Research Topics
| ROGER L contact SHAPIROSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
High prevalence of hypertension and placental insufficiency, but no in utero HIV transmission, among women on HAART with stillbirths in BotswanaRoger L Shapiro
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
PLoS ONE 7:e31580. 2012..It is also unknown whether HIV infection of the fetus is associated with stillbirth...- Antiretroviral regimens in pregnancy and breast-feeding in BotswanaR L Shapiro
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, 110 Francis St, Suite GB, Boston, MA 02215, USA
N Engl J Med 362:2282-94. 2010..The most effective highly active antiretroviral therapy (HAART) to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) in pregnancy and its efficacy during breast-feeding are unknown... - Risk factors for early and late transmission of HIV via breast-feeding among infants born to HIV-infected women in a randomized clinical trial in BotswanaRoger L Shapiro
Beth Israel Deaconess Medical Center, Division of Infectious Diseases, Boston, Massachusetts 02215, USA
J Infect Dis 199:414-8. 2009..001) predicted late MTCT. These findings support the safety of 1 month of breast-feeding in combination with maternal and infant antiretroviral prophylaxis. Trial registration. ClinicalTrials.gov identifiers: NCT00197691 and NCT00197652... 
Drawing lines in the sand: the boundaries of the HIV pandemic in perspectiveRoger L Shapiro
Harvard School of Public Health, 651 Huntington Ave FXB 401, Boston, MA 02115, USA
Soc Sci Med 55:2189-91. 2002- Low adherence to recommended infant feeding strategies among HIV-infected women: results from the pilot phase of a randomized trial to prevent mother-to-child transmission in BotswanaRoger L Shapiro
Botswana Harvard AIDS Institute Partnership, Botswana
AIDS Educ Prev 15:221-30. 2003..Breast examination may be a useful adjunct to self-report, but needs to be validated and standardized. Low adherence to infant feeding strategies that differ from local norms will reduce their effectiveness in preventing MTCT... - Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi StudyIbou Thior
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Mass 02115, USA
JAMA 296:794-805. 2006..These results demonstrate the risk of formula feeding to infants in sub-Saharan Africa, and the need for studies of alternative strategies. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00197587... - Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in BotswanaRoger L Shapiro
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
AIDS 20:1281-8. 2006..This strategy avoids the potential for maternal nevirapine resistance... - Infant morbidity, mortality, and breast milk immunologic profiles among breast-feeding HIV-infected and HIV-uninfected women in BotswanaRoger L Shapiro
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Infect Dis 196:562-9. 2007..Infants of human immunodeficiency virus (HIV)-infected women have high mortality, but the immunologic integrity and protection afforded by the breast milk of HIV-infected women is unknown... - Response to antiretroviral therapy after a single, peripartum dose of nevirapineShahin Lockman
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
N Engl J Med 356:135-47. 2007..A single dose of nevirapine during labor reduces perinatal transmission of human immunodeficiency virus type 1 (HIV-1) but often leads to viral nevirapine resistance mutations in mothers and infants... - Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milkRoger L Shapiro
Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Infect Dis 192:713-9. 2005..The ability of highly active antiretroviral therapy (HAART) to reduce human immunodeficiency virus type 1 (HIV-1) RNA and DNA in breast milk has not been described... - Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatmentRoger L Shapiro
Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Infect Dis 192:720-7. 2005..The magnitude of infant antiretroviral (ARV) exposure from breast milk is unknown... 
Antiretroviral treatment initiation among HIV-infected pregnant women with low CD4(+) cell counts in Gaborone, BotswanaJennifer Y Chen
Harvard Medical School, Boston, MA, USA
J Acquir Immune Defic Syndr 54:102-6. 2010..We analyzed rates of HIV testing, CD4 cell count testing, and HAART initiation during pregnancy...- Hematologic and hepatic toxicities associated with antenatal and postnatal exposure to maternal highly active antiretroviral therapy among infantsWoong Hwan Bae
Harvard College, Harvard Faculty of Arts and Sciences, Harvard University, Cambridge, Massachusetts, USA
AIDS 22:1633-40. 2008..To assess hematologic and hepatic toxicities associated with in utero and breastfeeding exposure to maternal highly active antiretroviral therapy (HAART) among infants in Botswana... - Epidemiology of sporadic bloody diarrhea in rural Western KenyaJohn T Brooks
Foodborne and Diarrheal Diseases Branch, and Biostatistics and Information Management Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Am J Trop Med Hyg 68:671-7. 2003..Washing hands after defecating was protective. Providing safe drinking water and more latrines, and promoting hand washing could reduce the burden of illness from bloody diarrhea while limiting injudicious antimicrobial use... - Surveillance for bacterial diarrhea and antimicrobial resistance in rural western Kenya, 1997-2003John T Brooks
Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Clin Infect Dis 43:393-401. 2006..More judicious use of appropriate antimicrobials is warranted. Efforts to prevent illness through provision of clean water, improved hygiene, and vaccine development should be strengthened...
Research Grants
- DIARRHEAL DISEASE STUDYRoger Shapiro; Fiscal Year: 2004..The study will be carried out in three towns in southeast Botswana as a collaborative effort between the Harvard AIDS Institute and the AIDS/STD Unit of Botswana at Gaborone (AIDSBG). ..
- HAART to Prevent HIV Transmission to Infants In BotswanaRoger Shapiro; Fiscal Year: 2007..The Botswana government has given explicit support for this protocol to occur in four existing Botswana-Harvard AIDS Institute Partnership (BHP) locations to help guide future policy decisions. ..
- Short Breastfeeding and Cotrimoxazole among HIV-Exposed Infants in BotswanaROGER L contact SHAPIRO; Fiscal Year: 2010..If proven effective, these simple interventions -- used in the novel manner proposed in this randomized study -- could be combined to optimize HIV-free infant survival throughout much of the developing world. ..
- Short Breastfeeding and Cotrimoxazole among HIV-Exposed Infants in BotswanaROGER L contact SHAPIRO; Fiscal Year: 2010..If proven effective, these simple interventions -- used in the novel manner proposed in this randomized study -- could be combined to optimize HIV-free infant survival throughout much of the developing world. ..