity and tolerance, in the local environment has an impact... - Lobular damage caused by cellular and humoral immunity in liver allograft rejectionTokihiko Sawada
Second Department of Surgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
Clin Transplant 19:110-4. 2005..In this study, changes in the hepatic lobules were investigated retrospectively by immunohistochemistry, and compared with changes in the portal areas. Humoral immunity in ALAR was also studied by C4d-staining... - Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsinReiko Inagi
Molecular and Cellular Nephrology, Institute of Medical Sciences, Tokai University, Kanagawa, Japan
J Am Soc Nephrol 16:1339-49. 2005..This model of serpinopathy is the first to involve the kidney and the pancreas... - Differential-expression and tyrosine-phosphorylation profiles of caveolin isoforms in human T cell leukemia cell linesYuichiro Tsuji
Department of Otolaryngology, Osaka Medical College, Daigakumachi, Takatsuki 569-8686, Japan
Int J Mol Med 16:889-93. 2005..This modification is likely to cause the lack of reactivity of caveolin-1alpha to the mAb, and suggests a possible close relationship to cell activation... - Isolation of the feline alpha1,3-galactosyltransferase gene, expression in transfected human cells and its phylogenetic analysisBibhuti Bhusan Roy
Department of Virology and Preventive Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
J Exp Zool B Mol Dev Evol 306:59-69. 2006..Ratios of non-synonymous nucleotide changes among the primate pseudogenes as well as the primate genes are still higher than the ratios of non-primates, suggesting that the primate alpha1,3-GT genes tend to be divergent... - [Effective measurement of coronary flow velocity reserve (CFVR) with transthoracic Doppler echocardiography (TTDE) for plasma cell leukemia with hyperviscosity syndrome]Satoko Oka
First Department of Internal Medicine, Osaka Medical College
Rinsho Ketsueki 47:16-22. 2006..Noninvasive assessment of CFVR by TTDE is significantly useful for the patients who have renal failure and need chemotherapy... - Isolation and species distribution of staphylococci from animal and human skinNaoko Nagase
Department of Microbiology and Immunology, Faculty of Agriculture, Kobe University, Kobe-shi, Hyogo, Japan
J Vet Med Sci 64:245-50. 2002..epidermidis isolated most frequently from human skin. Strains of S. epidermidis showed the greatest genomic diversity in their fragment patterns...