J M Serrador
Affiliation: Harvard University
- Dynamic cerebral autoregulation after intracerebral hemorrhage: A case-control studyKazuma Nakagawa
Neuroscience Institute, The Queen s Medical Center, Honolulu, Hawaii, USA
BMC Neurol 11:108. 2011..Dynamic cerebral autoregulation after intracerebral hemorrhage (ICH) remains poorly understood. We performed a case-control study to compare dynamic autoregulation between ICH patients and healthy controls...
- Vestibular effects on cerebral blood flowJorge M Serrador
Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
BMC Neurosci 10:119. 2009..In this study, we tested the hypothesis that stimulation of the vestibular system, specifically the otoliths organs, would result in changes in cerebral blood flow...
- Cerebral pressure-flow relations in hypertensive elderly humans: transfer gain in different frequency domainsJorge M Serrador
Hebrew Rehabilitation Center for Aged, Beth Israel Deaconess Medical Center Gerontology Palmer 117, One Deaconess Road, Boston, MA 02215, USA
J Appl Physiol 98:151-9. 2005..Pressure regulation of cerebral blood flow is unrelated to cerebrovascular reactivity to CO(2)...
- Cerebral hypoperfusion precedes nausea during centrifugationJorge M Serrador
Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Aviat Space Environ Med 76:91-6. 2005..The goal of this work was to determine if changes in cerebral blood flow precede the development of nausea in subjects susceptible to motion sickness...
- Cerebral blood flow during orthostasis: role of arterial CO2J M Serrador
Division on Aging, Harvard Medical School, Beth Israel Deaconess Medical Center, One Deaconess Rd, Palmer 117, Boston, MA 02215, USA
Am J Physiol Regul Integr Comp Physiol 290:R1087-93. 2006..Furthermore, the reduction in Pa(CO(2)) did not fully explain the decrease in CFV throughout HUT. These data suggest that factors in addition to a reduction in Pa(CO(2)) play a role in the CBF response to orthostatic stress...
- Loss of otolith function with age is associated with increased postural sway measuresJorge M Serrador
Harvard Medical School, Boston, MA, United States Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Neurosci Lett 465:10-5. 2009..These data suggest a role for loss of otolith function in contributing to fall risk in the elderly. Further prospective, longitudinal studies are necessary to confirm these findings...
- The sit-to-stand technique for the measurement of dynamic cerebral autoregulationFarzaneh A Sorond
Department of Neurology, Stroke Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Ultrasound Med Biol 35:21-9. 2009..The sit-to-stand technique appears to be a suitable measure of individual ARI values for inferring dynamic cerebral autoregulation...
- Cerebrovascular hemodynamics, gait, and falls in an elderly population: MOBILIZE Boston StudyF A Sorond
Department of Neurology, Stroke Division, Brigham and Women s Hospital, 45 Francis St, Boston, MA 02115, USA
Neurology 74:1627-33. 2010..To determine whether alterations in cerebral blood flow regulation are associated with slow gait speed and falls in community-dwelling elderly individuals...
- Effect of acute exposure to hypergravity (GX vs. GZ) on dynamic cerebral autoregulationJ M Serrador
Cerebral Blood Flow Research Lab, School of Kinesiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7
J Appl Physiol 91:1986-94. 2001..We speculate that this leftward shift may have been due to vestibular activation (especially during +GX) or potentially to an adaptation to reduced cerebral perfusion pressure during +GZ...
- Enhanced vasoreactivity and its response to antihypertensive therapy in hypertensive elderly womenLewis A Lipsitz
Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Hypertension 47:377-83. 2006..These results highlight the beneficial effects of antihypertensive therapy on the systemic vasculature, particularly for elderly women in whom enhanced vasoreactivity may contribute to excessive cardiovascular morbidity and mortality...
- Cardiovascular, inflammatory, and metabolic consequences of sleep deprivationJanet M Mullington
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School Division of Cardiology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA
Prog Cardiovasc Dis 51:294-302. 2009..These studies show that insufficient sleep alters established cardiovascular risk factors in a direction that is known to increase the risk of cardiac morbidity...
- Cerebral blood flow regulation during cognitive tasks: effects of healthy agingFarzaneh A Sorond
Department of Neurology, Stroke Division, Brigham and Women s Hospital, Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA 02115, USA
Cortex 44:179-84. 2008..Our data suggest that there is differential blood flow increase in the ACA and PCA in young versus elderly subjects during cognitive tasks...
- Autoregulation in the posterior circulation is altered by the metabolic state of the visual cortexKazuma Nakagawa
Department of Neurology, Stroke Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Stroke 40:2062-7. 2009..We examined the role of cerebral vasodilation caused by metabolic activation (ie, visual stimulus) on autoregulatory characteristics in the 2 vascular territories...
- Regional cerebral autoregulation during orthostatic stress: age-related differencesFarzaneh A Sorond
Brigham and Women s Hospital, Neurology Stroke Division, 45 Francis St, Boston, MA 02115, USA
J Gerontol A Biol Sci Med Sci 60:1484-7. 2005....
- Elderly women regulate brain blood flow better than men doBrian M Deegan
Electrical and Electronic Engineering, School of Engineering and Informatics, NUI Galway, University Road, Galway, Ireland
Stroke 42:1988-93. 2011..This study was designed to determine whether cerebral autoregulation, assessed using transcranial Doppler ultrasound, is more effective in elderly females than in males...
- Head position modifies cerebrovascular response to orthostatic stressTimothy D Wilson
Neurovascular Research Laboratory, The University of Western Ontario, Thames Hall 3110, London, Canada N6A 3K7
Brain Res 961:261-8. 2003..05) during LBNP. These results suggest that the vestibular system may affect cerebrovascular tone during simulated postural stress by either constriction or dilation, depending on the vestibular stimulus...
- VESTIBULAR-CEREBROVASCULAR INTERACTIONS IN HUMANSJorge Serrador; Fiscal Year: 2004..This work may lead to new methods to diagnose those at risk for falls, as well as ways to train the vestibular system to minimize cerebral hypo-perfusion, syncope, and falls in the elderly. ..