Research Topics
| Roger L ShapiroSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in BotswanaRoger L Shapiro
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
AIDS 20:1281-8. 2006..This strategy avoids the potential for maternal nevirapine resistance...- Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milkRoger L Shapiro
Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Infect Dis 192:713-9. 2005..The ability of highly active antiretroviral therapy (HAART) to reduce human immunodeficiency virus type 1 (HIV-1) RNA and DNA in breast milk has not been described... - Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatmentRoger L Shapiro
Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Infect Dis 192:720-7. 2005..The magnitude of infant antiretroviral (ARV) exposure from breast milk is unknown... - Infant morbidity, mortality, and breast milk immunologic profiles among breast-feeding HIV-infected and HIV-uninfected women in BotswanaRoger L Shapiro
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Infect Dis 196:562-9. 2007..Infants of human immunodeficiency virus (HIV)-infected women have high mortality, but the immunologic integrity and protection afforded by the breast milk of HIV-infected women is unknown... 
Risk factors for early and late transmission of HIV via breast-feeding among infants born to HIV-infected women in a randomized clinical trial in BotswanaRoger L Shapiro
Beth Israel Deaconess Medical Center, Division of Infectious Diseases, Boston, Massachusetts 02215, USA
J Infect Dis 199:414-8. 2009..001) predicted late MTCT. These findings support the safety of 1 month of breast-feeding in combination with maternal and infant antiretroviral prophylaxis. Trial registration. ClinicalTrials.gov identifiers: NCT00197691 and NCT00197652...- Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi StudyIbou Thior
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Mass 02115, USA
JAMA 296:794-805. 2006..These results demonstrate the risk of formula feeding to infants in sub-Saharan Africa, and the need for studies of alternative strategies. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00197587... - Response to antiretroviral therapy after a single, peripartum dose of nevirapineShahin Lockman
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
N Engl J Med 356:135-47. 2007..A single dose of nevirapine during labor reduces perinatal transmission of human immunodeficiency virus type 1 (HIV-1) but often leads to viral nevirapine resistance mutations in mothers and infants... - Increased risk of severe infant anemia after exposure to maternal HAART, BotswanaScott Dryden-Peterson
Department of Medicine, Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 56:428-36. 2011..Maternal highly-active antiretroviral therapy (HAART) reduces mother-to-child HIV transmission but may increase the risk for infant anemia... - Abacavir alters the transcription of inflammatory cytokines in virologically suppressed, HIV-infected womenIain J MacLeod
Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
J Int AIDS Soc 15:17393. 2012..Abacavir (ABC) may be associated with a small, increased risk of myocardial infarction in HIV-infected adults, possibly related to cytokine-mediated inflammation... - Prevalence of human papillomavirus genotypes and associated cervical squamous intraepithelial lesions in HIV-infected women in BotswanaIain J MacLeod
Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
J Med Virol 83:1689-95. 2011..The associations attributed to specific oncogenic HPV subtypes and cervical squamous intraepithelial lesions presented here provide critical information to inform future vaccine policy within Botswana... - High prevalence of hypertension and placental insufficiency, but no in utero HIV transmission, among women on HAART with stillbirths in BotswanaRoger L Shapiro
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
PLoS ONE 7:e31580. 2012..It is also unknown whether HIV infection of the fetus is associated with stillbirth... - Increased risk of preterm delivery among HIV-infected women randomized to protease versus nucleoside reverse transcriptase inhibitor-based HAART during pregnancyKathleen M Powis
Departments of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Infect Dis 204:506-14. 2011..Protease inhibitor (PI)-based highly active antiretroviral therapy (HAART) use in pregnancy has been associated with preterm deliveries in some observational studies... - Effects of in utero antiretroviral exposure on longitudinal growth of HIV-exposed uninfected infants in BotswanaKathleen M Powis
Department of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, MA, USA
J Acquir Immune Defic Syndr 56:131-8. 2011..The impact of in utero exposure to highly active antiretroviral therapy (HAART) on longitudinal growth of HIV-uninfected infants is unknown... - Highly active antiretroviral therapy versus zidovudine for prevention of mother-to-child transmission in a programmatic setting, BotswanaScott Dryden-Peterson
Department of Medicine, Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 58:353-7. 2011..Maternal HAART was associated with decreased prevention of mother-to-child transmission (P = 0.001) and improved HIV-free survival (P = 0.040) compared with zidovudine (with or without single-dose nevirapine) in a programmatic setting... - Birth weight for gestational age norms for a large cohort of infants born to HIV-negative women in Botswana compared with norms for U.S.-born black infantsLynn T Matthews
Beth Israel Deaconess Medical Center, Division of Infectious Disease, Boston, MA 02115, USA
BMC Pediatr 11:115. 2011.... 
Antiretroviral treatment initiation among HIV-infected pregnant women with low CD4(+) cell counts in Gaborone, BotswanaJennifer Y Chen
Harvard Medical School, Boston, MA, USA
J Acquir Immune Defic Syndr 54:102-6. 2010..We analyzed rates of HIV testing, CD4 cell count testing, and HAART initiation during pregnancy...- Low adherence to recommended infant feeding strategies among HIV-infected women: results from the pilot phase of a randomized trial to prevent mother-to-child transmission in BotswanaRoger L Shapiro
Botswana Harvard AIDS Institute Partnership, Botswana
AIDS Educ Prev 15:221-30. 2003..Breast examination may be a useful adjunct to self-report, but needs to be validated and standardized. Low adherence to infant feeding strategies that differ from local norms will reduce their effectiveness in preventing MTCT... - Drawing lines in the sand: the boundaries of the HIV pandemic in perspectiveRoger L Shapiro
Harvard School of Public Health, 651 Huntington Ave FXB 401, Boston, MA 02115, USA
Soc Sci Med 55:2189-91. 2002 - Hematologic and hepatic toxicities associated with antenatal and postnatal exposure to maternal highly active antiretroviral therapy among infantsWoong Hwan Bae
Harvard College, Harvard Faculty of Arts and Sciences, Harvard University, Cambridge, Massachusetts, USA
AIDS 22:1633-40. 2008..To assess hematologic and hepatic toxicities associated with in utero and breastfeeding exposure to maternal highly active antiretroviral therapy (HAART) among infants in Botswana... - Surveillance for bacterial diarrhea and antimicrobial resistance in rural western Kenya, 1997-2003John T Brooks
Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Clin Infect Dis 43:393-401. 2006..More judicious use of appropriate antimicrobials is warranted. Efforts to prevent illness through provision of clean water, improved hygiene, and vaccine development should be strengthened... - Epidemiology of sporadic bloody diarrhea in rural Western KenyaJohn T Brooks
Foodborne and Diarrheal Diseases Branch, and Biostatistics and Information Management Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Am J Trop Med Hyg 68:671-7. 2003..Washing hands after defecating was protective. Providing safe drinking water and more latrines, and promoting hand washing could reduce the burden of illness from bloody diarrhea while limiting injudicious antimicrobial use...