Genomes and Genes
Mikhail V Semenov
Affiliation: Harvard University
- SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitorMikhail Semenov
Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 280:26770-5. 2005..Our findings suggest that SOST is an antagonist for Wnt signaling and that the loss of SOST function likely leads to the hyperactivation of Wnt signaling that underlies bone overgrowth seen in sclerosteosis patients...
- LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOSTMikhail V Semenov
Neurobiology Program, Children s Hospital Boston, 61 Binmney Street, Boston, MA 02115, USA
J Biol Chem 281:38276-84. 2006....
- Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6Bryan T MacDonald
F M Kirby Neurobiology Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e23537. 2011..Our studies therefore uncover a new and important molecular tuning mechanism for differential regulation of LRP5 and LRP6 phosphorylation and signaling activity...
- DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradationMikhail V Semenov
F M Kirby Neurobiology Center, Children s Hospital Boston and Department of Neurology, Harvard Medical School, 61 Binney Street, Boston, MA 02115, USA
J Biol Chem 283:21427-32. 2008..7 h) of LRP6. We conclude that DKK1 inhibition of LRP6 is independent of LRP6 internalization and degradation...
- R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signalingQiou Wei
Program of Neurobiology, Children s Hospital Boston, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 282:15903-11. 2007..Our study reveals interesting similarity and distinction between Wnt and R-spondin signaling...
- SnapShot: Wnt/beta-catenin signalingBryan T MacDonald
The F M Kirb Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Cell 131:1204. 2007