Roger L Shapiro

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    AIDS 20:1281-8. 2006
  2. ncbi request reprint Infant morbidity, mortality, and breast milk immunologic profiles among breast-feeding HIV-infected and HIV-uninfected women in Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Infect Dis 196:562-9. 2007
  3. ncbi request reprint Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk
    Roger L Shapiro
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 192:713-9. 2005
  4. ncbi request reprint Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatment
    Roger L Shapiro
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 192:720-7. 2005
  5. ncbi request reprint Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study
    Ibou Thior
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 296:794-805. 2006
  6. pmc Risk factors for early and late transmission of HIV via breast-feeding among infants born to HIV-infected women in a randomized clinical trial in Botswana
    Roger L Shapiro
    Beth Israel Deaconess Medical Center, Division of Infectious Diseases, Boston, Massachusetts 02215, USA
    J Infect Dis 199:414-8. 2009
  7. ncbi request reprint Response to antiretroviral therapy after a single, peripartum dose of nevirapine
    Shahin Lockman
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 356:135-47. 2007
  8. doi request reprint Therapeutic levels of lopinavir in late pregnancy and abacavir passage into breast milk in the Mma Bana Study, Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Antivir Ther 18:585-90. 2013
  9. pmc Increased risk of severe infant anemia after exposure to maternal HAART, Botswana
    Scott Dryden-Peterson
    Department of Medicine, Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 56:428-36. 2011
  10. pmc Cotrimoxazole prophylaxis and risk of severe anemia or severe neutropenia in HAART-exposed, HIV-uninfected infants
    Scott Dryden-Peterson
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 8:e74171. 2013

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    AIDS 20:1281-8. 2006
    ..Single-dose nevirapine given to women and infants reduces mother-to-child HIV transmission, but nevirapine resistance develops in a large percentage of women...
  2. ncbi request reprint Infant morbidity, mortality, and breast milk immunologic profiles among breast-feeding HIV-infected and HIV-uninfected women in Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Infect Dis 196:562-9. 2007
    ..Infants of human immunodeficiency virus (HIV)-infected women have high mortality, but the immunologic integrity and protection afforded by the breast milk of HIV-infected women is unknown...
  3. ncbi request reprint Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk
    Roger L Shapiro
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 192:713-9. 2005
    ..The ability of highly active antiretroviral therapy (HAART) to reduce human immunodeficiency virus type 1 (HIV-1) RNA and DNA in breast milk has not been described...
  4. ncbi request reprint Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatment
    Roger L Shapiro
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 192:720-7. 2005
    ..The magnitude of infant antiretroviral (ARV) exposure from breast milk is unknown...
  5. ncbi request reprint Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study
    Ibou Thior
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 296:794-805. 2006
    ..Postnatal transmission of human immunodeficiency virus-1 (HIV) via breastfeeding reverses gains achieved by perinatal antiretroviral interventions...
  6. pmc Risk factors for early and late transmission of HIV via breast-feeding among infants born to HIV-infected women in a randomized clinical trial in Botswana
    Roger L Shapiro
    Beth Israel Deaconess Medical Center, Division of Infectious Diseases, Boston, Massachusetts 02215, USA
    J Infect Dis 199:414-8. 2009
    ..001) predicted late MTCT. These findings support the safety of 1 month of breast-feeding in combination with maternal and infant antiretroviral prophylaxis. Trial registration. ClinicalTrials.gov identifiers: NCT00197691 and NCT00197652...
  7. ncbi request reprint Response to antiretroviral therapy after a single, peripartum dose of nevirapine
    Shahin Lockman
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 356:135-47. 2007
    ..A single dose of nevirapine during labor reduces perinatal transmission of human immunodeficiency virus type 1 (HIV-1) but often leads to viral nevirapine resistance mutations in mothers and infants...
  8. doi request reprint Therapeutic levels of lopinavir in late pregnancy and abacavir passage into breast milk in the Mma Bana Study, Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Antivir Ther 18:585-90. 2013
    ..Pharmacokinetic data for lopinavir in late pregnancy and in breastfeeding are limited, and no data for abacavir in breast milk are available...
  9. pmc Increased risk of severe infant anemia after exposure to maternal HAART, Botswana
    Scott Dryden-Peterson
    Department of Medicine, Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 56:428-36. 2011
    ..Maternal highly-active antiretroviral therapy (HAART) reduces mother-to-child HIV transmission but may increase the risk for infant anemia...
  10. pmc Cotrimoxazole prophylaxis and risk of severe anemia or severe neutropenia in HAART-exposed, HIV-uninfected infants
    Scott Dryden-Peterson
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 8:e74171. 2013
    ..Prophylactic cotrimoxazole is recommended for infants born to HIV-infected mothers. However, cotrimoxazole may increase the risk of severe anemia or neutropenia...
  11. pmc Abacavir alters the transcription of inflammatory cytokines in virologically suppressed, HIV-infected women
    Iain J MacLeod
    Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Int AIDS Soc 15:17393. 2012
    ..Abacavir (ABC) may be associated with a small, increased risk of myocardial infarction in HIV-infected adults, possibly related to cytokine-mediated inflammation...
  12. pmc High viral load and elevated angiogenic markers associated with increased risk of preeclampsia among women initiating highly active antiretroviral therapy in pregnancy in the Mma Bana study, Botswana
    Kathleen M Powis
    Department of Internal Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 62:517-24. 2013
    ..Systemic angiogenic imbalance contributes to preeclampsia in HIV-uninfected women, but changes in angiogenic markers after highly active antiretroviral therapy (HAART) initiation have not been studied...
  13. pmc Prevalence of human papillomavirus genotypes and associated cervical squamous intraepithelial lesions in HIV-infected women in Botswana
    Iain J MacLeod
    Harvard School of Public Health AIDS Initiative, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    J Med Virol 83:1689-95. 2011
    ..The associations attributed to specific oncogenic HPV subtypes and cervical squamous intraepithelial lesions presented here provide critical information to inform future vaccine policy within Botswana...
  14. pmc High prevalence of hypertension and placental insufficiency, but no in utero HIV transmission, among women on HAART with stillbirths in Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e31580. 2012
    ..It is also unknown whether HIV infection of the fetus is associated with stillbirth...
  15. pmc Increased risk of preterm delivery among HIV-infected women randomized to protease versus nucleoside reverse transcriptase inhibitor-based HAART during pregnancy
    Kathleen M Powis
    Departments of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 204:506-14. 2011
    ..Protease inhibitor (PI)-based highly active antiretroviral therapy (HAART) use in pregnancy has been associated with preterm deliveries in some observational studies...
  16. pmc Effects of in utero antiretroviral exposure on longitudinal growth of HIV-exposed uninfected infants in Botswana
    Kathleen M Powis
    Department of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, MA, USA
    J Acquir Immune Defic Syndr 56:131-8. 2011
    ..The impact of in utero exposure to highly active antiretroviral therapy (HAART) on longitudinal growth of HIV-uninfected infants is unknown...
  17. pmc Highly active antiretroviral therapy versus zidovudine for prevention of mother-to-child transmission in a programmatic setting, Botswana
    Scott Dryden-Peterson
    Department of Medicine, Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 58:353-7. 2011
    ..Maternal HAART was associated with decreased prevention of mother-to-child transmission (P = 0.001) and improved HIV-free survival (P = 0.040) compared with zidovudine (with or without single-dose nevirapine) in a programmatic setting...
  18. ncbi request reprint Risk factors for mortality among human immunodeficiency virus-exposed and unexposed infants admitted to a neonatal intensive care unit in Botswana
    Rebecca M Zash
    Division of Infectious Disease, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States Botswana Harvard AIDS Institute Partnership for HIV Research and Education, Gaborone, Botswana
    J Paediatr Child Health 50:189-95. 2014
    ..We describe risk factors for NNU mortality in an area with high prevalence of human immunodeficiency virus (HIV)...
  19. pmc Birth weight for gestational age norms for a large cohort of infants born to HIV-negative women in Botswana compared with norms for U.S.-born black infants
    Lynn T Matthews
    Beth Israel Deaconess Medical Center, Division of Infectious Disease, Boston, MA 02115, USA
    BMC Pediatr 11:115. 2011
    ....
  20. doi request reprint Antiretroviral treatment initiation among HIV-infected pregnant women with low CD4(+) cell counts in Gaborone, Botswana
    Jennifer Y Chen
    Harvard Medical School, Boston, MA, USA
    J Acquir Immune Defic Syndr 54:102-6. 2010
    ..We analyzed rates of HIV testing, CD4 cell count testing, and HAART initiation during pregnancy...
  21. ncbi request reprint Low adherence to recommended infant feeding strategies among HIV-infected women: results from the pilot phase of a randomized trial to prevent mother-to-child transmission in Botswana
    Roger L Shapiro
    Botswana Harvard AIDS Institute Partnership, Botswana
    AIDS Educ Prev 15:221-30. 2003
    ..Breast examination may be a useful adjunct to self-report, but needs to be validated and standardized. Low adherence to infant feeding strategies that differ from local norms will reduce their effectiveness in preventing MTCT...
  22. ncbi request reprint Drawing lines in the sand: the boundaries of the HIV pandemic in perspective
    Roger L Shapiro
    Harvard School of Public Health, 651 Huntington Ave FXB 401, Boston, MA 02115, USA
    Soc Sci Med 55:2189-91. 2002
  23. pmc Hematologic and hepatic toxicities associated with antenatal and postnatal exposure to maternal highly active antiretroviral therapy among infants
    Woong Hwan Bae
    Harvard College, Harvard Faculty of Arts and Sciences, Harvard University, Cambridge, Massachusetts, USA
    AIDS 22:1633-40. 2008
    ..To assess hematologic and hepatic toxicities associated with in utero and breastfeeding exposure to maternal highly active antiretroviral therapy (HAART) among infants in Botswana...
  24. ncbi request reprint Surveillance for bacterial diarrhea and antimicrobial resistance in rural western Kenya, 1997-2003
    John T Brooks
    Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 43:393-401. 2006
    ..We examined the bacterial causes of diarrhea and monitored antimicrobial susceptibilities of isolates through clinic-based surveillance in a rural Kenyan community...
  25. ncbi request reprint Epidemiology of sporadic bloody diarrhea in rural Western Kenya
    John T Brooks
    Foodborne and Diarrheal Diseases Branch, and Biostatistics and Information Management Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 68:671-7. 2003
    ..Washing hands after defecating was protective. Providing safe drinking water and more latrines, and promoting hand washing could reduce the burden of illness from bloody diarrhea while limiting injudicious antimicrobial use...