Donald R Senger

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Angiogenesis
    Donald R Senger
    Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cold Spring Harb Perspect Biol 3:a005090. 2011
  2. pmc Vascular endothelial growth factor: much more than an angiogenesis factor
    Donald R Senger
    Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Mol Biol Cell 21:377-9. 2010
  3. ncbi request reprint Functional overlap and cooperativity among alphav and beta1 integrin subfamilies during skin angiogenesis
    Carole A Perruzzi
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Invest Dermatol 120:1100-9. 2003
  4. ncbi request reprint In vivo and in vitro models of Mammalian angiogenesis
    Mien V Hoang
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 294:269-85. 2005
  5. pmc Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion
    Mien V Hoang
    Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Biochim Biophys Acta 1812:549-57. 2011
  6. pmc Molecular profiling of angiogenesis markers
    Shu Ching Shih
    Department of Ophthalmology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 161:35-41. 2002
  7. pmc Rho activity critically and selectively regulates endothelial cell organization during angiogenesis
    Mien V Hoang
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:1874-9. 2004
  8. ncbi request reprint Matrix-specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells
    Yanqiu Liu
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 18:457-68. 2004
  9. pmc Cdc42-mediated inhibition of GSK-3β improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis
    Mien V Hoang
    Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Microvasc Res 81:34-43. 2011
  10. ncbi request reprint Collagen I initiates endothelial cell morphogenesis by inducing actin polymerization through suppression of cyclic AMP and protein kinase A
    Mary C Whelan
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:327-34. 2003

Collaborators

Detail Information

Publications16

  1. pmc Angiogenesis
    Donald R Senger
    Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cold Spring Harb Perspect Biol 3:a005090. 2011
    ..In the embryo, ECM is equally critical for angiogenesis and vessel stabilization, although there are likely important distinctions from the adult because of differences in composition and abundance of specific ECM components...
  2. pmc Vascular endothelial growth factor: much more than an angiogenesis factor
    Donald R Senger
    Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Mol Biol Cell 21:377-9. 2010
    ..These findings have important implications for the use of VEGF antagonists and VEGF receptor antagonists in patients for which inhibition of pathological angiogenesis is the therapeutic goal...
  3. ncbi request reprint Functional overlap and cooperativity among alphav and beta1 integrin subfamilies during skin angiogenesis
    Carole A Perruzzi
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Invest Dermatol 120:1100-9. 2003
    ....
  4. ncbi request reprint In vivo and in vitro models of Mammalian angiogenesis
    Mien V Hoang
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 294:269-85. 2005
    ..This in vitro model provides a complementary strategy for investigating the importance of specific molecules for angiogenesis...
  5. pmc Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion
    Mien V Hoang
    Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Biochim Biophys Acta 1812:549-57. 2011
    ....
  6. pmc Molecular profiling of angiogenesis markers
    Shu Ching Shih
    Department of Ophthalmology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 161:35-41. 2002
    ....
  7. pmc Rho activity critically and selectively regulates endothelial cell organization during angiogenesis
    Mien V Hoang
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:1874-9. 2004
    ....
  8. ncbi request reprint Matrix-specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells
    Yanqiu Liu
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 18:457-68. 2004
    ....
  9. pmc Cdc42-mediated inhibition of GSK-3β improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis
    Mien V Hoang
    Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Microvasc Res 81:34-43. 2011
    ....
  10. ncbi request reprint Collagen I initiates endothelial cell morphogenesis by inducing actin polymerization through suppression of cyclic AMP and protein kinase A
    Mary C Whelan
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:327-34. 2003
    ....
  11. pmc Moderation of calpain activity promotes neovascular integration and lumen formation during VEGF-induced pathological angiogenesis
    Mien V Hoang
    Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e13612. 2010
    ..Calpains are a family of intracellular calcium-dependent, non-lysosomal cysteine proteases that regulate cellular functions through proteolysis of numerous substrates...
  12. pmc Moderate GSK-3β inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy
    Mien V Hoang
    Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Angiogenesis 13:269-77. 2010
    ..Thus, GSK-3β inhibitors offer a promising strategy for alleviating retinal hypoxia by correcting key vascular defects typically associated with ischemia-driven neovascularization...
  13. pmc Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity
    Huiyan Zeng
    Department of Pathology, Gastroenterology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 203:719-29. 2006
    ..e., through transcriptional activity)...
  14. ncbi request reprint VEGF-A, cytoskeletal dynamics, and the pathological vascular phenotype
    Janice A Nagy
    Department of Pathology, Beth Israel Deaconess Medical Center, Research North Building, 99 Brookline Avenue, Boston, MA 02215, USA
    Exp Cell Res 312:538-48. 2006
    ..We offer this perspective to draw attention to the importance of endothelial cytoskeletal dynamics for proper neovascularization and to suggest new therapeutic strategies with the potential to improve the pathological vascular phenotype...
  15. pmc The alpha(1)beta(1) and alpha(2)beta(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis
    Donald R Senger
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston 02215, USA
    Am J Pathol 160:195-204. 2002
    ..Collectively, these studies identify critical collaborative functions for the alpha(1)beta(1) and alpha(2)beta(1) integrins in supporting VEGF signal transduction, EC migration, and tumor angiogenesis...
  16. pmc Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1
    Mien V Hoang
    Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Blood 117:1751-60. 2011
    ..These studies distinguish augmentation of Rac1 activity as a means to rectify the pathologic angioarchitecture and dysfunctionality of VEGF neovessels, and they identify a rational pharmacologic strategy for improving VEGF angiogenesis...