K I Seyb

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform
    K I Seyb
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas, USA
    J Biomol Screen 13:870-8. 2008
  2. ncbi request reprint Cytoskeletal integrity as a drug target
    M L Michaelis
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045, USA
    Curr Alzheimer Res 2:227-9. 2005
  3. ncbi request reprint {beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents
    M L Michaelis
    Department of Pharmacology and Toxicology, 1251 Wescoe Hall Dr, 5064 Malott Hall, University of Kansas, Lawrence, KS 66045, USA
    J Pharmacol Exp Ther 312:659-68. 2005

Collaborators

Detail Information

Publications3

  1. pmc Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform
    K I Seyb
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas, USA
    J Biomol Screen 13:870-8. 2008
    ..In fact, of the compounds that inhibited calpain activation by Abeta with IC(50) values of <10 microM and showed little or no toxicity at concentrations up to 30 microM, none inhibit the calpain enzyme directly...
  2. ncbi request reprint Cytoskeletal integrity as a drug target
    M L Michaelis
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045, USA
    Curr Alzheimer Res 2:227-9. 2005
    ..In vivo proof-of-concept studies in animal models will require the development of agents that can protect cytoskeletal integrity and also cross the blood brain barrier...
  3. ncbi request reprint {beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents
    M L Michaelis
    Department of Pharmacology and Toxicology, 1251 Wescoe Hall Dr, 5064 Malott Hall, University of Kansas, Lawrence, KS 66045, USA
    J Pharmacol Exp Ther 312:659-68. 2005
    ....