Christine E Seidman
Affiliation: Harvard University
Yotti R, Seidman C, Seidman J. Advances in the Genetic Basis and Pathogenesis of Sarcomere Cardiomyopathies. Annu Rev Genomics Hum Genet. 2019;: pubmed publisher
..Expected final online publication date for the Annual Review of Genomics and Human Genetics Volume 22 is August 30, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates. ..
Garfinkel A, Seidman J, Seidman C. Genetic Pathogenesis of Hypertrophic and Dilated Cardiomyopathy. Heart Fail Clin. 2018;14:139-146 pubmed publisher
..Here, the authors review current understandings of how human hypertrophic cardiomyopathy- and hypertrophic dilated cardiomyopathy-linked mutations disrupt the normal structure and function of the sarcomere. ..
Burke M, Cook S, Seidman J, Seidman C. Clinical and Mechanistic Insights Into theÂ Genetics of Cardiomyopathy. J Am Coll Cardiol. 2016;68:2871-2886 pubmed publisher
..Such data hold the promise that mutation-specific pathophysiology will uncover novel therapeutic targets, and herald the beginning of precision therapy for cardiomyopathy patients. ..
Chopra A, Kutys M, Zhang K, Polacheck W, Sheng C, Luu R, et al
. Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Dev Cell. 2018;44:87-96.e5 pubmed publisher
..Ablating protocostameres or decoupling titin from protocostameres abolishes sarcomere assembly. Together these results identify the mechanical and molecular components critical for human cardiac sarcomerogenesis. ..
Delaughter D, Bick A, Wakimoto H, McKean D, Gorham J, Kathiriya I, et al
. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev Cell. 2016;39:480-490 pubmed publisher
..5 that cause human heart malformations. This spatiotemporal transcriptome analysis of heart development reveals lineage-specific gene programs underlying normal cardiac development and congenital heart disease. ..
Hinson J, Chopra A, Lowe A, Sheng C, Gupta R, Kuppusamy R, et al
. Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Rep. 2016;17:3292-3304 pubmed publisher
..Our results establish critical connections among metabolic sensing, myocyte survival, and TGF? signaling. ..
Bick A, Wakimoto H, Kamer K, Sancak Y, Goldberger O, Axelsson A, et al
. Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter. Proc Natl Acad Sci U S A. 2017;114:E9096-E9104 pubmed publisher
Seidman C, Seidman J. Identifying sarcomere gene mutations in hypertrophic cardiomyopathy: a personal history. Circ Res. 2011;108:743-50 pubmed publisher