C N Serhan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1197-204. 2000
  2. pmc Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses
    K Gronert
    Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 158:3-9. 2001
  3. ncbi request reprint Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation
    C B Clish
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 275:25372-80. 2000
  4. pmc Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation
    N Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 191:1197-208. 2000
  5. ncbi request reprint Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Physiol Pharmacol 51:643-54. 2000
  6. pmc Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release
    K Gronert
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 187:1285-94. 1998
  7. ncbi request reprint Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Chem Lab Med 37:299-309. 1999
  8. ncbi request reprint Lipid mediator class switching during acute inflammation: signals in resolution
    B D Levy
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Nat Immunol 2:612-9. 2001
  9. pmc Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion
    N Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 104:309-16. 1999
  10. ncbi request reprint RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis
    H Hasturk
    Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, Massachusetts, USA
    FASEB J 20:401-3. 2006

Collaborators

Detail Information

Publications34

  1. pmc Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1197-204. 2000
    ..The generation of these and related compounds provides a novel mechanism(s) for the therapeutic benefits of omega-3 dietary supplementation, which may be important in inflammation, neoplasia, and vascular diseases...
  2. pmc Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses
    K Gronert
    Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 158:3-9. 2001
    ....
  3. ncbi request reprint Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation
    C B Clish
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 275:25372-80. 2000
    ..Moreover, they suggest that these eicosanoid oxidoreductases have multifaceted roles controlling the levels of specific eicosanoids involved in the regulation of inflammation...
  4. pmc Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation
    N Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 191:1197-208. 2000
    ....
  5. ncbi request reprint Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Physiol Pharmacol 51:643-54. 2000
    ..Moreover, they provide novel mechanism(s) that could underlie the many reported therapeutic benefits of omega-3 dietary supplementation of interest in inflammation, cancer, and vascular disorders...
  6. pmc Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release
    K Gronert
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 187:1285-94. 1998
    ..Taken together, these results identify an endogenous pathway for downregulating mucosal inflammatory events and suggest a potential therapeutic benefit for LXA4 stable analogs...
  7. ncbi request reprint Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Chem Lab Med 37:299-309. 1999
    ..Here, we review recent developments on the cellular interactions of these novel anti-inflammatory mediators...
  8. ncbi request reprint Lipid mediator class switching during acute inflammation: signals in resolution
    B D Levy
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Nat Immunol 2:612-9. 2001
    ....
  9. pmc Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion
    N Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 104:309-16. 1999
    ..Moreover, LXA4 and ATL counter BLTR-amplified networks, revealing a novel protective role for LX and ATL in stress responses that has applications in perioperative medicine...
  10. ncbi request reprint RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis
    H Hasturk
    Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, Massachusetts, USA
    FASEB J 20:401-3. 2006
    ..Consistent with these potent actions, topical application of RvE1 in rabbit periodontitis conferred dramatic protection against inflammation induced tissue and bone loss associated with periodontitis...
  11. ncbi request reprint Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 166:3650-4. 2001
    ..The present results identify nociceptin as a potent chemoattractant and provide a novel link between the neural and immune systems that are blocked by aspirin-triggered lipid mediators and may be relevant in neurogenic inflammation...
  12. pmc Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor
    S Fiore
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    J Exp Med 180:253-60. 1994
    ..Together, they suggest that the encoded protein is a candidate for a LXA4 receptor in myeloid cells...
  13. ncbi request reprint Inosine monophosphate and aspirin-triggered 15-epi-lipoxin A4 act in concert to regulate neutrophil trafficking: additive actions of two new endogenous anti-inflammatory mediators
    K Wada
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Hematother Stem Cell Res 10:75-9. 2001
    ..The additive inhibition by IMP and aspirin-triggered LX may represent key pathways that protect and resolve inflammatory responses that could be harnessed for treatment...
  14. ncbi request reprint Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins
    I M Fierro
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Braz J Med Biol Res 34:555-66. 2001
    ..Here, we present an overview of the recent knowledge about the biosynthesis and bioactions of these anti-inflammatory lipid mediators...
  15. ncbi request reprint Lipoxins and aspirin-triggered 15-epi-lipoxins are endogenous components of antiinflammation: emergence of the counterregulatory side
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Immunol Ther Exp (Warsz) 49:177-88. 2001
    ..Here, an overview of these recent developments is presented, with a focus on the cellular and molecular interactions of these novel antiinflammatory lipid mediators...
  16. ncbi request reprint Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils
    F H Qiu
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    FASEB J 15:2736-8. 2001
    ....
  17. doi request reprint Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination
    L V Norling
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Intern Med 268:15-24. 2010
    ..Together these findings indicate that defective mechanisms and pathways in resolution may underlie our current appreciation of the inflammatory phenotype(s) that characterize some prevalent human diseases...
  18. pmc Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro
    C N Serhan
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    J Clin Invest 85:772-80. 1990
    ..These results indicate that neutrophil-platelet interactions can lead to the formation of lipoxins from endogenous sources and provide a role for platelet 12-LO in the formation of lipoxins from LTA4...
  19. pmc An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption
    B S Herrera
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 2118, USA
    Br J Pharmacol 155:1214-23. 2008
    ..It was of interest to determine whether RvE1 has direct actions on osteoclast (OC) development and bone resorption...
  20. ncbi request reprint Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases
    T E Van Dyke
    Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118, USA
    J Dent Res 82:82-90. 2003
    ....
  21. ncbi request reprint Polyisoprenyl phosphates: natural antiinflammatory lipid signals
    B D Levy
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 59:729-41. 2002
    ....
  22. pmc Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4
    A Planagumà
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mucosal Immunol 3:270-9. 2010
    ....
  23. ncbi request reprint Leukotrienes stimulate neutrophil adhesion to mesangial cells: modulation with lipoxins
    H R Brady
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Am J Physiol 259:F809-15. 1990
    ..Together, these results provide further evidence that LO-derived eicosanoids may constitute important early signals that regulate PMN-MC interaction in glomerular inflammation...
  24. ncbi request reprint Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia
    O Levy
    Children s Hospital of Boston, Boston, MA 02115, U S A and Channing Laboratory, Boston, MA 02115, USA
    Biochem Soc Trans 31:795-800. 2003
    ....
  25. doi request reprint Systems approach to inflammation resolution: identification of novel anti-inflammatory and pro-resolving mediators
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Thromb Haemost 7:44-8. 2009
    ..Moreover, identification of functional SPM biosynthesized during inflammation-resolution indicates that resolution is an active process...
  26. pmc Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus
    C N Serhan
    Department of Anesthesiology, Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Br J Pharmacol 153:S200-15. 2008
    ..These may be useful in the design of new therapeutics and treatments for diseases with the underlying trait of uncontrolled inflammation and redox organ stress...
  27. pmc Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors
    T Takano
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 185:1693-704. 1997
    ..These findings provide direct in vivo evidence for an anti-inflammatory action for both aspirin-triggered LXA4 and LXA4 stable analogues and their site of action in vivo...
  28. ncbi request reprint Identification of dual cyclooxygenase-eicosanoid oxidoreductase inhibitors: NSAIDs that inhibit PG-LX reductase/LTB(4) dehydrogenase
    C B Clish
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochem Biophys Res Commun 288:868-74. 2001
    ..Moreover, they suggest that the impact of NSAIDs on PG-LXR/LTB(4)DH activities as targets in the local tissue regulation of eicosanoid-mediated processes should be taken into account...
  29. pmc Resolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress
    M Spite
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Br J Pharmacol 158:1062-73. 2009
    ..Here, we sought to determine whether GS-HNE is a mediator of oxidative stress-initiated inflammation and if its actions can be regulated by the anti-inflammatory and pro-resolving lipid mediator, resolvin D1 (RvD1)...
  30. pmc Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion
    D Li
    Department of Ophthalmology, Massachusetts Eye and Ear, Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA
    Mucosal Immunol 6:1119-30. 2013
    ..We suggest that D-series resolvins regulate histamine responses in the eye and offer new treatment approaches for allergic conjunctivitis or other histamine-dependent pathologies. ..
  31. pmc The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R
    M Resnati
    Molecular Genetics Unit, Department of Cell Biology and Functional Genomics, DIBIT Istituto Scientifico San Raffaele and Università Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Proc Natl Acad Sci U S A 99:1359-64. 2002
    ..These results provide the first direct link, to our knowledge, between the fibrinolytic machinery and the inflammatory response, demonstrating that uPA-derived peptide fragments can activate a specific chemotactic receptor...
  32. ncbi request reprint Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity
    J Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Nat Immunol 3:76-82. 2002
    ..Together, these findings indicate that the induction of lipoxins in response to microbial stimulation can provide a potent mechanism for regulating DC function during the innate response to pathogens...
  33. ncbi request reprint Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor
    J F Maddox
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:6972-8. 1997
    ..Moreover, they provide additional evidence that the LXA4 stable analogs retain selective bioactivity in monocytes and are valuable instruments for examining the functions and modes of action of LXA4...
  34. ncbi request reprint Interactions between lipoxin A4, the stable analogue 16-phenoxy-lipoxin A4 and leukotriene B4 in cytokine generation by human monocytes
    P Andersson
    Department of Medicine, Karolinska Institutet at Stockholm Soder Hospital, Stockholm, Sweden
    Scand J Immunol 60:249-56. 2004
    ..Thus, a stable LXA analogue, that resists rapid inactivation by monocytes, displays novel actions in cytokine generation, intimately involved in the regulation of inflammation...