L J Seidman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc MRI study of caudate nucleus volume and its cognitive correlates in neuroleptic-naive patients with schizotypal personality disorder
    James J Levitt
    Clinical Neuroscience Division, Laboratory of Neuroscience, Dept of Psychiatry, VA Boston Healthcare System Brockton Division, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
    Am J Psychiatry 159:1190-7. 2002
  2. ncbi request reprint Brain function and structure in adults with attention-deficit/hyperactivity disorder
    Larry J Seidman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychiatr Clin North Am 27:323-47. 2004
  3. ncbi request reprint Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives
    Larry J Seidman
    Neuropsychology Laboratory, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:839-49. 2002
  4. ncbi request reprint A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses
    Larry J Seidman
    Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, and Harvard Institute of Psychiatric Epidemiology and Genetics, 74 Fenwood Road, Boston, MA 02115, USA
    Schizophr Res 53:31-44. 2002
  5. ncbi request reprint Learning disabilities and executive dysfunction in boys with attention-deficit/hyperactivity disorder
    L J Seidman
    Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston 02114, USA
    Neuropsychology 15:544-56. 2001
  6. ncbi request reprint Genetically mediated brain abnormalities in schizophrenia
    Larry J Seidman
    Neuropsychology Laboratory, Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA
    Curr Psychiatry Rep 5:135-44. 2003
  7. ncbi request reprint The effect of housing interventions on neuropsychological functioning among homeless persons with mental illness
    Larry J Seidman
    Department of psychiatry of Harvard Medical School in Boston, USA
    Psychiatr Serv 54:905-8. 2003
  8. ncbi request reprint Organizational and visual memory deficits in schizophrenia and bipolar psychoses using the Rey-Osterrieth complex figure: effects of duration of illness
    Larry J Seidman
    Harvard Medical, School Department of Psychiatry at Massachusetts Mental Health Center, Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA 02115, USA
    J Clin Exp Neuropsychol 25:949-64. 2003
  9. ncbi request reprint A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus
    Larry J Seidman
    Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Bull 29:803-30. 2003
  10. ncbi request reprint Impact of gender and age on executive functioning: do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years?
    Larry J Seidman
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Dev Neuropsychol 27:79-105. 2005

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. pmc MRI study of caudate nucleus volume and its cognitive correlates in neuroleptic-naive patients with schizotypal personality disorder
    James J Levitt
    Clinical Neuroscience Division, Laboratory of Neuroscience, Dept of Psychiatry, VA Boston Healthcare System Brockton Division, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
    Am J Psychiatry 159:1190-7. 2002
    ....
  2. ncbi request reprint Brain function and structure in adults with attention-deficit/hyperactivity disorder
    Larry J Seidman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychiatr Clin North Am 27:323-47. 2004
    ..Because the literature on ADHD in children is more extensive than that reported heretofore in ADHD in adults,the authors include brief summaries of the child literature to help inform that found in adults...
  3. ncbi request reprint Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives
    Larry J Seidman
    Neuropsychology Laboratory, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:839-49. 2002
    ....
  4. ncbi request reprint A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses
    Larry J Seidman
    Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, and Harvard Institute of Psychiatric Epidemiology and Genetics, 74 Fenwood Road, Boston, MA 02115, USA
    Schizophr Res 53:31-44. 2002
    ..Further research is required to determine whether similar mechanisms underly the neurocognitive deficits in these disorders...
  5. ncbi request reprint Learning disabilities and executive dysfunction in boys with attention-deficit/hyperactivity disorder
    L J Seidman
    Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston 02114, USA
    Neuropsychology 15:544-56. 2001
    ..These data indicate that comorbid LD, especially arithmetic disability, significantly increases the severity of executive function impairment in ADHD...
  6. ncbi request reprint Genetically mediated brain abnormalities in schizophrenia
    Larry J Seidman
    Neuropsychology Laboratory, Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA
    Curr Psychiatry Rep 5:135-44. 2003
    ..Linking genes and brain regions or networks is an important step in identification of the pathophysiology of schizophrenia...
  7. ncbi request reprint The effect of housing interventions on neuropsychological functioning among homeless persons with mental illness
    Larry J Seidman
    Department of psychiatry of Harvard Medical School in Boston, USA
    Psychiatr Serv 54:905-8. 2003
    ..The findings suggest that providing housing for persons who have severe and persistent mental illness improves cognitive functioning but that independent living may diminish executive functioning...
  8. ncbi request reprint Organizational and visual memory deficits in schizophrenia and bipolar psychoses using the Rey-Osterrieth complex figure: effects of duration of illness
    Larry J Seidman
    Harvard Medical, School Department of Psychiatry at Massachusetts Mental Health Center, Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA 02115, USA
    J Clin Exp Neuropsychol 25:949-64. 2003
    ..Further research is required to determine whether similar mechanisms underlie the neurocognitive deficits in these psychotic disorders...
  9. ncbi request reprint A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus
    Larry J Seidman
    Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Bull 29:803-30. 2003
    ..Implications of genetic risk studies for prodromal research are discussed...
  10. ncbi request reprint Impact of gender and age on executive functioning: do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years?
    Larry J Seidman
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Dev Neuropsychol 27:79-105. 2005
    ..These findings suggest that executive dysfunctions are correlates of ADHD regardless of gender and age, at least through the late teen years...
  11. ncbi request reprint Neuropsychological function in adults with attention-deficit/hyperactivity disorder
    Larry J Seidman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, 15 Parkma Street, WACC 725, Boston, MA 02114, USA
    Psychiatr Clin North Am 27:261-82. 2004
    ....
  12. ncbi request reprint The relationship of prenatal and perinatal complications to cognitive functioning at age 7 in the New England Cohorts of the National Collaborative Perinatal Project
    L J Seidman
    Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, Boston 02115, USA
    Schizophr Bull 26:309-21. 2000
    ..Future studies will evaluate the effects of specific PPCs and genetic risk factors for psychosis on cognitive functioning in childhood...
  13. ncbi request reprint Structural brain imaging of attention-deficit/hyperactivity disorder
    Larry J Seidman
    Pediatric Psychopharmacology Unit and Psychiatric Neuroscience Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Biol Psychiatry 57:1263-72. 2005
    ..These results suggest that the brain is altered in a more widespread manner than has been previously hypothesized. Developmental studies are needed to address the evolution of this brain disorder into adulthood...
  14. ncbi request reprint Association of neuropsychological vulnerability markers in relatives of schizophrenic patients
    R Toomey
    Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA, USA
    Schizophr Res 31:89-98. 1998
    ..We discuss how the use of multiple risk indicators may help us better identify those relatives that carry the schizophrenia genotype...
  15. ncbi request reprint IQ decline during childhood and adult psychotic symptoms in a community sample: a 19-year longitudinal study
    W S Kremen
    Department of Psychiatry, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    Am J Psychiatry 155:672-7. 1998
    ..The goal of this study was to examine cognitive antecedents of psychosis by determining whether variability in IQ during childhood was predictive of psychotic symptoms in adulthood...
  16. pmc Neurocognitive impairment in unaffected siblings of youth with bipolar disorder
    A E Doyle
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Child Psychiatry Service, 55 Fruit Street, Boston, MA 02114, USA
    Psychol Med 39:1253-63. 2009
    ..The current study investigated whether these neurocognitive impairments index the familial risk underlying the diagnosis...
  17. ncbi request reprint Neuropsychological risk indicators for schizophrenia: a preliminary study of female relatives of schizophrenic and bipolar probands
    W S Kremen
    Department of Psychiatry, University of California, Davis School of Medicine, Sacramento 95817, USA
    Psychiatry Res 79:227-40. 1998
    ..Replication with a larger REL-BP sample and with male relatives is needed to evaluate the generalizability of the results...
  18. ncbi request reprint Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a 4-year follow-up study
    S V Faraone
    Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, South Easton 02375, USA
    J Abnorm Psychol 108:176-81. 1999
    ..These results support the idea that neuropsychological dysfunction among relatives of patients with schizophrenia is a stable trait caused by the familial predisposition to schizophrenia...
  19. ncbi request reprint Stability of executive function deficits into young adult years: a prospective longitudinal follow-up study of grown up males with ADHD
    J Biederman
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Acta Psychiatr Scand 116:129-36. 2007
    ..Although individuals with attention deficit-hyperactivity disorder (ADHD) commonly exhibit deficits in executive functions that greatly increase the morbidity of the disorder, all available information on the subject is cross sectional...
  20. ncbi request reprint Impact of genetic vulnerability and hypoxia on overall intelligence by age 7 in offspring at high risk for schizophrenia compared with affective psychoses
    J M Goldstein
    Department of Psychiatry at Massachusetts Mental Health Center, Boston 02115, USA
    Schizophr Bull 26:323-34. 2000
    ..Specificity of the effects for schizophrenia compared with affective psychoses and sex effects were also tested. Low IQ at age 7 was significantly associated with genetic vulnerability to psychoses, in particular with schizophrenia...
  21. ncbi request reprint Are there sex differences in neuropsychological functions among patients with schizophrenia?
    J M Goldstein
    Harvard Institute of Psychiatric Epidemiology and Genetics, Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston 02115, USA
    Am J Psychiatry 155:1358-64. 1998
    ....
  22. ncbi request reprint Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes?
    S V Faraone
    Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Boston, USA
    Am J Psychiatry 152:1286-90. 1995
    ..However, most of these studies do not address a key measurement question: does the diagnostic accuracy of these spectrum classifications warrant their use in genetic linkage studies of schizophrenia?..
  23. pmc Shape of caudate nucleus and its cognitive correlates in neuroleptic-naive schizotypal personality disorder
    James J Levitt
    Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 55:177-84. 2004
    ..We believe MRI shape analysis complements traditional MRI volume measurements...
  24. ncbi request reprint Medial temporal and prefrontal lobe activation during verbal encoding following glucose ingestion in schizophrenia: A pilot fMRI study
    William S Stone
    Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, USA
    Neurobiol Learn Mem 83:54-64. 2005
    ....
  25. pmc Neuroanatomic substrates of sex differences in language dysfunction in schizophrenia: a pilot study
    Deborah J Walder
    Psychiatric Neuroscience Division, Harvard Medical School Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02120, USA
    Schizophr Res 90:295-301. 2007
    ....
  26. pmc Neuropsychological performance and family history in children at age 7 who develop adult schizophrenia or bipolar psychosis in the New England Family Studies
    L J Seidman
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Psychol Med 43:119-31. 2013
    ..We evaluated the specificity and impact of family history (FH) of psychosis on pre-morbid neuropsychological functioning...
  27. pmc A multivariate twin study of hippocampal volume, self-esteem and well-being in middle-aged men
    T S Kubarych
    Department of Psychiatry, Virginia Commonwealth University, Richmond, 23219 0126, USA
    Genes Brain Behav 11:539-44. 2012
    ..09 (P > 0.05). Our results indicate that largely different genetic and environmental factors underlie self-esteem and well-being on one hand and hippocampal volume on the other...
  28. ncbi request reprint A functional magnetic resonance imaging study of auditory vigilance with low and high information processing demands
    L J Seidman
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Neuropsychology 12:505-18. 1998
    ..Performance and degree of activation was associated with an estimate of IQ. Further research should clarify the contributions of working memory and interference filtering to the activated network...
  29. ncbi request reprint The effects of increasing resource demand on vigilance performance in adults with schizophrenia or developmental attentional/learning disorders: a preliminary study
    L J Seidman
    Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Boston 02115, USA
    Schizophr Res 34:101-12. 1998
    ..Further study comparing schizophrenic patients with patients who have other neuropsychiatric disorders, controlling for severity of illness, is required to determine the specificity of this deficit in schizophrenia...
  30. ncbi request reprint Reduced subcortical brain volumes in nonpsychotic siblings of schizophrenic patients: a pilot magnetic resonance imaging study
    L J Seidman
    Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, Boston 02115, USA
    Am J Med Genet 74:507-14. 1997
    ..If replicated in a larger sample including both sexes, these results would suggest that the genetic liability to schizophrenia is also expressed as structural brain abnormalities...
  31. ncbi request reprint Sex differences in self-reported schizotypal traits in relatives of schizophrenic probands
    W S Kremen
    Department of Psychiatry, University of California, Davis School of Medicine, Sacramento 95817, USA
    Schizophr Res 34:27-37. 1998
    ....
  32. pmc Fronto-temporal disconnectivity in schizotypal personality disorder: a diffusion tensor imaging study
    Motoaki Nakamura
    Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, MA 02301, USA
    Biol Psychiatry 58:468-78. 2005
    ..Here, we investigate these two bundles in unmedicated subjects with schizotypal personality disorder (SPD)...
  33. pmc Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study
    Scott W Woods
    PRIME Prodromal Research Clinic, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Schizophr Bull 35:894-908. 2009
    ..The strong evidence of diagnostic validity for the prodromal risk syndrome for first psychosis raises the question of its evaluation for inclusion in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)...
  34. ncbi request reprint Impact of psychometrically defined deficits of executive functioning in adults with attention deficit hyperactivity disorder
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, 32 Fruit St, Boston, 02114, USA
    Am J Psychiatry 163:1730-8. 2006
    ..The association between deficits in executive functioning and functional outcomes was examined among adults with attention deficit hyperactivity disorder (ADHD)...
  35. ncbi request reprint Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging
    J M Goldstein
    Department of Psychiatry, Institute of Psychiatric Epidemiology and Genetics, Massachusetts Mental Health Center, Boston 02115, USA
    Arch Gen Psychiatry 56:537-47. 1999
    ..We hypothesized, based on previous empirical and theoretical work, that dorsolateral prefrontal and paralimbic cortices would be significantly volumetrically reduced in patients with schizophrenia compared with normal controls...
  36. ncbi request reprint The paradox of normal neuropsychological function in schizophrenia
    W S Kremen
    Department of Psychiatry, University of California, Davis, School of Medicine, 4430 V Street, Sacramento, California 95817, USA
    J Abnorm Psychol 109:743-52. 2000
    ..Our results favor the view that even neuropsychologically normal schizophrenia patients have compromised cognitive function relative to their presumed expected or premorbid level of intellectual ability...
  37. ncbi request reprint Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging
    J M Goldstein
    Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, Boston, MA 02115, USA
    Cereb Cortex 11:490-7. 2001
    ..These findings have implications for developmental studies that would directly test hypotheses about mechanisms relating sex steroid hormones to sexual dimorphisms in humans...
  38. ncbi request reprint Concurrent validation of schizotaxia: a pilot study
    W S Stone
    Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
    Biol Psychiatry 50:434-40. 2001
    ....
  39. ncbi request reprint Intelligence quotient and neuropsychological profiles in patients with schizophrenia and in normal volunteers
    W S Kremen
    Department of Psychiatry, University of California, Davis School of Medicine, 2516 Stockton Boulevard, Sacramento, CA 95817, USA
    Biol Psychiatry 50:453-62. 2001
    ..The results strengthen the argument that neurocognitive deficits are core deficits of schizophrenic illness...
  40. ncbi request reprint Comparative effects of schizophrenia and temporal lobe epilepsy on memory
    L J Seidman
    Neuropsychology Laboratory, Harvard Institute of Psychiatric Epidemiology and Genetics, Massachusetts Mental Health Center, Harvard Medical School, Boston, MA 02115, USA
    J Int Neuropsychol Soc 4:342-52. 1998
    ..Patients with schizophrenia, even those relatively early in the course of illness, have a mild episodic memory disorder...
  41. ncbi request reprint Diagnostic efficiency of neuropsychological test scores for discriminating boys with and without attention deficit-hyperactivity disorder
    A E Doyle
    Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston 02114, USA
    J Consult Clin Psychol 68:477-88. 2000
    ..The prognostic implications of variable neuropsychological deficits in children with ADHD require further investigation...
  42. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
    ..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
  43. pmc The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypes
    Raquel E Gur
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:49-68. 2007
    ....
  44. ncbi request reprint Effects of stimulant medication on neuropsychological functioning in young adults with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:1150-6. 2008
    ..The main goal of this study was to evaluate the impact of stimulant medication on executive function deficits in a group of adolescents and young adults with attention-deficit/hyperactivity disorder (ADHD; DSM-III-R criteria)...
  45. ncbi request reprint Sex differences in language dysfunction in schizophrenia
    Deborah J Walder
    Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Psychiatry 163:470-7. 2006
    ..The current study investigated this issue in the domains of phonology, semantics, and grammar, which have been closely linked with neuroanatomic regions for which sex differences have been identified...
  46. ncbi request reprint Is there disproportionate impairment in semantic or phonemic fluency in schizophrenia?
    William S Kremen
    Department of Psychiatry, University of California, Davis School of Medicine, 2230 Stockton Blvd, Sacramento, CA 95817, USA
    J Int Neuropsychol Soc 9:79-88. 2003
    ..48 < rs < .79). These results mirror a literature that overall suggests a small degree of disproportionate semantic fluency impairment in schizophrenia, but also some heterogeneity in fluency deficits...
  47. ncbi request reprint Towards further understanding of the co-morbidity between attention deficit hyperactivity disorder and bipolar disorder: a MRI study of brain volumes
    J Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychol Med 38:1045-56. 2008
    ....
  48. ncbi request reprint Impact of executive function deficits and attention-deficit/hyperactivity disorder (ADHD) on academic outcomes in children
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Consult Clin Psychol 72:757-66. 2004
    ..Children and adolescents with ADHD and EFDs were found to be at high risk for significant impairments in academic functioning. These results support screening children with ADHD for EFDs to prevent academic failure...
  49. pmc Children of parents with affective and nonaffective psychoses: a longitudinal study of behavior problems
    Jo Ann L Donatelli
    Department of Psychiatry, Community Health, Brown University, Providence, RI 02903, USA
    Am J Psychiatry 167:1331-8. 2010
    ..g., schizophrenia, other nonaffective psychoses, and affective psychoses) have distinct forms of behavioral problems (i.e., internalizing and externalizing)...
  50. doi request reprint IQ decline in cross-sectional studies of schizophrenia: methodology and interpretation
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego School of Medicine, 9500 Gilman Drive MC 0738, La Jolla, CA 92093 0738, USA
    Psychiatry Res 158:181-94. 2008
    ..Overall, these results strongly suggest that differences in current neuropsychological function in schizophrenia are attributable primarily to current IQ instead of to IQ trajectory over time...
  51. pmc Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
    ....
  52. doi request reprint A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHD
    Michael C Monuteaux
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1436-41. 2008
    ..These result support the heterogeneity of ADHD and provides insights as to its underlying pathophysiology...
  53. pmc Neural substrates of impaired sensorimotor timing in adult attention-deficit/hyperactivity disorder
    Eve M Valera
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult Attention Deficit Hyperactivity Disorder, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 68:359-67. 2010
    ..Also, the neural substrates of these deficits are largely unknown for both youth and adults with ADHD. The present study examined subsecond sensorimotor timing and its neural substrates in ADHD adults...
  54. pmc Smaller left Heschl's gyrus volume in patients with schizotypal personality disorder
    Chandlee C Dickey
    Harvard Medical School, Clinical Neuroscience Division, Department of Psychiatry, VA Boston Healthcare System, Brockton, MA 02401, USA
    Am J Psychiatry 159:1521-7. 2002
    ..In a further exploration, the authors studied two components of the superior temporal gyrus: Heschl's gyrus and the planum temporale...
  55. ncbi request reprint Educational and occupational underattainment in adults with attention-deficit/hyperactivity disorder: a controlled study
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:1217-22. 2008
    ..This study evaluated subjects to determine whether the educational and occupational deficits associated with ADHD are what would be expected given their intellectual abilities or lower than expected given their intellectual abilities...
  56. ncbi request reprint Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia
    Stephen J Glatt
    Center for Behavioral Genomics, Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 920923, USA
    Br J Psychiatry 189:337-45. 2006
    ..Evaluation of individuals at high genetic risk of schizophrenia is a powerful method for identifying precursors of the illness...
  57. pmc Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Massachusetts, USA
    Schizophr Bull 34:37-46. 2008
    ..The limbic structures in early-onset schizophrenia-spectrum illness (SZ) and bipolar disorder (BPD) were studied to discern patterns associated with diagnosis and sex...
  58. pmc Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
    ..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
  59. ncbi request reprint Discordance between psychometric testing and questionnaire-based definitions of executive function deficits in individuals with ADHD
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Research Unit, Boston, MA 02114, USA
    J Atten Disord 12:92-102. 2008
    ....
  60. pmc Reduction of caudate nucleus volumes in neuroleptic-naïve female subjects with schizotypal personality disorder
    Min Seong Koo
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, and Harvard Medical School, Boston, MA 02401, USA
    Biol Psychiatry 60:40-8. 2006
    ....
  61. ncbi request reprint Evidence for reduced cerebellar volumes in trichotillomania
    Nancy J Keuthen
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 61:374-81. 2007
    ..Limited knowledge exists regarding the neurobiology of trichotillomania (TTM). Cerebellum (CBM) volumes were explored, given its role in complex, coordinated motor sequences...
  62. pmc Cortical thickness abnormalities in cocaine addiction--a reflection of both drug use and a pre-existing disposition to drug abuse?
    Nikos Makris
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuron 60:174-88. 2008
    ..These observations suggest that brain structure abnormalities in addicts are related in part to drug use and in part to predisposition toward addiction...
  63. pmc A MRI study of fusiform gyrus in schizotypal personality disorder
    Chandlee C Dickey
    Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, and Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 64:35-9. 2003
    ..This suggests that future studies may be useful in determining the functional competence of this gyrus in SPD...
  64. ncbi request reprint Striatal volume loss in HD as measured by MRI and the influence of CAG repeat
    H D Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School 02114, USA
    Neurology 57:1025-8. 2001
    ..Progressive degeneration of the striatum is the pathologic hallmark of the disease. Little is known about the regional selectivity of the neurodegeneration and its relationship to the genetic expansion...
  65. ncbi request reprint Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis
    H D Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Neurology 60:1615-20. 2003
    ....
  66. ncbi request reprint Poor perception of nonverbal social-emotional cues in relatives of schizophrenic patients
    R Toomey
    Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center, Boston 02301, USA
    Schizophr Res 40:121-30. 1999
    ..Further research is needed to clarify the nature of this relationship, to better characterize social perception deficits in relatives, and to determine whether these perceptual deficits are part of the genetic diathesis to schizophrenia...
  67. pmc Neuropsychological profiles in individuals at clinical high risk for psychosis: relationship to psychosis and intelligence
    Kristen A Woodberry
    Center for Psychiatric Research, Maine Medical Center, 295 Park Avenue, Portland, ME 04102, USA
    Schizophr Res 123:188-98. 2010
    ..The degree to which NP impairments are associated with general cognitive ability and/or later emergence of full psychosis in CHR samples requires study with well-matched controls...
  68. pmc Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis
    Larry J Seidman
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Gen Psychiatry 67:578-88. 2010
    ..Early detection and prospective evaluation of clinical high-risk (CHR) individuals who may develop schizophrenia or other psychotic disorders is critical for predicting psychosis onset and for testing preventive interventions...
  69. pmc Specificity of familial transmission of schizophrenia psychosis spectrum and affective psychoses in the New England family study's high-risk design
    Jill M Goldstein
    Division of Women s Health, Mary Horrigan Connors Center for Women s Health and Gender Biology, and Department of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Arch Gen Psychiatry 67:458-67. 2010
    ..However, few studies have investigated the specificity of the transmission of schizophrenia-psychosis spectrum (SPS) disorders and affective psychoses (APs) or observed high-risk offspring into mid-adulthood...
  70. pmc White matter volume abnormalities and associations with symptomatology in schizophrenia
    Nikolaos Makris
    Athinoula A Martinos Imaging Center, Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA, United States
    Psychiatry Res 183:21-9. 2010
    ..These observations suggest a pattern of volume WM alterations associated with symptomatology in schizophrenia that may be related in part to predisposition to schizophrenia...
  71. doi request reprint Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference task
    George Bush
    Departments of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 65:102-14. 2008
    ..Stimulant medications are effective treatments for ADHD, but their neural effects have not been fully characterized...
  72. pmc Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: a pilot study
    Nikos Makris
    Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Atten Disord 13:407-13. 2010
    ..Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD...
  73. pmc Regional prefrontal cortex gray matter volumes in youth at familial risk for schizophrenia from the Harvard Adolescent High Risk Study
    Isabelle M Rosso
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Schizophr Res 123:15-21. 2010
    ..We conducted a region-of-interest morphometric study of prefrontal subregions in adolescent and young adult relatives of schizophrenia patients...
  74. pmc An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorder
    Heidi W Thermenos
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 153:120-31. 2010
    ..Persons with BD and RELs exhibit altered activity in the frontopolar cortex and insula, which may represent biomarkers of genetic risk for BD...
  75. pmc Sex differences in the functional neuroanatomy of working memory in adults with ADHD
    Eve M Valera
    Department of Psychiatry, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Am J Psychiatry 167:86-94. 2010
    ..The authors examined sex differences in the neural functioning of adults with ADHD during performance of a verbal working memory task...
  76. ncbi request reprint Attention and executive systems abnormalities in adults with childhood ADHD: A DT-MRI study of connections
    Nikos Makris
    Harvard Medical School Departments of Neurology and Radiology Services, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Cereb Cortex 18:1210-20. 2008
    ..The demonstration of FA abnormalities in the CB and SLF II in adults with childhood ADHD provides further support for persistent structural abnormalities into adulthood...
  77. pmc Toward a model of memory enhancement in schizophrenia: glucose administration and hippocampal function
    William S Stone
    Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    Schizophr Bull 34:93-108. 2008
    ..More generally, the discussion underlines the promise of cognitive improvement in schizophrenia and the need to approach the issue in a programmatic manner...
  78. ncbi request reprint Decreased volume of left and total anterior insular lobule in schizophrenia
    Nikos Makris
    Athinoula A Martinos Center, Harvard Medical School Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, United States
    Schizophr Res 83:155-71. 2006
    ....
  79. ncbi request reprint Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging
    Jill M Goldstein
    Department of Psychiatry, Harvard Medical School, Brigham and Women s Hospital, Connors Center for Women s Health and Gender Biology, Boston, Massachusetts 02115, USA
    J Neurosci 25:9309-16. 2005
    ..Findings have important implications for normal sex-specific physiological functioning and may contribute to understanding higher rates of mood and anxiety disorders in women and differential sensitivity to trauma than men...
  80. ncbi request reprint Neuropsychological functioning in relatives of girls with and without ADHD
    Alysa E Doyle
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 35:1121-32. 2005
    ..A limited number of studies have examined neuropsychological functioning in the family members of ADHD youth, and none have focused exclusively on relatives of females...
  81. ncbi request reprint Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directions
    George Bush
    Psychiatric Neuroscience Program and Department of Psychiatry, Harvard Medical School and Massachusettes General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 57:1273-84. 2005
    ..Although at present there are no accepted uses for functional imaging in diagnosing ADHD, this article mentions possible future clinical uses of imaging in ADHD...
  82. ncbi request reprint MRI-based surface-assisted parcellation of human cerebellar cortex: an anatomically specified method with estimate of reliability
    Nikos Makris
    Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 25:1146-60. 2005
    ..933. Whereas the individual units provide a high level of detail and anatomical specificity, the clusters add flexibility to the analysis by providing higher reliability...
  83. pmc A comparative profile analysis of neuropsychological function in men and women with schizotypal personality disorder
    Martina M Voglmaier
    Harvard Medical School, Department of Psychiatry at the Massachusetts Mental Health Center, Boston, MA 02139, USA
    Schizophr Res 74:43-9. 2005
    ..The results suggest a less severe pattern of cognitive deficits in women with SPD compared to men, consistent with hypotheses of gender differences in cognitive function in schizophrenia...
  84. ncbi request reprint Automatically parcellating the human cerebral cortex
    Bruce Fischl
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH MIT Harvard Medical School, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
    Cereb Cortex 14:11-22. 2004
    ..Examples are given from two different training sets generated using different neuroanatomical conventions, illustrating the flexibility of the algorithm. The technique is shown to be comparable in accuracy to manual labeling...
  85. ncbi request reprint A twin study of the neuropsychological consequences of stimulant abuse
    Rosemary Toomey
    Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, 02129, USA
    Arch Gen Psychiatry 60:303-10. 2003
    ..Previous studies document neuropsychological deficits associated with stimulant abuse, but findings are inconsistent...
  86. ncbi request reprint Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging
    Jill M Goldstein
    Massachusetts Mental Health Center, Harvard Institute of Psychiatric Epidemiology and Genetics, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:154-64. 2002
    ....
  87. ncbi request reprint Intellectual decline in schizophrenia: evidence from a prospective birth cohort 28 year follow-up study
    Larry J Seidman
    Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, Boston, USA
    J Clin Exp Neuropsychol 28:225-42. 2006
    ..Future research on this sample will evaluate the prospective roles of family history and perinatal complications on cognition, and assess the specificity of these findings...
  88. ncbi request reprint Neuropsychological functioning in girls with attention-deficit/hyperactivity disorder with and without learning disabilities
    Larry J Seidman
    Massachusetts General Hospital, Boston, MA 02114, USA
    Neuropsychology 20:166-77. 2006
    ..These results extend to females the previously documented association of LDs with neuropsychological functioning in males with ADHD...
  89. ncbi request reprint Human cerebral cortex: a system for the integration of volume- and surface-based representations
    Nikos Makris
    Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 33:139-53. 2006
    ..This system of topographical analysis of the cerebral cortex is consistent with current views of cortical development and neural systems organization of the human and non-human primate brain...
  90. ncbi request reprint Cortical thinning of the attention and executive function networks in adults with attention-deficit/hyperactivity disorder
    Nikos Makris
    Departments of Neurology and Radiology Services, Center for Morphometric Analysis, Health Sciences and Technology Athinoula A Martinos Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Cereb Cortex 17:1364-75. 2007
    ..This is the first documentation that ADHD in adults is associated with thinner cortex in the cortical networks that modulate attention and EF...
  91. doi request reprint Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds
    E C del Re
    1 VA Boston Healthcare System, Brockton, MA, USA 2 Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Transl Psychiatry 4:e346. 2014
    ..Our results suggest pleiotropic effects of ZNF804A on risk for SZ and neural mechanisms that are indexed by the novel P300b ERP component. ..
  92. doi request reprint Altered language network activity in young people at familial high-risk for schizophrenia
    H W Thermenos
    Harvard Medical School, Boston, MA, USA Massachusetts Mental Health Center Division of Public Psychiatry, Boston, MA, USA Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Electronic address
    Schizophr Res 151:229-37. 2013
    ..The neural underpinnings of these deficits in people with FHR are unclear...
  93. ncbi request reprint Topographic abnormalities of P3 in schizotypal personality disorder
    D F Salisbury
    Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, Boston, USA
    Biol Psychiatry 40:165-72. 1996
    ..Asymmetry of P3 amplitude, with left-sided deficit, may be associated with the schizophrenia diathesis, but overall P3 reductions may be more associated with chronic effects...
  94. pmc Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men
    M S Panizzon
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 9293 0738, USA
    Neurology 75:874-80. 2010
    ..The aim of the present study was to examine the potential interaction of testosterone and APOE genotype with respect to hippocampal volume in middle age...
  95. doi request reprint A review of neuroimaging studies of young relatives of individuals with schizophrenia: a developmental perspective from schizotaxia to schizophrenia
    H W Thermenos
    Harvard Medical School, Boston, Massachusetts Massachusetts Mental Health Center, Division of Public Psychiatry, Boston, Massachusetts Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts
    Am J Med Genet B Neuropsychiatr Genet 162:604-35. 2013
    ..Future research should focus on the genetic and environmental contributions to these alterations, determine how early they emerge, and determine whether they can be partially or fully remediated by innovative treatments...
  96. ncbi request reprint Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosis
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA
    Biol Psychiatry 59:97-105. 2006
    ..Neurocognitive deficits are severe in first-episode psychosis...
  97. pmc The uncinate fasciculus and extraversion in schizotypal personality disorder: a diffusion tensor imaging study
    Ronald J Gurrera
    Schizophr Res 90:360-2. 2007
  98. ncbi request reprint Successful multi-site measurement of antisaccade performance deficits in schizophrenia
    Allen D Radant
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
    Schizophr Res 89:320-9. 2007
    ..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies...
  99. pmc An MRI study of superior temporal gyrus volume in women with schizotypal personality disorder
    Chandlee C Dickey
    VA Boston Healthcare System, Psychiatry 116A, 940 Belmont St, Brockton, MA 02401, USA
    Am J Psychiatry 160:2198-201. 2003
    ..This is the first structural magnetic resonance imaging study to examine a group of female subjects with schizotypal personality disorder...
  100. doi request reprint Functional co-primary measures for clinical trials in schizophrenia: results from the MATRICS Psychometric and Standardization Study
    Michael F Green
    Semel Institute for Neuroscience and Human Behavior, UCLA, 300 Medical Plaza, Rm 2263, Los Angeles, CA 90095 6968, USA
    Am J Psychiatry 165:221-8. 2008
    ..e., a co-primary) that is considered functionally meaningful. The goal of the current study was to describe steps to evaluate four potential co-primary measures for psychometric properties and validity...
  101. ncbi request reprint Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, 90095, USA
    Schizophr Bull 29:653-69. 2003
    ....