K I Seyb

Summary

Affiliation: Harvard University

Country: USA

Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform
K I Seyb
Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas, USA
J Biomol Screen 13:870-8. 2008
Cytoskeletal integrity as a drug target
M L Michaelis
Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045, USA
Curr Alzheimer Res 2:227-9. 2005
{beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents
M L Michaelis
Department of Pharmacology and Toxicology, 1251 Wescoe Hall Dr, 5064 Malott Hall, University of Kansas, Lawrence, KS 66045, USA
J Pharmacol Exp Ther 312:659-68. 2005

Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform
K I Seyb
Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas, USA
J Biomol Screen 13:870-8. 2008
..In fact, of the compounds that inhibited calpain activation by Abeta with IC(50) values of <10 microM and showed little or no toxicity at concentrations up to 30 microM, none inhibit the calpain enzyme directly...
Cytoskeletal integrity as a drug target
M L Michaelis
Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045, USA
Curr Alzheimer Res 2:227-9. 2005
..In vivo proof-of-concept studies in animal models will require the development of agents that can protect cytoskeletal integrity and also cross the blood brain barrier...
{beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents
M L Michaelis
Department of Pharmacology and Toxicology, 1251 Wescoe Hall Dr, 5064 Malott Hall, University of Kansas, Lawrence, KS 66045, USA
J Pharmacol Exp Ther 312:659-68. 2005
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