Research Topics
Genomes and Genes | C N SerhanSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediatorsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 20 Shattuck Street, Boston, MA 02115, USA
J Periodontol 79:1520-6. 2008..The new families of endogenous proresolving and anti-inflammatory agonists constitute a new genus of anti-inflammatories...
Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptorsT Takano
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Exp Med 185:1693-704. 1997..These findings provide direct in vivo evidence for an anti-inflammatory action for both aspirin-triggered LXA4 and LXA4 stable analogues and their site of action in vivo...
Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienesCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 176:1848-59. 2006..PD1 also reduced PMN infiltration after initiation (2 h) of inflammation and was additive with resolvin E1. These results indicate that PD1 is a potent stereoselective anti-inflammatory molecule...- Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls painCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, 77 Ave Louis Pasteur, HIM 829, Boston, MA 02115, USA
FASEB J 26:1755-65. 2012..Moreover, immunoresolvents of the innate immune response, such as MaR1, offer new opportunities for assessing MΦs and their local DHA metabolome in the return to tissue homeostasis... - Novel proresolving aspirin-triggered DHA pathwayCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
Chem Biol 18:976-87. 2011..These results indicate that AT-(NPD1/PD1) is a potent anti-inflammatory proresolving molecule... - Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolutionCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Prostaglandins Leukot Essent Fatty Acids 73:141-62. 2005..Hence, the LX pathways and mechanisms reviewed to date in this work provide a basis for new approaches to treatment of many common human diseases that involve inflammation... - The allergy archives: pioneer and milestones. The discovery and characterization of the leukotrienesCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
J Allergy Clin Immunol 118:972-80. 2006 - Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimersCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Lipids 39:1125-32. 2004..In this article, we provide an overview of the formation and actions of these newly uncovered pathways and products... - Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectinsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Curr Opin Clin Nutr Metab Care 8:115-21. 2005..Many clinical studies suggest that omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial actions in human diseases. The molecular basis of these actions remains of interest... - Novel omega -- 3-derived local mediators in anti-inflammation and resolutionCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Pharmacol Ther 105:7-21. 2005.... - Clues for new therapeutics in osteoporosis and periodontal disease: new roles for lipoxygenases?Charles N Serhan
Brigham and Women s Hospital and Harvard Medical School, Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, 75 Francis Street, Boston, MA 02115, USA
Expert Opin Ther Targets 8:643-52. 2004..This article discusses the recent findings that may link aberrant LOX pathway expression in these diseases, suggesting new avenues for therapeutic approaches via activation of endogenous pathways for resolution of local inflammation... - A search for endogenous mechanisms of anti-inflammation uncovers novel chemical mediators: missing links to resolutionCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Histochem Cell Biol 122:305-21. 2004..These new pathways open new opportunities for appreciating the role of neutrophils in the generation of potent protective lipid mediators and protective host signaling... - Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasisCharles N Serhan
Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Prostaglandins Other Lipid Mediat 73:155-72. 2004..Here, we provide a syntomy overview of the formation and actions of these newly uncovered pathways and products as well as highlight their role(s) as endogenous protective mediators generated in anti-inflammation and catabasis... - Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entrée for resoleomicsCharles N Serhan
The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Rheum Dis Clin North Am 30:69-95. 2004..Together with the lipoxins and 15-epi-lipoxins, the identification of the resolvins gives us new avenues of approach in considering therapies for inflammation, cardiovascular diseases and cancer... - Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediatorsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Immunol 171:6856-65. 2003..Moreover, they suggest that LXs can be targets for novel approaches to diseases, e.g., periodontitis and arthritis, where inflammation and bone destruction are features... - Novel pathways and endogenous mediators in anti-inflammation and resolutionCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. 02115, USA
Chem Immunol Allergy 83:115-45. 2003 - Success of prostaglandin E2 in structure-function is a challenge for structure-based therapeuticsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:8609-11. 2003 - Lipid-derived mediators in endogenous anti-inflammation and resolution: lipoxins and aspirin-triggered 15-epi-lipoxinsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
ScientificWorldJournal 2:169-204. 2002.... - Mediator lipidomicsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Prostaglandins Other Lipid Mediat 77:4-14. 2005..Metabolism of fatty acids is also an important energy source; hence, catabolism breakdown of fatty acids, areas of metabolomics that link to the signaling pathways, and roles of lipid mediators discussed herein... - Resolution of inflammation: the beginning programs the endCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 6:1191-7. 2005..Understanding these and further details of the mechanism required for inflammation resolution may underpin the development of drugs that can resolve inflammatory processes in directed and controlled ways... - Novel anti-inflammatory--pro-resolving mediators and their receptorsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Curr Top Med Chem 11:629-47. 2011..This approach may offer new targets suitable for drug design for treating inflammation related diseases, for the new terrain of resolution pharmacology... - Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?Charles N Serhan
Director, Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, HIM 8, Boston, MA 02115, USA
Am J Pathol 177:1576-91. 2010.... - Systems approach to inflammation resolution: identification of novel anti-inflammatory and pro-resolving mediatorsC N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Thromb Haemost 7:44-8. 2009..Moreover, identification of functional SPM biosynthesized during inflammation-resolution indicates that resolution is an active process... - Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actionsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Exp Med 206:15-23. 2009..These findings suggest that maresins and this new metabolome may be involved in some of the beneficial actions of DHA and MPhis in tissue homeostasis, inflammation resolution, wound healing, and host defense... - Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediatorsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Immunol 8:349-61. 2008..These mediators have anti-inflammatory and pro-resolution properties, thereby protecting organs from collateral damage, stimulating the clearance of inflammatory debris and promoting mucosal antimicrobial defence... - Anti-inflammatory and proresolving lipid mediatorsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Annu Rev Pathol 3:279-312. 2008..Here, we review the recent advances in our understanding of the biosynthesis and stereospecific actions of these new proresolving mediators, which have also proven to be organ protective and antifibrotic... - Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genusC N Serhan
Department of Anesthesiology, Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA, USA
Br J Pharmacol 153:S200-15. 2008..These may be useful in the design of new therapeutics and treatments for diseases with the underlying trait of uncontrolled inflammation and redox organ stress... - Resolution of inflammation: state of the art, definitions and termsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Thorn 724, Boston, MA 02115, USA
FASEB J 21:325-32. 2007..Hence, resolution is an active rather than a passive process, as once believed, which now promises novel approaches for the treatment of inflammation-associated diseases based on endogenous agonists of resolution... - Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathwaysCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Immunol 25:101-37. 2007..Given the potent actions of lipoxins, resolvins, and protectins in models of human disease, deficiencies in resolution pathways may contribute to many diseases and offer exciting new potential for therapeutic control via resolution... - Novel chemical mediators in the resolution of inflammation: resolvins and protectinsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Anesthesiol Clin 24:341-64. 2006..In view of the essential roles of DHA and EPA in human biology and medicine uncovered to date, the physiologic relevance of the resolvins and protectins is likely to extend beyond our current appreciation... - Lipid mediator informatics-lipidomics: novel pathways in mapping resolutionCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Thorn Building for Medical Research, 7th Floor, Brigham and Women s Hospital, Boston, MA 02115, USA
AAPS J 8:E284-97. 2006..Here, we review liquid chromatography tandem mass spectrometry-based lipidomic analyses to address bioactive lipid mediators in signaling pathways and the roles of lipid-derived mediators in resolution of inflammation... - Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signalsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Exp Med 196:1025-37. 2002..These biosynthetic pathways utilize omega-3 DHA and EPA during multicellular events in resolution to produce a family of protective compounds, i.e., resolvins, that enhance proresolution status... - Systems approach with inflammatory exudates uncovers novel anti-inflammatory and pro-resolving mediatorsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Thorn 724, MA 02115, USA
Prostaglandins Leukot Essent Fatty Acids 79:157-63. 2008.... - Lipoxins and aspirin-triggered 15-epi-lipoxins are endogenous components of antiinflammation: emergence of the counterregulatory sideC N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Arch Immunol Ther Exp (Warsz) 49:177-88. 2001..Here, an overview of these recent developments is presented, with a focus on the cellular and molecular interactions of these novel antiinflammatory lipid mediators... - Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediatorsC N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Clin Chem Lab Med 37:299-309. 1999..Here, we review recent developments on the cellular interactions of these novel anti-inflammatory mediators... - Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4C N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 166:3650-4. 2001..The present results identify nociceptin as a potent chemoattractant and provide a novel link between the neural and immune systems that are blocked by aspirin-triggered lipid mediators and may be relevant in neurogenic inflammation... - Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actionsC N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Physiol Pharmacol 51:643-54. 2000..Moreover, they provide novel mechanism(s) that could underlie the many reported therapeutic benefits of omega-3 dietary supplementation of interest in inflammation, cancer, and vascular disorders... - MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuitsAntonio Recchiuti
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Harvard Institutes of Medicine 829, Boston, MA 02115, USA
FASEB J 25:544-60. 2011..Taken together, these results indicate that resolvin-regulated specific miRNAs target genes involved in resolution and establish a novel resolution circuit involving RvD1 receptor-dependent regulation of specific miRNAs... - Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processingC N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Exp Med 192:1197-204. 2000..The generation of these and related compounds provides a novel mechanism(s) for the therapeutic benefits of omega-3 dietary supplementation, which may be important in inflammation, neoplasia, and vascular diseases... - Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammationN Chiang
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Exp Med 191:1197-208. 2000.... - Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responsesK Gronert
Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
Am J Pathol 158:3-9. 2001.... - Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammationC B Clish
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Biol Chem 275:25372-80. 2000..Moreover, they suggest that these eicosanoid oxidoreductases have multifaceted roles controlling the levels of specific eicosanoids involved in the regulation of inflammation... - Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusionN Chiang
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Clin Invest 104:309-16. 1999..Moreover, LXA4 and ATL counter BLTR-amplified networks, revealing a novel protective role for LX and ATL in stress responses that has applications in perioperative medicine... - Lipid mediator class switching during acute inflammation: signals in resolutionB D Levy
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Nat Immunol 2:612-9. 2001.... - Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 releaseK Gronert
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Exp Med 187:1285-94. 1998..Taken together, these results identify an endogenous pathway for downregulating mucosal inflammatory events and suggest a potential therapeutic benefit for LXA4 stable analogs... - RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitisH Hasturk
Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, Massachusetts, USA
FASEB J 20:401-3. 2006..Consistent with these potent actions, topical application of RvE1 in rabbit periodontitis conferred dramatic protection against inflammation induced tissue and bone loss associated with periodontitis... - Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxinsI M Fierro
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Braz J Med Biol Res 34:555-66. 2001..Here, we present an overview of the recent knowledge about the biosynthesis and bioactions of these anti-inflammatory lipid mediators... - Adhesion promotes transcellular leukotriene biosynthesis during neutrophil-glomerular endothelial cell interactions: inhibition by antibodies against CD18 and L-selectinH R Brady
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
Biochem Biophys Res Commun 186:1307-14. 1992..They suggest that adhesion promotes transcellular eicosanoid biosynthesis and that adhesion molecules may also be targets for blockade of transcellular biosynthesis of lipid mediators... - Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseasesT E Van Dyke
Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118, USA
J Dent Res 82:82-90. 2003.... - Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitroC N Serhan
Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
J Clin Invest 85:772-80. 1990..These results indicate that neutrophil-platelet interactions can lead to the formation of lipoxins from endogenous sources and provide a role for platelet 12-LO in the formation of lipoxins from LTA4... - Lipoxins stimulate prostacyclin generation by human endothelial cellsM E Brezinski
Department of Medicine, Brigham and Women s Hospital, Boston, MA
FEBS Lett 245:167-72. 1989..Moreover, they suggest a role for these lipoxygenase products of arachidonic acid in the regulation of hemostasis, inflammation and vascular reactivity... - Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptorJ F Maddox
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 272:6972-8. 1997..Moreover, they provide additional evidence that the LXA4 stable analogs retain selective bioactivity in monocytes and are valuable instruments for examining the functions and modes of action of LXA4... - Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptorS Fiore
Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
J Exp Med 180:253-60. 1994..Together, they suggest that the encoded protein is a candidate for a LXA4 receptor in myeloid cells... - Remodeling of neutrophil phospholipids with 15(S)-hydroxyeicosatetraenoic acid inhibits leukotriene B4-induced neutrophil migration across endotheliumS Takata
Renal Division, Brigham and Women s Hospital, Boston, Massachusetts
J Clin Invest 93:499-508. 1994..They suggest that 15(S)-HETE may be a potent endogenous inhibitor of PMN-endothelial interactions in vivo and serve to limit or reverse acute inflammation... - Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defensePallavi R Devchand
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
FASEB J 17:652-9. 2003..Together these results demonstrate a gain-of-function with hALX transgenic mouse and indicate that ALX is a key receptor and sensor in formation of acute exudates and their resolution... - Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophilsF H Qiu
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
FASEB J 15:2736-8. 2001.... - Inosine monophosphate and aspirin-triggered 15-epi-lipoxin A4 act in concert to regulate neutrophil trafficking: additive actions of two new endogenous anti-inflammatory mediatorsK Wada
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Hematother Stem Cell Res 10:75-9. 2001..The additive inhibition by IMP and aspirin-triggered LX may represent key pathways that protect and resolve inflammatory responses that could be harnessed for treatment... - Ca2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophilsF W Luscinskas
Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115
Biochem Pharmacol 39:355-65. 1990.... - Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cellsIolanda M Fierro
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 170:2688-94. 2003.... - Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolutionKie Kasuga
Department of Anesthesiology, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 181:8677-87. 2008..Together, these results indicate that circulating omega-3 fatty acids rapidly appear in inflammatory sites that require conversion to resolvins that control excessive neutrophil infiltration, protect organs, and foster resolution... - New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseasesStephanie Yacoubian
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Nat Clin Pract Rheumatol 3:570-9; quiz 1 p following 589. 2007..Possible deficiencies in the biosynthesis of lipoxins, resolvins, and protectins, and/or their signal transduction, might underlie some aspects of pathogenesis in chronic inflammatory diseases... - Lipoxins and aspirin-triggered 15-epi-lipoxin biosynthesis: an update and role in anti-inflammation and pro-resolutionCharles N Serhan
Department of Anesthesiology, Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Prostaglandins Other Lipid Mediat 68:433-55. 2002..An overview of these recent developments is presented with a focus on the cellular and molecular interactions of these novel anti-inflammatory lipid mediators that also appear to facilitate the resolution of acute inflammatory responses... - Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivoHatice Hasturk
Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, MA 02118, USA
J Immunol 179:7021-9. 2007..This report is the first to show that resolution of inflammation by a naturally occurring endogenous lipid mediator results in complete regeneration of pathologically lost tissues, including bone... - The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clusteringAmiram Ariel
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 280:43079-86. 2005..These results demonstrated novel anti-inflammatory roles for PD1 in regulating events associated with inflammation and resolution... - Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4A Planagumà
Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Mucosal Immunol 3:270-9. 2010.... - Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for terminationL V Norling
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Intern Med 268:15-24. 2010..Together these findings indicate that defective mechanisms and pathways in resolution may underlie our current appreciation of the inflammatory phenotype(s) that characterize some prevalent human diseases... - Polyisoprenyl phosphates: natural antiinflammatory lipid signalsB D Levy
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cell Mol Life Sci 59:729-41. 2002.... - Leukotrienes stimulate neutrophil adhesion to mesangial cells: modulation with lipoxinsH R Brady
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115
Am J Physiol 259:F809-15. 1990..Together, these results provide further evidence that LO-derived eicosanoids may constitute important early signals that regulate PMN-MC interaction in glomerular inflammation... - Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administrationGerard Bannenberg
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA
Br J Pharmacol 143:43-52. 2004..The 3-oxa-ATL analogs, which have enhanced metabolic and chemical stability and a superior pharmacokinetic profile, provide new opportunities to explore the actions and therapeutic potential for LX and ATL... - Resolvin E1 and protectin D1 activate inflammation-resolution programmesJan M Schwab
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 447:869-74. 2007..Together, these results identify new active components for postexudate resolution traffic, and demonstrate that RvE1 and PD1 are potent agonists for resolution of inflamed tissues... - Exploring new approaches to the treatment of asthma: potential roles for lipoxins and aspirin-triggered lipid mediatorsBruce D Levy
Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Drugs Today (Barc) 39:373-84. 2003.... - Resolvin E1 metabolome in local inactivation during inflammation-resolutionSong Hong
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 180:3512-9. 2008..e., RvE1, to permit the coordinated return to homeostasis. Moreover, the RvE1 metabolome may serve as a biomarker of these processes... - An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorptionB S Herrera
Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 2118, USA
Br J Pharmacol 155:1214-23. 2008..It was of interest to determine whether RvE1 has direct actions on osteoclast (OC) development and bone resorption... - Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epitheliaO Levy
Children s Hospital of Boston, Boston, MA 02115, U S A and Channing Laboratory, Boston, MA 02115, USA
Biochem Soc Trans 31:795-800. 2003.... - Lipoxins and new lipid mediators in the resolution of inflammationJan M Schwab
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston MA 02115, USA
Curr Opin Pharmacol 6:414-20. 2006..e. RvDs). These bioactive molecules open new avenues and approaches to therapeutic interventions via accelerated resolution of inflammation... - Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statinsMatthew Spite
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Circ Res 107:1170-84. 2010..Here, we overview and update the biosynthesis and actions of proresolving lipid mediators, highlighting their diverse protective roles relevant to vascular systems and their relation to aspirin and statin therapies... - Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesisEric Tjonahen
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Chem Biol 13:1193-202. 2006..Moreover, they indicate that the 5-lipoxygenase in human leukocytes is a pivotal enzyme that can produce both pro- and anti-inflammatory chemical mediators... - Anti-inflammatory and pro-resolving properties of benzo-lipoxin A(4) analogsYee Ping Sun
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Prostaglandins Leukot Essent Fatty Acids 81:357-66. 2009..These benzo-LXA(4) analogs are promising tools for new therapeutic approaches as well as assessing endogenous mechanisms in anti-inflammation and resolution... - Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediatorsYiping Jin
Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
Invest Ophthalmol Vis Sci 50:4743-52. 2009..Here the authors investigated the potential of aspirin-triggered lipoxin (LX) A4 analog (ATLa), resolving (Rv) D1, and RvE1, in regulating angiogenesis in a murine model... - Mediator-lipidomics: databases and search algorithms for PUFA-derived mediatorsYan Lu
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
J Lipid Res 46:790-802. 2005..These results indicate that COCAD has many advantages for profiling and identification of LMs compared with the conventional dot-product algorithm... - Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivationYee Ping Sun
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 282:9323-34. 2007..These results may contribute to the beneficial actions of aspirin and omega-3 fish oils in humans... - Resolvin E1 receptor activation signals phosphorylation and phagocytosisTaisuke Ohira
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Center for Experimental Therapeutics and Reperfusion Injury, Boston, Massachusetts 02115, USA
J Biol Chem 285:3451-61. 2010..These phosphorylation-signaling pathways identified for RvE1 receptor-ligand interactions underscore the importance of endogenous pro-resolving agonists in resolving acute inflammation... - Anesthetics impact the resolution of inflammationNan Chiang
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 3:e1879. 2008..Here we investigated whether a commonly used local anesthetic (lidocaine) and a widely used inhaled anesthetic (isoflurane) impact the active process of resolution of inflammation... - Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage deathMinjian Chen
Department of Medicine, Division of Rheumatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Exp Med 205:2791-801. 2008..These in vitro and in vivo data indicate that PGE(2) plays a critical role in inhibition of Mtb replication... - Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitisChristian A Hudert
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 103:11276-81. 2006..They add insight into the molecular mechanisms of inflammation protection afforded by n-3 PUFA through formation of resolvins and protectins other than inhibition of n-6 PUFA-derived eicosanoid formation... - Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsisMatthew Spite
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 461:1287-91. 2009..Together, these results identify RvD2 as a potent endogenous regulator of excessive inflammatory responses that acts via multiple cellular targets to stimulate resolution and preserve immune vigilance... - Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammationOliver Haworth
Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 9:873-9. 2008.... - Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trialNan Chiang
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:15178-83. 2004..These results also emphasize the importance of cell-cell interactions in the modulation of hemostatic, thrombotic, and inflammatory processes... - Molecular circuits of resolution: formation and actions of resolvins and protectinsGerard L Bannenberg
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:4345-55. 2005..These results characterize the first molecular resolution circuits and their major components activated by specific novel lipid mediators (i.e., resolvin E1 and 10,17S-docosatriene) to promote resolution... - A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophilsPallavi R Devchand
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02115, USA
FASEB J 19:203-10. 2005..A., Primo, V. C., Zhang, Q.-y., Arnaout, M. A., Serhan, C. N., Nikolic, B. A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils... - Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathiesRonit Sharon
Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 278:49874-81. 2003..Together with our earlier observations, these results suggest that alphaS-PUFA interactions help regulate neuronal PUFA levels as well as the oligomerization state of alphaS, both normally and in human synucleinopathies... - Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cellsAmiram Ariel
Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 170:6266-72. 2003..Moreover, they provide potential counterregulatory signals in communication(s) between the innate and acquired immune systems... - Lipoxins and aspirin-triggered lipoxins in airway responsesBruce D Levy
Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA
Adv Exp Med Biol 525:19-23. 2003..Moreover, these results indicate that LX's play pivotal and previously unappreciated roles in regulating allergy and pulmonary inflammation... - A novel rat lipoxin A4 receptor that is conserved in structure and functionNan Chiang
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, U S A
Br J Pharmacol 139:89-98. 2003..7. Together, these results are the first demonstration of a rat ALX that is conserved in both structure and function suggesting that ALX plays key roles in regulating effector immune responses from murine to human species... - Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4)Iolanda M Fierro
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Pharmacol Exp Ther 300:385-92. 2002..Together, these results identify a novel and potent previously unappreciated action of aspirin-triggered 15-epi-LX... - Lipoxins in chronic inflammationAlpdogan Kantarci
Boston University Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, 100 East Newton Street G-05, Boston, MA 02118, USA
Crit Rev Oral Biol Med 14:4-12. 2003..The parallels and possible associations with periodontal diseases are discussed... - Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processingCamilla I Svensson
Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA
J Exp Med 204:245-52. 2007..Targeting mechanisms that counterregulate the spinal consequences of persistent peripheral inflammation provide a novel endogenous mechanism by which chronic pain may be controlled... - Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actionsMakoto Arita
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Harvard School of Dental Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 281:22847-54. 2006..Moreover, the designed RvE1 analog, which resisted further metabolism/inactivation, could be a useful tool to evaluate the actions of RvE1 in complex disease models... - The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivoNan Chiang
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA
Pharmacol Rev 58:463-87. 2006..The information in this review provides further support for the initial nomenclature proposition for this GPCR as ALX... - Localized aggressive periodontitis is linked to human chromosome 1q25Yefu Li
Department of Oral and Developmental Biology, Harvard School of Dental Medicine, 180 Longwood Avenue, Boston, MA 02115, USA
Hum Genet 114:291-7. 2004..No mutation in COX2 was identified in the patients... - Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitisAlpdogan Kantarci
Boston University Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston, MA 02118, USA
J Periodontol 74:66-75. 2003..In this model, it appears that a hyperresponsiveness of the neutrophil, due to cell priming/predisposition, results in enhanced tissue damage...
Research Grants
- Novel Mechanisms in Resolution to Harness Inflammation for ReconstructionThomas E Van Dyke; Fiscal Year: 2010..The proposed studies focus on novel pro-resolving mediators that activate resolution of inflammation to control inflammation and tissue regeneration. ..
- Novel Mechanisms in Resolution to Harness Inflammation for ReconstructionCharles Serhan; Fiscal Year: 2009..The proposed studies focus on novel pro-resolving mediators that activate resolution of inflammation to control inflammation and tissue regeneration. ..
- PHAGOCYTE RESOLVING METABOLISMCharles Serhan; Fiscal Year: 2009..abstract_text> ..
- Specialized Center for Oral Inflammation and ResolutionCharles Serhan; Fiscal Year: 2007..abstract_text> ..
- BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION AND ACTIONCharles Serhan; Fiscal Year: 2007..Completion of these aims will provide a new paradigm to address inflammatory diseases, namely by elucidating endogenous lipid mediators of antiinflammation. ..
- BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION AND ACTIONCHARLES NICHOLAS SERHAN; Fiscal Year: 2010....