Masako Shimada

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Overview of calpain-mediated regulation of bone and fat mass in osteoblasts
    Masako Shimada
    Endocrine Unit, Massachusetts General Hospital, Thier 10, 50 Blossom Street, Boston, MA 02114, USA
    Cell Biochem Biophys 66:23-8. 2013
  2. pmc In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation
    Masako Shimada
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
    J Biol Chem 283:21002-10. 2008
  3. pmc Targeted deletion of Capn4 in cells of the chondrocyte lineage impairs chondrocyte proliferation and differentiation
    Aki Kashiwagi
    50 Blossom Street, Thier 10, Boston, MA 02114, USA
    Mol Cell Biol 30:2799-810. 2010
  4. pmc A high fat diet-induced impaired glucose metabolism in mice with targeted deletion of calpain in osteoblasts
    Aki Kashiwagi
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
    Biochem Biophys Res Commun 409:235-40. 2011
  5. pmc Calpain modulates cyclin-dependent kinase inhibitor 1B (p27(Kip1)) in cells of the osteoblast lineage
    Aki Kashiwagi
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Calcif Tissue Int 89:36-42. 2011
  6. ncbi request reprint Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Wellman 501, Boston, MA 02114 2696, USA
    FEBS Lett 579:803-7. 2005
  7. ncbi request reprint The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit
    Masako Shimada
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 146:2336-44. 2005

Research Grants

Collaborators

Detail Information

Publications7

  1. pmc Overview of calpain-mediated regulation of bone and fat mass in osteoblasts
    Masako Shimada
    Endocrine Unit, Massachusetts General Hospital, Thier 10, 50 Blossom Street, Boston, MA 02114, USA
    Cell Biochem Biophys 66:23-8. 2013
    ..Moreover, we utilized the mutant mice as a disease model of osteoporosis accompanied with impaired bone resorptive function and suggested a possible clinical translation of our basic research finding...
  2. pmc In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation
    Masako Shimada
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
    J Biol Chem 283:21002-10. 2008
    ..Collectively, our findings provide the first in vivo demonstration that the calpain small subunit is essential for proper osteoblast activity and bone remodeling...
  3. pmc Targeted deletion of Capn4 in cells of the chondrocyte lineage impairs chondrocyte proliferation and differentiation
    Aki Kashiwagi
    50 Blossom Street, Thier 10, Boston, MA 02114, USA
    Mol Cell Biol 30:2799-810. 2010
    ..Collectively, our findings suggest that the calpain small subunit is essential for proper chondrocyte functions in embryonic growth plates...
  4. pmc A high fat diet-induced impaired glucose metabolism in mice with targeted deletion of calpain in osteoblasts
    Aki Kashiwagi
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
    Biochem Biophys Res Commun 409:235-40. 2011
    ....
  5. pmc Calpain modulates cyclin-dependent kinase inhibitor 1B (p27(Kip1)) in cells of the osteoblast lineage
    Aki Kashiwagi
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Calcif Tissue Int 89:36-42. 2011
    ..In conclusion, calpain is a critical modulator for regulation of p27(Kip1) in cells of the osteoblast lineage...
  6. ncbi request reprint Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Wellman 501, Boston, MA 02114 2696, USA
    FEBS Lett 579:803-7. 2005
    ..Fluphenazine, a calmodulin antagonist, enhances PTH-mediated accumulation of total inositol phosphates, suggesting that calmodulin regulates signaling via phospholipase C...
  7. ncbi request reprint The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit
    Masako Shimada
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 146:2336-44. 2005
    ..The calpain small subunit is the second protein, in addition to the sodium-hydrogen exchanger regulatory factor, and the first enzyme that binds the PTH1R; PTH1R bound to both of these proteins results in altered PTH signaling...

Research Grants6

  1. DIRECT CALPAIN-PTH1R BINDING AFFECTS ACTIONS OF PTH/PTHrP
    Masako Shimada; Fiscal Year: 2010
    ..Specific Aim 3 characterizes the phenotype of mice with osteoblast-specific deletion of Capn4 in vivo and of Capn4-null osteoblsts isolated from these mice. ..