Carl S Shelley

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb
    C S Shelley
    Leukocyte Biology and Inflammation Program, Massachusetts General Hospital, Harvard Medical School, Boston 02115, USA
    Genomics 49:334-6. 1998
  2. ncbi request reprint During U937 monocytic differentiation repression of the CD43 gene promoter is mediated by the single-stranded DNA binding protein Pur alpha
    C S Shelley
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Br J Haematol 115:159-66. 2001
  3. ncbi request reprint During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter
    C Simon Shelley
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 168:3887-93. 2002
  4. ncbi request reprint hnRNP-K and Pur(alpha) act together to repress the transcriptional activity of the CD43 gene promoter
    Nicolas Da Silva
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Blood 100:3536-44. 2002
  5. ncbi request reprint The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene
    Heiyoung Park
    Leukocyte Biology and Inflammation Program, Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Blood 101:894-902. 2003
  6. pmc Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression
    Tianqing Kong
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:10440-5. 2004
  7. ncbi request reprint Identification of Pur alpha as a new hypoxia response factor responsible for coordinated induction of the beta 2 integrin family
    Tianqing Kong
    Renal Division, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:1934-41. 2007
  8. ncbi request reprint CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD
    Fotini Nicolaou
    Renal Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Blood 101:4033-41. 2003
  9. ncbi request reprint The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells
    Xiangen Li
    Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Development 133:3641-50. 2006

Collaborators

  • M A Arnaout
  • Tianqing Kong
  • Heiyoung Park
  • Nicolas Da Silva
  • Xiangen Li
  • Sean P Colgan
  • Fotini Nicolaou
  • Melanie Scully
  • Jing Wei Xiong
  • Jorn Karhausen
  • Holger K Eltzschig
  • Philippe Rousselot
  • Jens M Teodoridis
  • Christine Chomienne
  • Alexander Georgakis
  • Omid C Farokhzad
  • Katalin Ferenczi
  • Erwin P Bottinger
  • Ajit Bharti

Detail Information

Publications9

  1. ncbi request reprint Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb
    C S Shelley
    Leukocyte Biology and Inflammation Program, Massachusetts General Hospital, Harvard Medical School, Boston 02115, USA
    Genomics 49:334-6. 1998
  2. ncbi request reprint During U937 monocytic differentiation repression of the CD43 gene promoter is mediated by the single-stranded DNA binding protein Pur alpha
    C S Shelley
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Br J Haematol 115:159-66. 2001
    ..Consequently, Pur alpha represents a potential means by which the induction of pro-adhesive molecules and the repression of anti-adhesive molecules is co-ordinated during leucocyte differentiation...
  3. ncbi request reprint During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter
    C Simon Shelley
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 168:3887-93. 2002
    ..Together, these increases in the functional activity of both Puralpha and Sp1 combine to induce CD11c expression...
  4. ncbi request reprint hnRNP-K and Pur(alpha) act together to repress the transcriptional activity of the CD43 gene promoter
    Nicolas Da Silva
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Blood 100:3536-44. 2002
    ..The hnRNP-K molecule and Pur(alpha) bind single-stranded DNA. Therefore, exposure of single-stranded structures within the CD43 promoter probably plays a major role in effecting CD43 repression...
  5. ncbi request reprint The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene
    Heiyoung Park
    Leukocyte Biology and Inflammation Program, Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Blood 101:894-902. 2003
    ..A clear inverse relationship was observed in the latter but not the former state, suggesting that ZBP-89 represses CD11b gene expression during the further differentiation of monocytes into macrophages...
  6. pmc Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression
    Tianqing Kong
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:10440-5. 2004
    ..Taken together, these results demonstrate that hypoxia induces leukocyte beta2 integrin expression and function by transcriptional mechanisms dependent upon HIF-1...
  7. ncbi request reprint Identification of Pur alpha as a new hypoxia response factor responsible for coordinated induction of the beta 2 integrin family
    Tianqing Kong
    Renal Division, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:1934-41. 2007
    ..Taken together, our findings demonstrate that hypoxia induces a coordinated up-regulation in beta(2) integrin expression that is dependent upon transcriptional mechanisms mediated by HIF-1 and Pur alpha...
  8. ncbi request reprint CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD
    Fotini Nicolaou
    Renal Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Blood 101:4033-41. 2003
    ..Together, these data indicate that the abnormal expression of the CD11c gene characteristic of HCL is dependent upon activation of the proto-oncogenes ras and junD...
  9. ncbi request reprint The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells
    Xiangen Li
    Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Development 133:3641-50. 2006
    ..These findings establish a unique regulatory role for ZBP-89, positioned at the interface between early blood and blood vessel development...