Nathan I Shapiro

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Crit Care Med 31:670-5. 2003
  2. ncbi request reprint A review of therapeutic attempts to recruit the microcirculation in patients with sepsis
    N I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Minerva Anestesiol 80:225-35. 2014
  3. pmc The association of near-infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction and mortality in emergency department patients with sepsis
    Nathan I Shapiro
    Department of Emergency Medicine and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Crit Care 15:R223. 2011
  4. ncbi request reprint A blueprint for a sepsis protocol
    Nathan I Shapiro
    Beth Israel Deaconess Medical Center, 1 Deaconess Road, CC2 W, Boston, MA 02215, USA
    Acad Emerg Med 12:352-9. 2005
  5. pmc Sepsis and the broken endothelium
    Nathan I Shapiro
    Department of Emergency Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Crit Care 15:135. 2011
  6. ncbi request reprint The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection
    Nathan Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
    Ann Emerg Med 48:583-90, 590.e1. 2006
  7. ncbi request reprint A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Masachusetts 02215, USA
    Shock 29:452-7. 2008
  8. pmc The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road CC2 W, Boston, MA 02215, USA
    Crit Care 14:R182. 2010
  9. doi request reprint A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Crit Care Med 37:96-104. 2009
  10. doi request reprint Skin biopsies demonstrate site-specific endothelial activation in mouse models of sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    J Vasc Res 46:495-502. 2009

Detail Information

Publications87

  1. ncbi request reprint Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Crit Care Med 31:670-5. 2003
    ....
  2. ncbi request reprint A review of therapeutic attempts to recruit the microcirculation in patients with sepsis
    N I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Minerva Anestesiol 80:225-35. 2014
    ..The objective of this review is to discuss human trials that have assessed interventions aimed at improving microcirculatory flow in patients with sepsis. ..
  3. pmc The association of near-infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction and mortality in emergency department patients with sepsis
    Nathan I Shapiro
    Department of Emergency Medicine and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Crit Care 15:R223. 2011
    ....
  4. ncbi request reprint A blueprint for a sepsis protocol
    Nathan I Shapiro
    Beth Israel Deaconess Medical Center, 1 Deaconess Road, CC2 W, Boston, MA 02215, USA
    Acad Emerg Med 12:352-9. 2005
    ..We propose and describe the Multiple Urgent Sepsis Therapies (MUST) protocol as a practical way to implement a comprehensive treatment plan using available evidence-based therapies...
  5. pmc Sepsis and the broken endothelium
    Nathan I Shapiro
    Department of Emergency Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Crit Care 15:135. 2011
    ....
  6. ncbi request reprint The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection
    Nathan Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
    Ann Emerg Med 48:583-90, 590.e1. 2006
    ....
  7. ncbi request reprint A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Masachusetts 02215, USA
    Shock 29:452-7. 2008
    ..Vascular endothelial cell growth factor and its signaling axis are important in the endothelial cell response to sepsis, and further elucidation of these mechanisms may lead to advances in future diagnostic and therapeutic opportunities...
  8. pmc The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road CC2 W, Boston, MA 02215, USA
    Crit Care 14:R182. 2010
    ..We investigated the association between biomarkers of endothelial cell activation and sepsis severity, organ dysfunction sequential organ failure assessment (SOFA) score, and death...
  9. doi request reprint A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Crit Care Med 37:96-104. 2009
    ..To define a biomarker panel to predict organ dysfunction, shock, and in-hospital mortality in emergency department (ED) patients with suspected sepsis...
  10. doi request reprint Skin biopsies demonstrate site-specific endothelial activation in mouse models of sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    J Vasc Res 46:495-502. 2009
    ..Skin biopsies allow for direct phenotyping of the endothelium in clinical settings...
  11. ncbi request reprint Barriers to the use of outpatient enoxaparin therapy in patients with deep venous thrombosis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Emerg Med 23:30-4. 2005
    ..To establish a clinical pathway for outpatient enoxaparin therapy in deep venous thrombosis (DVT) and then characterize its implementation and barriers to use...
  12. doi request reprint The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis
    Nathan I Shapiro
    Beth Israel Deaconess Medical Center, Boston, MA 02116, USA
    Ann Emerg Med 56:52-59.e1. 2010
    ..We assess the diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin (NGAL) to predict acute kidney injury in emergency department (ED) patients with suspected sepsis...
  13. ncbi request reprint Serum lactate as a predictor of mortality in emergency department patients with infection
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Emerg Med 45:524-8. 2005
    ..We determine whether a serum venous lactate is associated with an increased risk of death in ED patients with infection...
  14. pmc Identifying infected emergency department patients admitted to the hospital ward at risk of clinical deterioration and intensive care unit transfer
    Maura Kennedy
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Acad Emerg Med 17:1080-5. 2010
    ..Understanding risk factors leading to undertriage would be useful, but these factors are not well characterized...
  15. pmc Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock
    Michael A Puskarich
    Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Chest 143:1548-53. 2013
    ..We sought to compare the association of whole-blood lactate kinetics with survival in patients with septic shock undergoing early quantitative resuscitation...
  16. ncbi request reprint Mortality in Emergency Department Sepsis (MEDS) score predicts 1-year mortality
    Nathan I Shapiro
    Department of Emergency Medicine, Pulmonary and Critical Care Division, Beth Israel Deaconess Medical Center, Boston, MA
    Crit Care Med 35:192-8. 2007
    ..To assess the predictive performance for 1-yr mortality of the previously derived and validated Mortality in Emergency Department Sepsis (MEDS) score...
  17. doi request reprint Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest
    J Hope Kilgannon
    Department of Emergency Medicine, Cooper University Hospital, Camden, NJ 08103, USA
    Circulation 123:2717-22. 2011
    ..We aimed to define the relationship between supranormal oxygen tension and outcome in postresuscitation patients...
  18. doi request reprint Statin therapy is associated with decreased mortality in patients with infection
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Acad Emerg Med 16:230-4. 2009
    ..The objective was to investigate the association between statin therapy and mortality in emergency department (ED) patients with suspected infection...
  19. doi request reprint Multicenter observational study of the development of progressive organ dysfunction and therapeutic interventions in normotensive sepsis patients in the emergency department
    Ryan C Arnold
    Department of Emergency Medicine, Cooper University Hospital, Camden, NJ, USA
    Acad Emerg Med 20:433-40. 2013
    ....
  20. pmc Biomarkers of endothelial cell activation in early sepsis
    Simon Skibsted
    Department of Emergency Medicine and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Shock 39:427-32. 2013
    ..We hypothesize that (i) endothelial biomarkers will be associated with organ dysfunction and mortality in sepsis and that (ii) soluble fms-like tyrosine kinase 1 (sFlt-1) holds promise as a novel prognostic marker in sepsis...
  21. ncbi request reprint Performance of severity of illness scoring systems in emergency department patients with infection
    Michael D Howell
    Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Acad Emerg Med 14:709-14. 2007
    ....
  22. doi request reprint Reducing admissions utilizing the Boston Syncope Criteria
    Shamai A Grossman
    Division of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Emerg Med 42:345-52. 2012
    ..We previously developed criteria to identify patients with syncope at risk for adverse events. Although we proposed a theoretical substantial reduction in admission, these criteria were untested in actual practice...
  23. ncbi request reprint Occult hypoperfusion and mortality in patients with suspected infection
    Michael D Howell
    Beth Israel Deaconess Medical Center and Harvard Medical School, Department of Medicine, KB 23, 330 Brookline Avenue, Boston, MA 02215, USA
    Intensive Care Med 33:1892-9. 2007
    ..To determine, in the early stages of suspected clinically significant infection, the independent relationship of the presenting venous lactate level to 28-day in-hospital mortality...
  24. doi request reprint Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department
    Sarah M Perman
    Beth Israel Deaconess Medical Center, Boston, MA, USA
    Acad Emerg Med 18:219-22. 2011
    ..The authors hypothesized that an elevated BNP in patients presenting to the emergency department (ED) with suspected sepsis are at increased risk for development of adverse events...
  25. doi request reprint Initial management of septic patients with hyperglycemia in the noncritical care inpatient setting
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Med 125:670-8. 2012
    ..The impact of hyperglycemia and glycemic control in patients with infection before developing severe sepsis or shock remains undefined...
  26. pmc The feasibility and accuracy of point-of-care lactate measurement in emergency department patients with suspected infection
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02116, USA
    J Emerg Med 39:89-94. 2010
    ..Prior studies show that lactate is a useful prognostic marker in sepsis...
  27. doi request reprint Proof of principle: the predisposition, infection, response, organ failure sepsis staging system
    Michael D Howell
    Pulmonary and Critical Care Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Crit Care Med 39:322-7. 2011
    ..The objective of this investigation was to derive and validate a sepsis staging system based on the PIRO concept that risk stratifies patients with suspected infection...
  28. pmc Diabetes is not associated with increased mortality in emergency department patients with sepsis
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Emerg Med 58:438-44. 2011
    ..Our aim is to investigate the association of diabetes and initial glucose level with mortality in patients with suspected infection from the ED...
  29. pmc Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol
    Michael A Puskarich
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 39:2066-71. 2011
    ..We sought to determine the association between time to initial antibiotics and mortality of patients with septic shock treated with an emergency department-based early resuscitation protocol...
  30. pmc Predicting adverse outcomes in syncope
    Shamai A Grossman
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Emerg Med 33:233-9. 2007
    ..This pathway may be useful in identifying patients with syncope who are likely to have adverse outcome or critical interventions. Implementation and multicenter validation is needed before widespread application...
  31. ncbi request reprint Sex differences in the emergency department evaluation of elderly patients with syncope
    Shamai A Grossman
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, WCC2, One Deaconess Road, Boston, Massachusetts 02115, USA
    J Gerontol A Biol Sci Med Sci 60:1202-5. 2005
    ..Recent studies have shown significant differences in both presentation and therapy in women with coronary disease and congestive heart failure...
  32. doi request reprint Lactate clearance as a predictor of mortality in trauma patients
    Stephen R Odom
    Division of Acute Care Surgery, Trauma and Surgical Critical Care, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Trauma Acute Care Surg 74:999-1004. 2013
    ..Initial serum lactate has been associated with mortality in trauma patients. It is not known if lactate clearance is predictive of death in a broad cohort of trauma patients...
  33. doi request reprint Applying the Boston syncope criteria to near syncope
    Shamai A Grossman
    Department of Emergency Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Emerg Med 43:958-63. 2012
    ..The Boston Syncope Criteria (BSC) identify patients with syncope unlikely to have adverse outcomes and reduce hospitalizations. It is unclear whether these guidelines could reduce hospitalization in near syncope as well...
  34. doi request reprint Discordance between microcirculatory alterations and arterial pressure in patients with hemodynamic instability
    Ryan C Arnold
    Department of Emergency Medicine, Division of Critical Care Medicine, Cooper University Hospital, Camden, NJ 08103, USA
    J Crit Care 27:531.e1-7. 2012
    ..We selected cardiopulmonary bypass (CPB) patients with expected and rapidly reversible hemodynamic instability to test the hypothesis that microcirculatory alterations can occur independent of mean arterial pressure (MAP)...
  35. pmc Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
    JAMA 303:739-46. 2010
    ..Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department...
  36. ncbi request reprint Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Crit Care Med 34:1025-32. 2006
    ....
  37. pmc The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 36:2734-9. 2008
    ..Quantitative resuscitation consists of structured cardiovascular intervention targeting predefined hemodynamic end points. We sought to measure the treatment effect of quantitative resuscitation on mortality from sepsis...
  38. ncbi request reprint Charlson Index is associated with one-year mortality in emergency department patients with suspected infection
    Scott B Murray
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Acad Emerg Med 13:530-6. 2006
    ..The purpose of this study was to examine the utility of the Charlson Index as a predictor of one-year mortality in a population of ED patients with suspected infection...
  39. doi request reprint Risk factors for radiocontrast nephropathy after emergency department contrast-enhanced computerized tomography
    Stephen J Traub
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Acad Emerg Med 20:40-5. 2013
    ..The authors sought to determine the risk factors for RCN after emergency department (ED) contrast-enhanced computerized tomography (CECT)...
  40. doi request reprint Abnormal coagulation tests obtained in the emergency department are associated with mortality in patients with suspected infection
    Christopher M Fischer
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Emerg Med 42:127-32. 2012
    ..The hematologic system is often overlooked in the evaluation and management of patients with infection because it is poorly circumscribed and serves a multitude of functions...
  41. pmc Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis
    Jennifer V Pope
    Harvard Affiliated Emergency Medicine Residency, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Emerg Med 55:40-46.e1. 2010
    ..Abnormal (both low and high) central venous saturation (ScvO(2)) is associated with increased mortality in emergency department (ED) patients with suspected sepsis...
  42. doi request reprint The incremental benefit of a shortness-of-breath biomarker panel in emergency department patients with dyspnea
    Adam J Singer
    Department of Emergency Medicine, Stony Brook University, Stony Brook, NY, USA
    Acad Emerg Med 16:488-94. 2009
    ..The objective was to determine the incremental benefit of a shortness-of-breath (SOB) point-of-care biomarker panel on the diagnostic accuracy of emergency department (ED) patients presenting with dyspnea...
  43. doi request reprint Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock
    Sarah A Sterling
    Department of Emergency Medicine, University of Mississippi School of Medicine, Jackson, Mississippi 39216, USA
    Shock 40:11-4. 2013
    ..Some patients with septic shock present with hypotension and hyperlactatemia greater than 2 mmol/L (tissue dysoxic shock), whereas others have hypotension alone with normal lactate (vasoplegic shock)...
  44. doi request reprint N-acetylcysteine plus intravenous fluids versus intravenous fluids alone to prevent contrast-induced nephropathy in emergency computed tomography
    Stephen J Traub
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA Department of Emergency Medicine, Mayo Clinic Arizona, Phoenix, AZ Mayo Clinic College of Medicine, Rochester, MN Department of Emergency Medicine, Mayo Clinic Arizona, Phoenix, AZ Electronic address
    Ann Emerg Med 62:511-520.e25. 2013
    ..We test the hypothesis that N-acetylcysteine plus normal saline solution is more effective than normal saline solution alone in the prevention of contrast-induced nephropathy...
  45. doi request reprint Identifying patients with cellulitis who are likely to require inpatient admission after a stay in an ED observation unit
    Kathryn A Volz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Emerg Med 31:360-4. 2013
    ..Because institutional regulations typically limit EDOU stays to 24 hours, patients lacking a clinical response within this period will often be subsequently admitted to the hospital for further treatment...
  46. pmc Plasma levels of mitochondrial DNA in patients presenting to the emergency department with sepsis
    Michael A Puskarich
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina, USA
    Shock 38:337-40. 2012
    ..Mitochondrial DNA levels were negatively associated with organ dysfunction, suggesting that plasma mtDNA does not significantly contribute to the pathophysiology of sepsis...
  47. pmc Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*
    Sascha David
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Crit Care Med 40:3034-41. 2012
    ..We hypothesized that angiopoietin-2, a partial antagonist of the endothelium-stabilizing receptor Tie-2 secreted by endothelium, contributes to adverse outcomes in this disease...
  48. ncbi request reprint Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis
    Ryan C Arnold
    Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, New Jersey 08103, USA
    Shock 32:35-9. 2009
    ..These data provide rationale for a clinical trial of lactate clearance as a distinct end point of early sepsis resuscitation...
  49. pmc Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Shock 36:104-8. 2011
    ..4; CI, 0.8-2.3; P = 0.2) did not reach statistical significance. This study found a sepsis-specific activation of endothelium activation markers, particularly E-selectin and sFLT-1, in emergency department patients with hypotension...
  50. ncbi request reprint Do emergency department blood cultures change practice in patients with pneumonia?
    Maura Kennedy
    Harvard Medical School, Boston, MA, USA
    Ann Emerg Med 46:393-400. 2005
    ..The objective of this study is to determine the impact of emergency department (ED) blood cultures on antimicrobial therapy for patients with pneumonia...
  51. ncbi request reprint Simple triage scoring system predicting death and the need for critical care resources for use during epidemics
    Daniel Talmor
    Trauma Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Crit Care Med 35:1251-6. 2007
    ..To date, no standardized method for allocating scarce resources when the number of patients in need far exceeds capacity exists. We sought to derive and validate such a triage scheme...
  52. doi request reprint Who needs a blood culture? A prospectively derived and validated prediction rule
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Emerg Med 35:255-64. 2008
    ..We developed and validated a promising clinical decision rule for predicting bacteremia in patients with suspected infection...
  53. doi request reprint Characteristics of out-of-hospital shock care
    Henry E Wang
    Department of Emergency Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Crit Care Med 39:2431-9. 2011
    ..We sought to describe the incidence, demographic, clinical, and regional characteristics of patients with traumatic and nontraumatic medical shock treated by out-of-hospital emergency medical services...
  54. doi request reprint Point-of-care assessment of microvascular blood flow in critically ill patients
    Ryan C Arnold
    Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA
    Intensive Care Med 35:1761-6. 2009
    ..We hypothesized that a real-time point-of-care (POC) determination of the microcirculatory flow index (MFI), an established metric for assessing microcirculatory perfusion, agrees well with the conventional off-line analysis...
  55. doi request reprint Can benign etiologies predict benign outcomes in high-risk syncope patients?
    Shamai A Grossman
    Division of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Emerg Med 40:592-7. 2011
    ..We previously studied and validated risk factors for adverse outcomes or need for critical intervention in syncope...
  56. doi request reprint Risk factors for death in elderly emergency department patients with suspected infection
    Jeffrey M Caterino
    Department of Emergency Medicine, Ohio State University, Columbus, Ohio, USA
    J Am Geriatr Soc 57:1184-90. 2009
    ..To identify independent risk factors for death in elderly emergency department (ED) patients admitted for infection and to derive and validate a mortality-prediction rule for such patients...
  57. doi request reprint Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality
    J Hope Kilgannon
    Department of Emergency Medicine, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA
    JAMA 303:2165-71. 2010
    ..Laboratory investigations suggest that exposure to hyperoxia after resuscitation from cardiac arrest may worsen anoxic brain injury; however, clinical data are lacking...
  58. pmc Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock
    Michael A Puskarich
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Resuscitation 82:1289-93. 2011
    ..We sought to compare the outcomes of patients with cryptic versus overt shock treated with an emergency department (ED) based early sepsis resuscitation protocol...
  59. doi request reprint Anion gap as a screening tool for elevated lactate in patients with an increased risk of developing sepsis in the Emergency Department
    Matthew Berkman
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard University School of Medicine, Boston Massachusetts, USA
    J Emerg Med 36:391-4. 2009
    ..The objective of this study was to determine if a readily available anion gap (AG) could be used as a surrogate marker for abnormal lactate level in Emergency Department (ED) patients at risk for sepsis...
  60. doi request reprint Serum lactate is a better predictor of short-term mortality when stratified by C-reactive protein in adult emergency department patients hospitalized for a suspected infection
    Jeffrey P Green
    Department of Emergency Medicine, New York Hospital Queens, Weill Cornell Medical College, Flushing, NY, USA
    Ann Emerg Med 57:291-5. 2011
    ..We determine whether C-reactive protein (CRP) adds prognostic value to serum lactate levels when assessing mortality risk in emergency department (ED) patients admitted for a suspected infection...
  61. doi request reprint Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients
    David W Callaway
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Trauma 66:1040-4. 2009
    ..No study has defined the role of these markers in the triage and management of the normotensive injured elderly patient...
  62. doi request reprint Predictors of bacteremia in emergency department patients with suspected infection
    Maureen Chase
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Emerg Med 30:1691-7. 2012
    ..The goal of this study is to identify clinical variables associated with bacteremia. Such data could provide a rational basis for blood culture testing in emergency department (ED) patients with suspected infection...
  63. doi request reprint Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis
    Matijs van Meurs
    Center for Vascular Biology Research, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, Massachusetts, USA
    Shock 37:392-8. 2012
    ..These data suggest a protective role of adiponectin in diminishing microvascular organ-specific endothelial cell activation during sepsis...
  64. doi request reprint Inadequacy of temperature and white blood cell count in predicting bacteremia in patients with suspected infection
    Todd A Seigel
    Department of Emergency Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Emerg Med 42:254-9. 2012
    ..The presence of systemic inflammatory response criteria aids in recognition of infection, although the reliability of these markers is variable...
  65. doi request reprint Do outcomes of near syncope parallel syncope?
    Shamai A Grossman
    Division of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Am J Emerg Med 30:203-6. 2012
    ..Limited information on the evaluation of emergency department (ED) patients complaining of "near syncope" exists. Multiple studies of syncope exclude near syncope claiming near syncope is poorly defined and its definition is nonuniform...
  66. doi request reprint Evaluation of end-tidal carbon dioxide role in predicting elevated SOFA scores and lactic acidosis
    Daniel C McGillicuddy
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, WCC 2, Boston, MA 02215, USA
    Intern Emerg Med 4:41-4. 2009
    ..Larger confirmatory studies are required before final assessment...
  67. doi request reprint Leptin exacerbates sepsis-mediated morbidity and mortality
    Nathan I Shapiro
    Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 185:517-24. 2010
    ..Human septic patients have increased circulating sLR concentrations, which were correlated with disease severity indices. Together, these data support a pathogenic role for leptin signaling during sepsis...
  68. pmc Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 14:1072-8. 2007
    ....
  69. ncbi request reprint The effects of clinical workload on teaching in the emergency department
    Sean P Kelly
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Acad Emerg Med 14:526-31. 2007
    ..Academic emergency physicians have expressed concern that increased clinical workload and overcrowding adversely affect clinical teaching...
  70. doi request reprint The costs and cost-effectiveness of an integrated sepsis treatment protocol
    Daniel Talmor
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA
    Crit Care Med 36:1168-74. 2008
    ..Sepsis is associated with high mortality and treatment costs. International guidelines recommend the implementation of integrated sepsis protocols; however, the true cost and cost-effectiveness of these are unknown...
  71. ncbi request reprint The value of cardiac enzymes in elderly patients presenting to the emergency department with syncope
    Shamai A Grossman
    Department of Emergency Medicine Department of Medicine, Gerontology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Gerontol A Biol Sci Med Sci 58:1055-8. 2003
    ..Most patients admitted to the hospital from the emergency department (ED) with syncope do not have a myocardial infarction (MI), yet a common practice is to draw serial cardiac enzymes...
  72. doi request reprint Opportunities for Emergency Medical Services care of sepsis
    Henry E Wang
    Department of Emergency Medicine, University of Alabama at Birmingham, 619 19th Street South, JTN 266 Birmingham, AL 35249, USA
    Resuscitation 81:193-7. 2010
    ..EMS often provides care for sepsis, a life-threatening sequelae of infection. In this study of Emergency Department patients admitted to the hospital with an infection, we characterized the patients receiving initial care by EMS...
  73. pmc Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials
    Stephen Trzeciak
    Department of Emergency Medicine, Division of Critical Care Medicine, University of Medicine and Dentistry of New Jersey UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ, USA
    Acad Emerg Med 15:399-413. 2008
    ..We also present the scientific rationale for clinical trials of exogenous NO administration to treat microcirculatory dysfunction and augment microcirculatory blood flow in early sepsis therapy...
  74. doi request reprint Emergency department abnormal vital sign "triggers" program improves time to therapy
    Daniel C McGillicuddy
    Beth Israel Deaconess Medical Center FJO, SAC, JCR, Boston, MA, USA
    Acad Emerg Med 18:483-7. 2011
    ..A "trigger" system using vital sign abnormalities to initiate evaluation by physician was recently described as an effective rapid response method...
  75. doi request reprint Is telemetry useful in evaluating chest pain patients in an observation unit?
    Shamai A Grossman
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, WCC2, One Deaconess Road, Boston, MA 02115, USA
    Intern Emerg Med 6:543-6. 2011
    ....
  76. ncbi request reprint Guillain-Barré syndrome in the emergency department
    Daniel C McGillicuddy
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Ann Emerg Med 47:390-3. 2006
  77. doi request reprint Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection
    Adit A Ginde
    Department of Emergency Medicine, University of Colorado School of Medicine AAG, Aurora, CO, USA
    Acad Emerg Med 18:551-4. 2011
    ..We sought to evaluate the association between vitamin D status and sepsis severity and hypothesized that vitamin D insufficiency would be associated with increased sepsis severity...
  78. ncbi request reprint Isolated prehospital hypotension after traumatic injuries: a predictor of mortality?
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Emerg Med 25:175-9. 2003
    ..9 (1.1-7.6, p < 0.03). In this study of normotensive trauma center patients, prehospital hypotension was associated with increased risk of mortality and significant chest or abdominal injury...
  79. ncbi request reprint When is critical care medicine cost-effective? A systematic review of the cost-effectiveness literature
    Daniel Talmor
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Crit Care Med 34:2738-47. 2006
    ..Cost-effectiveness analyses (CEAs) have become increasingly common to aid decisions about the allocation of scarce healthcare resources...
  80. doi request reprint Industry relations with emergency medicine graduate medical education programs
    Terry Kowalenko
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
    Acad Emerg Med 16:1025-30. 2009
    ..In addition, the team used a question-answer format to provide educators and residents with a practical approach to these interactions. The SAEM Board of Directors endorsed the guidelines in June 2009...
  81. doi request reprint Summary of NIH Medical-Surgical Emergency Research Roundtable held on April 30 to May 1, 2009
    Amy H Kaji
    Department of Emergency Medicine, Harbor UCLA Medical Center, 1000 W Carson Street, Box 21, Torrance, CA 90509 2910, USA
    Ann Emerg Med 56:522-37. 2010
    ....
  82. ncbi request reprint Concordance of field and emergency department assessment in the prehospital management of patients with dyspnea
    Charles N Pozner
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Prehosp Emerg Care 7:440-4. 2003
    ..The authors evaluated the degree of agreement related to cardiac versus noncardiac sources of dyspnea between field and emergency department (ED) assessment of patients transported at the advanced life support level...
  83. ncbi request reprint National estimates of severe sepsis in United States emergency departments
    Henry E Wang
    Departments of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 35:1928-36. 2007
    ..We sought to determine national estimates of the number, timing, ED length of stay, and case distribution of patients presenting to the ED with suspected severe sepsis...
  84. ncbi request reprint Surviving sepsis outside the intensive care unit
    Michael D Howell
    Crit Care Med 35:1422-3. 2007
  85. ncbi request reprint National study of emergency department visits for sepsis, 1992 to 2001
    Matthew C Strehlow
    Stanford Kaiser Emergency Medicine Residency Program, Stanford University School of Medicine, Palo Alto, CA, USA
    Ann Emerg Med 48:326-31, 331.e1-3. 2006
    ..Inpatient discharge records from 1979 to 2000 show that hospitalizations for sepsis are increasing. We examine the epidemiology of sepsis in US EDs and the hypothesis that sepsis visits are increasing...
  86. ncbi request reprint Sepsis: the changing times
    Nathan I Shapiro
    Crit Care Med 33:2700-1. 2005
  87. ncbi request reprint Predicting mortality in the intensive care unit: man against machine
    Nathan I Shapiro
    Crit Care Med 34:932-3. 2006

Research Grants4

  1. Endothelial Cell Signaling and Microcirculatory Flow in Severe Sepsis
    Nathan Shapiro; Fiscal Year: 2009
    ..The information gained from this project may lead to new methods to diagnose and treat this important patient population. (End of Abstract) ..
  2. Endothelial Cell Signaling and Microcirculatory Flow in Severe Sepsis
    Nathan Shapiro; Fiscal Year: 2009
    ..The information gained from this project may lead to new methods to diagnose and treat this important patient population. (End of Abstract) ..
  3. Endothelial Cell Signaling and Microcirculatory Flow in Severe Sepsis
    Nathan I Shapiro; Fiscal Year: 2010
    ..The information gained from this project may lead to new methods to diagnose and treat this important patient population. (End of Abstract) ..