H D Sesso

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Predictors of 14-year changes in the total cholesterol to high-density lipoprotein cholesterol ratio in men
    Richard Scranton
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Am Heart J 147:1033-8. 2004
  2. doi request reprint Alcohol consumption and the risk of hypertension in women and men
    Howard D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston MA 02215 1204, USA
    Hypertension 51:1080-7. 2008
  3. pmc Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    JAMA 308:1751-60. 2012
  4. pmc Tomato-based food products are related to clinically modest improvements in selected coronary biomarkers in women
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Nutr 142:326-33. 2012
  5. pmc Cigarette advertising on taxicabs in Boston, Massachusetts (USA)
    H D Sesso
    Department of Medicine, Brigham and Women s Hospital, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Tob Control 6:128-30. 1997
  6. ncbi request reprint Comparison of interleukin-6 and C-reactive protein for the risk of developing hypertension in women
    Howard D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Hypertension 49:304-10. 2007
  7. ncbi request reprint Comparison of baseline characteristics and mortality experience of participants and nonparticipants in a randomized clinical trial: the Physicians' Health Study
    Howard D Sesso
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Control Clin Trials 23:686-702. 2002
  8. ncbi request reprint Alcohol and cardiovascular health: recent findings
    H D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Cardiovasc Drugs 1:167-72. 2001
  9. pmc Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 300:2123-33. 2008
  10. ncbi request reprint Carotenoids and cardiovascular disease: what research gaps remain?
    Howard D Sesso
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School and Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, Massachusetts 02215 1204, USA
    Curr Opin Lipidol 17:11-6. 2006

Collaborators

Detail Information

Publications96

  1. ncbi request reprint Predictors of 14-year changes in the total cholesterol to high-density lipoprotein cholesterol ratio in men
    Richard Scranton
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Am Heart J 147:1033-8. 2004
    ..We examined predictors of a change in TC/HDL ratio over a period of 14 years among 4451 men free of CVD from the Physicians' Health Study...
  2. doi request reprint Alcohol consumption and the risk of hypertension in women and men
    Howard D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston MA 02215 1204, USA
    Hypertension 51:1080-7. 2008
    ..The threshold above which alcohol became deleterious for hypertension risk emerged at >or=4 drinks per day in women versus a moderate level of >or=1 drink per day in men...
  3. pmc Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    JAMA 308:1751-60. 2012
    ..Observational studies have shown inconsistent associations between regular multivitamin use and CVD, with no long-term clinical trials of multivitamin use...
  4. pmc Tomato-based food products are related to clinically modest improvements in selected coronary biomarkers in women
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Nutr 142:326-33. 2012
    ..5 servings/wk of tomato-based food products had clinically modest but significant improvements in TC, the TC:HDL cholesterol ratio, and hemoglobin A1c but not other coronary biomarkers...
  5. pmc Cigarette advertising on taxicabs in Boston, Massachusetts (USA)
    H D Sesso
    Department of Medicine, Brigham and Women s Hospital, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Tob Control 6:128-30. 1997
    ..To examine the frequency of tobacco advertisements on taxicabs within Boston, Massachusetts (USA)...
  6. ncbi request reprint Comparison of interleukin-6 and C-reactive protein for the risk of developing hypertension in women
    Howard D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Hypertension 49:304-10. 2007
    ..In models simultaneously examining IL-6 and CRP, only CRP remained strongly associated with an increased risk of hypertension...
  7. ncbi request reprint Comparison of baseline characteristics and mortality experience of participants and nonparticipants in a randomized clinical trial: the Physicians' Health Study
    Howard D Sesso
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Control Clin Trials 23:686-702. 2002
    ..In contrast, diseases and risk factors explain some, but not all, of the lower mortality rates of physicians based on eligibility status and their ability to complete a run-in phase...
  8. ncbi request reprint Alcohol and cardiovascular health: recent findings
    H D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Cardiovasc Drugs 1:167-72. 2001
    ....
  9. pmc Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 300:2123-33. 2008
    ..However, few long-term trials have evaluated men at initially low risk of cardiovascular disease, and no previous trial in men has examined vitamin C alone in the prevention of cardiovascular disease...
  10. ncbi request reprint Carotenoids and cardiovascular disease: what research gaps remain?
    Howard D Sesso
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School and Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, Massachusetts 02215 1204, USA
    Curr Opin Lipidol 17:11-6. 2006
    ..This review assimilated the existing and recent literature on carotenoids and cardiovascular disease and considered what research gaps may remain...
  11. ncbi request reprint Flavonoid intake and the risk of cardiovascular disease in women
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 77:1400-8. 2003
    ..Despite emerging evidence of the role of flavonoids in cardiovascular disease (CVD) prevention, the association remains unclear...
  12. ncbi request reprint Dietary lycopene, tomato-based food products and cardiovascular disease in women
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Nutr 133:2336-41. 2003
    ....
  13. ncbi request reprint Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 79:47-53. 2004
    ..Growing evidence suggests that lycopene has significant in vitro antioxidant potential. Lycopene has rarely been tested in prospective studies for its role in cardiovascular disease (CVD) prevention...
  14. ncbi request reprint C-reactive protein and the risk of developing hypertension
    Howard D Sesso
    Department of Medicine, Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02215 1204, USA
    JAMA 290:2945-51. 2003
    ..Although it has been hypothesized that hypertension is in part an inflammatory disorder, clinical data linking inflammation with incident hypertension are scarce...
  15. ncbi request reprint Value of an Endpoints Committee versus the use of nosologists for validating cause of death
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Contemp Clin Trials 27:333-9. 2006
    ..Few studies have directly compared the use of nosologists versus other sources of mortality information deemed a gold standard, including the use of an Endpoints Committee (EC), which is commonly utilized in clinical studies...
  16. ncbi request reprint Alcohol intake and cardiovascular morbidity and mortality
    H D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Curr Opin Nephrol Hypertens 8:353-7. 1999
    ..All types of alcoholic beverage reduce the risk of cardiovascular disease, suggesting that ethanol is responsible for the protective effect...
  17. ncbi request reprint Strawberry intake, lipids, C-reactive protein, and the risk of cardiovascular disease in women
    Howard D Sesso
    Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston MA 02215 1204, USA
    J Am Coll Nutr 26:303-10. 2007
    ..In the Women's Health Study, we examined strawberry intake for both its prospective association with CVD risk in 38,176 women and its cross-sectional association with lipids and C-reactive protein (CRP) in a subset of 26,966 women...
  18. ncbi request reprint Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Am J Clin Nutr 81:990-7. 2005
    ..Emerging evidence suggests a possible role of lycopene in the primary prevention of cardiovascular disease (CVD)...
  19. ncbi request reprint Invited commentary: a challenge for physical activity epidemiology
    Howard D Sesso
    Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Am J Epidemiol 165:1351-3; discussion 1354-5. 2007
    ..Our challenge is therefore to more accurately and consistently measure these more subtle components of nonexercise physical activity to better understand its potential clinical effects and role in disease prevention...
  20. ncbi request reprint Physical activity and coronary heart disease in men: The Harvard Alumni Health Study
    H D Sesso
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Circulation 102:975-80. 2000
    ..Therefore, we examined the association of the quantity and intensity of physical activity with CHD risk and the impact of other coronary risk factors...
  21. ncbi request reprint Dietary and plasma lycopene and the risk of breast cancer
    Howard D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215 1204, USA
    Cancer Epidemiol Biomarkers Prev 14:1074-81. 2005
    ..In conclusion, neither higher dietary nor plasma lycopene levels were associated with a reduced risk of breast cancer in middle-aged and older women...
  22. ncbi request reprint Seven-year changes in alcohol consumption and subsequent risk of cardiovascular disease in men
    H D Sesso
    Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204
    Arch Intern Med 160:2605-12. 2000
    ..Few studies have examined whether changes in alcohol consumption influence future cardiovascular risk...
  23. ncbi request reprint A prospective study of plasma lipid levels and hypertension in women
    Howard D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    Arch Intern Med 165:2420-7. 2005
    ..Although dyslipidemia and hypertension occur together more often than can be explained by chance, few studies have carefully explored the nature of the relationship between plasma lipid levels and the risk of developing hypertension...
  24. ncbi request reprint Maternal and paternal history of myocardial infarction and risk of cardiovascular disease in men and women
    H D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Circulation 104:393-8. 2001
    ..Few studies have examined the effects of paternal and maternal history of myocardial infarction (MI), including age at MI, on cardiovascular disease (CVD) risk, particularly among women...
  25. ncbi request reprint Alcohol consumption and risk of prostate cancer: The Harvard Alumni Health Study
    H D Sesso
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Epidemiol 30:749-55. 2001
    ..Few data exist on beverage-specific associations as well as lifetime patterns of alcohol consumption and prostate cancer risk...
  26. ncbi request reprint Blood pressure lowering and life expectancy based on a Markov model of cardiovascular events
    Howard D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, Mass 02215 1204, USA
    Hypertension 42:885-90. 2003
    ..Greater gains in life expectancy among hypertensive and diabetic women suggest that blood pressure lowering may yield greater benefits in selected subgroups...
  27. ncbi request reprint Light-to-moderate alcohol consumption and mortality in the Physicians' Health Study enrollment cohort
    J M Gaziano
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215 1204, USA
    J Am Coll Cardiol 35:96-105. 2000
    ..This study examined the relationship between light-to-moderate alcohol consumption and cause-specific mortality...
  28. ncbi request reprint Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians
    A Elisabeth Hak
    Department of Epidemiology, Harvard School of Public Health, Channing Laboratory, 181 Longwood Ave, Boston, Mass 02115 5804, USA
    Circulation 108:802-7. 2003
    ..Increased intake of carotenoids and vitamin E may protect against myocardial infarction (MI). However, prospective data on blood levels of carotenoids other than beta-carotene and vitamin E (tocopherol) and risk of MI are sparse...
  29. doi request reprint The relationship between total plasma carotenoids and risk factors for chronic disease among middle-aged and older men
    Wildon R Farwell
    Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston Division 151 MAV, 150 South Huntington Avenue, Boston, MA, USA
    Br J Nutr 100:883-9. 2008
    ..12, 1.57), using logistic regression. Few lifestyle and clinical risk factors appear to be related to levels of total plasma carotenoids; however, levels of biomarkers such as plasma lipids and alpha-tocopherol may be strongly related...
  30. ncbi request reprint A prospective cohort study of physical activity and body size in relation to prostate cancer risk (United States)
    I M Lee
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 12:187-93. 2001
    ..To examine the associations of physical activity and body size with risk of prostate cancer...
  31. ncbi request reprint Physical activity and coronary heart disease risk in men: does the duration of exercise episodes predict risk?
    I M Lee
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Circulation 102:981-6. 2000
    ..However, it is unclear whether the duration of exercise episodes is important: Are accumulated shorter sessions as predictive of decreased risk as longer sessions if the same amount of energy is expended?..
  32. pmc Physical activity and weight gain prevention in older men
    E J Shiroma
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02215, USA
    Int J Obes (Lond) 36:1165-9. 2012
    ..Physical activity and adiposity are important predictors of mortality, even in older individuals. However, it is unclear how much physical activity is needed to prevent weight gain in older persons...
  33. ncbi request reprint Two-year changes in blood pressure and subsequent risk of cardiovascular disease in men
    H D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Circulation 102:307-12. 2000
    ..Clinicians may need to consider the previous pattern of DBP change when considering the risk associated with the current DBP level. These data require confirmation in other studies in which blood pressure is measured...
  34. pmc Eight-year change in body mass index and subsequent risk of cardiovascular disease among healthy non-smoking men
    Thomas S Bowman
    VA Boston Healthcare System Massachusetts Veterans Affairs Epidemiology, Research, and Information Center MAVERIC, Boston, MA, USA
    Prev Med 45:436-41. 2007
    ..To determine how change in BMI over 8 years is associated with risk of subsequent cardiovascular disease (CVD) among middle aged men...
  35. ncbi request reprint Blood levels of long-chain polyunsaturated fatty acids, aspirin, and the risk of colorectal cancer
    Megan N Hall
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 16:314-21. 2007
    ..Aspirin also inhibits the cyclooxygenase-2 enzyme and may share with n-3 fatty acids a potential mechanism to decrease the risk of colorectal cancer...
  36. pmc Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial
    J Michael Gaziano
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    JAMA 301:52-62. 2009
    ..No previous trial in men at usual risk has examined vitamin C alone in the prevention of cancer...
  37. pmc Relation of alcohol consumption and coronary heart disease in hypertensive male physicians (from the Physicians' Health Study)
    Kathryn A Britton
    Harvard Medical School, Massachusetts Veterans Epidemiology and Research Information Center MAVERIC, Boston Veterans Affairs Healthcare System, Boston, MA, USA
    Am J Cardiol 104:932-5. 2009
    ..In conclusion, our data demonstrated an inverse relation between moderate alcohol consumption and CHD in hypertensive men...
  38. ncbi request reprint Sense of exhaustion and coronary heart disease among college alumni
    S R Cole
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Cardiol 84:1401-5. 1999
    ..In a prospective observational study, frequent sense of exhaustion appeared to be independently associated with increased risk of CHD mortality in men...
  39. pmc Physical activity and risk of Parkinson's disease: a prospective cohort study
    G Logroscino
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Neurol Neurosurg Psychiatry 77:1318-22. 2006
    ..Laboratory experiments indicate that physical activity may have a neuroprotective effect; however, there are few data on whether physical activity is associated with decreased risk of Parkinson's disease...
  40. pmc Physical activity and all cause mortality in women: a review of the evidence
    Y Oguma
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Br J Sports Med 36:162-72. 2002
    ..It was concluded that, by adhering to current guidelines for physical activity and expending about 4200 kJ of energy a week, women can postpone mortality. The magnitude of benefit experienced by women is similar to that seen in men...
  41. ncbi request reprint Blood pressure and risk of secondary cardiovascular events in women: the Women's Antioxidant Cardiovascular Study (WACS)
    Peter J Mason
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215 1204, USA
    Circulation 109:1623-9. 2004
    ..In apparently healthy people, the relation between blood pressure and risk of subsequent cardiovascular disease (CVD) is linear. In persons with CVD, the relation is uncertain...
  42. pmc Physical activity, body weight, and pancreatic cancer mortality
    I M Lee
    Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Br J Cancer 88:679-83. 2003
    ..00, 0.98, 0.92, and 1.31, respectively) nor BMI (corresponding findings: 1.00, 0.84, 1.08, and 0.99, respectively) significantly predicted pancreatic cancer mortality...
  43. ncbi request reprint Homocysteine and risk of developing hypertension in men
    T S Bowman
    Veterans Affairs Boston Healthcare System, Massachusetts Veterans Affairs Epidemiology, Research, and Information Center, Boston, MA, USA
    J Hum Hypertens 20:631-4. 2006
    ..63 (95% CI, 0.97-2.74; P for trend=0.13). Higher plasma homocysteine levels at baseline were associated with an increased but non-significant risk of incident hypertension that was minimally affected by multivariable adjustment...
  44. ncbi request reprint Blood pressure measures and risk of total, ischemic, and hemorrhagic stroke in men
    T S Bowman
    Veterans Affairs Boston Healthcare System Massachusetts Veterans Affairs Epidemiology, Research and Information Center, Boston, MA 02130, USA
    Neurology 67:820-3. 2006
    ..To evaluate which blood pressure measure is the best predictor of risk of total, ischemic, and hemorrhagic stroke...
  45. ncbi request reprint Effect of age on blood pressure parameters and risk of cardiovascular death in men
    Thomas S Bowman
    Veterans Affairs Boston Healthcare System, Massachusetts Veterans Affairs Epidemiology, Research, and Information Center, Boston, MA, USA
    Am J Hypertens 19:47-52. 2006
    ..We sought to determine which BP parameters are important predictors of CVD death across a wide age range...
  46. ncbi request reprint Cholesterol and the risk of ischemic stroke
    Thomas S Bowman
    Harvard University General Internal Medicine Fellowship Program, Veterans Affairs Boston Healthcare System Massachusetts Veterans Affairs Epidemiology, Research, and Information Center, Boston, MA 02130, USA
    Stroke 34:2930-4. 2003
    ....
  47. pmc Physical activity, body mass index, and diabetes risk in men: a prospective study
    Lydia C Siegel
    Massachusetts Veterans Epidemiology Research and Information Center at the VA Boston Healthcare System, Boston, Mass, USA
    Am J Med 122:1115-21. 2009
    ..We investigated the independent and joint associations between vigorous activity and BMI on diabetes risk in men...
  48. ncbi request reprint Dyslipidemia and the risk of incident hypertension in men
    Ruben O Halperin
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 47:45-50. 2006
    ..These prospective cohort data suggest that dyslipidemias may lead to the subsequent development of hypertension. Thus, plasma lipids may be useful in the identification of men at risk for hypertension...
  49. ncbi request reprint JNC 7 category and risk of cardiovascular death in men: are there differences by age?
    Thomas S Bowman
    Harvard University General Internal Medicine Fellowship Program, Veterans Affairs Boston Healthcare System Massachusetts Veterans Affairs Epidemiology, Research, and Information Center, Boston, MA 02120, USA
    Am J Geriatr Cardiol 14:126-31; quiz 132-3. 2005
    ..22). In this large cohort, the JNC 7 categorization of prehypertension was not associated with a significantly increased risk of cardiovascular disease death, and there was no significant effect modification by age...
  50. doi request reprint Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events
    Lu Wang
    Brigham and Women s Hospital and Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Ann Intern Med 152:315-23. 2010
    ..Vitamin D and calcium may affect the cardiovascular system independently and interactively...
  51. pmc The built environment and physical activity levels: the Harvard Alumni Health Study
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Prev Med 37:293-8. 2009
    ....
  52. doi request reprint Meat intake and the risk of hypertension in middle-aged and older women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    J Hypertens 26:215-22. 2008
    ....
  53. doi request reprint Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women
    Lu Wang
    Division of Preventive Medicine, Harvard School of Public Health, Boston, Mass, USA harvard edu
    Hypertension 51:1073-9. 2008
    ....
  54. pmc Age-related cataract in a randomized trial of vitamins E and C in men
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Arch Ophthalmol 128:1397-405. 2010
    ..To test whether supplementation with alternate-day vitamin E or daily vitamin C affects the incidence of age-related cataract in a large cohort of men...
  55. pmc Alcohol consumption, weight gain, and risk of becoming overweight in middle-aged and older women
    Lu Wang
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Arch Intern Med 170:453-61. 2010
    ..Alcohol consumption is a source of energy intake that may contribute to body weight gain and development of obesity. However, previous studies of this relationship have been limited, with inconsistent results...
  56. pmc Immunohistochemical expression of BRCA1 and lethal prostate cancer
    Michelangelo Fiorentino
    Department of Pathology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 70:3136-9. 2010
    ..6; 95% confidence interval, 2.4-8.7). These findings strengthen the hypothesis that BRCA1 plays a role in cell cycle control and show that BRCA1 is a marker of clinical prostate cancer prognosis. Cancer Res; 70(8); 3136-9. (c)2010 AACR...
  57. pmc Dietary fatty acids and the risk of hypertension in middle-aged and older women
    Lu Wang
    900 Commonwealth Ave East, Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Hypertension 56:598-604. 2010
    ....
  58. pmc Prediction of incident hypertension risk in women with currently normal blood pressure
    Nina P Paynter
    The Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Mass 02215, USA
    Am J Med 122:464-71. 2009
    ..We examined whether a hypertension risk prediction model based on clinical characteristics and blood biomarkers might improve on risk prediction based on current blood pressure alone...
  59. doi request reprint The joint effects of physical activity and body mass index on coronary heart disease risk in women
    Amy R Weinstein
    Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Shapiro 1, Atrium Suite, Boston, MA 02215, USA
    Arch Intern Med 168:884-90. 2008
    ..Our objective was to study the combined association of physical activity and body mass index on CHD...
  60. pmc A 22-y prospective study of fish intake in relation to prostate cancer incidence and mortality
    Jorge E Chavarro
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 88:1297-303. 2008
    ..Fish and seafood n-3 fatty acids may prevent or delay the progression of prostate cancer, but epidemiologic studies do not uniformly support this hypothesis...
  61. pmc Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Am J Clin Nutr 89:905-12. 2009
    ..Flavonoids may protect against cancer development through several biological mechanisms. However, epidemiologic studies on dietary flavonoids and cancer risk have yielded inconsistent results...
  62. pmc Body mass index and vigorous physical activity and the risk of heart failure among men
    Satish Kenchaiah
    Physicians Health Study, Brigham and Women s Hospital, Boston, MA 02215, USA
    Circulation 119:44-52. 2009
    ..However, the impact of overweight or preobese (BMI, 25 to 29.9 kg/m(2)) status and physical activity on HF risk is unclear...
  63. pmc Genetic variation in RNASEL associated with prostate cancer risk and progression
    Mara S Meyer
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Carcinogenesis 31:1597-603. 2010
    ..The results of this study support a link between RNASEL and prostate cancer and suggest that the association may be mediated through inflammation. These novel findings warrant replication in future studies...
  64. pmc Physical activity and weight gain prevention
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 303:1173-9. 2010
    ..In 2008, federal guidelines recommended at least 150 minutes per week (7.5 metabolic equivalent [MET] hours per week) of moderate-intensity activity for "substantial health benefits."..
  65. pmc Change in high-density lipoprotein cholesterol and incident coronary heart disease in apparently healthy male physicians
    Catherine Rahilly-Tierney
    Massachusetts Veterans Epidemiology and Research Information Center, Office of Research and Development, Department of Veterans Affairs, Boston, Massachusetts, USA
    Am J Cardiol 102:1663-7. 2008
    ..43 (95% CI 0.23 to 0.83) for subjects with an HDL cholesterol increase >or=12.5 mg/dl. In conclusion, our findings were consistent with an inverse graded relation between 14-year increase in HDL cholesterol and risk of subsequent CHD...
  66. ncbi request reprint Body mass index and risk of Parkinson's disease: a prospective cohort study
    Giancarlo Logroscino
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 166:1186-90. 2007
    ....
  67. ncbi request reprint Joint effects of physical activity and body weight on diabetes and cardiovascular disease
    Amy R Weinstein
    Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Exerc Sport Sci Rev 34:10-5. 2006
    ..The combined effect seems to be different and to be dependent on the disease mechanism. Studies reveal that body weight has a greater influence on diabetes, and physical activity plays a greater role in CVD...
  68. ncbi request reprint Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    J Am Coll Nutr 24:376-84. 2005
    ..The aim of the present study was to examine the association of dietary flavonol and flavone intake with type 2 diabetes, and biomarkers of insulin resistance and systemic inflammation...
  69. ncbi request reprint Analgesic use and risk of subsequent hypertension in apparently healthy men
    Tobias Kurth
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Arch Intern Med 165:1903-9. 2005
    ..We tested whether apparently healthy male physicians who reported analgesic use had an increased risk of subsequent hypertension...
  70. ncbi request reprint Weight change and risk of developing type 2 diabetes
    Yuko Oguma
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Obes Res 13:945-51. 2005
    ..To examine the association between weight change and risk of type 2 diabetes and whether initial weight modifies the association...
  71. ncbi request reprint The "weekend warrior" and risk of mortality
    I Min Lee
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 160:636-41. 2004
    ..However, among those with no major risk factors, even 1-2 episodes/week generating 1,000 kcal/week or more can postpone mortality...
  72. ncbi request reprint Relationship of physical activity vs body mass index with type 2 diabetes in women
    Amy R Weinstein
    Boston VA Healthcare System, MA, USA
    JAMA 292:1188-94. 2004
    ..Physical inactivity and body mass index (BMI) are established independent risk factors in the development of type 2 diabetes; however, their comparative importance and joint relationship with diabetes are unclear...
  73. ncbi request reprint Relative intensity of physical activity and risk of coronary heart disease
    I Min Lee
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 107:1110-6. 2003
    ..It is unknown whether moderate-intensity exercise, relative to an individual's capacity, is associated with reduced coronary heart disease (CHD) rates...
  74. ncbi request reprint Is intake of breakfast cereals related to total and cause-specific mortality in men?
    Simin Liu
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 77:594-9. 2003
    ..Although breakfast cereals are a major source of whole and refined grains, little is known about their direct association with the risk of premature mortality...
  75. ncbi request reprint Development of predictive models for long-term cardiovascular risk associated with systolic and diastolic blood pressure
    Robert J Glynn
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Hypertension 39:105-10. 2002
    ..These predictive models may be useful for risk estimation associated with hypertension in similar populations and may also be used to infer the benefits of antihypertensive therapy...
  76. ncbi request reprint The consumption of lycopene and tomato-based food products is not associated with the risk of type 2 diabetes in women
    Lu Wang
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Nutr 136:620-5. 2006
    ..Our study found little evidence for an association between dietary intake of lycopene or lycopene-containing foods and the risk of type 2 DM...
  77. ncbi request reprint A prospective study of fruit and vegetable intake and the risk of type 2 diabetes in women
    Simin Liu
    Division of Preventive Medicine, Brigham Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Diabetes Care 27:2993-6. 2004
  78. ncbi request reprint p53 Arg72Pro polymorphism and risk of colorectal adenoma and cancer
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 119:1863-8. 2006
    ..09, 95% CI = 1.28-3.40) but not proximal colon or rectal cancers. Our results suggest that Arg72Pro may play a role in the early stages of colorectal neoplasia and possibly in progression to invasive disease, depending on site and sex...
  79. ncbi request reprint Whole- and refined-grain intakes and the risk of hypertension in women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Am J Clin Nutr 86:472-9. 2007
    ..Prospective studies linking whole- and refined-grain intakes with the risk of hypertension, a major cardiovascular disease risk factor, remain limited...
  80. pmc A prospective study of body mass index and the risk of developing hypertension in men
    Rebecca P Gelber
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Hypertens 20:370-7. 2007
    ..Although obesity is known to increase the risk of hypertension, few studies have prospectively evaluated body mass index (BMI) across the range of normal weight and overweight as a primary risk factor...
  81. ncbi request reprint Plasma lycopene, other carotenoids, and the risk of type 2 diabetes in women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Epidemiol 164:576-85. 2006
    ..91 (95% CI: 0.46, 1.81) for beta-cryptoxanthin, and 1.35 (95% CI: 0.68, 2.69) for lutein/zeaxanthin. There was no prospective association between baseline plasma carotenoids and the risk of type 2 diabetes in middle-aged and older women...
  82. ncbi request reprint Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Cardiol 98:1616-21. 2006
    ..In conclusion, the results suggest that higher intake of dietary magnesium may have a modest effect on the development of hypertension in women...
  83. pmc Associations of plasma carotenoids with risk factors and biomarkers related to cardiovascular disease in middle-aged and older women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Am J Clin Nutr 88:747-54. 2008
    ..Cardiovascular disease (CVD) risk factors may potentially influence plasma concentrations of carotenoids. However, data on the association of plasma carotenoids with CVD related biomarkers are only limited...
  84. ncbi request reprint A prospective study of dietary fiber intake and risk of cardiovascular disease among women
    Simin Liu
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 39:49-56. 2002
    ..This study was designed to examine the hypothesis that higher intake of dietary fiber is inversely related to the risk of cardiovascular disease (CVD) and myocardial infarction (MI) in a large prospective cohort of women...
  85. ncbi request reprint Comparison of National Death Index and World Wide Web death searches
    H D Sesso
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 152:107-11. 2000
    ..This study demonstrated that the World Wide Web may provide an alternative, inexpensive method of determining the mortality status of subjects in relatively small epidemiologic studies...
  86. ncbi request reprint Body mass index and total and cardiovascular mortality in men with a history of cardiovascular disease
    Michael E Widlansky
    Evans Department of Medicine and Whittaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02215 1204, USA
    Arch Intern Med 164:2326-32. 2004
    ....
  87. ncbi request reprint Non-high-density lipoprotein cholesterol versus low-density lipoprotein cholesterol as a risk factor for a first nonfatal myocardial infarction
    Wildon R Farwell
    Department of Medicine, Veterans Affairs Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 96:1129-34. 2005
    ....
  88. ncbi request reprint A comparison of the Framingham and European Society of Cardiology coronary heart disease risk prediction models in the normative aging study
    James L Orford
    Massachusetts Veterans Epidemiology Research and Information Center, Boston, Mass 02130, USA
    Am Heart J 144:95-100. 2002
    ....
  89. doi request reprint Smoking and the risk of incident hypertension in middle-aged and older men
    Ruben O Halperin
    Providence Portland Medical Center, Department of Medical Education, Portland, Oregon, USA
    Am J Hypertens 21:148-52. 2008
    ..Previous epidemiological studies have shown inconsistent results, having demonstrated inverse and positive associations between cigarette smoking and the development of hypertension...
  90. ncbi request reprint Alcohol consumption and mortality in men with preexisting cerebrovascular disease
    Vicki A Jackson
    Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA, USA
    Arch Intern Med 163:1189-93. 2003
    ..In counseling patients with a history of stroke, clinicians have limited information regarding the risks and benefits of alcohol consumption...
  91. ncbi request reprint Lack of association between tea and cardiovascular disease in college alumni
    Howard D Sesso
    Department of Epidemiology, Harvard School of Public Health, Boston, MA USA
    Int J Epidemiol 32:527-33. 2003
    ..Epidemiological studies suggest that tea intake, a major dietary source of flavonoids, may be associated with a decreased risk of cardiovascular disease (CVD)...
  92. ncbi request reprint Alcohol consumption and cardiovascular disease mortality in hypertensive men
    Maciej K Malinski
    St Vincent Hospital, Worcester Medical Center, University of Massachusetts Medical School, Worcester, USA
    Arch Intern Med 164:623-8. 2004
    ..Heavy alcohol drinking is associated with a dose-dependent increase in blood pressure, but data on the relation between alcohol consumption and mortality in hypertensive patients are sparse...
  93. ncbi request reprint Characteristics associated with differences in reported versus measured total cholesterol among male physicians
    Richard E Scranton
    New England VA Healthcare System, Boston, Massachusetts 02130, USA
    J Prim Prev 26:51-61. 2005
    ....
  94. ncbi request reprint A prospective study of cigarette smoking and risk of incident hypertension in women
    Thomas S Bowman
    Veterans Affairs Boston Healthcare System, Massachusetts Veterans Affairs Epidemiology, Research, and Information Center, Boston, Massachusetts, USA
    J Am Coll Cardiol 50:2085-92. 2007
    ..We undertook this study to prospectively evaluate whether cigarette smoking was associated with an increased risk of developing hypertension...
  95. doi request reprint Differential effects of lipids on the risk of heart failure and coronary heart disease: the Physicians' Health Study
    Ravi Dhingra
    Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA, USA
    Am Heart J 155:869-75. 2008
    ..Hypercholesterolemia, however, being a well-recognized risk factor for CHD, has an unclear association with incident heart failure...
  96. ncbi request reprint Health care utilization and receipt of cholesterol testing by veterans with and those without mental illness
    Rebekah A Kaplowitz
    Massachusetts Veterans Epidemiology Research and Information Center MAVERIC, Veterans Affairs Boston Healthcare System, Boston, MA, USA
    Gen Hosp Psychiatry 28:137-44. 2006
    ..We examined the relationship between mental illness, health care utilization and rates of cholesterol testing...