ROGER L contact SHAPIRO

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Therapeutic levels of lopinavir in late pregnancy and abacavir passage into breast milk in the Mma Bana Study, Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Antivir Ther 18:585-90. 2013
  2. pmc High prevalence of hypertension and placental insufficiency, but no in utero HIV transmission, among women on HAART with stillbirths in Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e31580. 2012
  3. pmc Antiretroviral regimens in pregnancy and breast-feeding in Botswana
    R L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, 110 Francis St, Suite GB, Boston, MA 02215, USA
    N Engl J Med 362:2282-94. 2010
  4. pmc Risk factors for early and late transmission of HIV via breast-feeding among infants born to HIV-infected women in a randomized clinical trial in Botswana
    Roger L Shapiro
    Beth Israel Deaconess Medical Center, Division of Infectious Diseases, Boston, Massachusetts 02215, USA
    J Infect Dis 199:414-8. 2009
  5. ncbi request reprint Drawing lines in the sand: the boundaries of the HIV pandemic in perspective
    Roger L Shapiro
    Harvard School of Public Health, 651 Huntington Ave FXB 401, Boston, MA 02115, USA
    Soc Sci Med 55:2189-91. 2002
  6. ncbi request reprint Low adherence to recommended infant feeding strategies among HIV-infected women: results from the pilot phase of a randomized trial to prevent mother-to-child transmission in Botswana
    Roger L Shapiro
    Botswana Harvard AIDS Institute Partnership, Botswana
    AIDS Educ Prev 15:221-30. 2003
  7. ncbi request reprint Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    AIDS 20:1281-8. 2006
  8. ncbi request reprint Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study
    Ibou Thior
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 296:794-805. 2006
  9. ncbi request reprint Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk
    Roger L Shapiro
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 192:713-9. 2005
  10. ncbi request reprint Response to antiretroviral therapy after a single, peripartum dose of nevirapine
    Shahin Lockman
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 356:135-47. 2007

Research Grants

Collaborators

Detail Information

Publications16

  1. doi request reprint Therapeutic levels of lopinavir in late pregnancy and abacavir passage into breast milk in the Mma Bana Study, Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Antivir Ther 18:585-90. 2013
    ..Pharmacokinetic data for lopinavir in late pregnancy and in breastfeeding are limited, and no data for abacavir in breast milk are available...
  2. pmc High prevalence of hypertension and placental insufficiency, but no in utero HIV transmission, among women on HAART with stillbirths in Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e31580. 2012
    ..It is also unknown whether HIV infection of the fetus is associated with stillbirth...
  3. pmc Antiretroviral regimens in pregnancy and breast-feeding in Botswana
    R L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, 110 Francis St, Suite GB, Boston, MA 02215, USA
    N Engl J Med 362:2282-94. 2010
    ..The most effective highly active antiretroviral therapy (HAART) to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) in pregnancy and its efficacy during breast-feeding are unknown...
  4. pmc Risk factors for early and late transmission of HIV via breast-feeding among infants born to HIV-infected women in a randomized clinical trial in Botswana
    Roger L Shapiro
    Beth Israel Deaconess Medical Center, Division of Infectious Diseases, Boston, Massachusetts 02215, USA
    J Infect Dis 199:414-8. 2009
    ..001) predicted late MTCT. These findings support the safety of 1 month of breast-feeding in combination with maternal and infant antiretroviral prophylaxis. Trial registration. ClinicalTrials.gov identifiers: NCT00197691 and NCT00197652...
  5. ncbi request reprint Drawing lines in the sand: the boundaries of the HIV pandemic in perspective
    Roger L Shapiro
    Harvard School of Public Health, 651 Huntington Ave FXB 401, Boston, MA 02115, USA
    Soc Sci Med 55:2189-91. 2002
  6. ncbi request reprint Low adherence to recommended infant feeding strategies among HIV-infected women: results from the pilot phase of a randomized trial to prevent mother-to-child transmission in Botswana
    Roger L Shapiro
    Botswana Harvard AIDS Institute Partnership, Botswana
    AIDS Educ Prev 15:221-30. 2003
    ..Breast examination may be a useful adjunct to self-report, but needs to be validated and standardized. Low adherence to infant feeding strategies that differ from local norms will reduce their effectiveness in preventing MTCT...
  7. ncbi request reprint Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    AIDS 20:1281-8. 2006
    ..Single-dose nevirapine given to women and infants reduces mother-to-child HIV transmission, but nevirapine resistance develops in a large percentage of women...
  8. ncbi request reprint Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study
    Ibou Thior
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 296:794-805. 2006
    ..Postnatal transmission of human immunodeficiency virus-1 (HIV) via breastfeeding reverses gains achieved by perinatal antiretroviral interventions...
  9. ncbi request reprint Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk
    Roger L Shapiro
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 192:713-9. 2005
    ..The ability of highly active antiretroviral therapy (HAART) to reduce human immunodeficiency virus type 1 (HIV-1) RNA and DNA in breast milk has not been described...
  10. ncbi request reprint Response to antiretroviral therapy after a single, peripartum dose of nevirapine
    Shahin Lockman
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 356:135-47. 2007
    ..A single dose of nevirapine during labor reduces perinatal transmission of human immunodeficiency virus type 1 (HIV-1) but often leads to viral nevirapine resistance mutations in mothers and infants...
  11. ncbi request reprint Infant morbidity, mortality, and breast milk immunologic profiles among breast-feeding HIV-infected and HIV-uninfected women in Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Infect Dis 196:562-9. 2007
    ..Infants of human immunodeficiency virus (HIV)-infected women have high mortality, but the immunologic integrity and protection afforded by the breast milk of HIV-infected women is unknown...
  12. ncbi request reprint Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatment
    Roger L Shapiro
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 192:720-7. 2005
    ..The magnitude of infant antiretroviral (ARV) exposure from breast milk is unknown...
  13. doi request reprint Antiretroviral treatment initiation among HIV-infected pregnant women with low CD4(+) cell counts in Gaborone, Botswana
    Jennifer Y Chen
    Harvard Medical School, Boston, MA, USA
    J Acquir Immune Defic Syndr 54:102-6. 2010
    ..We analyzed rates of HIV testing, CD4 cell count testing, and HAART initiation during pregnancy...
  14. pmc Hematologic and hepatic toxicities associated with antenatal and postnatal exposure to maternal highly active antiretroviral therapy among infants
    Woong Hwan Bae
    Harvard College, Harvard Faculty of Arts and Sciences, Harvard University, Cambridge, Massachusetts, USA
    AIDS 22:1633-40. 2008
    ..To assess hematologic and hepatic toxicities associated with in utero and breastfeeding exposure to maternal highly active antiretroviral therapy (HAART) among infants in Botswana...
  15. ncbi request reprint Epidemiology of sporadic bloody diarrhea in rural Western Kenya
    John T Brooks
    Foodborne and Diarrheal Diseases Branch, and Biostatistics and Information Management Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 68:671-7. 2003
    ..Washing hands after defecating was protective. Providing safe drinking water and more latrines, and promoting hand washing could reduce the burden of illness from bloody diarrhea while limiting injudicious antimicrobial use...
  16. ncbi request reprint Surveillance for bacterial diarrhea and antimicrobial resistance in rural western Kenya, 1997-2003
    John T Brooks
    Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 43:393-401. 2006
    ..We examined the bacterial causes of diarrhea and monitored antimicrobial susceptibilities of isolates through clinic-based surveillance in a rural Kenyan community...

Research Grants5

  1. DIARRHEAL DISEASE STUDY
    Roger Shapiro; Fiscal Year: 2004
    ..The study will be carried out in three towns in southeast Botswana as a collaborative effort between the Harvard AIDS Institute and the AIDS/STD Unit of Botswana at Gaborone (AIDSBG). ..
  2. HAART to Prevent HIV Transmission to Infants In Botswana
    Roger Shapiro; Fiscal Year: 2007
    ..The Botswana government has given explicit support for this protocol to occur in four existing Botswana-Harvard AIDS Institute Partnership (BHP) locations to help guide future policy decisions. ..
  3. Short Breastfeeding and Cotrimoxazole among HIV-Exposed Infants in Botswana
    ROGER L contact SHAPIRO; Fiscal Year: 2010
    ..If proven effective, these simple interventions -- used in the novel manner proposed in this randomized study -- could be combined to optimize HIV-free infant survival throughout much of the developing world. ..
  4. Short Breastfeeding and Cotrimoxazole among HIV-Exposed Infants in Botswana
    ROGER L contact SHAPIRO; Fiscal Year: 2010
    ..If proven effective, these simple interventions -- used in the novel manner proposed in this randomized study -- could be combined to optimize HIV-free infant survival throughout much of the developing world. ..