Research Topics
Genomes and Genes | Yoko ShibataSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Mechanisms shaping the membranes of cellular organellesYoko Shibata
Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Cell Dev Biol 25:329-54. 2009..Mechanisms affecting local membrane curvature may also shape peripheral ER sheets and the nuclear envelope as well as mitochondria and caveolae...
The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulumYoko Shibata
Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 283:18892-904. 2008..We propose that oligomerization of the reticulons and DP1/Yop1p is important for both their localization to the tubular domains of the ER and for their ability to form tubules...
Mechanisms determining the morphology of the peripheral ERYoko Shibata
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
Cell 143:774-88. 2010..These proteins may generate sheets by stabilizing the high curvature of edges...
A class of dynamin-like GTPases involved in the generation of the tubular ER networkJunjie Hu
Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Cell 138:549-61. 2009..Since atlastin-1 mutations cause a common form of hereditary spastic paraplegia, we suggest ER-shaping defects as a neuropathogenic mechanism...
Membrane proteins of the endoplasmic reticulum induce high-curvature tubulesJunjie Hu
Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Science 319:1247-50. 2008..Tubules made in vitro were narrower than normal ER tubules, due to a higher concentration of tubule-inducing proteins. The shape and oligomerization of the "morphogenic" proteins could explain the formation of the tubular ER...
The signal sequence coding region promotes nuclear export of mRNAAlexander F Palazzo
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Biol 5:e322. 2007..The discovery of an SSCR-mediated pathway explains the previously noted amino acid bias in signal sequences and suggests a link between nuclear export and membrane targeting of mRNAs...
Rough sheets and smooth tubulesYoko Shibata
Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Cell 126:435-9. 2006..Key proteins may drive the formation of these structural morphologies, which in turn could generate the rough and smooth functional domains of the ER...
