Khalid A Shah

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylation
    K Shah
    Laboratory of Molecular Biology, Wageningen University and Research Center, 6703 HA Wageningen, The Netherlands
    J Biol Chem 276:41263-9. 2001
  2. ncbi request reprint Current advances in molecular imaging of gene and cell therapy for cancer
    Khalid Shah
    Center for Molecular Imaging, Massachusetts Gneral Hospital, Boston, MA, USA
    Cancer Biol Ther 4:518-23. 2005
  3. ncbi request reprint HSV amplicon vectors for cancer therapy
    Khalid Shah
    Center for Molecular Imaging Research and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Curr Gene Ther 6:361-70. 2006
  4. ncbi request reprint MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors
    Adly Yacoub
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Cancer Biol Ther 7:917-33. 2008
  5. pmc Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model
    Khalid Shah
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:4406-13. 2008
  6. pmc Mesenchymal stem cells engineered for cancer therapy
    Khalid Shah
    Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Adv Drug Deliv Rev 64:739-48. 2012
  7. ncbi request reprint In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis
    Khalid Shah
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mol Ther 11:926-31. 2005
  8. pmc Molecular optical imaging: applications leading to the development of present day therapeutics
    Khalid Shah
    Center for Molecular Imaging Research, Massachusetts General Hospital, MA 02129, USA
    NeuroRx 2:215-25. 2005
  9. ncbi request reprint Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression
    Khalid Shah
    Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, 13th Street, Building 149, Charlestown, MA 02129, USA
    Ann Neurol 57:34-41. 2005
  10. ncbi request reprint Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy
    Khalid Shah
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 64:3236-42. 2004

Research Grants

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylation
    K Shah
    Laboratory of Molecular Biology, Wageningen University and Research Center, 6703 HA Wageningen, The Netherlands
    J Biol Chem 276:41263-9. 2001
    ....
  2. ncbi request reprint Current advances in molecular imaging of gene and cell therapy for cancer
    Khalid Shah
    Center for Molecular Imaging, Massachusetts Gneral Hospital, Boston, MA, USA
    Cancer Biol Ther 4:518-23. 2005
    ..In this review we will discuss different imaging modalities that have found applications in gene and cell therapies of cancer...
  3. ncbi request reprint HSV amplicon vectors for cancer therapy
    Khalid Shah
    Center for Molecular Imaging Research and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Curr Gene Ther 6:361-70. 2006
    ..Amplicon vectors have also proven to be a versatile tool to explore imaging modalities to monitor gene delivery and tumor responses to therapeutic intervention...
  4. ncbi request reprint MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors
    Adly Yacoub
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Cancer Biol Ther 7:917-33. 2008
    ....
  5. pmc Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model
    Khalid Shah
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:4406-13. 2008
    ..These studies demonstrate the utility of bimodal viral vectors and real-time imaging in evaluating fate of NSCs in diseased models and thus provide a platform for accelerating cell-based therapies for CNS disorders...
  6. pmc Mesenchymal stem cells engineered for cancer therapy
    Khalid Shah
    Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Adv Drug Deliv Rev 64:739-48. 2012
    ..This review aims to provide an in depth status of current MSC-based cancer therapies, as well as the prospects for their clinical translation...
  7. ncbi request reprint In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis
    Khalid Shah
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mol Ther 11:926-31. 2005
    ..The use of S-TRAIL as a therapeutic protein and the ability to image noninvasively both apoptosis and any other cellular events in real time have important clinical implications...
  8. pmc Molecular optical imaging: applications leading to the development of present day therapeutics
    Khalid Shah
    Center for Molecular Imaging Research, Massachusetts General Hospital, MA 02129, USA
    NeuroRx 2:215-25. 2005
    ..Furthermore, we will also shed some light on the use of these imaging modalities in neurotherapeutics, for example imaging different parameters of vector-mediated gene expression in glioma tumors and stem cell tracking in vivo...
  9. ncbi request reprint Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression
    Khalid Shah
    Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, 13th Street, Building 149, Charlestown, MA 02129, USA
    Ann Neurol 57:34-41. 2005
    ..These studies demonstrate the potential of NPCs as therapeutically effective delivery vehicles for the treatment of gliomas and also provide important tools to evaluate the migration of NPCs and changes in glioma burden in vivo...
  10. ncbi request reprint Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy
    Khalid Shah
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 64:3236-42. 2004
    ..This study serves as a template for design of recombinant proteins to enhance and control apoptosis of tumor cells via specific viral proteases and for use of viral proteases as in vivo reporters for cancer therapy...
  11. ncbi request reprint Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo
    Khalid Shah
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Oncogene 22:6865-72. 2003
    ....
  12. ncbi request reprint Neural precursor cells and their role in neuro-oncology
    Khalid Shah
    Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Dev Neurosci 26:118-30. 2004
    ..Examples are provided of monitoring migration of NPCs by bioluminescence imaging in living animals and of using them to deliver the apoptotic protein, TRAIL, to kill tumor cells...
  13. ncbi request reprint MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas
    Maarten F Corsten
    Center for Molecular Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Cancer Res 67:8994-9000. 2007
    ..Furthermore, our findings provide the basis for developing combination therapies using miRNA modulation and cytotoxic tumor therapies...
  14. ncbi request reprint In vivo tracking of neural progenitor cell migration to glioblastomas
    Yi Tang
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Hum Gene Ther 14:1247-54. 2003
    ..These results confirm the migratory capability of NPCs over considerable distances and their preferential accumulation in brain tumors on CNS rather than peripheral injection...
  15. pmc Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide
    Shawn Hingtgen
    Massachusetts General Hospital, Harvard Medical School, 13th Street, Charlestown, MA 02129, USA
    Mol Cancer Ther 7:3575-85. 2008
    ..This study elucidates novel means of delivering S-TRAIL to gliomas and suggests combination of clinically relevant temozolomide and S-TRAIL may represent a new therapeutic option with increased potency for glioblastoma patients...
  16. ncbi request reprint Imaging of stem cell recruitment to ischemic infarcts in a murine model
    Dong Eog Kim
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Charlestown, Mass, USA
    Stroke 35:952-7. 2004
    ..There is a need for imaging tools to study the in vivo migratory behavior of these cells...
  17. doi request reprint Imaging neural stem cell fate in mouse model of glioma
    Khalid Shah
    Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Curr Protoc Stem Cell Biol . 2009
    ..With the cells labeled in this manner, bioluminescence imaging can be used to study the fate of stem cells in glioma-bearing brains in vivo...
  18. ncbi request reprint Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo
    Esther Arwert
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Cancer Res 67:7335-42. 2007
    ..This study serves as a template to follow the role of growth factor receptor expression in tumor progression and to image therapeutic efficacy of targeted therapies in cancer...
  19. pmc Performance of the red-shifted fluorescent proteins in deep-tissue molecular imaging applications
    Nikolaos C Deliolanis
    Massachusetts General Hospital and Harvard Medical School, Center for Molecular Imaging Research, Laboratory for Bio optics and Molecular Imaging, Charlestown, Massachusetts 02139, USA
    J Biomed Opt 13:044008. 2008
    ....
  20. doi request reprint Imaging fate of stem cells at a cellular resolution in the brains of mice
    Khalid Shah
    Molecular Neurotherapy and Imaging Laboratory, Department of Radiology and Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Methods Mol Biol 680:91-101. 2011
    ..The ability to monitor fate of stem cells in disease models enables studies aimed at evaluating the efficacy of their treatment for CNS disorders...
  21. doi request reprint In vivo imaging of the dynamics of different variants of EGFR in glioblastomas
    Khalid Shah
    Molecular Neurotherapy and Imaging Laboratory, Department of Radiology and Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Methods Mol Biol 680:153-64. 2011
    ..The protocol details characterization of engineered glioma cells in culture, surgical preparation, craniotomy, cell implantation, animal recovery, and imaging procedures to study kinetics of EGFR expression and GBM progression...
  22. pmc Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Opt Lett 34:2066-8. 2009
    ..These results suggest the potential for exploiting fluorescence lifetime for imaging FPs for a variety of whole-body small-animal imaging applications...
  23. ncbi request reprint In vivo imaging of HIV protease activity in amplicon vector-transduced gliomas
    Khalid Shah
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Cancer Res 64:273-8. 2004
    ..These findings may be directly applicable in using viral protease expression as a transgene marker in tumor therapy and may have implications in testing the efficacy of HIV-1PR inhibitors in vivo...
  24. ncbi request reprint In vivo imaging of beta-galactosidase activity using far red fluorescent switch
    Ching Hsuan Tung
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Cancer Res 64:1579-83. 2004
    ..The results indicated that in vivo real-time detection of beta-gal activity is possible by fluorescence imaging technology...
  25. pmc A novel molecule integrating therapeutic and diagnostic activities reveals multiple aspects of stem cell-based therapy
    Shawn D Hingtgen
    Molecular Neurotherapy and Imaging Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Stem Cells 28:832-41. 2010
    ..Together, the integrated diagnostic and therapeutic properties of SRL(O)L(2)TR answer critical questions necessary for successful utilization of stem cells as novel therapeutic vehicles...
  26. pmc Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors
    Hiroaki Wakimoto
    Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Res 69:3472-81. 2009
    ..This is important for designing new oHSV vectors and clinical trials. Moreover, the new glioma models described in this study provide powerful tools for testing experimental therapeutics and studying invasion and angiogenesis...
  27. pmc Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy
    Laura S Sasportas
    Molecular Neurotherapy and Imaging Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 106:4822-7. 2009
    ..This study demonstrates the efficacy of diagnostic and therapeutic MSC in preclinical glioma models and forms the basis for developing stem cell-based therapies for different cancers...
  28. ncbi request reprint Stem-cell based therapies for brain tumors
    Stephen Yip
    Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Opin Mol Ther 10:334-42. 2008
    ..Progress has validated the feasibility of using engineered NSCs as cell-based therapeutic agents to eliminate malignant cells in the brain. This review discusses the therapeutic potential of NSCs focusing on brain tumors...
  29. pmc A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe
    Shanta M Messerli
    Departments of Neurology and Radiology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA 02115, USA
    Neoplasia 6:95-105. 2004
    ..This novel ICE-NIRF probe should prove useful in monitoring endogenous and vector-expressed caspase-1 activity, and potentially apoptosis in cell culture and in vivo...
  30. pmc Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL
    Norman Kock
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neoplasia 9:435-42. 2007
    ....
  31. doi request reprint Therapeutic stem-cells for cancer treatment: hopes and hurdles in tactical warfare
    Maarten F Corsten
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Lancet Oncol 9:376-84. 2008
    ..In this Review, we provide an outline of the rationale and status of stem-cell-based treatments for tumours, and we discuss prospects for clinical implementation and the factors crucial for maintaining momentum towards this goal...
  32. pmc The Arabidopsis kinase-associated protein phosphatase controls internalization of the somatic embryogenesis receptor kinase 1
    Khalid Shah
    Laboratory of Molecular Biology, Department of Plant Sciences, Wageningen University, 6703 HA Wageningen, The Netherlands
    Genes Dev 16:1707-20. 2002
    ..These results suggest that KAPP is an integral part of the AtSERK1 endocytosis mechanism...
  33. pmc Fluorescence fluctuation analysis of Arabidopsis thaliana somatic embryogenesis receptor-like kinase and brassinosteroid insensitive 1 receptor oligomerization
    Mark A Hink
    MicroSpectroscopy Centre, Laboratory of Biochemistry, Wageningen University, 6703 HA Wageningen, The Netherlands
    Biophys J 94:1052-62. 2008
    ..Although no oligomeric structures were detected for AtSERK3, 15% (AtSERK1) to 20% (BRI1) of the labeled proteins in the plasma membrane was found to be present as homodimers, whereas no evidence was found for higher oligomeric complexes...

Research Grants2

  1. Developing diagnostic and therapeutic stem cells for cancer therapy
    Khalid A Shah; Fiscal Year: 2010
    ..The developed agents and strategies will be designed to be clinically translatable and should have a major impact in developing efficient therapies for brain tumors. ..