Research Topics
Species | Khalid A ShahSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylationK Shah
Laboratory of Molecular Biology, Wageningen University and Research Center, 6703 HA Wageningen, The Netherlands
J Biol Chem 276:41263-9. 2001....- Current advances in molecular imaging of gene and cell therapy for cancerKhalid Shah
Center for Molecular Imaging, Massachusetts Gneral Hospital, Boston, MA, USA
Cancer Biol Ther 4:518-23. 2005..In this review we will discuss different imaging modalities that have found applications in gene and cell therapies of cancer... - HSV amplicon vectors for cancer therapyKhalid Shah
Center for Molecular Imaging Research and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Curr Gene Ther 6:361-70. 2006..Amplicon vectors have also proven to be a versatile tool to explore imaging modalities to monitor gene delivery and tumor responses to therapeutic intervention... - MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumorsAdly Yacoub
Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
Cancer Biol Ther 7:917-33. 2008.... 
Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma modelKhalid Shah
Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 28:4406-13. 2008..These studies demonstrate the utility of bimodal viral vectors and real-time imaging in evaluating fate of NSCs in diseased models and thus provide a platform for accelerating cell-based therapies for CNS disorders...- Mesenchymal stem cells engineered for cancer therapyKhalid Shah
Massachusetts General Hospital, Harvard Medical School, Boston, USA
Adv Drug Deliv Rev 64:739-48. 2012..This review aims to provide an in depth status of current MSC-based cancer therapies, as well as the prospects for their clinical translation... - In vivo imaging of S-TRAIL-mediated tumor regression and apoptosisKhalid Shah
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Mol Ther 11:926-31. 2005..The use of S-TRAIL as a therapeutic protein and the ability to image noninvasively both apoptosis and any other cellular events in real time have important clinical implications... - Molecular optical imaging: applications leading to the development of present day therapeuticsKhalid Shah
Center for Molecular Imaging Research, Massachusetts General Hospital, MA 02129, USA
NeuroRx 2:215-25. 2005..Furthermore, we will also shed some light on the use of these imaging modalities in neurotherapeutics, for example imaging different parameters of vector-mediated gene expression in glioma tumors and stem cell tracking in vivo... - Glioma therapy and real-time imaging of neural precursor cell migration and tumor regressionKhalid Shah
Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, 13th Street, Building 149, Charlestown, MA 02129, USA
Ann Neurol 57:34-41. 2005..These studies demonstrate the potential of NPCs as therapeutically effective delivery vehicles for the treatment of gliomas and also provide important tools to evaluate the migration of NPCs and changes in glioma burden in vivo... - Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapyKhalid Shah
Molecular Neurogenetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 64:3236-42. 2004..This study serves as a template for design of recombinant proteins to enhance and control apoptosis of tumor cells via specific viral proteases and for use of viral proteases as in vivo reporters for cancer therapy... - Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivoKhalid Shah
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Oncogene 22:6865-72. 2003.... - Neural precursor cells and their role in neuro-oncologyKhalid Shah
Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA, USA
Dev Neurosci 26:118-30. 2004..Examples are provided of monitoring migration of NPCs by bioluminescence imaging in living animals and of using them to deliver the apoptotic protein, TRAIL, to kill tumor cells... - MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomasMaarten F Corsten
Center for Molecular Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Cancer Res 67:8994-9000. 2007..Furthermore, our findings provide the basis for developing combination therapies using miRNA modulation and cytotoxic tumor therapies... - In vivo tracking of neural progenitor cell migration to glioblastomasYi Tang
Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Hum Gene Ther 14:1247-54. 2003..These results confirm the migratory capability of NPCs over considerable distances and their preferential accumulation in brain tumors on CNS rather than peripheral injection... - Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and TemozolomideShawn Hingtgen
Massachusetts General Hospital, Harvard Medical School, 13th Street, Charlestown, MA 02129, USA
Mol Cancer Ther 7:3575-85. 2008..This study elucidates novel means of delivering S-TRAIL to gliomas and suggests combination of clinically relevant temozolomide and S-TRAIL may represent a new therapeutic option with increased potency for glioblastoma patients... - Imaging of stem cell recruitment to ischemic infarcts in a murine modelDong-Eog Kim
Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Charlestown, Mass, USA
Stroke 35:952-7. 2004..NPC are recruited to infarcts with both parenchymal and cerebrospinal fluid administration, but higher initial photon counts suggest that cerebrospinal fluid administration is more efficient at early infarct seeding... 
Imaging neural stem cell fate in mouse model of gliomaKhalid Shah
Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
Curr Protoc Stem Cell Biol . 2009..With the cells labeled in this manner, bioluminescence imaging can be used to study the fate of stem cells in glioma-bearing brains in vivo...- Visualizing the dynamics of EGFR activity and antiglioma therapies in vivoEsther Arwert
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Cancer Res 67:7335-42. 2007..This study serves as a template to follow the role of growth factor receptor expression in tumor progression and to image therapeutic efficacy of targeted therapies in cancer... - Performance of the red-shifted fluorescent proteins in deep-tissue molecular imaging applicationsNikolaos C Deliolanis
Massachusetts General Hospital and Harvard Medical School, Center for Molecular Imaging Research, Laboratory for Bio optics and Molecular Imaging, Charlestown, Massachusetts 02139, USA
J Biomed Opt 13:044008. 2008.... - Imaging fate of stem cells at a cellular resolution in the brains of miceKhalid Shah
Molecular Neurotherapy and Imaging Laboratory, Department of Radiology and Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Methods Mol Biol 680:91-101. 2011..The ability to monitor fate of stem cells in disease models enables studies aimed at evaluating the efficacy of their treatment for CNS disorders... - In vivo imaging of the dynamics of different variants of EGFR in glioblastomasKhalid Shah
Molecular Neurotherapy and Imaging Laboratory, Department of Radiology and Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Methods Mol Biol 680:153-64. 2011..The protocol details characterization of engineered glioma cells in culture, surgical preparation, craniotomy, cell implantation, animal recovery, and imaging procedures to study kinetics of EGFR expression and GBM progression... - Feasibility of in vivo imaging of fluorescent proteins using lifetime contrastAnand T N Kumar
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Opt Lett 34:2066-8. 2009..These results suggest the potential for exploiting fluorescence lifetime for imaging FPs for a variety of whole-body small-animal imaging applications... - In vivo imaging of HIV protease activity in amplicon vector-transduced gliomasKhalid Shah
Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Cancer Res 64:273-8. 2004..These findings may be directly applicable in using viral protease expression as a transgene marker in tumor therapy and may have implications in testing the efficacy of HIV-1PR inhibitors in vivo... - In vivo imaging of beta-galactosidase activity using far red fluorescent switchChing Hsuan Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Cancer Res 64:1579-83. 2004..The results indicated that in vivo real-time detection of beta-gal activity is possible by fluorescence imaging technology... - A novel molecule integrating therapeutic and diagnostic activities reveals multiple aspects of stem cell-based therapyShawn D Hingtgen
Molecular Neurotherapy and Imaging Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Stem Cells 28:832-41. 2010..Together, the integrated diagnostic and therapeutic properties of SRL(O)L(2)TR answer critical questions necessary for successful utilization of stem cells as novel therapeutic vehicles... - Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectorsHiroaki Wakimoto
Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
Cancer Res 69:3472-81. 2009..This is important for designing new oHSV vectors and clinical trials. Moreover, the new glioma models described in this study provide powerful tools for testing experimental therapeutics and studying invasion and angiogenesis... - Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapyLaura S Sasportas
Molecular Neurotherapy and Imaging Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School Boston, MA 02114, USA
Proc Natl Acad Sci U S A 106:4822-7. 2009..This study demonstrates the efficacy of diagnostic and therapeutic MSC in preclinical glioma models and forms the basis for developing stem cell-based therapies for different cancers... - Stem-cell based therapies for brain tumorsStephen Yip
Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Curr Opin Mol Ther 10:334-42. 2008..Progress has validated the feasibility of using engineered NSCs as cell-based therapeutic agents to eliminate malignant cells in the brain. This review discusses the therapeutic potential of NSCs focusing on brain tumors... - A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probeShanta M Messerli
Departments of Neurology and Radiology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA 02115, USA
Neoplasia 6:95-105. 2004..This novel ICE-NIRF probe should prove useful in monitoring endogenous and vector-expressed caspase-1 activity, and potentially apoptosis in cell culture and in vivo... - Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAILNorman Kock
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Neoplasia 9:435-42. 2007.... - Therapeutic stem-cells for cancer treatment: hopes and hurdles in tactical warfareMaarten F Corsten
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Lancet Oncol 9:376-84. 2008..In this Review, we provide an outline of the rationale and status of stem-cell-based treatments for tumours, and we discuss prospects for clinical implementation and the factors crucial for maintaining momentum towards this goal... - The Arabidopsis kinase-associated protein phosphatase controls internalization of the somatic embryogenesis receptor kinase 1Khalid Shah
Laboratory of Molecular Biology, Department of Plant Sciences, Wageningen University, 6703 HA Wageningen, The Netherlands
Genes Dev 16:1707-20. 2002..These results suggest that KAPP is an integral part of the AtSERK1 endocytosis mechanism... - Fluorescence fluctuation analysis of Arabidopsis thaliana somatic embryogenesis receptor-like kinase and brassinosteroid insensitive 1 receptor oligomerizationMark A Hink
MicroSpectroscopy Centre, Laboratory of Biochemistry, Wageningen University, 6703 HA Wageningen, The Netherlands
Biophys J 94:1052-62. 2008..Although no oligomeric structures were detected for AtSERK3, 15% (AtSERK1) to 20% (BRI1) of the labeled proteins in the plasma membrane was found to be present as homodimers, whereas no evidence was found for higher oligomeric complexes...
Research Grants
- Developing diagnostic and therapeutic stem cells for cancer therapyKhalid A Shah; Fiscal Year: 2010..The developed agents and strategies will be designed to be clinically translatable and should have a major impact in developing efficient therapies for brain tumors. ..