C N Serhan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 20 Shattuck Street, Boston, MA 02115, USA
    J Periodontol 79:1520-6. 2008
  2. pmc Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors
    T Takano
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 185:1693-704. 1997
  3. ncbi request reprint Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:1848-59. 2006
  4. pmc Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation
    N Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 191:1197-208. 2000
  5. pmc Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
    Matthew Spite
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 461:1287-91. 2009
  6. pmc Anesthetics impact the resolution of inflammation
    Nan Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e1879. 2008
  7. pmc Novel n-3 immunoresolvents: structures and actions
    Jesmond Dalli
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Sci Rep 3:1940. 2013
  8. pmc Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
    Makoto Arita
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:713-22. 2005
  9. pmc Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution
    Gabrielle Fredman
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine and Harvard Medical School, Boston, MA 02115, USA
    Biochem J 437:185-97. 2011
  10. pmc Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis
    Gerard L Bannenberg
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 199:515-23. 2004

Research Grants

  1. Novel Mechanisms in Resolution to Harness Inflammation for Reconstruction
    Charles Serhan; Fiscal Year: 2009
  2. Novel Mechanisms in Resolution to Harness Inflammation for Reconstruction
    Thomas E Van Dyke; Fiscal Year: 2010
  3. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2005
  4. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2009
  5. Specialized Center for Oral Inflammation and Resolution
    Charles Serhan; Fiscal Year: 2007
  6. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2007
  7. BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION AND ACTION
    Charles Serhan; Fiscal Year: 2007
  8. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2006
  9. BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION AND ACTION
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010

Collaborators

Detail Information

Publications163 found, 100 shown here

  1. ncbi request reprint Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 20 Shattuck Street, Boston, MA 02115, USA
    J Periodontol 79:1520-6. 2008
    ..The new families of endogenous proresolving and anti-inflammatory agonists constitute a new genus of anti-inflammatories...
  2. pmc Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors
    T Takano
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 185:1693-704. 1997
    ..These findings provide direct in vivo evidence for an anti-inflammatory action for both aspirin-triggered LXA4 and LXA4 stable analogues and their site of action in vivo...
  3. ncbi request reprint Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:1848-59. 2006
    ..PD1 also reduced PMN infiltration after initiation (2 h) of inflammation and was additive with resolvin E1. These results indicate that PD1 is a potent stereoselective anti-inflammatory molecule...
  4. pmc Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation
    N Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 191:1197-208. 2000
    ....
  5. pmc Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
    Matthew Spite
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 461:1287-91. 2009
    ..Together, these results identify RvD2 as a potent endogenous regulator of excessive inflammatory responses that acts via multiple cellular targets to stimulate resolution and preserve immune vigilance...
  6. pmc Anesthetics impact the resolution of inflammation
    Nan Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e1879. 2008
    ..Here we investigated whether a commonly used local anesthetic (lidocaine) and a widely used inhaled anesthetic (isoflurane) impact the active process of resolution of inflammation...
  7. pmc Novel n-3 immunoresolvents: structures and actions
    Jesmond Dalli
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Sci Rep 3:1940. 2013
    ..Together, these findings demonstrate that n-3 DPA is converted to novel immunoresolvents with actions comparable to resolvins and are likely produced in humans when n-3 DPA is elevated...
  8. pmc Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
    Makoto Arita
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:713-22. 2005
    ..These results demonstrate novel counterregulatory responses in inflammation initiated via RvE1 receptor activation that provide the first evidence for EPA-derived potent endogenous agonists of antiinflammation...
  9. pmc Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution
    Gabrielle Fredman
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine and Harvard Medical School, Boston, MA 02115, USA
    Biochem J 437:185-97. 2011
    ..We also give an overview of newly described resolution circuitry whereby resolvins govern miRNAs (microRNAs), and transcription factors that counter-regulate pro-inflammatory chemokines, cytokines and lipid mediators...
  10. pmc Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis
    Gerard L Bannenberg
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 199:515-23. 2004
    ....
  11. pmc Infection regulates pro-resolving mediators that lower antibiotic requirements
    Nan Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 484:524-8. 2012
    ..These results demonstrate that specific SPMs are temporally and differentially regulated during infections and that they are anti-phlogistic, enhance containment and lower antibiotic requirements for bacterial clearance...
  12. pmc Functional Metabolomics Reveals Novel Active Products in the DHA Metabolome
    Masakazu Shinohara
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School Boston, MA, USA
    Front Immunol 3:81. 2012
    ....
  13. pmc Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA
    Gabrielle Fredman
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Sci Rep 2:639. 2012
    ....
  14. pmc Resolution phase lipid mediators of inflammation: agonists of resolution
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, United States
    Curr Opin Pharmacol 13:632-40. 2013
    ..Collectively, they support the concept that return of acute inflammation involves active biosynthesis and SPM signaling toward homeostasis. ..
  15. pmc The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype
    Jesmond Dalli
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 27:2573-83. 2013
    ....
  16. pmc Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, 77 Ave Louis Pasteur, HIM 829, Boston, MA 02115, USA
    FASEB J 26:1755-65. 2012
    ..Moreover, immunoresolvents of the innate immune response, such as MaR1, offer new opportunities for assessing MΦs and their local DHA metabolome in the return to tissue homeostasis...
  17. ncbi request reprint Resolution of inflammation: the beginning programs the end
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1191-7. 2005
    ..Understanding these and further details of the mechanism required for inflammation resolution may underpin the development of drugs that can resolve inflammatory processes in directed and controlled ways...
  18. ncbi request reprint Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Immunol 171:6856-65. 2003
    ..Moreover, they suggest that LXs can be targets for novel approaches to diseases, e.g., periodontitis and arthritis, where inflammation and bone destruction are features...
  19. pmc Lipid mediator informatics-lipidomics: novel pathways in mapping resolution
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Thorn Building for Medical Research, 7th Floor, Brigham and Women s Hospital, Boston, MA 02115, USA
    AAPS J 8:E284-97. 2006
    ..Here, we review liquid chromatography tandem mass spectrometry-based lipidomic analyses to address bioactive lipid mediators in signaling pathways and the roles of lipid-derived mediators in resolution of inflammation...
  20. ncbi request reprint Novel chemical mediators in the resolution of inflammation: resolvins and protectins
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Anesthesiol Clin 24:341-64. 2006
    ..In view of the essential roles of DHA and EPA in human biology and medicine uncovered to date, the physiologic relevance of the resolvins and protectins is likely to extend beyond our current appreciation...
  21. ncbi request reprint The allergy archives: pioneer and milestones. The discovery and characterization of the leukotrienes
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 118:972-80. 2006
  22. pmc Resolution of inflammation: state of the art, definitions and terms
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Thorn 724, Boston, MA 02115, USA
    FASEB J 21:325-32. 2007
    ..Hence, resolution is an active rather than a passive process, as once believed, which now promises novel approaches for the treatment of inflammation-associated diseases based on endogenous agonists of resolution...
  23. pmc Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 196:1025-37. 2002
    ..These biosynthetic pathways utilize omega-3 DHA and EPA during multicellular events in resolution to produce a family of protective compounds, i.e., resolvins, that enhance proresolution status...
  24. ncbi request reprint Mediator lipidomics
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Prostaglandins Other Lipid Mediat 77:4-14. 2005
    ..Metabolism of fatty acids is also an important energy source; hence, catabolism breakdown of fatty acids, areas of metabolomics that link to the signaling pathways, and roles of lipid mediators discussed herein...
  25. ncbi request reprint Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 25:101-37. 2007
    ..Given the potent actions of lipoxins, resolvins, and protectins in models of human disease, deficiencies in resolution pathways may contribute to many diseases and offer exciting new potential for therapeutic control via resolution...
  26. ncbi request reprint Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entrée for resoleomics
    Charles N Serhan
    The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Rheum Dis Clin North Am 30:69-95. 2004
    ..Together with the lipoxins and 15-epi-lipoxins, the identification of the resolvins gives us new avenues of approach in considering therapies for inflammation, cardiovascular diseases and cancer...
  27. ncbi request reprint Novel pathways and endogenous mediators in anti-inflammation and resolution
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Chem Immunol Allergy 83:115-45. 2003
  28. ncbi request reprint Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis
    Charles N Serhan
    Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Prostaglandins Other Lipid Mediat 73:155-72. 2004
    ..Here, we provide a syntomy overview of the formation and actions of these newly uncovered pathways and products as well as highlight their role(s) as endogenous protective mediators generated in anti-inflammation and catabasis...
  29. ncbi request reprint A search for endogenous mechanisms of anti-inflammation uncovers novel chemical mediators: missing links to resolution
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Histochem Cell Biol 122:305-21. 2004
    ..These new pathways open new opportunities for appreciating the role of neutrophils in the generation of potent protective lipid mediators and protective host signaling...
  30. ncbi request reprint Clues for new therapeutics in osteoporosis and periodontal disease: new roles for lipoxygenases?
    Charles N Serhan
    Brigham and Women s Hospital and Harvard Medical School, Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, 75 Francis Street, Boston, MA 02115, USA
    Expert Opin Ther Targets 8:643-52. 2004
    ..This article discusses the recent findings that may link aberrant LOX pathway expression in these diseases, suggesting new avenues for therapeutic approaches via activation of endogenous pathways for resolution of local inflammation...
  31. pmc Success of prostaglandin E2 in structure-function is a challenge for structure-based therapeutics
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:8609-11. 2003
  32. ncbi request reprint Lipid-derived mediators in endogenous anti-inflammation and resolution: lipoxins and aspirin-triggered 15-epi-lipoxins
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    ScientificWorldJournal 2:169-204. 2002
    ....
  33. ncbi request reprint Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Clin Nutr Metab Care 8:115-21. 2005
    ..Many clinical studies suggest that omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial actions in human diseases. The molecular basis of these actions remains of interest...
  34. ncbi request reprint Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Lipids 39:1125-32. 2004
    ..In this article, we provide an overview of the formation and actions of these newly uncovered pathways and products...
  35. ncbi request reprint Novel omega -- 3-derived local mediators in anti-inflammation and resolution
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Pharmacol Ther 105:7-21. 2005
    ....
  36. pmc Anti-inflammatory and proresolving lipid mediators
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Pathol 3:279-312. 2008
    ..Here, we review the recent advances in our understanding of the biosynthesis and stereospecific actions of these new proresolving mediators, which have also proven to be organ protective and antifibrotic...
  37. pmc Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:349-61. 2008
    ..These mediators have anti-inflammatory and pro-resolution properties, thereby protecting organs from collateral damage, stimulating the clearance of inflammatory debris and promoting mucosal antimicrobial defence...
  38. pmc Novel proresolving aspirin-triggered DHA pathway
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Chem Biol 18:976-87. 2011
    ..These results indicate that AT-(NPD1/PD1) is a potent anti-inflammatory proresolving molecule...
  39. ncbi request reprint Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Chem Lab Med 37:299-309. 1999
    ..Here, we review recent developments on the cellular interactions of these novel anti-inflammatory mediators...
  40. ncbi request reprint Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 166:3650-4. 2001
    ..The present results identify nociceptin as a potent chemoattractant and provide a novel link between the neural and immune systems that are blocked by aspirin-triggered lipid mediators and may be relevant in neurogenic inflammation...
  41. ncbi request reprint Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Physiol Pharmacol 51:643-54. 2000
    ..Moreover, they provide novel mechanism(s) that could underlie the many reported therapeutic benefits of omega-3 dietary supplementation of interest in inflammation, cancer, and vascular disorders...
  42. ncbi request reprint Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Prostaglandins Leukot Essent Fatty Acids 73:141-62. 2005
    ..Hence, the LX pathways and mechanisms reviewed to date in this work provide a basis for new approaches to treatment of many common human diseases that involve inflammation...
  43. pmc Novel anti-inflammatory--pro-resolving mediators and their receptors
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Curr Top Med Chem 11:629-47. 2011
    ..This approach may offer new targets suitable for drug design for treating inflammation related diseases, for the new terrain of resolution pharmacology...
  44. pmc Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus
    C N Serhan
    Department of Anesthesiology, Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Br J Pharmacol 153:S200-15. 2008
    ..These may be useful in the design of new therapeutics and treatments for diseases with the underlying trait of uncontrolled inflammation and redox organ stress...
  45. ncbi request reprint Lipoxins and aspirin-triggered 15-epi-lipoxins are endogenous components of antiinflammation: emergence of the counterregulatory side
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Immunol Ther Exp (Warsz) 49:177-88. 2001
    ..Here, an overview of these recent developments is presented, with a focus on the cellular and molecular interactions of these novel antiinflammatory lipid mediators...
  46. pmc Systems approach with inflammatory exudates uncovers novel anti-inflammatory and pro-resolving mediators
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Thorn 724, MA 02115, USA
    Prostaglandins Leukot Essent Fatty Acids 79:157-63. 2008
    ....
  47. pmc Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?
    Charles N Serhan
    Director, Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, HIM 8, Boston, MA 02115, USA
    Am J Pathol 177:1576-91. 2010
    ....
  48. ncbi request reprint Systems approach to inflammation resolution: identification of novel anti-inflammatory and pro-resolving mediators
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Thromb Haemost 7:44-8. 2009
    ..Moreover, identification of functional SPM biosynthesized during inflammation-resolution indicates that resolution is an active process...
  49. pmc Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 206:15-23. 2009
    ..These findings suggest that maresins and this new metabolome may be involved in some of the beneficial actions of DHA and MPhis in tissue homeostasis, inflammation resolution, wound healing, and host defense...
  50. pmc MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits
    Antonio Recchiuti
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Harvard Institutes of Medicine 829, Boston, MA 02115, USA
    FASEB J 25:544-60. 2011
    ..Taken together, these results indicate that resolvin-regulated specific miRNAs target genes involved in resolution and establish a novel resolution circuit involving RvD1 receptor-dependent regulation of specific miRNAs...
  51. pmc Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1197-204. 2000
    ..The generation of these and related compounds provides a novel mechanism(s) for the therapeutic benefits of omega-3 dietary supplementation, which may be important in inflammation, neoplasia, and vascular diseases...
  52. ncbi request reprint Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation
    C B Clish
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 275:25372-80. 2000
    ..Moreover, they suggest that these eicosanoid oxidoreductases have multifaceted roles controlling the levels of specific eicosanoids involved in the regulation of inflammation...
  53. pmc Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses
    K Gronert
    Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 158:3-9. 2001
    ....
  54. pmc Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion
    N Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 104:309-16. 1999
    ..Moreover, LXA4 and ATL counter BLTR-amplified networks, revealing a novel protective role for LX and ATL in stress responses that has applications in perioperative medicine...
  55. ncbi request reprint Lipid mediator class switching during acute inflammation: signals in resolution
    B D Levy
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Nat Immunol 2:612-9. 2001
    ....
  56. pmc Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release
    K Gronert
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 187:1285-94. 1998
    ..Taken together, these results identify an endogenous pathway for downregulating mucosal inflammatory events and suggest a potential therapeutic benefit for LXA4 stable analogs...
  57. ncbi request reprint RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis
    H Hasturk
    Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, Massachusetts, USA
    FASEB J 20:401-3. 2006
    ..Consistent with these potent actions, topical application of RvE1 in rabbit periodontitis conferred dramatic protection against inflammation induced tissue and bone loss associated with periodontitis...
  58. ncbi request reprint Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor
    J F Maddox
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:6972-8. 1997
    ..Moreover, they provide additional evidence that the LXA4 stable analogs retain selective bioactivity in monocytes and are valuable instruments for examining the functions and modes of action of LXA4...
  59. pmc Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro
    C N Serhan
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    J Clin Invest 85:772-80. 1990
    ..These results indicate that neutrophil-platelet interactions can lead to the formation of lipoxins from endogenous sources and provide a role for platelet 12-LO in the formation of lipoxins from LTA4...
  60. ncbi request reprint Adhesion promotes transcellular leukotriene biosynthesis during neutrophil-glomerular endothelial cell interactions: inhibition by antibodies against CD18 and L-selectin
    H R Brady
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Biochem Biophys Res Commun 186:1307-14. 1992
    ..They suggest that adhesion promotes transcellular eicosanoid biosynthesis and that adhesion molecules may also be targets for blockade of transcellular biosynthesis of lipid mediators...
  61. ncbi request reprint Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins
    I M Fierro
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Braz J Med Biol Res 34:555-66. 2001
    ..Here, we present an overview of the recent knowledge about the biosynthesis and bioactions of these anti-inflammatory lipid mediators...
  62. ncbi request reprint Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases
    T E Van Dyke
    Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118, USA
    J Dent Res 82:82-90. 2003
    ....
  63. pmc Remodeling of neutrophil phospholipids with 15(S)-hydroxyeicosatetraenoic acid inhibits leukotriene B4-induced neutrophil migration across endothelium
    S Takata
    Renal Division, Brigham and Women s Hospital, Boston, Massachusetts
    J Clin Invest 93:499-508. 1994
    ..They suggest that 15(S)-HETE may be a potent endogenous inhibitor of PMN-endothelial interactions in vivo and serve to limit or reverse acute inflammation...
  64. ncbi request reprint Lipoxins stimulate prostacyclin generation by human endothelial cells
    M E Brezinski
    Department of Medicine, Brigham and Women s Hospital, Boston, MA
    FEBS Lett 245:167-72. 1989
    ..Moreover, they suggest a role for these lipoxygenase products of arachidonic acid in the regulation of hemostasis, inflammation and vascular reactivity...
  65. pmc Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor
    S Fiore
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    J Exp Med 180:253-60. 1994
    ..Together, they suggest that the encoded protein is a candidate for a LXA4 receptor in myeloid cells...
  66. ncbi request reprint Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense
    Pallavi R Devchand
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    FASEB J 17:652-9. 2003
    ..Together these results demonstrate a gain-of-function with hALX transgenic mouse and indicate that ALX is a key receptor and sensor in formation of acute exudates and their resolution...
  67. pmc Lipoxin synthase activity of human platelet 12-lipoxygenase
    M Romano
    Department of Medicine, Brigham and Women s Hospital, Boston, MA
    Biochem J 296:127-33. 1993
    ..These results provide direct evidence for LXA4 and LXB4 synthase activity of human platelet 12-LO. Moreover, they suggest that 12-LO is a dual-function enzyme that carries both oxygenase and lipoxin synthase activity...
  68. ncbi request reprint Inosine monophosphate and aspirin-triggered 15-epi-lipoxin A4 act in concert to regulate neutrophil trafficking: additive actions of two new endogenous anti-inflammatory mediators
    K Wada
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Hematother Stem Cell Res 10:75-9. 2001
    ..The additive inhibition by IMP and aspirin-triggered LX may represent key pathways that protect and resolve inflammatory responses that could be harnessed for treatment...
  69. ncbi request reprint Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils
    F H Qiu
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    FASEB J 15:2736-8. 2001
    ....
  70. ncbi request reprint Ca2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophils
    F W Luscinskas
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115
    Biochem Pharmacol 39:355-65. 1990
    ....
  71. ncbi request reprint New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases
    Stephanie Yacoubian
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Nat Clin Pract Rheumatol 3:570-9; quiz 1 p following 589. 2007
    ..Possible deficiencies in the biosynthesis of lipoxins, resolvins, and protectins, and/or their signal transduction, might underlie some aspects of pathogenesis in chronic inflammatory diseases...
  72. ncbi request reprint Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells
    Iolanda M Fierro
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:2688-94. 2003
    ....
  73. ncbi request reprint Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo
    Hatice Hasturk
    Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, MA 02118, USA
    J Immunol 179:7021-9. 2007
    ..This report is the first to show that resolution of inflammation by a naturally occurring endogenous lipid mediator results in complete regeneration of pathologically lost tissues, including bone...
  74. ncbi request reprint The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering
    Amiram Ariel
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:43079-86. 2005
    ..These results demonstrated novel anti-inflammatory roles for PD1 in regulating events associated with inflammation and resolution...
  75. ncbi request reprint Lipoxins and aspirin-triggered 15-epi-lipoxin biosynthesis: an update and role in anti-inflammation and pro-resolution
    Charles N Serhan
    Department of Anesthesiology, Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Prostaglandins Other Lipid Mediat 68:433-55. 2002
    ..An overview of these recent developments is presented with a focus on the cellular and molecular interactions of these novel anti-inflammatory lipid mediators that also appear to facilitate the resolution of acute inflammatory responses...
  76. pmc Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution
    Kie Kasuga
    Department of Anesthesiology, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 181:8677-87. 2008
    ..Together, these results indicate that circulating omega-3 fatty acids rapidly appear in inflammatory sites that require conversion to resolvins that control excessive neutrophil infiltration, protect organs, and foster resolution...
  77. ncbi request reprint Polyisoprenyl phosphates: natural antiinflammatory lipid signals
    B D Levy
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 59:729-41. 2002
    ....
  78. pmc Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4
    A Planagumà
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mucosal Immunol 3:270-9. 2010
    ....
  79. ncbi request reprint Leukotrienes stimulate neutrophil adhesion to mesangial cells: modulation with lipoxins
    H R Brady
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Am J Physiol 259:F809-15. 1990
    ..Together, these results provide further evidence that LO-derived eicosanoids may constitute important early signals that regulate PMN-MC interaction in glomerular inflammation...
  80. ncbi request reprint Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination
    L V Norling
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Intern Med 268:15-24. 2010
    ..Together these findings indicate that defective mechanisms and pathways in resolution may underlie our current appreciation of the inflammatory phenotype(s) that characterize some prevalent human diseases...
  81. pmc Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration
    Gerard Bannenberg
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Br J Pharmacol 143:43-52. 2004
    ..The 3-oxa-ATL analogs, which have enhanced metabolic and chemical stability and a superior pharmacokinetic profile, provide new opportunities to explore the actions and therapeutic potential for LX and ATL...
  82. ncbi request reprint Exploring new approaches to the treatment of asthma: potential roles for lipoxins and aspirin-triggered lipid mediators
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Drugs Today (Barc) 39:373-84. 2003
    ....
  83. pmc Resolvin E1 and protectin D1 activate inflammation-resolution programmes
    Jan M Schwab
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 447:869-74. 2007
    ..Together, these results identify new active components for postexudate resolution traffic, and demonstrate that RvE1 and PD1 are potent agonists for resolution of inflamed tissues...
  84. ncbi request reprint Resolvin E1 metabolome in local inactivation during inflammation-resolution
    Song Hong
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:3512-9. 2008
    ..e., RvE1, to permit the coordinated return to homeostasis. Moreover, the RvE1 metabolome may serve as a biomarker of these processes...
  85. pmc An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption
    B S Herrera
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 2118, USA
    Br J Pharmacol 155:1214-23. 2008
    ..It was of interest to determine whether RvE1 has direct actions on osteoclast (OC) development and bone resorption...
  86. ncbi request reprint Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia
    O Levy
    Children s Hospital of Boston, Boston, MA 02115, U S A and Channing Laboratory, Boston, MA 02115, USA
    Biochem Soc Trans 31:795-800. 2003
    ....
  87. pmc Anti-inflammatory and pro-resolving properties of benzo-lipoxin A(4) analogs
    Yee Ping Sun
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Prostaglandins Leukot Essent Fatty Acids 81:357-66. 2009
    ..These benzo-LXA(4) analogs are promising tools for new therapeutic approaches as well as assessing endogenous mechanisms in anti-inflammation and resolution...
  88. ncbi request reprint Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis
    Eric Tjonahen
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Chem Biol 13:1193-202. 2006
    ..Moreover, they indicate that the 5-lipoxygenase in human leukocytes is a pivotal enzyme that can produce both pro- and anti-inflammatory chemical mediators...
  89. ncbi request reprint Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation
    Yee Ping Sun
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:9323-34. 2007
    ..These results may contribute to the beneficial actions of aspirin and omega-3 fish oils in humans...
  90. pmc Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators
    Yiping Jin
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 50:4743-52. 2009
    ..Here the authors investigated the potential of aspirin-triggered lipoxin (LX) A4 analog (ATLa), resolving (Rv) D1, and RvE1, in regulating angiogenesis in a murine model...
  91. ncbi request reprint Lipoxins and new lipid mediators in the resolution of inflammation
    Jan M Schwab
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston MA 02115, USA
    Curr Opin Pharmacol 6:414-20. 2006
    ..e. RvDs). These bioactive molecules open new avenues and approaches to therapeutic interventions via accelerated resolution of inflammation...
  92. pmc Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins
    Matthew Spite
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circ Res 107:1170-84. 2010
    ..Here, we overview and update the biosynthesis and actions of proresolving lipid mediators, highlighting their diverse protective roles relevant to vascular systems and their relation to aspirin and statin therapies...
  93. ncbi request reprint Mediator-lipidomics: databases and search algorithms for PUFA-derived mediators
    Yan Lu
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Lipid Res 46:790-802. 2005
    ..These results indicate that COCAD has many advantages for profiling and identification of LMs compared with the conventional dot-product algorithm...
  94. pmc Resolvin E1 receptor activation signals phosphorylation and phagocytosis
    Taisuke Ohira
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Center for Experimental Therapeutics and Reperfusion Injury, Boston, Massachusetts 02115, USA
    J Biol Chem 285:3451-61. 2010
    ..These phosphorylation-signaling pathways identified for RvE1 receptor-ligand interactions underscore the importance of endogenous pro-resolving agonists in resolving acute inflammation...
  95. pmc Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death
    Minjian Chen
    Department of Medicine, Division of Rheumatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:2791-801. 2008
    ..These in vitro and in vivo data indicate that PGE(2) plays a critical role in inhibition of Mtb replication...
  96. ncbi request reprint Lipoxins and aspirin-triggered lipoxins in airway responses
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Adv Exp Med Biol 525:19-23. 2003
    ..Moreover, these results indicate that LX's play pivotal and previously unappreciated roles in regulating allergy and pulmonary inflammation...
  97. ncbi request reprint A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils
    Pallavi R Devchand
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston 02115, USA
    FASEB J 19:203-10. 2005
    ..A., Primo, V. C., Zhang, Q.-y., Arnaout, M. A., Serhan, C. N., Nikolic, B. A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils...
  98. ncbi request reprint Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cells
    Amiram Ariel
    Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:6266-72. 2003
    ..Moreover, they provide potential counterregulatory signals in communication(s) between the innate and acquired immune systems...
  99. pmc Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial
    Nan Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:15178-83. 2004
    ..These results also emphasize the importance of cell-cell interactions in the modulation of hemostatic, thrombotic, and inflammatory processes...
  100. pmc Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation
    Oliver Haworth
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 9:873-9. 2008
    ....

Research Grants12

  1. Novel Mechanisms in Resolution to Harness Inflammation for Reconstruction
    Charles Serhan; Fiscal Year: 2009
    ..The proposed studies focus on novel pro-resolving mediators that activate resolution of inflammation to control inflammation and tissue regeneration. ..
  2. Novel Mechanisms in Resolution to Harness Inflammation for Reconstruction
    Thomas E Van Dyke; Fiscal Year: 2010
    ..The proposed studies focus on novel pro-resolving mediators that activate resolution of inflammation to control inflammation and tissue regeneration. ..
  3. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2005
    ..abstract_text> ..
  4. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2009
    ..abstract_text> ..
  5. Specialized Center for Oral Inflammation and Resolution
    Charles Serhan; Fiscal Year: 2007
    ..abstract_text> ..
  6. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2007
    ..abstract_text> ..
  7. BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION AND ACTION
    Charles Serhan; Fiscal Year: 2007
    ..Completion of these aims will provide a new paradigm to address inflammatory diseases, namely by elucidating endogenous lipid mediators of antiinflammation. ..
  8. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2006
    ..abstract_text> ..
  9. BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION AND ACTION
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ....