M Sheng

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint CYRL, a novel cytokine receptor-like protein expressed in testis, lung, and spleen
    S L Chritton
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, 02114, USA
    Biochem Biophys Res Commun 267:697-702. 2000
  2. ncbi request reprint Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP
    D T Pak
    Department of Neurobiology, Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neuron 31:289-303. 2001
  3. pmc GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules
    E Kim
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Cell Biol 136:669-78. 1997
  4. ncbi request reprint Ligand-gated ion channel interactions with cytoskeletal and signaling proteins
    M Sheng
    Department of Neurobiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Annu Rev Physiol 62:755-78. 2000
  5. ncbi request reprint Ion channel targeting in neurons
    M Sheng
    Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, USA
    Bioessays 19:847-53. 1997
  6. ncbi request reprint PDZ domains and the organization of supramolecular complexes
    M Sheng
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Neurosci 24:1-29. 2001
  7. ncbi request reprint The Shank family of scaffold proteins
    M Sheng
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Cell Sci 113:1851-6. 2000
  8. ncbi request reprint Ion channel associated proteins
    M Sheng
    Howard Hughes Medical Institute, Massachusetts General Hospital, Boston 02114, USA
    Curr Opin Neurobiol 6:602-8. 1996
  9. ncbi request reprint Glutamate receptor anchoring proteins and the molecular organization of excitatory synapses
    M Sheng
    Howard Hughes Medical Institute, Massachussets General Hospital, Boston 02114, USA
    Ann N Y Acad Sci 868:483-93. 1999
  10. pmc Molecular organization of the postsynaptic specialization
    M Sheng
    Department of Neurobiology, and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street Wel 423, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 98:7058-61. 2001

Collaborators

Detail Information

Publications43

  1. ncbi request reprint CYRL, a novel cytokine receptor-like protein expressed in testis, lung, and spleen
    S L Chritton
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, 02114, USA
    Biochem Biophys Res Commun 267:697-702. 2000
    ..CYRL appears to be a novel cytokine receptor alpha-subunit of unknown function and with no defined ligands...
  2. ncbi request reprint Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP
    D T Pak
    Department of Neurobiology, Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neuron 31:289-303. 2001
    ..The effects of SPAR on spine morphology depend on the RapGAP and actin-interacting domains, implicating Rap signaling in the regulation of postsynaptic structure...
  3. pmc GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules
    E Kim
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Cell Biol 136:669-78. 1997
    ....
  4. ncbi request reprint Ligand-gated ion channel interactions with cytoskeletal and signaling proteins
    M Sheng
    Department of Neurobiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Annu Rev Physiol 62:755-78. 2000
    ..In addition to structural functions, receptor-associated proteins can play important roles as activity modulators or downstream effectors of ligand-gated channels...
  5. ncbi request reprint Ion channel targeting in neurons
    M Sheng
    Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, USA
    Bioessays 19:847-53. 1997
    ..Recognition of specific C-terminal peptide sequences by different PDZ domain-containing proteins may be a general mechanism for differential targeting of proteins to a variety of subcellular locations...
  6. ncbi request reprint PDZ domains and the organization of supramolecular complexes
    M Sheng
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Neurosci 24:1-29. 2001
    ..Some PDZ-containing proteins are more dynamically regulated in distribution and may also be involved in the trafficking of interacting proteins within the cell...
  7. ncbi request reprint The Shank family of scaffold proteins
    M Sheng
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Cell Sci 113:1851-6. 2000
    ..The specific localization of Shank proteins at postsynaptic sites of brain excitatory synapses suggests a role for this family of proteins in the organization of cytoskeletal/ signaling complexes at specialized cell junctions...
  8. ncbi request reprint Ion channel associated proteins
    M Sheng
    Howard Hughes Medical Institute, Massachusetts General Hospital, Boston 02114, USA
    Curr Opin Neurobiol 6:602-8. 1996
    ..Recent findings suggest that non-pore-forming subunits of ion channels may also have cell biological functions independent of their effects on channel electrophysiological properties...
  9. ncbi request reprint Glutamate receptor anchoring proteins and the molecular organization of excitatory synapses
    M Sheng
    Howard Hughes Medical Institute, Massachussets General Hospital, Boston 02114, USA
    Ann N Y Acad Sci 868:483-93. 1999
    ..The network of protein-protein interactions mediated by these abundant PDZ proteins is likely to contribute significantly to the molecular scaffold of the postsynaptic density...
  10. pmc Molecular organization of the postsynaptic specialization
    M Sheng
    Department of Neurobiology, and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street Wel 423, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 98:7058-61. 2001
    ..The distinctive cell biological behaviors of N-methyl-d-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors can be explained by their differential interactions with cytoplasmic proteins...
  11. ncbi request reprint Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
    S Naisbitt
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 23:569-82. 1999
    ..Shank may function as a scaffold protein in the PSD, potentially cross-linking NMDA receptor/PSD-95 complexes and coupling them to regulators of the actin cytoskeleton...
  12. ncbi request reprint Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein
    S Naisbitt
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 20:4524-34. 2000
    ..We discuss the possibility that the GKAP/DLC interaction may be involved in trafficking of the PSD-95 complex by motor proteins...
  13. ncbi request reprint CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90
    M Niethammer
    Department of Neurobiology and Howard Huges Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 20:693-707. 1998
    ..These findings suggest that CRIPT may regulate PSD-95 interaction with a tubulin-based cytoskeleton in excitatory synapses...
  14. ncbi request reprint Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases
    M Niethammer
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 16:2157-63. 1996
    ..Members of the PSD-95 family might serve to anchor NMDA receptors to the submembrane cytoskeleton and aid in the assembly of signal transduction complexes at postsynaptic sites...
  15. ncbi request reprint Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95
    Y P Hsueh
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02214, USA
    Neuron 18:803-14. 1997
    ..PSD-95 and its relative chapsyn-110 exist as disulfide-linked complexes in rat brain, consistent with head-to-head multimerization of these proteins in vivo...
  16. ncbi request reprint Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases
    E Kim
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital, Boston 02114, USA
    Neuropharmacology 35:993-1000. 1996
    ..4 clustering occurs in > 60% of cotransfected cells, whereas Kv1.1 and Kv1.2 form convincing clusters with PSD-95 only in approximately 10% of cells...
  17. ncbi request reprint Competitive binding of alpha-actinin and calmodulin to the NMDA receptor
    M Wyszynski
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 385:439-42. 1997
    ..Intriguingly, NR1-alpha-actinin binding is directly antagonized by Ca2+/calmodulin. Thus alpha-actinin may play a role in both the localization of NMDA receptors and their modulation by Ca2+...
  18. ncbi request reprint Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95
    M Passafaro
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, HHMI Wellman 423, 50 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Neurosci 2:1063-9. 1999
    ..However, the number of synapses and the synaptic clustering of NMDA receptors were unaffected, suggesting that PSD-95-family proteins are not essential for the maintenance of synapses and the synaptic localization of NMDA receptors...
  19. ncbi request reprint Regulation of dendritic spine morphology and synaptic function by Shank and Homer
    C Sala
    Howard Hughes Medical Institute and, Department of Neurobiology, Massachusetts General Hospital and, Harvard Medical School, 02114, Boston, MA, USA
    Neuron 31:115-30. 2001
    ..These data suggest a central role for the Shank scaffold in the structural and functional organization of the dendritic spine and synaptic junction...
  20. ncbi request reprint Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2
    Y P Hsueh
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Nature 404:298-302. 2000
    ..Our findings show that a MAGUK which is usually associated with cell junctions has a transcription regulation function...
  21. ncbi request reprint Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins
    E Kim
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital, Boston 02114, USA
    Neuron 17:103-13. 1996
    ..Thus, chapsyn-110 and PSD-95 may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signalling proteins...
  22. ncbi request reprint Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development
    Y P Hsueh
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 19:7415-25. 1999
    ..Moreover, CASK is appropriately expressed and localized to interact with both syndecan-2 and -3 in different compartments of the neuron throughout postnatal development...
  23. ncbi request reprint Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo
    M Wyszynski
    Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 19:6528-37. 1999
    ..Collectively, these findings support a role for GRIP in the synaptic anchoring of AMPA receptors but also suggest that GRIP has additional functions unrelated to the binding of AMPA receptors...
  24. pmc Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses
    Y P Hsueh
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Cell Biol 142:139-51. 1998
    ..The synaptic localization of CASK and syndecan suggests a potential role for these proteins in adhesion and signaling at neuronal synapses...
  25. ncbi request reprint Biochemical and morphological characterization of an intracellular membrane compartment containing AMPA receptors
    S H Lee
    Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuropharmacology 41:680-92. 2001
    ..Taken together, these results suggest that a pool of intracellular GluR2/3 resides in a syntaxin 13-positive tubulovesicular membrane compartment, which might serve as a reservoir for the dendritic recycling of AMPA receptors...
  26. ncbi request reprint Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases
    E Kim
    Howard Hughes Medical Institute, Massachusetts General Hospital, Department of Neurobiology, Harvard Medical School, Boston 02114, USA
    Nature 378:85-8. 1995
    ..3) and syntrophin), suggest that PDZ-domain-containing polypeptides may be widely involved in the organization of proteins at sites of membrane specialization...
  27. ncbi request reprint Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90
    S Naisbitt
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachussetts 02114, USA
    J Neurosci 17:5687-96. 1997
    ..Thus GKAP is a widely expressed neuronal protein localized specifically in the PSD of glutamatergic synapses, consistent with its direct interaction with PSD-95 family proteins...
  28. ncbi request reprint Association of dystrophin-related protein 2 (DRP2) with postsynaptic densities in rat brain
    R G Roberts
    Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Neurosci 16:674-85. 2000
    ....
  29. ncbi request reprint Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex
    R S Westphal
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health Sciences University, 3181 S W Sam Jackson Road, Portland, OR 97201, USA
    Science 285:93-6. 1999
    ..Hence, yotiao is a scaffold protein that physically attaches PP1 and PKA to NMDA receptors to regulate channel activity...
  30. ncbi request reprint Plasma membrane Ca2+ ATPase isoform 4b binds to membrane-associated guanylate kinase (MAGUK) proteins via their PDZ (PSD-95/Dlg/ZO-1) domains
    E Kim
    Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Biol Chem 273:1591-5. 1998
    ..Alternative splicing may dictate their specific interaction with PDZ domain-containing proteins, potentially influencing their localization and incorporation into functional multiprotein complexes at the plasma membrane...
  31. ncbi request reprint Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1
    J W Lin
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 18:2017-27. 1998
    ..Consistent with a general involvement in postsynaptic structure, yotiao was also found to be specifically concentrated at the neuromuscular junction in skeletal muscle...
  32. ncbi request reprint Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization
    J W Lin
    Howard Hughes Medical Institute, Massachusetts General Hospital Wellman 423, 50 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Neurosci 3:1282-90. 2000
    ..Thus, the molecular mechanisms and intracellular sorting of AMPA receptors are diverse, and depend on the internalizing stimulus...
  33. ncbi request reprint Neurobiology. A stargazer foretells the way to the synapse
    T Nakagawa
    Department of Neurobiology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    Science 290:2270-1. 2000
    ....
  34. ncbi request reprint Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons
    M Passafaro
    Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Neurosci 4:917-26. 2001
    ..We propose that GluR1 controls the exocytosis and GluR2/3, the recycling and endocytosis of AMPA receptors...
  35. ncbi request reprint Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
    J C Tu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 23:583-92. 1999
    ..Thus, Shank may cross-link Homer and PSD-95 complexes in the PSD and play a role in the signaling mechanisms of both mGluRs and NMDA receptors...
  36. ncbi request reprint Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins
    S Lim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yusong Ku, Daejon, 305 701, Korea
    Mol Cell Neurosci 17:385-97. 2001
    ....
  37. ncbi request reprint Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development
    S Lim
    Department of Pharmacology, Pusan National University, Kumjeong Ku, Pusan 609 735, Korea
    J Biol Chem 274:29510-8. 1999
    ..These results suggest that alternative splicing in the Shank family may be a mechanism that regulates the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain...
  38. ncbi request reprint Targeting of nonexpressed genes in embryonic stem cells via homologous recombination
    R S Johnson
    Dana Farber Cancer Institute, Boston, MA
    Science 245:1234-6. 1989
    ..These studies demonstrate the feasibility of altering genes in ES cells that are expressed in a tissue-specific manner in the mouse, in order to study their function at later developmental stages...
  39. ncbi request reprint Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans
    Y P Hsueh
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, 115, Republic of China
    J Neurosci 21:3764-70. 2001
    ..Our findings suggest that interaction with different members of the syndecan family may be a mechanism for localizing neurofibromin to specialized domains of the plasma membrane...
  40. ncbi request reprint Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family
    R B Nehring
    Molecular Neurobiology of Signal Transduction, Max Planck Institut for Biophysical Chemistry, 37070 Gottingen, Germany
    J Neurosci 20:156-62. 2000
    ..3 channels by >50%. This inhibitory action of PSD-95, which predominantly affects the single-channel conductance, is likely attributable to a molecular association with additional internal interaction sites in the Kir2.3 protein...
  41. ncbi request reprint Tbr1 regulates differentiation of the preplate and layer 6
    R F Hevner
    Nina Ireland Laboratory of, Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 29:353-66. 2001
    ..These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development...
  42. ncbi request reprint Differential cellular and subcellular localization of ampa receptor-binding protein and glutamate receptor-interacting protein
    A Burette
    Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 21:495-503. 2001
    ..This heterogeneity could be seen even within adjacent spines of a single dendrite. These data suggest that ABP may act as a scaffold for AMPA receptors either in concert with or independently from GRIP...
  43. ncbi request reprint Proteolysis of glutamate receptor-interacting protein by calpain in rat brain: implications for synaptic plasticity
    X Lu
    Neuroscience Program, University of Southern California, Los Angeles 90089-2520, USA
    J Neurochem 77:1553-60. 2001
    ....