Sanja Sever

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Physical and functional connection between auxilin and dynamin during endocytosis
    Sanja Sever
    Renal Unit, Nephrology Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA
    EMBO J 25:4163-74. 2006
  2. pmc CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival
    Suma Yaddanapudi
    Nephrology Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Clin Invest 121:3965-80. 2011
  3. ncbi request reprint Assays and functional properties of auxilin-dynamin interactions
    Sanja Sever
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Methods Enzymol 404:570-85. 2005
  4. pmc Direct dynamin-actin interactions regulate the actin cytoskeleton
    Changkyu Gu
    Nephrology Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA
    EMBO J 29:3593-606. 2010
  5. ncbi request reprint Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation
    Sharif R Nankoe
    Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Trends Cell Biol 16:607-9. 2006
  6. ncbi request reprint Dynamin and endocytosis
    Sanja Sever
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Dana Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Curr Opin Cell Biol 14:463-7. 2002
  7. pmc Dynamin rings: not just for fission
    Sanja Sever
    Nephrology Division, Massachusetts General Hospital, CNY 149 8 113, 149 13th Street, Charlestown, MA, 02129, USA
    Traffic 14:1194-9. 2013
  8. pmc Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease
    Sanja Sever
    Department of Medicine, Nephrology Division and Program in Glomerular Disease, Massachusetts General Hospital MGH and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 117:2095-104. 2007
  9. pmc Podocyte biology and pathogenesis of kidney disease
    Jochen Reiser
    Department of Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA
    Annu Rev Med 64:357-66. 2013
  10. ncbi request reprint Signal transduction in podocytes-spotlight on receptor tyrosine kinases
    Jochen Reiser
    Department of Medicine, Rush University Medical Center, 1735 West Harrison Street, Cohn Building, Suite 724, Chicago, IL 60612, USA
    Nat Rev Nephrol 10:104-15. 2014

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc Physical and functional connection between auxilin and dynamin during endocytosis
    Sanja Sever
    Renal Unit, Nephrology Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA
    EMBO J 25:4163-74. 2006
    ..Together, our findings support the model that the GTP-bound conformation of dynamin tetramers stimulates formation of constricted coated pits at the plasma membrane by regulating the chaperone activity of hsc70/auxilin...
  2. pmc CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival
    Suma Yaddanapudi
    Nephrology Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Clin Invest 121:3965-80. 2011
    ..Our study identifies CD2AP as the gatekeeper of the podocyte TGF-β response through its regulation of CatL expression and defines a molecular mechanism underlying proteinuric kidney disease...
  3. ncbi request reprint Assays and functional properties of auxilin-dynamin interactions
    Sanja Sever
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Methods Enzymol 404:570-85. 2005
    ..Here we describe three different in vitro assays that monitor auxilin-dynamin interactions, as well as fluorescence lifetime imaging microscopy that identify direct interactions between dynamin and auxilin in cells...
  4. pmc Direct dynamin-actin interactions regulate the actin cytoskeleton
    Changkyu Gu
    Nephrology Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA
    EMBO J 29:3593-606. 2010
    ..Together, our results support a model in which assembled dynamin, generated through interactions with short actin filaments, promotes actin polymerization via displacement of actin-CPs...
  5. ncbi request reprint Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation
    Sharif R Nankoe
    Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Trends Cell Biol 16:607-9. 2006
    ....
  6. ncbi request reprint Dynamin and endocytosis
    Sanja Sever
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Dana Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Curr Opin Cell Biol 14:463-7. 2002
    ..Novel data point more clearly than ever towards a role for this protein in the actin cytoskeleton, mitogen-activated protein kinase signaling and apoptosis, suggesting that dynamin might be a signaling GTPase...
  7. pmc Dynamin rings: not just for fission
    Sanja Sever
    Nephrology Division, Massachusetts General Hospital, CNY 149 8 113, 149 13th Street, Charlestown, MA, 02129, USA
    Traffic 14:1194-9. 2013
    ..Recent insights into the mechanism and role of dynamin oligomerization in the regulation of actin polymerization point to a novel role for dynamin oligomerization in the cell. ..
  8. pmc Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease
    Sanja Sever
    Department of Medicine, Nephrology Division and Program in Glomerular Disease, Massachusetts General Hospital MGH and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 117:2095-104. 2007
    ..Our study identifies dynamin as a critical regulator of renal permselectivity that is specifically targeted by proteolysis under pathological conditions...
  9. pmc Podocyte biology and pathogenesis of kidney disease
    Jochen Reiser
    Department of Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA
    Annu Rev Med 64:357-66. 2013
    ..Loss of these actin-driven membrane extensions is tightly connected to the presence of protein in the urine, podocyte loss, development of CKD, and ultimately renal failure...
  10. ncbi request reprint Signal transduction in podocytes-spotlight on receptor tyrosine kinases
    Jochen Reiser
    Department of Medicine, Rush University Medical Center, 1735 West Harrison Street, Cohn Building, Suite 724, Chicago, IL 60612, USA
    Nat Rev Nephrol 10:104-15. 2014
    ..The identification of pathological RTK-mediated signal transduction pathways in podocytes could provide a starting point for the development of novel therapies for glomerular disorders. ..
  11. ncbi request reprint AP-2 makes room for rivals
    Sanja Sever
    Department of Medicine, Harvard Medical School and Program in Membrane Biology, Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Dev Cell 5:530-2. 2003
    ..These novel data suggest the intriguing possibility that the major role of AP-2 is in cargo recruitment, and not in assembly of functionally active clathrin-coated pits...
  12. ncbi request reprint Auxilin-dynamin interactions link the uncoating ATPase chaperone machinery with vesicle formation
    Sherri L Newmyer
    G W Hooper Foundation, The University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 4:929-40. 2003
    ..The data suggest that dynamin regulates the action of molecular chaperones in vesicle budding during endocytosis...

Research Grants4

  1. Role of dynamin-auxilin interactions in endocytosis
    Sanja Sever; Fiscal Year: 2006
    ..The function of lipid binding/phosphatase activity by auxilin in endocytosis will be examined using a semi-permeable cell assay. ..
  2. Role of dynamin-auxilin interactions in endocytosis
    Sanja Sever; Fiscal Year: 2007
    ..The function of lipid binding/phosphatase activity by auxilin in endocytosis will be examined using a semi-permeable cell assay. ..
  3. Role of dynamin-auxilin interactions in endocytosis
    Sanja Sever; Fiscal Year: 2009
    ..The function of lipid binding/phosphatase activity by auxilin in endocytosis will be examined using a semi-permeable cell assay. ..