Research Topics
Genomes and Genes | Nathan I ShapiroSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction ruleNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Crit Care Med 31:670-5. 2003..As new therapies become available for patients with sepsis syndromes, the ability to predict mortality risk may be helpful in triage and treatment decisions...
The association of near-infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction and mortality in emergency department patients with sepsisNathan I Shapiro
Department of Emergency Medicine and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Crit Care 15:R223. 2011....- A blueprint for a sepsis protocolNathan I Shapiro
Beth Israel Deaconess Medical Center, 1 Deaconess Road, CC2 W, Boston, MA 02215, USA
Acad Emerg Med 12:352-9. 2005..We propose and describe the Multiple Urgent Sepsis Therapies (MUST) protocol as a practical way to implement a comprehensive treatment plan using available evidence-based therapies... 
The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsisNathan I Shapiro
Beth Israel Deaconess Medical Center, Boston, MA 02116, USA
Ann Emerg Med 56:52-59.e1. 2010..We assess the diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin (NGAL) to predict acute kidney injury in emergency department (ED) patients with suspected sepsis...- Sepsis and the broken endotheliumNathan I Shapiro
Department of Emergency Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Crit Care 15:135. 2011.... - A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsisNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Masachusetts 02215, USA
Shock 29:452-7. 2008..Vascular endothelial cell growth factor and its signaling axis are important in the endothelial cell response to sepsis, and further elucidation of these mechanisms may lead to advances in future diagnostic and therapeutic opportunities... - The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infectionNathan Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
Ann Emerg Med 48:583-90, 590.e1. 2006.... - The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsisNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road CC2 W, Boston, MA 02215, USA
Crit Care 14:R182. 2010..We investigated the association between biomarkers of endothelial cell activation and sepsis severity, organ dysfunction sequential organ failure assessment (SOFA) score, and death... - A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsisNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Crit Care Med 37:96-104. 2009..To define a biomarker panel to predict organ dysfunction, shock, and in-hospital mortality in emergency department (ED) patients with suspected sepsis... - Skin biopsies demonstrate site-specific endothelial activation in mouse models of sepsisNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
J Vasc Res 46:495-502. 2009..Skin biopsies allow for direct phenotyping of the endothelium in clinical settings... - Barriers to the use of outpatient enoxaparin therapy in patients with deep venous thrombosisNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am J Emerg Med 23:30-4. 2005..To establish a clinical pathway for outpatient enoxaparin therapy in deep venous thrombosis (DVT) and then characterize its implementation and barriers to use... - Serum lactate as a predictor of mortality in emergency department patients with infectionNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Ann Emerg Med 45:524-8. 2005..We determine whether a serum venous lactate is associated with an increased risk of death in ED patients with infection... - Identifying infected emergency department patients admitted to the hospital ward at risk of clinical deterioration and intensive care unit transferMaura Kennedy
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Acad Emerg Med 17:1080-5. 2010..Understanding risk factors leading to undertriage would be useful, but these factors are not well characterized... - Mortality in Emergency Department Sepsis (MEDS) score predicts 1-year mortalityNathan I Shapiro
Department of Emergency Medicine, Pulmonary and Critical Care Division, Beth Israel Deaconess Medical Center, Boston, MA
Crit Care Med 35:192-8. 2007..To assess the predictive performance for 1-yr mortality of the previously derived and validated Mortality in Emergency Department Sepsis (MEDS) score... - Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrestJ Hope Kilgannon
Department of Emergency Medicine, Cooper University Hospital, Camden, NJ 08103, USA
Circulation 123:2717-22. 2011..We aimed to define the relationship between supranormal oxygen tension and outcome in postresuscitation patients... - Statin therapy is associated with decreased mortality in patients with infectionMichael W Donnino
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Acad Emerg Med 16:230-4. 2009..The objective was to investigate the association between statin therapy and mortality in emergency department (ED) patients with suspected infection... - Performance of severity of illness scoring systems in emergency department patients with infectionMichael D Howell
Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Acad Emerg Med 14:709-14. 2007.... - Reducing admissions utilizing the Boston Syncope CriteriaShamai A Grossman
Division of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Emerg Med 42:345-52. 2012..We previously developed criteria to identify patients with syncope at risk for adverse events. Although we proposed a theoretical substantial reduction in admission, these criteria were untested in actual practice... - Occult hypoperfusion and mortality in patients with suspected infectionMichael D Howell
Beth Israel Deaconess Medical Center and Harvard Medical School, Department of Medicine, KB 23, 330 Brookline Avenue, Boston, MA 02215, USA
Intensive Care Med 33:1892-9. 2007..To determine, in the early stages of suspected clinically significant infection, the independent relationship of the presenting venous lactate level to 28-day in-hospital mortality... - Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency departmentSarah M Perman
Beth Israel Deaconess Medical Center, Boston, MA, USA
Acad Emerg Med 18:219-22. 2011..The authors hypothesized that an elevated BNP in patients presenting to the emergency department (ED) with suspected sepsis are at increased risk for development of adverse events... - Initial management of septic patients with hyperglycemia in the noncritical care inpatient settingPhilipp Schuetz
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am J Med 125:670-8. 2012..The impact of hyperglycemia and glycemic control in patients with infection before developing severe sepsis or shock remains undefined... - Proof of principle: the predisposition, infection, response, organ failure sepsis staging systemMichael D Howell
Pulmonary and Critical Care Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Crit Care Med 39:322-7. 2011..The objective of this investigation was to derive and validate a sepsis staging system based on the PIRO concept that risk stratifies patients with suspected infection... - The feasibility and accuracy of point-of-care lactate measurement in emergency department patients with suspected infectionNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02116, USA
J Emerg Med 39:89-94. 2010..Prior studies show that lactate is a useful prognostic marker in sepsis... - Sex differences in the emergency department evaluation of elderly patients with syncopeShamai A Grossman
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, WCC2, One Deaconess Road, Boston, Massachusetts 02115, USA
J Gerontol A Biol Sci Med Sci 60:1202-5. 2005..Recent studies have shown significant differences in both presentation and therapy in women with coronary disease and congestive heart failure... - Diabetes is not associated with increased mortality in emergency department patients with sepsisPhilipp Schuetz
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Ann Emerg Med 58:438-44. 2011..Our aim is to investigate the association of diabetes and initial glucose level with mortality in patients with suspected infection from the ED... - Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocolMichael A Puskarich
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
Crit Care Med 39:2066-71. 2011..We sought to determine the association between time to initial antibiotics and mortality of patients with septic shock treated with an emergency department-based early resuscitation protocol... - Predicting adverse outcomes in syncopeShamai A Grossman
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Emerg Med 33:233-9. 2007..This pathway may be useful in identifying patients with syncope who are likely to have adverse outcome or critical interventions. Implementation and multicenter validation is needed before widespread application... - Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trialAlan E Jones
Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
JAMA 303:739-46. 2010..Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department... - The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysisAlan E Jones
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
Crit Care Med 36:2734-9. 2008..Quantitative resuscitation consists of structured cardiovascular intervention targeting predefined hemodynamic end points. We sought to measure the treatment effect of quantitative resuscitation on mortality from sepsis... - Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocolNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Crit Care Med 34:1025-32. 2006..No statistically significant decrease in mortality was demonstrated, as this trial was not sufficiently powered to assess mortality benefits... - Charlson Index is associated with one-year mortality in emergency department patients with suspected infectionScott B Murray
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Acad Emerg Med 13:530-6. 2006..0; moderate, odds ratio of 2.5; and high, odds ratio of 4.7. CONCLUSIONS: This study suggests that the Charlson Index predicts one-year mortality among ED patients with suspected infection... - Abnormal coagulation tests obtained in the emergency department are associated with mortality in patients with suspected infectionChristopher M Fischer
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
J Emerg Med 42:127-32. 2012..The hematologic system is often overlooked in the evaluation and management of patients with infection because it is poorly circumscribed and serves a multitude of functions... - Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsisJennifer V Pope
Harvard Affiliated Emergency Medicine Residency, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Ann Emerg Med 55:40-46.e1. 2010..Abnormal (both low and high) central venous saturation (ScvO(2)) is associated with increased mortality in emergency department (ED) patients with suspected sepsis... - The incremental benefit of a shortness-of-breath biomarker panel in emergency department patients with dyspneaAdam J Singer
Department of Emergency Medicine, Stony Brook University, Stony Brook, NY, USA
Acad Emerg Med 16:488-94. 2009..The objective was to determine the incremental benefit of a shortness-of-breath (SOB) point-of-care biomarker panel on the diagnostic accuracy of emergency department (ED) patients presenting with dyspnea... - Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*Sascha David
From the Departments of Medicine SD, AM, CCG, EVK, sak, SMP and Emergency Medicine MY, Nis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA Center for Vascular Biology Research SD, AM, CCG, MY, EVK, sak, Nis, SMP, Beth Israel Deaconess Medical Center, Boston, MA Department of Medicine JB, Massachusetts General Hospital and Harvard Medical School, Boston, MA and Howard Hughes Medical Institute SAK, Chevy Chase, MD
Crit Care Med 40:3034-41. 2012..We hypothesized that angiopoietin-2, a partial antagonist of the endothelium-stabilizing receptor Tie-2 secreted by endothelium, contributes to adverse outcomes in this disease... - Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsisRyan C Arnold
Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, New Jersey 08103, USA
Shock 32:35-9. 2009..These data provide rationale for a clinical trial of lactate clearance as a distinct end point of early sepsis resuscitation... - Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotensionPhilipp Schuetz
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Shock 36:104-8. 2011..4; CI, 0.8-2.3; P = 0.2) did not reach statistical significance. This study found a sepsis-specific activation of endothelium activation markers, particularly E-selectin and sFLT-1, in emergency department patients with hypotension... - Do emergency department blood cultures change practice in patients with pneumonia?Maura Kennedy
Harvard Medical School, Boston, MA, USA
Ann Emerg Med 46:393-400. 2005..The objective of this study is to determine the impact of emergency department (ED) blood cultures on antimicrobial therapy for patients with pneumonia... - Characteristics of out-of-hospital shock careHenry E Wang
Department of Emergency Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Crit Care Med 39:2431-9. 2011..We sought to describe the incidence, demographic, clinical, and regional characteristics of patients with traumatic and nontraumatic medical shock treated by out-of-hospital emergency medical services... - Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortalityJ Hope Kilgannon
Department of Emergency Medicine, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA
JAMA 303:2165-71. 2010..Laboratory investigations suggest that exposure to hyperoxia after resuscitation from cardiac arrest may worsen anoxic brain injury; however, clinical data are lacking... - Can benign etiologies predict benign outcomes in high-risk syncope patients?Shamai A Grossman
Division of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Emerg Med 40:592-7. 2011..We previously studied and validated risk factors for adverse outcomes or need for critical intervention in syncope... - Who needs a blood culture? A prospectively derived and validated prediction ruleNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Emerg Med 35:255-64. 2008..We developed and validated a promising clinical decision rule for predicting bacteremia in patients with suspected infection... - Risk factors for death in elderly emergency department patients with suspected infectionJeffrey M Caterino
Department of Emergency Medicine, Ohio State University, Columbus, Ohio, USA
J Am Geriatr Soc 57:1184-90. 2009..To identify independent risk factors for death in elderly emergency department (ED) patients admitted for infection and to derive and validate a mortality-prediction rule for such patients... - Point-of-care assessment of microvascular blood flow in critically ill patientsRyan C Arnold
Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA
Intensive Care Med 35:1761-6. 2009..We hypothesized that a real-time point-of-care (POC) determination of the microcirculatory flow index (MFI), an established metric for assessing microcirculatory perfusion, agrees well with the conventional off-line analysis... - Simple triage scoring system predicting death and the need for critical care resources for use during epidemicsDaniel Talmor
Trauma Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Crit Care Med 35:1251-6. 2007..To date, no standardized method for allocating scarce resources when the number of patients in need far exceeds capacity exists. We sought to derive and validate such a triage scheme... - Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shockMichael A Puskarich
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
Resuscitation 82:1289-93. 2011..We sought to compare the outcomes of patients with cryptic versus overt shock treated with an emergency department (ED) based early sepsis resuscitation protocol... - Serum lactate is a better predictor of short-term mortality when stratified by C-reactive protein in adult emergency department patients hospitalized for a suspected infectionJeffrey P Green
Department of Emergency Medicine, New York Hospital Queens, Weill Cornell Medical College, Flushing, NY, USA
Ann Emerg Med 57:291-5. 2011..We determine whether C-reactive protein (CRP) adds prognostic value to serum lactate levels when assessing mortality risk in emergency department (ED) patients admitted for a suspected infection... - Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patientsDavid W Callaway
Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Trauma 66:1040-4. 2009..No study has defined the role of these markers in the triage and management of the normotensive injured elderly patient... - Anion gap as a screening tool for elevated lactate in patients with an increased risk of developing sepsis in the Emergency DepartmentMatthew Berkman
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard University School of Medicine, Boston Massachusetts, USA
J Emerg Med 36:391-4. 2009..The objective of this study was to determine if a readily available anion gap (AG) could be used as a surrogate marker for abnormal lactate level in Emergency Department (ED) patients at risk for sepsis... - Applying the Boston syncope criteria to near syncopeShamai A Grossman
Department of Emergency Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts
J Emerg Med 43:958-63. 2012..The Boston Syncope Criteria (BSC) identify patients with syncope unlikely to have adverse outcomes and reduce hospitalizations. It is unclear whether these guidelines could reduce hospitalization in near syncope as well... - Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsisMatijs van Meurs
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, Massachusetts, USA
Shock 37:392-8. 2012..These data suggest a protective role of adiponectin in diminishing microvascular organ-specific endothelial cell activation during sepsis... - Inadequacy of temperature and white blood cell count in predicting bacteremia in patients with suspected infectionTodd A Seigel
Department of Emergency Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
J Emerg Med 42:254-9. 2012..The presence of systemic inflammatory response criteria aids in recognition of infection, although the reliability of these markers is variable... - Do outcomes of near syncope parallel syncope?Shamai A Grossman
Division of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Am J Emerg Med 30:203-6. 2012..Multiple studies of syncope exclude near syncope claiming near syncope is poorly defined and its definition is nonuniform... - Evaluation of end-tidal carbon dioxide role in predicting elevated SOFA scores and lactic acidosisDaniel C McGillicuddy
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, WCC 2, Boston, MA 02215, USA
Intern Emerg Med 4:41-4. 2009..Larger confirmatory studies are required before final assessment... - Leptin exacerbates sepsis-mediated morbidity and mortalityNathan I Shapiro
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Immunol 185:517-24. 2010..Human septic patients have increased circulating sLR concentrations, which were correlated with disease severity indices. Together, these data support a pathogenic role for leptin signaling during sepsis... - Plasma levels of mitochondrial DNA in patients presenting to the emergency department with sepsisMichael A Puskarich
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina, USA
Shock 38:337-40. 2012..Mitochondrial DNA levels were negatively associated with organ dysfunction, suggesting that plasma mtDNA does not significantly contribute to the pathophysiology of sepsis... - Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settingsAlan E Jones
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
Acad Emerg Med 14:1072-8. 2007.... - The effects of clinical workload on teaching in the emergency departmentSean P Kelly
Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Acad Emerg Med 14:526-31. 2007..Academic emergency physicians have expressed concern that increased clinical workload and overcrowding adversely affect clinical teaching... - The costs and cost-effectiveness of an integrated sepsis treatment protocolDaniel Talmor
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA
Crit Care Med 36:1168-74. 2008..Sepsis is associated with high mortality and treatment costs. International guidelines recommend the implementation of integrated sepsis protocols; however, the true cost and cost-effectiveness of these are unknown... - Predictors of bacteremia in emergency department patients with suspected infectionMaureen Chase
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA Electronic address
Am J Emerg Med 30:1691-7. 2012..The goal of this study is to identify clinical variables associated with bacteremia. Such data could provide a rational basis for blood culture testing in emergency department (ED) patients with suspected infection... - The value of cardiac enzymes in elderly patients presenting to the emergency department with syncopeShamai A Grossman
Department of Emergency Medicine Department of Medicine, Gerontology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Gerontol A Biol Sci Med Sci 58:1055-8. 2003..Most patients admitted to the hospital from the emergency department (ED) with syncope do not have a myocardial infarction (MI), yet a common practice is to draw serial cardiac enzymes... - Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trialsStephen Trzeciak
Department of Emergency Medicine, Division of Critical Care Medicine, University of Medicine and Dentistry of New Jersey UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ, USA
Acad Emerg Med 15:399-413. 2008..We also present the scientific rationale for clinical trials of exogenous NO administration to treat microcirculatory dysfunction and augment microcirculatory blood flow in early sepsis therapy... - Opportunities for Emergency Medical Services care of sepsisHenry E Wang
Department of Emergency Medicine, University of Alabama at Birmingham, 619 19th Street South, JTN 266 Birmingham, AL 35249, USA
Resuscitation 81:193-7. 2010..EMS often provides care for sepsis, a life-threatening sequelae of infection. In this study of Emergency Department patients admitted to the hospital with an infection, we characterized the patients receiving initial care by EMS... - Emergency department abnormal vital sign "triggers" program improves time to therapyDaniel C McGillicuddy
Beth Israel Deaconess Medical Center FJO, SAC, JCR, Boston, MA, USA
Acad Emerg Med 18:483-7. 2011..A "trigger" system using vital sign abnormalities to initiate evaluation by physician was recently described as an effective rapid response method... - Is telemetry useful in evaluating chest pain patients in an observation unit?Shamai A Grossman
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, WCC2, One Deaconess Road, Boston, MA 02115, USA
Intern Emerg Med 6:543-6. 2011.... - Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infectionAdit A Ginde
Department of Emergency Medicine, University of Colorado School of Medicine AAG, Aurora, CO, USA
Acad Emerg Med 18:551-4. 2011..We sought to evaluate the association between vitamin D status and sepsis severity and hypothesized that vitamin D insufficiency would be associated with increased sepsis severity... - Guillain-Barré syndrome in the emergency departmentDaniel C McGillicuddy
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Ann Emerg Med 47:390-3. 2006 - Isolated prehospital hypotension after traumatic injuries: a predictor of mortality?Nathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
J Emerg Med 25:175-9. 2003..9 (1.1-7.6, p < 0.03). In this study of normotensive trauma center patients, prehospital hypotension was associated with increased risk of mortality and significant chest or abdominal injury... - When is critical care medicine cost-effective? A systematic review of the cost-effectiveness literatureDaniel Talmor
Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Crit Care Med 34:2738-47. 2006..Cost-effectiveness analyses (CEAs) have become increasingly common to aid decisions about the allocation of scarce healthcare resources... - Summary of NIH Medical-Surgical Emergency Research Roundtable held on April 30 to May 1, 2009Amy H Kaji
Department of Emergency Medicine, Harbor UCLA Medical Center, 1000 W Carson Street, Box 21, Torrance, CA 90509 2910, USA
Ann Emerg Med 56:522-37. 2010.... - Industry relations with emergency medicine graduate medical education programsTerry Kowalenko
Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA
Acad Emerg Med 16:1025-30. 2009..In addition, the team used a question-answer format to provide educators and residents with a practical approach to these interactions. The SAEM Board of Directors endorsed the guidelines in June 2009... - Concordance of field and emergency department assessment in the prehospital management of patients with dyspneaCharles N Pozner
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Prehosp Emerg Care 7:440-4. 2003..The authors evaluated the degree of agreement related to cardiac versus noncardiac sources of dyspnea between field and emergency department (ED) assessment of patients transported at the advanced life support level... - National estimates of severe sepsis in United States emergency departmentsHenry E Wang
Departments of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Crit Care Med 35:1928-36. 2007..We sought to determine national estimates of the number, timing, ED length of stay, and case distribution of patients presenting to the ED with suspected severe sepsis... - Surviving sepsis outside the intensive care unitMichael D Howell
Crit Care Med 35:1422-3. 2007 - National study of emergency department visits for sepsis, 1992 to 2001Matthew C Strehlow
Stanford Kaiser Emergency Medicine Residency Program, Stanford University School of Medicine, Palo Alto, CA, USA
Ann Emerg Med 48:326-31, 331.e1-3. 2006..Inpatient discharge records from 1979 to 2000 show that hospitalizations for sepsis are increasing. We examine the epidemiology of sepsis in US EDs and the hypothesis that sepsis visits are increasing... - Sepsis: the changing timesNathan I Shapiro
Crit Care Med 33:2700-1. 2005 - Predicting mortality in the intensive care unit: man against machineNathan I Shapiro
Crit Care Med 34:932-3. 2006
Research Grants
- Endothelial Cell Signaling and Microcirculatory Flow in Severe SepsisNathan Shapiro; Fiscal Year: 2009..The information gained from this project may lead to new methods to diagnose and treat this important patient population. (End of Abstract) ..
- Endothelial Cell Signaling and Microcirculatory Flow in Severe SepsisNathan Shapiro; Fiscal Year: 2009..The information gained from this project may lead to new methods to diagnose and treat this important patient population. (End of Abstract) ..
- Endothelial Cell Signaling and Microcirculatory Flow in Severe SepsisNathan I Shapiro; Fiscal Year: 2010..The information gained from this project may lead to new methods to diagnose and treat this important patient population. (End of Abstract) ..