Research Topics
Genomes and GenesSpecies | Larry SeidmanSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Neuropsychological performance and family history in children at age 7 who develop adult schizophrenia or bipolar psychosis in the New England Family StudiesL J Seidman
Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA
Psychol Med 43:119-31. 2013..We evaluated the specificity and impact of family history (FH) of psychosis on pre-morbid neuropsychological functioning...
Auditory working memory impairments in individuals at familial high risk for schizophreniaLarry J Seidman
Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA
Neuropsychology 26:288-303. 2012..The goal of these studies was to develop new auditory continuous performance tests (ACPTs) and evaluate their effects in individuals with schizophrenia and their relatives...
Neurocognition in the psychosis risk syndrome: a quantitative and qualitative reviewAnthony J Giuliano
Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Harvard Medical School Department of Psychiatry, Boston, Massachusetts 02115, USA
Curr Pharm Des 18:399-415. 2012....- Intellectual decline in schizophrenia: evidence from a prospective birth cohort 28 year follow-up studyLarry J Seidman
Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, Boston, USA
J Clin Exp Neuropsychol 28:225-42. 2006..Future research on this sample will evaluate the prospective roles of family history and perinatal complications on cognition, and assess the specificity of these findings... - Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosisLarry J Seidman
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Arch Gen Psychiatry 67:578-88. 2010..Early detection and prospective evaluation of clinical high-risk (CHR) individuals who may develop schizophrenia or other psychotic disorders is critical for predicting psychosis onset and for testing preventive interventions... - Neuropsychological functioning in people with ADHD across the lifespanLarry J Seidman
Pediatric Psychopharmacology Clinical and Research Program, Boston, MA, USA
Clin Psychol Rev 26:466-85. 2006..Future research should clarify the multiple sources of ADHD impairments, continue to refine neuropsychological tools optimized for assessment, and incorporate longitudinal, developmental designs to understand ADHD across the lifespan... - Neuropsychological functioning in girls with attention-deficit/hyperactivity disorder with and without learning disabilitiesLarry J Seidman
Massachusetts General Hospital, Boston, MA 02114, USA
Neuropsychology 20:166-77. 2006..These results extend to females the previously documented association of LDs with neuropsychological functioning in males with ADHD... - Altered brain activation in dorsolateral prefrontal cortex in adolescents and young adults at genetic risk for schizophrenia: an fMRI study of working memoryLarry J Seidman
Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Schizophr Res 85:58-72. 2006..Because substantially less is known about these phenotypes in adolescent subjects we sought to demonstrate that young relatives of persons with schizophrenia manifest impaired WM and altered prefrontal activation... - Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk StudiesLarry J Seidman
Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, USA
Schizophr Bull 32:507-24. 2006..Ascertainment criteria for controls may markedly influence results and interpretation of group differences... - Dorsolateral prefrontal and anterior cingulate cortex volumetric abnormalities in adults with attention-deficit/hyperactivity disorder identified by magnetic resonance imagingLarry J Seidman
Harvard Medical School, Department of Psychiatry, Center for Morphometric Analysis, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
Biol Psychiatry 60:1071-80. 2006..This structural MRI study used an a priori region of interest approach... - Gray matter alterations in adults with attention-deficit/hyperactivity disorder identified by voxel based morphometryLarry J Seidman
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 69:857-66. 2011..This study used voxel based morphometry and applied an a priori region of interest approach based on our previous work, as well as from well-developed neuroanatomical theories of ADHD... - Auditory verbal working memory load and thalamic activation in nonpsychotic relatives of persons with schizophrenia: an fMRI replicationLarry J Seidman
Division of Public Psychiatry, Harvard Medical School Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, MA 02215, USA
Neuropsychology 21:599-610. 2007..This replication suggests that altered thalamic activation is a feature of neurobiological risk for schizophrenia... - Relationship of DAT1 and adult ADHD to task-positive and task-negative working memory networksAriel Beth Brown
Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
Psychiatry Res 193:7-16. 2011..Further, we show that DMN suppression is likely linked to DAT1 and to severity of inattention in ADHD. DMN may therefore be a target of DAT1 effects, and lie on the path between the gene and inattention in ADHD... - Shape of caudate nucleus and its cognitive correlates in neuroleptic-naive schizotypal personality disorderJames J Levitt
Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton, Massachusetts 02301, USA
Biol Psychiatry 55:177-84. 2004.... - Medial temporal and prefrontal lobe activation during verbal encoding following glucose ingestion in schizophrenia: A pilot fMRI studyWilliam S Stone
Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, USA
Neurobiol Learn Mem 83:54-64. 2005.... - Neuroanatomic substrates of sex differences in language dysfunction in schizophrenia: a pilot studyDeborah J Walder
Psychiatric Neuroscience Division, Harvard Medical School Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02120, USA
Schizophr Res 90:295-301. 2007.... - Impact of psychometrically defined deficits of executive functioning in adults with attention deficit hyperactivity disorderJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, 32 Fruit St, Boston, 02114, USA
Am J Psychiatry 163:1730-8. 2006..The association between deficits in executive functioning and functional outcomes was examined among adults with attention deficit hyperactivity disorder (ADHD)... - Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal StudyScott W Woods
PRIME Prodromal Research Clinic, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
Schizophr Bull 35:894-908. 2009..The strong evidence of diagnostic validity for the prodromal risk syndrome for first psychosis raises the question of its evaluation for inclusion in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)... - Fronto-temporal disconnectivity in schizotypal personality disorder: a diffusion tensor imaging studyMotoaki Nakamura
Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, MA 02301, USA
Biol Psychiatry 58:468-78. 2005.... - Phenomenology of childhood psychosis: findings from a large sample of psychiatrically referred youthJoseph Biederman
Clinical Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, USA
J Nerv Ment Dis 192:607-14. 2004..In conclusion, childhood-onset psychosis in referred youth is common and highly morbid. It remains an important topic of research deserving full clinical and scientific attention... - Statistical analysis of fiber bundles using multi-tensor tractography: application to first-episode schizophreniaYogesh Rathi
Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Magn Reson Imaging 29:507-15. 2011..Thus, the changes affecting first-episode patients seem to be global in nature (spread throughout the brain)... - The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypesRaquel E Gur
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Schizophr Bull 33:49-68. 2007.... - Effects of stimulant medication on neuropsychological functioning in young adults with attention-deficit/hyperactivity disorderJoseph Biederman
Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 69:1150-6. 2008..The main goal of this study was to evaluate the impact of stimulant medication on executive function deficits in a group of adolescents and young adults with attention-deficit/hyperactivity disorder (ADHD; DSM-III-R criteria)... - Sex differences in language dysfunction in schizophreniaDeborah J Walder
Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
Am J Psychiatry 163:470-7. 2006.... - Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probandsBruce I Turetsky
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Psychiatry 64:1051-9. 2008..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes... - Is there disproportionate impairment in semantic or phonemic fluency in schizophrenia?William S Kremen
Department of Psychiatry, University of California, Davis School of Medicine, 2230 Stockton Blvd, Sacramento, CA 95817, USA
J Int Neuropsychol Soc 9:79-88. 2003..48 < rs < .79). These results mirror a literature that overall suggests a small degree of disproportionate semantic fluency impairment in schizophrenia, but also some heterogeneity in fluency deficits... - MRI study of caudate nucleus volume and its cognitive correlates in neuroleptic-naive patients with schizotypal personality disorderJames J Levitt
Clinical Neuroscience Division, Laboratory of Neuroscience, Dept. of Psychiatry, VA Boston Healthcare System-Brockton Division, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
Am J Psychiatry 159:1190-7. 2002.... - IQ decline in cross-sectional studies of schizophrenia: methodology and interpretationWilliam S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego School of Medicine, 9500 Gilman Drive MC 0738, La Jolla, CA 92093 0738, USA
Psychiatry Res 158:181-94. 2008..Overall, these results strongly suggest that differences in current neuropsychological function in schizophrenia are attributable primarily to current IQ instead of to IQ trajectory over time... - Educational and occupational underattainment in adults with attention-deficit/hyperactivity disorder: a controlled studyJoseph Biederman
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 69:1217-22. 2008..This study evaluated subjects to determine whether the educational and occupational deficits associated with ADHD are what would be expected given their intellectual abilities or lower than expected given their intellectual abilities... - Children of parents with affective and nonaffective psychoses: a longitudinal study of behavior problemsJo Ann L Donatelli
Department of Psychiatry, Community Health, Brown University, Providence, RI 02903, USA
Am J Psychiatry 167:1331-8. 2010..g., schizophrenia, other nonaffective psychoses, and affective psychoses) have distinct forms of behavioral problems (i.e., internalizing and externalizing)... - Smaller left Heschl's gyrus volume in patients with schizotypal personality disorderChandlee C Dickey
Harvard Medical School, Clinical Neuroscience Division, Department of Psychiatry, VA Boston Healthcare System, Brockton, MA 02401, USA
Am J Psychiatry 159:1521-7. 2002.... - Neural substrates of impaired sensorimotor timing in adult attention-deficit/hyperactivity disorderEve M Valera
Clinical and Research Programs in Pediatric Psychopharmacology and Adult Attention Deficit Hyperactivity Disorder, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 68:359-67. 2010..Also, the neural substrates of these deficits are largely unknown for both youth and adults with ADHD. The present study examined subsecond sensorimotor timing and its neural substrates in ADHD adults... - Impact of executive function deficits and attention-deficit/hyperactivity disorder (ADHD) on academic outcomes in childrenJoseph Biederman
Pediatric Psychopharmacology Unit, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
J Consult Clin Psychol 72:757-66. 2004..Children and adolescents with ADHD and EFDs were found to be at high risk for significant impairments in academic functioning. These results support screening children with ADHD for EFDs to prevent academic failure... - Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of SchizophreniaAnn Olincy
Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
Schizophr Res 119:175-82. 2010.... - A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHDMichael C Monuteaux
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 147:1436-41. 2008..These result support the heterogeneity of ADHD and provides insights as to its underlying pathophysiology... - Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorderJean A Frazier
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Bipolar Disord 7:555-69. 2005..Cortical gray matter (GM) volume deficits have been reported in some studies of adults with BPD; this study assessed the presence of such deficits in children with BPD... - Discordance between psychometric testing and questionnaire-based definitions of executive function deficits in individuals with ADHDJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Research Unit, Boston, MA 02114, USA
J Atten Disord 12:92-102. 2008.... - Evidence for reduced cerebellar volumes in trichotillomaniaNancy J Keuthen
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
Biol Psychiatry 61:374-81. 2007..Limited knowledge exists regarding the neurobiology of trichotillomania (TTM). Cerebellum (CBM) volumes were explored, given its role in complex, coordinated motor sequences... - Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophreniaStephen J Glatt
Center for Behavioral Genomics, Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 920923, USA
Br J Psychiatry 189:337-45. 2006..Evaluation of individuals at high genetic risk of schizophrenia is a powerful method for identifying precursors of the illness... - Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of SchizophreniaNeal R Swerdlow
Department of Psychiatry, University of California San Diego, San Diego, California, USA
Schizophr Res 92:237-51. 2007..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies... - A MRI study of fusiform gyrus in schizotypal personality disorderChandlee C Dickey
Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, and Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Schizophr Res 64:35-9. 2003..This suggests that future studies may be useful in determining the functional competence of this gyrus in SPD... - Reduction of caudate nucleus volumes in neuroleptic-naïve female subjects with schizotypal personality disorderMin-Seong Koo
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, and Harvard Medical School, Boston, MA 02401, USA
Biol Psychiatry 60:40-8. 2006..CONCLUSIONS: These findings demonstrate that, for female SPD subjects, smaller caudate volume is associated with poorer cognitive performance and more schizotypal symptomatology... - Cortical thickness abnormalities in cocaine addiction--a reflection of both drug use and a pre-existing disposition to drug abuse?Nikos Makris
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Neuron 60:174-88. 2008..These observations suggest that brain structure abnormalities in addicts are related in part to drug use and in part to predisposition toward addiction... - Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophreniaJean A Frazier
Department of Psychiatry, Harvard Medical School, Massachusetts, USA
Schizophr Bull 34:37-46. 2008..The limbic structures in early-onset schizophrenia-spectrum illness (SZ) and bipolar disorder (BPD) were studied to discern patterns associated with diagnosis and sex... - Processing sentence context in women with schizotypal personality disorder: an ERP studyMargaret A Niznikiewicz
Department of Psychiatry, Harvard Medical School, Neuroscience Laboratory, Brockton West Roxbury VAMC, Brockton, Massachusetts 02301, USA
Psychophysiology 41:367-71. 2004..In SPD women, relative to their comparison group, a more negative N400 was found only to auditory congruent sentences... - Sex differences in the functional neuroanatomy of working memory in adults with ADHDEve M Valera
Department of Psychiatry, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
Am J Psychiatry 167:86-94. 2010..The authors examined sex differences in the neural functioning of adults with ADHD during performance of a verbal working memory task... - Regional prefrontal cortex gray matter volumes in youth at familial risk for schizophrenia from the Harvard Adolescent High Risk StudyIsabelle M Rosso
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Schizophr Res 123:15-21. 2010..We conducted a region-of-interest morphometric study of prefrontal subregions in adolescent and young adult relatives of schizophrenia patients... - Neuropsychological profiles in individuals at clinical high risk for psychosis: relationship to psychosis and intelligenceKristen A Woodberry
Center for Psychiatric Research, Maine Medical Center, 295 Park Avenue, Portland, ME 04102, USA
Schizophr Res 123:188-98. 2010..The degree to which NP impairments are associated with general cognitive ability and/or later emergence of full psychosis in CHR samples requires study with well-matched controls... - Specificity of familial transmission of schizophrenia psychosis spectrum and affective psychoses in the New England family study's high-risk designJill M Goldstein
Division of Women s Health, Mary Horrigan Connors Center for Women s Health and Gender Biology, and Department of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
Arch Gen Psychiatry 67:458-67. 2010..However, few studies have investigated the specificity of the transmission of schizophrenia-psychosis spectrum (SPS) disorders and affective psychoses (APs) or observed high-risk offspring into mid-adulthood... - White matter volume abnormalities and associations with symptomatology in schizophreniaNikolaos Makris
Athinoula A Martinos Imaging Center, Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA, United States
Psychiatry Res 183:21-9. 2010..These observations suggest a pattern of volume WM alterations associated with symptomatology in schizophrenia that may be related in part to predisposition to schizophrenia... - An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorderHeidi W Thermenos
Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 153:120-31. 2010..Persons with BD and RELs exhibit altered activity in the frontopolar cortex and insula, which may represent biomarkers of genetic risk for BD... - Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: a pilot studyNikos Makris
Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
J Atten Disord 13:407-13. 2010..Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD... - Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference taskGeorge Bush
Departments of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Arch Gen Psychiatry 65:102-14. 2008..Stimulant medications are effective treatments for ADHD, but their neural effects have not been fully characterized... - Attention and executive systems abnormalities in adults with childhood ADHD: A DT-MRI study of connectionsNikos Makris
Harvard Medical School Departments of Neurology and Radiology Services, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
Cereb Cortex 18:1210-20. 2008..The demonstration of FA abnormalities in the CB and SLF II in adults with childhood ADHD provides further support for persistent structural abnormalities into adulthood... - Toward a model of memory enhancement in schizophrenia: glucose administration and hippocampal functionWilliam S Stone
Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
Schizophr Bull 34:93-108. 2008..More generally, the discussion underlines the promise of cognitive improvement in schizophrenia and the need to approach the issue in a programmatic manner... - MRI-based surface-assisted parcellation of human cerebellar cortex: an anatomically specified method with estimate of reliabilityNikos Makris
Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
Neuroimage 25:1146-60. 2005..933. Whereas the individual units provide a high level of detail and anatomical specificity, the clusters add flexibility to the analysis by providing higher reliability... - Neuropsychological functioning in relatives of girls with and without ADHDAlysa E Doyle
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Psychol Med 35:1121-32. 2005..A limited number of studies have examined neuropsychological functioning in the family members of ADHD youth, and none have focused exclusively on relatives of females... - Impact of gender and age on executive functioning: do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years?Larry J Seidman
Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
Dev Neuropsychol 27:79-105. 2005..These findings suggest that executive dysfunctions are correlates of ADHD regardless of gender and age, at least through the late teen years... - Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imagingJill M Goldstein
Department of Psychiatry, Harvard Medical School, Brigham and Women s Hospital, Connors Center for Women s Health and Gender Biology, Boston, Massachusetts 02115, USA
J Neurosci 25:9309-16. 2005..Findings have important implications for normal sex-specific physiological functioning and may contribute to understanding higher rates of mood and anxiety disorders in women and differential sensitivity to trauma than men... - Decreased volume of left and total anterior insular lobule in schizophreniaNikos Makris
Athinoula A Martinos Center, Harvard Medical School Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, United States
Schizophr Res 83:155-71. 2006.... - Human cerebral cortex: a system for the integration of volume- and surface-based representationsNikos Makris
Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
Neuroimage 33:139-53. 2006..This system of topographical analysis of the cerebral cortex is consistent with current views of cortical development and neural systems organization of the human and non-human primate brain... - Cortical thinning of the attention and executive function networks in adults with attention-deficit/hyperactivity disorderNikos Makris
Departments of Neurology and Radiology Services, Center for Morphometric Analysis, Health Sciences and Technology Athinoula A Martinos Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Cereb Cortex 17:1364-75. 2007..This is the first documentation that ADHD in adults is associated with thinner cortex in the cortical networks that modulate attention and EF... - A comparative profile analysis of neuropsychological function in men and women with schizotypal personality disorderMartina M Voglmaier
Harvard Medical School, Department of Psychiatry at the Massachusetts Mental Health Center, Boston, MA 02139, USA
Schizophr Res 74:43-9. 2005..The results suggest a less severe pattern of cognitive deficits in women with SPD compared to men, consistent with hypotheses of gender differences in cognitive function in schizophrenia... - A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrusLarry J Seidman
Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
Schizophr Bull 29:803-30. 2003..Implications of genetic risk studies for prodromal research are discussed... - Brain function and structure in adults with attention-deficit/hyperactivity disorderLarry J Seidman
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Psychiatr Clin North Am 27:323-47. 2004..Because the literature on ADHD in children is more extensive than that reported heretofore in ADHD in adults,the authors include brief summaries of the child literature to help inform that found in adults... - Neuropsychological function in adults with attention-deficit/hyperactivity disorderLarry J Seidman
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, 15 Parkma Street, WACC 725, Boston, MA 02114, USA
Psychiatr Clin North Am 27:261-82. 2004.... - Automatically parcellating the human cerebral cortexBruce Fischl
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH MIT Harvard Medical School, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
Cereb Cortex 14:11-22. 2004..Examples are given from two different training sets generated using different neuroanatomical conventions, illustrating the flexibility of the algorithm. The technique is shown to be comparable in accuracy to manual labeling... - Genetically mediated brain abnormalities in schizophreniaLarry J Seidman
Neuropsychology Laboratory, Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA
Curr Psychiatry Rep 5:135-44. 2003..Linking genes and brain regions or networks is an important step in identification of the pathophysiology of schizophrenia... - A twin study of the neuropsychological consequences of stimulant abuseRosemary Toomey
Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, 02129, USA
Arch Gen Psychiatry 60:303-10. 2003..Previous studies document neuropsychological deficits associated with stimulant abuse, but findings are inconsistent... - Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imagingJill M Goldstein
Massachusetts Mental Health Center, Harvard Institute of Psychiatric Epidemiology and Genetics, 74 Fenwood Rd, Boston, MA 02115, USA
Arch Gen Psychiatry 59:154-64. 2002.... - Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directionsGeorge Bush
Psychiatric Neuroscience Program and Department of Psychiatry, Harvard Medical School and Massachusettes General Hospital, Boston, Massachusetts, USA
Biol Psychiatry 57:1273-84. 2005..Although at present there are no accepted uses for functional imaging in diagnosing ADHD, this article mentions possible future clinical uses of imaging in ADHD... - Engaging Asian American youth and their families in quality mental health servicesHuijun Li
Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Boston, United States
Asian J Psychiatr 3:169-72. 2010..We presented reasons for lack of engagement in mental health services among Asian American youth and families. Practical strategies to enhance their engagement in mental health services were provided... - Genetic and environmental influences of white and gray matter signal contrast: a new phenotype for imaging genetics?Matthew S Panizzon
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neuroimage 60:1686-95. 2012..The lack of significant genetic correlations with cortical thickness suggests that this measure potentially represents a unique source of genetic variance, one that has yet to be explored by the field of imaging genetics... - Biomarkers for identifying first-episode schizophrenia patients using diffusion weighted imagingYogesh Rathi
Harvard Medical School, Boston, USA
Med Image Comput Comput Assist Interv 13:657-65. 2010..Classification results using leave-many-out cross-validation scheme are given for each representation. This algorithm is a first step towards early detection of schizophrenia... - The uncinate fasciculus and extraversion in schizotypal personality disorder: a diffusion tensor imaging studyRonald J Gurrera
Schizophr Res 90:360-2. 2007 - Functional co-primary measures for clinical trials in schizophrenia: results from the MATRICS Psychometric and Standardization StudyMichael F Green
Semel Institute for Neuroscience and Human Behavior, UCLA, 300 Medical Plaza, Rm 2263, Los Angeles, CA 90095 6968, USA
Am J Psychiatry 165:221-8. 2008..e., a co-primary) that is considered functionally meaningful. The goal of the current study was to describe steps to evaluate four potential co-primary measures for psychometric properties and validity... - The MATRICS Consensus Cognitive Battery, part 2: co-norming and standardizationRobert S Kern
Department of Psychology, Geffen School of Medicine, University of California, Los Angeles CA 90073, USA
Am J Psychiatry 165:214-20. 2008..S. community sample with the battery administered as a unit... - An MRI study of superior temporal gyrus volume in women with schizotypal personality disorderChandlee C Dickey
VA Boston Healthcare System, Psychiatry 116A, 940 Belmont St, Brockton, MA 02401, USA
Am J Psychiatry 160:2198-201. 2003..Results from this study thus clearly reinforce the importance of studying female subjects separately... - The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validityKeith H Nuechterlein
Department of Psychology, UCLA Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Rm 2251, Los Angeles, CA 90095 6968, USA
Am J Psychiatry 165:203-13. 2008.... - Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactionsTyrone D Cannon
Department of Psychology, University of California, Los Angeles, 90095, USA
Schizophr Bull 29:653-69. 2003.... - Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorderJean A Frazier
Child and Adolescent Neuropsychiatric Research Program, Cambridge Health Alliance Mystic Center, 1493 Cambridge Street, Cambridge, MA 02139, USA
Am J Psychiatry 162:1256-65. 2005..On the basis of adult studies, the authors hypothesized a priori that youths with bipolar disorder would have amygdalar, hippocampal, and thalamic volume abnormalities... - Functional magnetic resonance imaging during auditory verbal working memory in nonpsychotic relatives of persons with schizophrenia: a pilot studyHeidi W Thermenos
Department of Psychology and Brain Research Institute (RP, University of California, Los Angeles, Los Angeles, California, USA
Biol Psychiatry 55:490-500. 2004..These differences add to the growing literature identifying neurobiological vulnerabilities to schizophrenia... - Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North AmericaTyrone D Cannon
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095
Arch Gen Psychiatry 65:28-37. 2008.... - Successful multi-site measurement of antisaccade performance deficits in schizophreniaAllen D Radant
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
Schizophr Res 89:320-9. 2007..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies... - Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: a randomized, double-blind trial of olanzapine versus low doses of haloperidolRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
Am J Psychiatry 161:985-95. 2004..This study compares the neurocognitive effects of olanzapine and low doses of haloperidol in patients with first-episode psychosis... - Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of SchizophreniaWilliam P Horan
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
Schizophr Res 103:218-28. 2008.... - Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosisRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA
Biol Psychiatry 59:97-105. 2006..Neurocognitive deficits are severe in first-episode psychosis... - The neuropsychological basis of competence to consent in first-episode schizophrenia: a pilot metacognitive studyDanny Koren
Psychology Department, University of Haifa, Technion Medical School, Haifa, Israel
Biol Psychiatry 57:609-16. 2005..This study was designed to explore the neuropsychological basis of competence to consent to treatment in first-episode schizophrenia by evaluating its differential and joint links with cognitive versus metacognitive performance... - Functional MRI in attention-deficit hyperactivity disorder: evidence for hypofrontalityYu-feng Zang
Institute of Mental Health, Peking University, Huayuanbeilu 51, Haidian Districk, Beijing 100083, China
Brain Dev 27:544-50. 2005..These findings are consistent with prior findings of hypofrontality in ADHD children and implicate a compensatory network including basal ganglia, insula and cerebellum for relative lower cognitive load tasks...
Research Grants
- Genetics of Endophenotypes and SchizophreniaLarry Seidman; Fiscal Year: 2007..Findings of heritable deficits in specific measures will be used to guide the next generation of studies of the genetics of schizophrenia. ..
- Family Study of Psychosis: Brain, Genes & Prenatal RiskLarry Seidman; Fiscal Year: 2005..Moreover, if rigorous definitions of PPCs are used, it will be possible to identify the specific types of PPCs associated with brain abnormalities, which can lead to prevention strategies. ..
- Neuroanatomy of Adult ADHD: An MRI Morphometric StudyLarry Seidman; Fiscal Year: 2006..abstract_text> ..
- SCHIZOPHRENIA--PSYCHOPATHOLOGY AND HETEROGENEITYLarry Seidman; Fiscal Year: 2004..Achievement of the second goal will help clarify which brain abnormalities in schizophrenic patients can be attributed to neurodevelop-mental events prior to onset and which are due to neurodegeneration after onset. ..