J M Seddon

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration
    Johanna M Seddon
    Massachusetts Eye and Ear Infirmary and Channing Laboratory, Harvard Medical School, 243 Charles Street, Boston, MA, USA
    Arch Ophthalmol 124:995-1001. 2006
  2. ncbi request reprint CFH gene variant, Y402H, and smoking, body mass index, environmental associations with advanced age-related macular degeneration
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Hum Hered 61:157-65. 2006
  3. ncbi request reprint Evaluation of plasma homocysteine and risk of age-related macular degeneration
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Am J Ophthalmol 141:201-3. 2006
  4. ncbi request reprint The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Department of Opthalmology, Harvaed Medical School, Boston, MA 02114, USA
    Arch Ophthalmol 123:321-7. 2005
  5. ncbi request reprint Association between C-reactive protein and age-related macular degeneration
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Mass 02114, USA
    JAMA 291:704-10. 2004
  6. ncbi request reprint Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    Arch Ophthalmol 121:785-92. 2003
  7. ncbi request reprint Assessment of mutations in the Best macular dystrophy (VMD2) gene in patients with adult-onset foveomacular vitelliform dystrophy, age-related maculopathy, and bull's-eye maculopathy
    J M Seddon
    Department of Ophthalmology, Massachusetts Eye Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 108:2060-7. 2001
  8. ncbi request reprint Dietary fat and risk for advanced age-related macular degeneration
    J M Seddon
    Epidemiology Unit, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Arch Ophthalmol 119:1191-9. 2001
  9. pmc A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions
    Johanna M Seddon
    Ophthalmology Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Am J Hum Genet 73:780-90. 2003
  10. ncbi request reprint Phenotype and genotype correlations in two best families
    J M Seddon
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 110:1724-31. 2003

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration
    Johanna M Seddon
    Massachusetts Eye and Ear Infirmary and Channing Laboratory, Harvard Medical School, 243 Charles Street, Boston, MA, USA
    Arch Ophthalmol 124:995-1001. 2006
    ..To evaluate modifiable risk and protective factors for age-related macular degeneration (AMD) among elderly twins...
  2. ncbi request reprint CFH gene variant, Y402H, and smoking, body mass index, environmental associations with advanced age-related macular degeneration
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Hum Hered 61:157-65. 2006
    ....
  3. ncbi request reprint Evaluation of plasma homocysteine and risk of age-related macular degeneration
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Am J Ophthalmol 141:201-3. 2006
    ..To assess the relationship between plasma levels of homocysteine and age-related macular degeneration (AMD)...
  4. ncbi request reprint The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Department of Opthalmology, Harvaed Medical School, Boston, MA 02114, USA
    Arch Ophthalmol 123:321-7. 2005
    ..The relative importance of genes and environment in the etiology of this major public health problem is not well understood...
  5. ncbi request reprint Association between C-reactive protein and age-related macular degeneration
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Mass 02114, USA
    JAMA 291:704-10. 2004
    ..Some risk factors for CVD are associated with age-related macular degeneration (AMD), but the association between CRP and AMD is unknown...
  6. ncbi request reprint Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    Arch Ophthalmol 121:785-92. 2003
    ..To advise these high-risk patients regarding preventive measures, we evaluated anthropomorphic, behavioral, and medical factors associated with progression to the advanced stages of AMD associated with visual loss...
  7. ncbi request reprint Assessment of mutations in the Best macular dystrophy (VMD2) gene in patients with adult-onset foveomacular vitelliform dystrophy, age-related maculopathy, and bull's-eye maculopathy
    J M Seddon
    Department of Ophthalmology, Massachusetts Eye Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 108:2060-7. 2001
    ..To study the presence of Best macular dystrophy (VMD2) gene mutations in patients diagnosed with maculopathies other than classic Best disease and to describe the clinical characteristics of these subjects...
  8. ncbi request reprint Dietary fat and risk for advanced age-related macular degeneration
    J M Seddon
    Epidemiology Unit, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Arch Ophthalmol 119:1191-9. 2001
    ..To evaluate the relationship between intake of total and specific types of fat and risk for advanced age-related macular degeneration (AMD), the leading cause of irreversible blindness in adults...
  9. pmc A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions
    Johanna M Seddon
    Ophthalmology Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Am J Hum Genet 73:780-90. 2003
    ..00001. The consistency of many of the other signals across both two-point and multipoint, as well as parametric and nonparametric, analyses indicate several other regions worthy of follow-up...
  10. ncbi request reprint Phenotype and genotype correlations in two best families
    J M Seddon
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 110:1724-31. 2003
    ..To evaluate mutations in the Best mascular dystrophy (VMD2) gene in two families with Best disease and to describe the phenotype-genotype correlations of genetically determined affected and unaffected individuals...
  11. ncbi request reprint Prospective study of dietary fat and the risk of age-related macular degeneration
    E Cho
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 73:209-18. 2001
    ..The relation between intakes of total fat and specific types of fat and age-related macular degeneration (AMD) remains unclear...
  12. ncbi request reprint A prospective study of carotenoid intake and risk of cataract extraction in US men
    L Brown
    Departments of Epidemiology, Nutrition, and Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 70:517-24. 1999
    ..However, prospective epidemiologic data concerning this phenomenon are limited...
  13. ncbi request reprint Prospective study of alcohol consumption and the risk of age-related macular degeneration
    E Cho
    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
    Arch Ophthalmol 118:681-8. 2000
    ..To describe the relationship between alcohol consumption and the incidence of age-related macular degeneration (AMD)...
  14. pmc Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:2044-53. 2009
    ..The joint effects of genetic, ocular, and environmental variables were evaluated and predictive models for prevalence and incidence of AMD were assessed...
  15. ncbi request reprint Prospective study of zinc intake and the risk of age-related macular degeneration
    E Cho
    Departments of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Ann Epidemiol 11:328-36. 2001
    ..Zinc is found in high concentrations in the retina and is hypothesized to reduce the risk of age-related macular degeneration (AMD). Any long-term benefit associated with dietary zinc intake has not been evaluated...
  16. ncbi request reprint C-reactive protein and homocysteine are associated with dietary and behavioral risk factors for age-related macular degeneration
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Nutrition 22:441-3. 2006
    ..We investigated whether age-related macular degeneration risk factors are associated with high-sensitivity C-reactive protein (CRP) and homocysteine (HCY), systemic biomarkers for cardiovascular disease...
  17. ncbi request reprint Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration
    Julian Maller
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, Boston, Massachusetts 02114, USA
    Nat Genet 38:1055-9. 2006
    ..Genotypes at these five common SNPs define a broad spectrum of interindividual disease risk and explain about half of the classical sibling risk of AMD in our study population...
  18. ncbi request reprint Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts New England Medical Center, Boston, MA 02111, USA
    JAMA 297:1793-800. 2007
    ..Studies have reported that single-nucleotide polymorphisms in the genes CFH and LOC387715 are associated with age-related macular degeneration (AMD)...
  19. ncbi request reprint Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake
    Johanna M Seddon
    Massachusetts Eye and Ear Infirmary, Epidemiology Unit, Harvard School of Public Health, Boston, Massachesetts 02114, USA
    Arch Ophthalmol 121:1728-37. 2003
    ..Evidence is sparse regarding modifiable factors that may decrease the risk of progression to the advanced forms of AMD...
  20. pmc C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Ophthalmology 117:1560-6. 2010
    ..We evaluated their independent and combined effects on risk of AMD, as well as their interactions...
  21. ncbi request reprint Phenotypic heterogeneity in families with age-related macular degeneration
    M A De La Paz
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Ophthalmol 124:331-43. 1997
    ..To evaluate the ophthalmic phenotype in families with three or more individuals who have age-related maculopathy...
  22. ncbi request reprint Multivitamin-multimineral supplements and eye disease: age-related macular degeneration and cataract
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 85:304S-307S. 2007
    ..The Age-Related Eye Disease Study II will evaluate some of these additional nutrients as dietary supplements in a randomized trial...
  23. doi request reprint Peripheral retinal drusen and reticular pigment: association with CFHY402H and CFHrs1410996 genotypes in family and twin studies
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts University School of Medicine and Tufts Medical Center, New England Eye Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:586-91. 2009
    ..To evaluate the relationship between peripheral retinal drusen and reticular pigment changes and genotypes associated with age-related macular degeneration (AMD)...
  24. ncbi request reprint A discordant sib-pair linkage analysis of age-related macular degeneration
    Susan L Santangelo
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA
    Ophthalmic Genet 26:61-7. 2005
    ..Our prior genome scan in 511 affected sib-pairs and other relative pairs identified significant or suggestive linkage signals on chromosomes 1, 2, 3, 6, 8, 10, 12, 16, and 22...
  25. ncbi request reprint Dietary glycemic load and risk of age-related cataract
    Debra A Schaumberg
    Division of Preventive Medicine and Nutrition, Harvard School of Public Health, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Am J Clin Nutr 80:489-95. 2004
    ..Although hyperglycemia is a risk factor for cataract, there is no information on the potential effect of a high dietary glycemic load on the incidence of age-related cataract...
  26. ncbi request reprint Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Ophthalmol 122:883-92. 2004
    ..To examine the intake of antioxidant vitamins and carotenoids as well as fruits and vegetables in relation to the development of age-related maculopathy (ARM)...
  27. ncbi request reprint Smoking cessation and risk of cataract extraction among US women and men
    June M Weintraub
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 155:72-9. 2002
    ..90, 95% CI: 0.71, 1.13). These findings suggest that any healing from damage due to cigarette smoking occurs at a very modest pace, and they emphasize the importance of never starting to smoke or quitting early in life...
  28. ncbi request reprint A prospective study of the relationship between body mass index and cataract extraction among US women and men
    J M Weintraub
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Int J Obes Relat Metab Disord 26:1588-95. 2002
    ..Obesity may influence several physiologic processes involved in cataract formation such as oxidative stress, glycosylation and osmotic stress...
  29. ncbi request reprint Familial aggregation of age-related maculopathy
    J M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Ophthalmol 123:199-206. 1997
    ....
  30. pmc Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes
    Robyn Reynolds
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:5818-27. 2009
    ..This study was conducted to determine whether alterations in circulating levels of these markers of complement activation and regulation are also independently associated with advanced AMD and whether they are related to AMD genotypes...
  31. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
    ..Results implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD...
  32. ncbi request reprint Evaluating the effectiveness of a vision rehabilitation intervention using an objective and subjective measure of functional performance
    P McCabe
    Department of Ophthalmology, Vision Rehabilitation Center, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmic Epidemiol 7:259-70. 2000
    ....
  33. pmc Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration
    Robyn Reynolds
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ophthalmology 117:1989-95. 2010
    ..In this study, we evaluated whether LIPC is associated with serum lipids, and whether this gene and serum lipids are independently associated with AMD...
  34. ncbi request reprint Variation in complement factor 3 is associated with risk of age-related macular degeneration
    Julian B Maller
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 39:1200-1. 2007
    ..We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample...
  35. ncbi request reprint The genetics of age-related macular degeneration: a review of progress to date
    Stephen Haddad
    Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, 02114, USA
    Surv Ophthalmol 51:316-63. 2006
    ..Among these, apolipoprotein E (APOE) may be a minor risk locus. Additional genes will likely be identified, and future studies should explore the potential interactions of these genes with other genes as well as environmental factors...
  36. ncbi request reprint Association between reproductive and hormonal factors and age-related maculopathy in postmenopausal women
    Kristin K Snow
    Massachusetts Eye and Ear Infirmary, Epidemiology Unit, Boston, Massachusetts 02114, USA
    Am J Ophthalmol 134:842-8. 2002
    ..We hypothesized that exposure to endogenous or exogenous estrogens would be associated with a reduced risk of advanced ARM...
  37. ncbi request reprint Review of genetics in age related macular degeneration
    Sandra R Montezuma
    Massachusetts Eye and Ear Infirmary and the Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Semin Ophthalmol 22:229-40. 2007
    ..Understanding the causative environmental and genetic interactions will facilitate the development of future preventive methods and treatments...
  38. pmc Genetic profile for five common variants associated with age-related macular degeneration in densely affected families: a novel analytic approach
    Lucia Sobrin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Eur J Hum Genet 18:496-501. 2010
    ..Given that these densely affected families may harbor rare, more penetrant variants for AMD, linkage analyses and resequencing targeting these families may be an effective approach to finding additional implicated genes...
  39. ncbi request reprint Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Arch Ophthalmol 123:774-82. 2005
    ..We previously found an association between AMD and CRP in a cross-sectional analysis, but the prospective relationships between AMD, CRP, and the other cardiovascular disease markers are unknown...
  40. ncbi request reprint The epidemiology of age-related macular degeneration
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    Int Ophthalmol Clin 44:17-39. 2004
  41. doi request reprint Cystoid macular edema without macular thickening: a retrospective optical coherence tomographic study
    Jason J Jun
    New England Eye Center, Tufts University School of Medicine, Boston, Massachusetts 02116, USA
    Retina 30:917-23. 2010
    ....
  42. pmc Spectral domain optical coherence tomography for quantitative evaluation of drusen and associated structural changes in non-neovascular age-related macular degeneration
    K Yi
    Harvard Medical School, Boston, Massachusetts, USA
    Br J Ophthalmol 93:176-81. 2009
    ....
  43. pmc Variation near complement factor I is associated with risk of advanced AMD
    Jesen A Fagerness
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Eur J Hum Genet 17:100-4. 2009
    ..No obvious functional variation was discovered that could be the proximate cause of the association, suggesting a noncoding regulatory mechanism...
  44. ncbi request reprint Evaluation of the clinical age-related maculopathy staging system
    Johanna M Seddon
    Epidemiology Unit, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 113:260-6. 2006
    ..To evaluate a clinical classification system, the Clinical Age-Related Maculopathy Staging (CARMS) system, for age-related maculopathy (ARM) using a simple grading scale designed for clinical practice and clinical research protocols...
  45. pmc The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23
    John Paul SanGiovanni
    National Eye Institute, Bethesda, Maryland, USA
    Arch Ophthalmol 126:1274-9. 2008
    ..To examine the association of dietary omega-3 long-chain polyunsaturated fatty acid and fish intake with incident neovascular age-related macular degeneration (AMD) and central geographic atrophy (CGA)...
  46. doi request reprint CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration
    Michael L Klein
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Ophthalmology 115:1019-25. 2008
    ..To determine if CFH and LOC387715/ARMS2 genotypes influence treatment response to AREDS-type nutritional supplementation with antioxidants and zinc...
  47. ncbi request reprint Genotype-phenotype analysis of ABCR variants in macular degeneration probands and siblings
    Paul S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Invest Ophthalmol Vis Sci 43:466-73. 2002
    ..This genetically related population provides a cohort of subjects with similar age and ethnic background for genotype-phenotype comparison to the original probands...
  48. ncbi request reprint The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22
    John Paul SanGiovanni
    The EMMES Corporation, 401 N Washington St, Ste 700, Rockville, MD 20850 1707, USA
    Arch Ophthalmol 125:1225-32. 2007
    ..To evaluate the relationship of dietary carotenoids, vitamin A, alpha-tocopherol, and vitamin C with prevalent age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS)...
  49. ncbi request reprint The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS Report No. 20
    John Paul SanGiovanni
    AREDS Coordinating Center, The EMMES Corporation, 401 N Washington Street, Rockville, MD 20850, USA
    Arch Ophthalmol 125:671-9. 2007
    ..To evaluate the association of lipid intake with baseline severity of age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS)...
  50. pmc Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19
    Traci E Clemons
    The EMMES Corporation, Rockville, Maryland 20850 1707, USA
    Ophthalmology 112:533-9. 2005
    ....
  51. ncbi request reprint The LOC387715 gene, smoking, body mass index, environmental associations with advanced age-related macular degeneration
    Peter J Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Hum Hered 63:212-8. 2007
    ....
  52. ncbi request reprint Meta-analysis of genome scans of age-related macular degeneration
    Sheila A Fisher
    Department of Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, London SE1 9RT, UK
    Hum Mol Genet 14:2257-64. 2005
    ..Several of the regions identified here showed only weak evidence for linkage in the individual studies. These results will help prioritize regions for future positional and functional candidate gene studies in AMD...
  53. ncbi request reprint Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: an extended follow-up
    Ruth A Kleinerman
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852 7362, USA
    J Clin Oncol 23:2272-9. 2005
    ..We have extended the follow-up of a large cohort of Rb patients for 7 more years to provide new information on the risk of additional cancers after radiotherapy in long-term survivors...
  54. pmc Potential public health impact of Age-Related Eye Disease Study results: AREDS report no. 11
    Neil M Bressler
    Arch Ophthalmol 121:1621-4. 2003
    ....
  55. ncbi request reprint Choroidal and cutaneous melanoma: distinctly different cousins
    Tara A Young
    Ophthalmic Epidemiol 12:221-2. 2005
  56. ncbi request reprint Hormone therapy and age-related macular degeneration: the Women's Health Initiative Sight Exam Study
    Mary N Haan
    Department of Epidemiology, University of Michigan, 611 Church Street, Ann Arbor, MI 48104, USA
    Arch Ophthalmol 124:988-92. 2006
    ..To determine the effectiveness of treatment with conjugated equine estrogens (CEE) or with CEE combined with progestin (CEE + P) on age-related macular degeneration (AMD)...
  57. ncbi request reprint Tobacco use in adult long-term survivors of retinoblastoma
    Meredith C Foster
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7044, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 15:1464-8. 2006
    ..Smoking did not account for the increased risk of lung cancer among hereditary Rb patients, and this may point to an enhanced sensitivity to the carcinogenic effects of tobacco. Adult survivors of Rb should be encouraged to stop smoking...
  58. ncbi request reprint Risk of soft tissue sarcomas by individual subtype in survivors of hereditary retinoblastoma
    Ruth A Kleinerman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS 7044, 6120 Executive Blvd, Rockville, MD 20852, USA
    J Natl Cancer Inst 99:24-31. 2007
    ..Survivors of hereditary retinoblastoma have an increased risk for second malignancies, especially soft tissue sarcomas. However, the risks of individual histologic subtypes of soft tissue sarcomas have not been evaluated...
  59. doi request reprint Cancer screening practices of adult survivors of retinoblastoma at risk of second cancers
    Victoria Sheen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Cancer 113:434-41. 2008
    ..The aim of the current study was to investigate the pattern of cancer screening behavior in adult retinoblastoma survivors, who are at high risk of developing second cancers...