M E Shenton

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc A review of MRI findings in schizophrenia
    M E Shenton
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Schizophr Res 49:1-52. 2001
  2. pmc Factors in sensory processing of prosody in schizotypal personality disorder: an fMRI experiment
    Chandlee C Dickey
    Serious Mental Illness Program, VA Boston Healthcare System, Psychiatry 116A 7, 940 Belmont St, Brockton, MA 02301, United States
    Schizophr Res 121:75-89. 2010
  3. pmc A cross-sectional and longitudinal magnetic resonance imaging study of cingulate gyrus gray matter volume abnormalities in first-episode schizophrenia and first-episode affective psychosis
    Min Seong Koo
    Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Arch Gen Psychiatry 65:746-60. 2008
  4. pmc Fornix integrity and hippocampal volume in male schizophrenic patients
    Noriomi Kuroki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, and Harvard Medical School, Brockton, Massachusetts, USA
    Biol Psychiatry 60:22-31. 2006
  5. pmc Word priming in schizophrenia: associational and semantic influences
    Paul G Nestor
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Schizophr Res 82:139-42. 2006
  6. pmc Amygdala-hippocampal shape differences in schizophrenia: the application of 3D shape models to volumetric MR data
    Martha E Shenton
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry 116A, VA Boston Healthcare System, Brockton Division, 940 Belmont Street, Harvard Medical School, Brockton, MA 02301, USA
    Psychiatry Res 115:15-35. 2002
  7. pmc Prefrontal cortex, negative symptoms, and schizophrenia: an MRI study
    C G Wible
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Psychiatry Res 108:65-78. 2001
  8. pmc First-episode schizophrenic psychosis differs from first-episode affective psychosis and controls in P300 amplitude over left temporal lobe
    D F Salisbury
    Harvard Medical School, Department of Psychiatry, McLean Hospital, Belmont, Mass, USA
    Arch Gen Psychiatry 55:173-80. 1998
  9. pmc Identification of neural circuits underlying P300 abnormalities in schizophrenia
    B F O'Donnell
    Department of Psychiatry, Harvard Medical School, Brockton, MA, USA
    Psychophysiology 36:388-98. 1999
  10. pmc Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia
    Kiyoto Kasai
    Clinical Neuroscience Division, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Am J Psychiatry 160:156-64. 2003

Detail Information

Publications113 found, 100 shown here

  1. pmc A review of MRI findings in schizophrenia
    M E Shenton
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Schizophr Res 49:1-52. 2001
    ..abstract truncated)..
  2. pmc Factors in sensory processing of prosody in schizotypal personality disorder: an fMRI experiment
    Chandlee C Dickey
    Serious Mental Illness Program, VA Boston Healthcare System, Psychiatry 116A 7, 940 Belmont St, Brockton, MA 02301, United States
    Schizophr Res 121:75-89. 2010
    ..The superior temporal gyrus (STG) was selected as the region-of-interest (ROI) given its known abnormalities in SPD and its important role in the processing of prosody...
  3. pmc A cross-sectional and longitudinal magnetic resonance imaging study of cingulate gyrus gray matter volume abnormalities in first-episode schizophrenia and first-episode affective psychosis
    Min Seong Koo
    Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Arch Gen Psychiatry 65:746-60. 2008
    ..However, it is unclear whether these gray matter abnormalities show a subregional specificity to either disorder and whether they show postonset progression...
  4. pmc Fornix integrity and hippocampal volume in male schizophrenic patients
    Noriomi Kuroki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, and Harvard Medical School, Brockton, Massachusetts, USA
    Biol Psychiatry 60:22-31. 2006
    ..Few studies have evaluated the fornix in schizophrenia, however. A focus on fornix abnormalities and their association with hippocampal abnormalities might figure importantly in our understanding of the pathophysiology of schizophrenia...
  5. pmc Word priming in schizophrenia: associational and semantic influences
    Paul G Nestor
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Schizophr Res 82:139-42. 2006
    ..Schizophrenic patients may show an associational bias, restricting semantic integration and contributing to their disturbed thinking...
  6. pmc Amygdala-hippocampal shape differences in schizophrenia: the application of 3D shape models to volumetric MR data
    Martha E Shenton
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry 116A, VA Boston Healthcare System, Brockton Division, 940 Belmont Street, Harvard Medical School, Brockton, MA 02301, USA
    Psychiatry Res 115:15-35. 2002
    ..An evaluation of shape deformations also suggests local abnormalities in the amygdala-hippocampal complex in schizophrenia...
  7. pmc Prefrontal cortex, negative symptoms, and schizophrenia: an MRI study
    C G Wible
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Psychiatry Res 108:65-78. 2001
    ..These results underscore the importance of temporal-prefrontal pathways in the symptomatology of schizophrenia, and they suggest an association between prefrontal abnormalities and negative symptoms...
  8. pmc First-episode schizophrenic psychosis differs from first-episode affective psychosis and controls in P300 amplitude over left temporal lobe
    D F Salisbury
    Harvard Medical School, Department of Psychiatry, McLean Hospital, Belmont, Mass, USA
    Arch Gen Psychiatry 55:173-80. 1998
    ..This P300 asymmetry suggests left temporal lobe dysfunction at the onset of schizophrenia...
  9. pmc Identification of neural circuits underlying P300 abnormalities in schizophrenia
    B F O'Donnell
    Department of Psychiatry, Harvard Medical School, Brockton, MA, USA
    Psychophysiology 36:388-98. 1999
    ....
  10. pmc Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia
    Kiyoto Kasai
    Clinical Neuroscience Division, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Am J Psychiatry 160:156-64. 2003
    ....
  11. ncbi request reprint Differences and similarities in insular and temporal pole MRI gray matter volume abnormalities in first-episode schizophrenia and affective psychosis
    Kiyoto Kasai
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System Brockton Division, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
    Arch Gen Psychiatry 60:1069-77. 2003
    ..Results of previous volumetric magnetic resonance imaging investigations indicate that gray matter volume reductions in neocortical regions may be specific to schizophrenia...
  12. pmc A functional magnetic resonance imaging study of auditory mismatch in schizophrenia
    C G Wible
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 158:938-43. 2001
    ..CONCLUSIONS: This result is consistent with those of mismatch negativity event-related potential studies and suggests that early auditory processing is abnormal in chronic schizophrenia...
  13. ncbi request reprint Mismatch negativity in chronic schizophrenia and first-episode schizophrenia
    Dean F Salisbury
    Harvard Medical School, Department of Psychiatry, McLean Hospital, Belmont, MA, USA
    Arch Gen Psychiatry 59:686-94. 2002
    ..The MMN is reported to be reduced in patients with chronic schizophrenia. However, it is unknown whether MMN is reduced in patients with first-episode schizophrenia (at first hospitalization)...
  14. pmc Semantic disturbance in schizophrenia and its relationship to the cognitive neuroscience of attention
    P G Nestor
    Department of Psychiatry, Harvard Medical School, Brockton VAMC 116A, 940 Belmont Street, Brockton, MA 02401, USA
    Biol Psychol 57:23-46. 2001
    ..We propose a similar failure of NMDA-mediated recurrent inhibition as a candidate biological substrate for attention and semantic anomalies of schizophrenia...
  15. pmc Shape of caudate nucleus and its cognitive correlates in neuroleptic-naive schizotypal personality disorder
    James J Levitt
    Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 55:177-84. 2004
    ..We believe MRI shape analysis complements traditional MRI volume measurements...
  16. pmc Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia: a longitudinal magnetic resonance imaging study
    Kiyoto Kasai
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, Mass, USA
    Arch Gen Psychiatry 60:766-75. 2003
    ....
  17. pmc Human middle longitudinal fascicle: segregation and behavioral-clinical implications of two distinct fiber connections linking temporal pole and superior temporal gyrus with the angular gyrus or superior parietal lobule using multi-tensor tractography
    N Makris
    Departments of Psychiatry and Neurology Services, Center for Neural Systems Investigations, Center for Morphometric Analysis, Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA, 02129, USA
    Brain Imaging Behav 7:335-52. 2013
    ....
  18. pmc Diffusion tractography of the fornix in schizophrenia
    J Fitzsimmons
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 107:39-46. 2009
    ..We applied these techniques to quantify fornix diffusion anisotropy in schizophrenia...
  19. ncbi request reprint P300 topography differs in schizophrenia and manic psychosis
    D F Salisbury
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 45:98-106. 1999
    ..The frontal reductions in bipolar psychosis may reflect abnormalities in a hypothetical frontal generator, consonant with reports of altered frontal lobe function in mania...
  20. ncbi request reprint Prefrontal gray matter volume reduction in first episode schizophrenia
    Y Hirayasu
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Brockton VA Medical Center and Harvard Medical School, Brockton, MA 02301, USA
    Cereb Cortex 11:374-81. 2001
    ..White matter volumes did not differ among groups. These data suggest that prefrontal cortical gray matter volume reduction is selectively present at first hospitalization in schizophrenia but not affective psychosis...
  21. pmc Restoration of DWI data using a Rician LMMSE estimator
    Santiago Aja-Fernandez
    Laboratory for Mathematics in Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    IEEE Trans Med Imaging 27:1389-403. 2008
    ..Filtering diffusion weighted magnetic resonance imaging (DW-MRI) with the proposed methodology leads to more accurate tensor estimations. Real and synthetic datasets are analyzed...
  22. pmc A prospective longitudinal volumetric MRI study of superior temporal gyrus gray matter and amygdala-hippocampal complex in chronic schizophrenia
    Takeshi Yoshida
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Brockton, MA 02301, USA
    Schizophr Res 113:84-94. 2009
    ..These data, and separately reported first episode data from our laboratory, suggest marked progression at the initial stage of schizophrenia, but less in chronic schizophrenia...
  23. pmc Thalamo-frontal white matter alterations in chronic schizophrenia: a quantitative diffusion tractography study
    Jungsu S Oh
    Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Hum Brain Mapp 30:3812-25. 2009
    ..These findings suggest that our method can enhance the regional and functional specificity of DTI group studies, thus improving our understanding of brain function...
  24. pmc Event-related potentials elicited during a context-free homograph task in normal versus schizophrenic subjects
    D F Salisbury
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Psychophysiology 37:456-63. 2000
    ....
  25. pmc Superior temporal gyrus volume abnormalities and thought disorder in left-handed schizophrenic men
    D P Holinger
    Department of Psychiatry, Harvard Medical School, Boston, USA
    Am J Psychiatry 156:1730-5. 1999
    ....
  26. pmc Electrophysiological and diffusion tensor imaging evidence of delayed corollary discharges in patients with schizophrenia
    T J Whitford
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA
    Psychol Med 41:959-69. 2011
    ..The nature of these abnormalities is unknown. This study investigated whether SZ patients experience CDs that are abnormally delayed in their arrival at the sensory cortex...
  27. pmc MRI study of caudate nucleus volume and its cognitive correlates in neuroleptic-naive patients with schizotypal personality disorder
    James J Levitt
    Clinical Neuroscience Division, Laboratory of Neuroscience, Dept of Psychiatry, VA Boston Healthcare System Brockton Division, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
    Am J Psychiatry 159:1190-7. 2002
    ....
  28. pmc White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study
    Hae Jeong Park
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA 02301, USA
    Neuroimage 23:213-23. 2004
    ..These findings of anisotropic asymmetry pattern differences between healthy controls and patients with schizophrenia are likely related to neurodevelopmental abnormalities in schizophrenia...
  29. pmc A new statistical method for testing hypotheses of neuropsychological/MRI relationships in schizophrenia: partial least squares analysis
    Paul G Nestor
    Harvard Medical School, Boston, MA, USA
    Schizophr Res 53:57-66. 2002
    ....
  30. pmc Fronto-temporal disconnectivity in schizotypal personality disorder: a diffusion tensor imaging study
    Motoaki Nakamura
    Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, MA 02301, USA
    Biol Psychiatry 58:468-78. 2005
    ..Here, we investigate these two bundles in unmedicated subjects with schizotypal personality disorder (SPD)...
  31. pmc Decreased axial diffusivity within language connections: a possible biomarker of schizophrenia risk
    M Kubicki
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 148:67-73. 2013
    ..AX should be considered a possible biomarker of risk for developing schizophrenia. ..
  32. pmc Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: a pilot study
    Z Kikinis
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 141:35-9. 2012
    ..Of note, studies in chronic schizophrenia patients report reduced FA, no changes in AD, and increases in RD in WM. Our findings suggest different WM microstructural pathology in 22q11.2DS than in patients with schizophrenia...
  33. ncbi request reprint ERP assessment of visual and auditory language processing in schizophrenia
    M A Niznikiewicz
    Department of Psychiatry, Harvard Medical School, Massachusetts, USA
    J Abnorm Psychol 106:85-94. 1997
    ..These results suggest that language abnormalities in schizophrenia are related to a dysfunction in the language system and not to a general cognitive dysfunction, and may be related to poor use of context in patients with schizophrenia...
  34. pmc Reduced interhemispheric connectivity in schizophrenia-tractography based segmentation of the corpus callosum
    M Kubicki
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, United States
    Schizophr Res 106:125-31. 2008
    ..Moreover, none of these studies has investigated corpus callosum systematically, using anatomical subdivisions...
  35. pmc Functional and structural deficits in brain regions subserving face perception in schizophrenia
    Toshiaki Onitsuka
    Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Am J Psychiatry 163:455-62. 2006
    ....
  36. pmc A geometry-based particle filtering approach to white matter tractography
    Peter Savadjiev
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Med Image Comput Comput Assist Interv 13:233-40. 2010
    ..We validate the method on synthetic data and present results on two types in vivo data: diffusion tensors and a spherical harmonic reconstruction of the fibre orientation distribution function (fODF)...
  37. pmc Neocortical gray matter volume in first-episode schizophrenia and first-episode affective psychosis: a cross-sectional and longitudinal MRI study
    Motoaki Nakamura
    Clinical Neuroscience Division, Laboratory of Neuroscience, Veterans Affairs Boston Healthcare System, Brockton Division, Boston, USA
    Biol Psychiatry 62:773-83. 2007
    ....
  38. pmc Two-tensor tractography using a constrained filter
    James G Malcolm
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Med Image Comput Comput Assist Interv 12:894-902. 2009
    ..In vivo experiments confirm the ability to trace out fibers in areas known to contain such crossing and branching while providing inherent path regularization...
  39. pmc Increased diffusivity in superior temporal gyrus in patients with schizophrenia: a Diffusion Tensor Imaging study
    KangUk Lee
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA
    Schizophr Res 108:33-40. 2009
    ..The goal of this study was to conduct the first Diffusion Tensor Imaging (DTI) study to investigate altered structural integrity in STG gray and white matter in patients with chronic schizophrenia compared with healthy controls...
  40. pmc Uncinate fasciculus findings in schizophrenia: a magnetic resonance diffusion tensor imaging study
    Marek Kubicki
    Department of Psychiatry, Harvard Medical School and VA Boston Healthcare System Brockton Division, MA 02301, USA
    Am J Psychiatry 159:813-20. 2002
    ..Here the authors focus on fiber tracts forming temporal-frontal connections...
  41. pmc Human middle longitudinal fascicle: variations in patterns of anatomical connections
    N Makris
    Department of Psychiatry, Neurology and Radiology Services, Center for Morphometric Analysis, A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Brain Struct Funct 218:951-68. 2013
    ....
  42. pmc Cognitive dysfunction in schizophrenia: unifying basic research and clinical aspects
    R W McCarley
    Harvard Medical School, Department of Psychiatry, Brockton, MA 02401, USA
    Eur Arch Psychiatry Clin Neurosci 249:69-82. 1999
    ..g. cat-dog, a result compatible with behavioral data. Other N400 data strongly and directly suggest that schizophrenics do not efficiently utilize context...
  43. pmc Button-pressing affects P300 amplitude and scalp topography
    D F Salisbury
    Department of Psychiatry, Cognitive Neuroscience Laboratory, McLean Hospital NBG-21, Harvard Medical School, 115 Mill Street, Belmont, MA 02178-9106, USA
    Clin Neurophysiol 112:1676-84. 2001
    ..Also, P300 topography in button-pressing tasks is confounded by motor potentials. The distortion can be corrected with a motor potential estimate. Motor potentials can occlude differences in P300 topography between groups...
  44. ncbi request reprint Visual hemifield mapping using transcranial magnetic stimulation coregistered with cortical surfaces derived from magnetic resonance images
    G F Potts
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Neurophysiol 15:344-50. 1998
    ..The results were consistent with disruption of secondary visual cortical areas...
  45. pmc Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, and Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 54:1171-80. 2003
    ..These data provide strong evidence for CB disruptions in schizophrenia, which may be related to disease-related attention and working memory abnormalities...
  46. pmc Biomarkers for identifying first-episode schizophrenia patients using diffusion weighted imaging
    Yogesh Rathi
    Harvard Medical School, Boston, USA
    Med Image Comput Comput Assist Interv 13:657-65. 2010
    ..Classification results using leave-many-out cross-validation scheme are given for each representation. This algorithm is a first step towards early detection of schizophrenia...
  47. pmc Global medical shape analysis using the Laplace-Beltrami spectrum
    Marc Niethammer
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA
    Med Image Comput Comput Assist Interv 10:850-7. 2007
    ..The discriminatory power of the method is tested on a population of female caudate shapes of normal control subjects and of subjects with schizotypal personality disorder...
  48. pmc An MRI study of temporal lobe abnormalities and negative symptoms in chronic schizophrenia
    Jane E Anderson
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Brockton Veterans Affairs Medical Center and Harvard Medical School, Boston, MA 02301, USA
    Schizophr Res 58:123-34. 2002
    ..The reduction in the anterior amygdala/hippocampal complex was an additional temporal lobe finding. These results underscore the role of temporal lobe structures in the pathophysiology of schizophrenia...
  49. pmc An MRI study of superior temporal gyrus volume in women with schizotypal personality disorder
    Chandlee C Dickey
    VA Boston Healthcare System, Psychiatry 116A, 940 Belmont St, Brockton, MA 02401, USA
    Am J Psychiatry 160:2198-201. 2003
    ..This is the first structural magnetic resonance imaging study to examine a group of female subjects with schizotypal personality disorder...
  50. pmc Voxel-based morphometric analysis of gray matter in first episode schizophrenia
    M Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Massachusetts, USA
    Neuroimage 17:1711-9. 2002
    ..They further suggest the importance of comparing VBM findings with more traditional ROI analyses until the reasons for the differences between methods are determined...
  51. pmc An fMRI study of semantic processing in men with schizophrenia
    M Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Neuroimage 20:1923-33. 2003
    ....
  52. pmc DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity
    M Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Neuroimage 26:1109-18. 2005
    ....
  53. pmc Gray matter volume reduction in rostral middle frontal gyrus in patients with chronic schizophrenia
    Z Kikinis
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 123:153-9. 2010
    ..This method of parcellation offers a more precise way of measuring MR-MFG that will likely be important in further documentation of DLPFC anomalies in schizophrenia...
  54. pmc Sparse multi-shell diffusion imaging
    Yogesh Rathi
    Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Med Image Comput Comput Assist Interv 14:58-65. 2011
    ..Our preliminary results show that around 20-24 directions per shell are enough for robustly recovering the diffusion propagator...
  55. pmc Smaller left Heschl's gyrus volume in patients with schizotypal personality disorder
    Chandlee C Dickey
    Harvard Medical School, Clinical Neuroscience Division, Department of Psychiatry, VA Boston Healthcare System, Brockton, MA 02401, USA
    Am J Psychiatry 159:1521-7. 2002
    ..In a further exploration, the authors studied two components of the superior temporal gyrus: Heschl's gyrus and the planum temporale...
  56. pmc Local white matter geometry indices from diffusion tensor gradients
    Peter Savadjiev
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Med Image Comput Comput Assist Interv 12:345-52. 2009
    ..We define two new scalar measures of (1) fibre dispersion and (2) fibre curving, and we demonstrate them on synthetic and in-vivo datasets. Finally, we illustrate their applicability in a group study on schizophrenia...
  57. pmc Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia: an MRI study
    Noriomi Kuroki
    Department of Psychiatry, Harvard Medical School, Boston, MA 02301, USA
    Am J Psychiatry 163:2103-10. 2006
    ..However, the middle and inferior temporal gyri have received little investigation, especially in first-episode schizophrenia...
  58. ncbi request reprint Fusiform gyrus volume reduction in first-episode schizophrenia: a magnetic resonance imaging study
    Chang Uk Lee
    Department of Psychiatry 116A, VA Boston Healthcare System, Brockton Division, Harvard Medical School, 940 Belmont St, Brockton, MA 02301, USA
    Arch Gen Psychiatry 59:775-81. 2002
    ..of postmortem studies have suggested that fusiform gyrus volume is reduced in schizophrenia, but there have been no in vivo structural studies of the fusiform gyrus in schizophrenia using magnetic resonance imaging...
  59. pmc Uncinate fasciculus abnormalities in recent onset schizophrenia and affective psychosis: a diffusion tensor imaging study
    Toshiro Kawashima
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Schizophr Res 110:119-26. 2009
    ..The CB abnormalities reported in chronic schizophrenia may develop during the later course of the disease...
  60. ncbi request reprint Smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorder
    Min Seong Koo
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Arch Gen Psychiatry 63:1090-100. 2006
    ..Structural brain abnormalities, including larger cerebrospinal fluid (CSF) volumes, have been observed in men diagnosed as having schizotypal personality disorder (SPD)...
  61. pmc Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study
    Kiyoto Kasai
    Laboratory of Neuroscience, Clinical Neuroscience Division, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, and Harvard Medical School, 940 Belmont St, Brockton, MA 02301, USA
    Schizophr Res 71:65-76. 2004
    ..However, the association between abnormal CSP and limbic systems may be more specific to schizophrenia...
  62. pmc Comparing prefrontal gray and white matter contributions to intelligence and decision making in schizophrenia and healthy controls
    Paul G Nestor
    Department of Psychology, University of Massachusetts, Boston and Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Brockton, Massachusetts 02125 3393, USA
    Neuropsychology 24:121-9. 2010
    ..These results point to the potentially important role of CB white matter in the neuropsychological disturbance in schizophrenia...
  63. pmc Reduction of caudate nucleus volumes in neuroleptic-naïve female subjects with schizotypal personality disorder
    Min Seong Koo
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, and Harvard Medical School, Boston, MA 02401, USA
    Biol Psychiatry 60:40-8. 2006
    ....
  64. pmc Neuropsychological correlates of diffusion tensor imaging in schizophrenia
    Paul G Nestor
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston Veterans Affairs Health Care System Brockton Division, Brockton, MA 02301, USA
    Neuropsychology 18:629-37. 2004
    ..The data suggested abnormal DTI patterns linking declarative-episodic verbal memory deficits to the left UF and executive function deficits to the left CB among patients with schizophrenia...
  65. pmc Neural synchrony indexes disordered perception and cognition in schizophrenia
    Kevin M Spencer
    Department of Psychiatry, Veterans Affairs Boston Healthcare System, Harvard Medical School, Psychiatry 116A, 940 Belmont Street, Brockton, MA 02301, USA
    Proc Natl Acad Sci U S A 101:17288-93. 2004
    ..These data provide support for linking dysfunctional neural circuitry and the core symptoms of schizophrenia...
  66. pmc Prefrontal cortical thickness in first-episode psychosis: a magnetic resonance imaging study
    Laura C Wiegand
    Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 55:131-40. 2004
    ..Findings from postmortem studies suggest reduced prefrontal cortical thickness in schizophrenia; however, cortical thickness in first-episode schizophrenia has not been evaluated using magnetic resonance imaging (MRI)...
  67. pmc A MRI study of fusiform gyrus in schizotypal personality disorder
    Chandlee C Dickey
    Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, and Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 64:35-9. 2003
    ..This suggests that future studies may be useful in determining the functional competence of this gyrus in SPD...
  68. pmc Pituitary volume in schizophrenia spectrum disorders
    F Romo-Nava
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 146:301-7. 2013
    ..However, previous magnetic resonance imaging (MRI) studies assessing pituitary volume (PV) in SSD are conflicting. The main objective of this study was to examine further PV in SSD...
  69. pmc Directional functions for orientation distribution estimation
    Yogesh Rathi
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Med Image Anal 13:432-44. 2009
    ..In particular, we discuss a complete Euclidean as well as a "hybrid" framework, comprising of the Riemannian as well as Euclidean spaces, to perform interpolation and compute geodesic distances between two ODF's...
  70. pmc Shape abnormalities of caudate nucleus in schizotypal personality disorder
    James J Levitt
    Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA, USA
    Schizophr Res 110:127-39. 2009
    ..Here, we use a new shape measure which importantly permits local in addition to global shape analysis, as well as local correlations with behavioral measures...
  71. pmc Semantic dysfunction in women with schizotypal personality disorder
    Margaret A Niznikiewicz
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 159:1767-74. 2002
    ..The N400 component of the EEG event-related potentials was used as a probe of semantic processes...
  72. pmc Tensor kernels for simultaneous fiber model estimation and tractography
    Yogesh Rathi
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 64:138-48. 2010
    ..In vivo experiments using two and three components examine the corpus callosum and corticospinal tract and confirm the ability to trace through regions known to contain such crossing and branching...
  73. pmc Dichotic listening in schizotypal personality disorder: evidence for gender and laterality effects
    Martina M Voglmaier
    Department of Psychiatry at MMHC Public Psychiatry Division of Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States
    Schizophr Res 115:290-2. 2009
    ..The results suggest that left hemisphere temporal lobe structures may be particularly involved in male, but not female, SPD...
  74. pmc Semantic bias, homograph comprehension, and event-related potentials in schizophrenia
    Dean F Salisbury
    Cognitive Neuroscience Laboratory NBG21, Harvard Medical School at McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Clin Neurophysiol 113:383-95. 2002
    ..Combined behavioral and event-related potential (ERP) data can indicate the nature and timing of such abnormalities...
  75. pmc Neural tractography using an unscented Kalman filter
    James G Malcolm
    Psychiatry Neuroimaging Laboratory, Harvard Medical School, Boston, MA, USA
    Inf Process Med Imaging 21:126-38. 2009
    ..In vivo experiments confirm the ability to trace out fibers in areas known to contain such crossing and branching while providing inherent path regularization...
  76. pmc Local white matter geometry from diffusion tensor gradients
    Peter Savadjiev
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Neuroimage 49:3175-86. 2010
    ..We derive new scalar indices of (1) fiber dispersion and (2) fiber curving, and we demonstrate them on synthetic and in vivo data. Finally, we illustrate their applicability to a group study on schizophrenia...
  77. pmc Structural neuroimaging in schizophrenia: from methods to insights to treatments
    Martha E Shenton
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, 1249 Boylston Street Boston, MA 02215, USA
    Dialogues Clin Neurosci 12:317-32. 2010
    ..We then review future prospects that need to be explored and pursued in order to translate our current knowledge into an understanding of the neurobiology of schizophrenia, which can then be translated into novel treatments...
  78. pmc Auditory processing abnormalities in schizotypal personality disorder: an fMRI experiment using tones of deviant pitch and duration
    Chandlee C Dickey
    Serious Mental Illness Program, VA Boston Healthcare System, Psychiatry 116A RC, 940 Belmont St, Brockton, MA 02401, United States
    Schizophr Res 103:26-39. 2008
    ..The focus of this study was to determine whether or not there are also processing abnormalities of pure tones differing in pitch and duration in SPD...
  79. pmc Clarifying the origin of biological abnormalities in PTSD through the study of identical twins discordant for combat exposure
    Roger K Pitman
    Massachusetts General Hospital, Room 2616, Bldg 149, 13th St, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 1071:242-54. 2006
    ..These results support the conclusion that the latter abnormalities represent antecedent, familial vulnerability factors for developing chronic PTSD upon exposure to a traumatic event...
  80. ncbi request reprint Fusiform gyrus volume reduction and facial recognition in chronic schizophrenia
    Toshiaki Onitsuka
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton, MA 02301, USA
    Arch Gen Psychiatry 60:349-55. 2003
    ....
  81. pmc The application of DTI to investigate white matter abnormalities in schizophrenia
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry 116A, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
    Ann N Y Acad Sci 1064:134-48. 2005
    ..With the development of DTI, we are now able to investigate white matter abnormalities in schizophrenia...
  82. pmc A comparative profile analysis of neuropsychological function in men and women with schizotypal personality disorder
    Martina M Voglmaier
    Harvard Medical School, Department of Psychiatry at the Massachusetts Mental Health Center, Boston, MA 02139, USA
    Schizophr Res 74:43-9. 2005
    ..The results suggest a less severe pattern of cognitive deficits in women with SPD compared to men, consistent with hypotheses of gender differences in cognitive function in schizophrenia...
  83. pmc The NoGo P300 'anteriorization' effect and response inhibition
    Dean F Salisbury
    Department of Psychiatry, Harvard Medical School, Boston, and Cognitive Neuroscience Laboratory, McLean Hospital, Belmont, MA, USA
    Clin Neurophysiol 115:1550-8. 2004
    ..Comparison of anteriorization between the silent-count and NoGo tasks is thus essential. P300 topography on NoGo and silent-count tasks has not been previously compared...
  84. pmc Outlier rejection for diffusion weighted imaging
    Marc Niethammer
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Med Image Comput Comput Assist Interv 10:161-8. 2007
    ..The approach is based on the thresholding of Laplacian measurements over the sphere of the apparent diffusion coefficient profiles defined for a given set of gradient directions. Exemplary results are presented...
  85. pmc Comparison of single-shot echo-planar and line scan protocols for diffusion tensor imaging
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, 940 Belmont St, Brockton, MA 02301, USA
    Acad Radiol 11:224-32. 2004
    ..To date, there has been no comparison of EPI and LSDI. Because EPI is the most commonly used technique for acquiring diffusion tensor data, it is important to understand the limitations and advantages of LSDI relative to EPI...
  86. pmc Combining ERP and structural MRI information in first episode schizophrenia and bipolar disorder
    Robert W McCarley
    Harvard Department of Psychiatry, Massachusetts, USA
    Clin EEG Neurosci 39:57-60. 2008
    ..Knowledge of those locations and brain signals affected early should help understand the basic physiological defect underlying this progression, with potential implications for new therapeutic interventions...
  87. pmc The effect of background noise on P300 to suprathreshold stimuli
    Dean F Salisbury
    Harvard Medical School, Department of Psychiatry, McLean Hospital, Belmont, Massachusetts 02478, USA
    Psychophysiology 39:111-5. 2002
    ..P300 scalp topography was stable across both conditions. P300 latency is affected by background noise, even when performance is not, but amplitude and amplitude topography remain unaffected...
  88. pmc Sensory-evoked gamma oscillations in chronic schizophrenia
    Kevin M Spencer
    Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 63:744-7. 2008
    ..We investigated these issues by examining the VGO and AGO in chronic schizophrenic (SZ) and matched healthy control (HC) subjects...
  89. pmc Gamma-band auditory steady-state responses are impaired in first episode psychosis
    Kevin M Spencer
    Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Brockton 02301, USA
    Biol Psychiatry 64:369-75. 2008
    ..Here we examined whether gamma ASSR deficits are also present at first hospitalization for psychosis...
  90. pmc Enhanced facilitation of spatial attention in schizophrenia
    Kevin M Spencer
    Veterans Affairs Boston Healthcare System Harvard Medical School, Research 151C, 150 S Huntington Avenue, Boston, MA 02130, USA
    Neuropsychology 25:76-85. 2011
    ..We tested this hypothesis with orienting tasks involving the cued detection of a laterally presented target stimulus...
  91. pmc A diffusion tensor imaging study of the anterior limb of the internal capsule in schizophrenia
    James J Levitt
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Brockton, MA 02301 and Harvard Medical School, Boston, MA 02115, United States
    Psychiatry Res 184:143-50. 2010
    ..Despite not demonstrating a group difference in FA, we found that AL-IC FA was a good predictor of spatial and verbal declarative/episodic memory performance in schizophrenia...
  92. pmc Transcranial magnetic stimulation coregistered with MRI: a comparison of a guided versus blind stimulation technique and its effect on evoked compound muscle action potentials
    L D Gugino
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, CWN L1, 75 Francis Street, Boston, MA 02115, USA
    Clin Neurophysiol 112:1781-92. 2001
    ..The latter consists of the conventional placement of the TMS coil on the optimal scalp position for activation of the first dorsal interossei (FDI) muscle...
  93. pmc Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds
    E C del Re
    1 VA Boston Healthcare System, Brockton, MA, USA 2 Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Transl Psychiatry 4:e346. 2014
    ..Our results suggest pleiotropic effects of ZNF804A on risk for SZ and neural mechanisms that are indexed by the novel P300b ERP component...
  94. pmc A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury
    M E Shenton
    Clinical Neuroscience Laboratory, Department of Psychiatry, VA Boston Healthcare System, Brockton, MA, USA
    Brain Imaging Behav 6:137-92. 2012
    ..Finally, we end with a discussion of future directions in research that will lead to the improved care of patients diagnosed with mTBI...
  95. pmc Clinical, cognitive, and social characteristics of a sample of neuroleptic-naive persons with schizotypal personality disorder
    Chandlee C Dickey
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Psychiatry 116A, 940 Belmont St, Brockton, MA 02401, USA
    Schizophr Res 78:297-308. 2005
    ..This report describes the clinical, cognitive and socio-occupational characteristics of a community sample of subjects diagnosed with SPD...
  96. pmc The startle reflex in schizophrenia: habituation and personality correlates
    Sare J Akdag
    Department of Psychology, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA
    Schizophr Res 64:165-73. 2003
    ..The relationship of these findings to cognitive disturbances in schizophrenia is considered and directions for future research are discussed...
  97. pmc Processing sentence context in women with schizotypal personality disorder: an ERP study
    Margaret A Niznikiewicz
    Department of Psychiatry, Harvard Medical School, Neuroscience Laboratory, Brockton West Roxbury VAMC, Brockton, Massachusetts 02301, USA
    Psychophysiology 41:367-71. 2004
    ..In SPD women, relative to their comparison group, a more negative N400 was found only to auditory congruent sentences...
  98. pmc A unifying approach to registration, segmentation, and intensity correction
    Kilian M Pohl
    Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA
    Med Image Comput Comput Assist Interv 8:310-8. 2005
    ..We demonstrate the approach on a set of 22 magnetic resonance images. In addition, we show that the approach performs better than similar methods which separate the registration and segmentation problems...
  99. pmc Two methods for validating brain tissue classifiers
    Marcos Martin-Fernandez
    Laboratory of Mathematics in Imaging, Brigham and Women s Hospital, Boston, MA, USA
    Med Image Comput Comput Assist Interv 8:515-22. 2005
    ..We provide an interpretation of the results and show how similar the output of the STAPLE analysis and Williams' index are. When no ground truth is required, we recommend the use of Williams' index as it is easy and fast to compute...
  100. pmc High-resolution line scan diffusion tensor MR imaging of white matter fiber tract anatomy
    Hatsuho Mamata
    Department of Radiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    AJNR Am J Neuroradiol 23:67-75. 2002
    ..This technique, unlike T2-weighted imaging, also provides information about fiber direction. We present findings of normal white matter fiber tract anatomy at high resolution obtained by using line scan diffusion tensor imaging...
  101. ncbi request reprint Episodic memory and neuroimaging of hippocampus and fornix in chronic schizophrenia
    Paul G Nestor
    Department of Psychology, University of Massachusetts, Boston, MA 02125 3393, USA
    Psychiatry Res 155:21-8. 2007
    ..However, increased hippocampal volume correlated, in the negative direction, with lower scores for executive functioning and IQ in the control subset. Implications of these results are discussed...