Research Topics
| G R SeageSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Comparison of patient comprehension of rapid HIV pre-test fundamentals by information delivery format in an emergency department settingRoland C Merchant
Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
BMC Public Health 7:238. 2007..Two trials were conducted to compare emergency department patient comprehension of rapid HIV pre-test information using different methods to deliver this information...
Case-crossover study of partner and situational factors for unprotected sexGeorge R Seage
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Acquir Immune Defic Syndr 31:432-9. 2002..To identify situational and partner characteristics associated with unprotected sex among women at risk for HIV infection...- The relationship of preventable opportunistic infections, HIV-1 RNA, and CD4 Cell counts to chronic mortalityGeorge R Seage
Department of Epidemiology and Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Acquir Immune Defic Syndr 30:421-8. 2002.... - Are US populations appropriate for trials of human immunodeficiency virus vaccine? The HIVNET Vaccine Preparedness StudyG R Seage
Abt Associates Inc, Cambridge, MA, USA
Am J Epidemiol 153:619-27. 2001..96/100 PY, 95% CI: 1.41, 2.73), and women who used crack cocaine (1.62/100 PY, 95% CI: 0.92, 2.85). Therefore, cohorts with HIV-1 seroincidence rates appropriate for HIV-1 vaccine trials can be recruited, enrolled, and retained... - The Pediatric AIDS Severity Score (PASS): a multidimensional AIDS-severity adjustment for pediatric HIV infectionGeorge R Seage
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 43:603-10. 2006..A severity staging system predictive of mortality for perinatally HIV-infected children is needed for clinical and research purposes... - Feasibility of chemoprophylaxis studies in high risk HIV-seronegative populationsM Gross
Abt Associates Inc, Cambridge, MA, USA
AIDS Educ Prev 12:71-8. 2000..Interest in studies declined as the hypothetical regimen became more demanding. Studies must emphasize the unknown efficacy of this approach, given increased interest among MSM at greater risk of exposure... - Risk factors for opportunistic illnesses in children with human immunodeficiency virus in the era of highly active antiretroviral therapyNathalie Ylitalo
Department of Epidemiology and Biostatistics and Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Mass 02155, USA
Arch Pediatr Adolesc Med 160:778-87. 2006..To examine the relationship between the use of highly active antiretroviral treatment (HAART) and the occurrence of opportunistic illnesses (OIs) among children perinatally infected with human immunodeficiency virus... - Childhood sexual abuse among homosexual men. Prevalence and association with unsafe sexW R Lenderking
Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
J Gen Intern Med 12:250-3. 1997..13; 95% confidence interval 1.15-3.95). Sexual abuse remained a significant predictor of unprotected receptive anal intercourse in a logistic model adjusting for potential confounding variables... - Impact of protease inhibitor-containing combination antiretroviral therapies on height and weight growth in HIV-infected childrenK Buchacz
Harvard School of Public Health, Boston, Massachusetts, USA
Pediatrics 108:E72. 2001..To examine beneficial or detrimental effects of protease inhibitor (PI)-containing antiretroviral regimens on height and weight growth in children with human immunodeficiency virus (HIV) infection... - Osteonecrosis of the hip (Legg-Calvé-Perthes disease) in human immunodeficiency virus-infected childrenDenise M Gaughan
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts, USA
Pediatrics 109:E74-4. 2002.... - Impact of opportunistic diseases on chronic mortality in HIV-infected adults in Côte d'IvoireE Losina
Departments of Biostatistics and Epidemiology, School of Public Health, Boston University, Boston, MA, USA
S Afr Med J 96:526-9. 2006..To estimate incidence rates of opportunistic diseases (ODs) and mortality for patients with and without a history of OD among HIV-infected patients in Côte d'Ivoire... - Human immunodeficiency virus type 1 among bar and hotel workers in northern Tanzania: the role of alcohol, sexual behavior, and herpes simplex virus type 2Trong T H Ao
Department of Epidemiology, University of Washington, Seattle, 98145, USA
Sex Transm Dis 33:163-9. 2006..We assessed baseline prevalence of human immunodeficiency virus type 1 (HIV-1) and other STDs, as well as behavioral and biologic risk factors for HIV-1 in a population of female bar/hotel workers in Moshi, Tanzania... - When to start antiretroviral therapy in resource-limited settingsRochelle P Walensky
Massachusetts General Hospital, Brigham and Women s Hospital, Harvard University Medical School, Harvard School of Public Health, and Boston University School of Public Health, Boston, Massachusetts 02114, USA
Ann Intern Med 151:157-66. 2009..The results of international clinical trials that are assessing when to initiate antiretroviral therapy (ART) will not be available for several years... - Test and treat DC: forecasting the impact of a comprehensive HIV strategy in Washington DCRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin Infect Dis 51:392-400. 2010..We forecast outcomes of this approach if implemented in Washington DC... - Prophylaxis for human immunodeficiency virus-related Pneumocystis carinii pneumonia: using simulation modeling to inform clinical guidelinesSue J Goldie
Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, 718 Huntington Ave, Second Floor, Boston, MA 02115-5924, USA
Arch Intern Med 162:921-8. 2002..quot; In TMP/SMX-intolerant patients, dapsone is more cost-effective than atovaquone... 
Intimate partner violence perpetration, standard and gendered STI/HIV risk behaviour, and STI/HIV diagnosis among a clinic-based sample of menM R Decker
Harvard School of Public Health, Department of Society, Human Development and Health, Boston, Massachusetts 02115, USA
Sex Transm Infect 85:555-60. 2009..To date, little empirical data exist to characterise the nature of men's sexual risk as it relates to both their violence perpetration, and STI/HIV infection...- Effect of combination therapy including protease inhibitors on mortality among children and adolescents infected with HIV-1S L Gortmaker
Center for Biostatistics in AIDS Research, and Department of Health and Social Behavior, Havard School of Public Health, Boston, MA 02115, USA
N Engl J Med 345:1522-8. 2001..33; 95 percent confidence interval, 0.19 to 0.58; P<0.001). CONCLUSIONS: The use of combination therapy including protease inhibitors has markedly reduced mortality among children and adolescents infected with HIV-1... - Antiretroviral treatment in pediatric HIV infection in the United States: from clinical trials to clinical practiceSusan Brogly
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Mass 02115 6017, USA
JAMA 293:2213-20. 2005..However, the integration of novel ART into the clinical care of pediatric HIV infection has not been examined... - The development and utility of a clinical algorithm to predict early HIV-1 infectionNeda Sharghi
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 40:472-8. 2005..Studying individuals during early and acute HIV-1 infection would allow scientists to investigate the impact of the intervention being studied on early transmission or pathogenesis of HIV-1 infection... - Reproductive health of adolescent girls perinatally infected with HIVSusan B Brogly
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Mass 02115 6017, USA
Am J Public Health 97:1047-52. 2007..We sought to describe the reproductive health of adolescent girls perinatally infected with HIV... - Association of hypercholesterolemia incidence with antiretroviral treatment, including protease inhibitors, among perinatally HIV-infected childrenKatherine Tassiopoulos
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 47:607-14. 2008..Antiretroviral therapy has been associated with hypercholesterolemia in HIV-infected children. Few longitudinal studies have been conducted to examine this association, however... - Long-term effectiveness of highly active antiretroviral therapy on the survival of children and adolescents with HIV infection: a 10-year follow-up studyKunjal Patel
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Clin Infect Dis 46:507-15. 2008..Given that HIV infection is chronic and that exposure to HAART is likely to be life-long, there is a need to evaluate the long-term effect of HAART on survival in this population... - Incidence of opportunistic and other infections in HIV-infected children in the HAART eraPhilimon Gona
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Mass, USA
JAMA 296:292-300. 2006.... - Scaling up antiretroviral therapy in South Africa: the impact of speed on survivalRochelle P Walensky
The Divisions of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
J Infect Dis 197:1324-32. 2008..Only 33% of eligible human immunodeficiency virus (HIV)-infected patients in South Africa receive antiretroviral therapy (ART). We sought to estimate the impact of alternative ART scale-up scenarios on patient outcomes from 2007-2012... - Substance use in HIV-Infected women during pregnancy: self-report versus meconium analysisKatherine Tassiopoulos
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
AIDS Behav 14:1269-78. 2010..Illicit substance use was low and substantially less than that reported in earlier studies of HIV-infected women, but alcohol and tobacco exposure was prevalent... - Association of site-specific and participant-specific factors with retention of children in a long-term pediatric HIV cohort studyPaige L Williams
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115 6017, USA
Am J Epidemiol 167:1375-86. 2008..Although participant characteristics are difficult to modify, the authors identified several potentially modifiable site practices that could be targeted to improve retention... - The prevalence of pain in pediatric human immunodeficiency virus/acquired immunodeficiency syndrome as reported by participants in the Pediatric Late Outcomes Study (PACTG 219)Denise M Gaughan
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Pediatrics 109:1144-52. 2002..The prevalence of pain in adults with AIDS ranges from 40% to 60%, depending on stage of illness. There is limited research concerning pain in HIV-infected children and youth... - Treatment for primary HIV infection: projecting outcomes of immediate, interrupted, or delayed therapyRochelle P Walensky
Division of Infectious Disease and the Partners AIDS Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
J Acquir Immune Defic Syndr 31:27-37. 2002..These results can assist decision makers and those planning clinical trials in defining evidence-based performance measures for primary HIV infection treatment and future trials... - Impact of HAART and CNS-penetrating antiretroviral regimens on HIV encephalopathy among perinatally infected children and adolescentsKunjal Patel
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
AIDS 23:1893-901. 2009.... - Delayed onset of pubertal development in children and adolescents with perinatally acquired HIV infectionKate Buchacz
Harvard School of Public Health, Boston, Massachusetts, USA
J Acquir Immune Defic Syndr 33:56-65. 2003..Further studies of perinatally HIV-infected and uninfected children are needed to better quantify the delay in pubertal onset and to compare the pace of pubertal maturation... - Projecting the cost-effectiveness of adherence interventions in persons with human immunodeficiency virus infectionSue J Goldie
Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115 5924, USA
Am J Med 115:632-41. 2003..To explore the cost-effectiveness of interventions to improve adherence to combination antiretroviral therapy in patients with human immunodeficiency virus (HIV) infection... - Intimate partner violence functions as both a risk marker and risk factor for women's HIV infection: findings from Indian husband-wife dyadsMichele R Decker
Department of Society, Human Development and Health, Harvard Injury Control Research Center, Harvard School of Public Health, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 51:593-600. 2009.... - A case-crossover analysis of predictors of condom use by female bar and hotel workers in Moshi, TanzaniaKatherine Tassiopoulos
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Int J Epidemiol 38:552-60. 2009..This study was undertaken to identify situation-specific factors associated with condom use among 465 female bar and hotel workers in Moshi, Tanzania... - Syphilis and hepatitis B Co-infection among HIV-infected, sex-trafficked women and girls, NepalJay G Silverman
Harvard School of Public Health, Boston, MA 02115, USA
Emerg Infect Dis 14:932-4. 2008..Those who were HIV positive were more likely than those who were HIV negative to be infected with syphilis and/or hepatitis B... - Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and countingKunjal Patel
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Clin Infect Dis 46:1751-60. 2008.... - The effect of antiretroviral therapy on secondary transmission of HIV among men who have sex with menAlethea W McCormick
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Clin Infect Dis 44:1115-22. 2007..However, the potential reduction in secondary transmission associated with ART may be offset by the longer duration of infectiousness... - Infectiousness of HIV between male homosexual partnersV DeGruttola
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115
J Clin Epidemiol 42:849-56. 1989..To model this variability over time and across individuals, more complex models must be fit to longitudinal studies of sexual partners... - Efficacy of antiretroviral drugs in reducing mother-to-child transmission of HIV in Africa: a meta-analysis of published clinical trialsPride Chigwedere
Harvard School of Public Health AIDS Initiative, Harvard School of Public Health, Boston, Massachusetts 02115, USA
AIDS Res Hum Retroviruses 24:827-37. 2008..This represents approximately 50% efficacy. The result is stable and not driven by any single study. All regimens were well tolerated. We conclude that ARV use to reduce MTCT of HIV in Africa is efficacious and well tolerated... - A therapeutic HIV vaccine: how good is good enough?Rochelle P Walensky
Department of Medicine, Massachusetts General Hospital, and the Partners AIDS Research Center, Harvard Medical School, Boston, MA 02114, USA
Vaccine 22:4044-53. 2004..91 months (cost-effectiveness ratio US$ 45,500/QALY). Even modestly effective therapeutic HIV vaccines may produce small but meaningful increases in life expectancy and compare favorably to alternative uses of scarce HIV care resources... - Antiretroviral drugs for preventing mother-to-child transmission of HIV in sub-Saharan Africa: balancing efficacy and infant toxicityAndrea L Ciaranello
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
AIDS 22:2359-69. 2008..We sought to identify the currently recommended regimen to prevent mother-to-child transmission that optimally balances risks of pediatric HIV infection and neurologic mitochondrial toxicity... - In utero nucleoside reverse transcriptase inhibitor exposure and signs of possible mitochondrial dysfunction in HIV-uninfected childrenSusan B Brogly
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts 02115, USA
AIDS 21:929-38. 2007..There is equivocal evidence of in utero nucleoside reverse transcriptase inhibitor (NRTI) exposure and the occurrence of mitochondrial dysfunction (MD) in HIV-uninfected children born of HIV-infected women... - Simple Pediatric AIDS Severity Score (PASS): a pediatric severity score for resource-limited settingsKunjal Patel
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 43:611-7. 2006..871). CONCLUSION: The Simple PASS scoring system provides a reasonable alternative to CD4% values and HIV viral-load levels to assess prognosis and guide decisions about antiretroviral therapy initiation in resource-limited settings... - Perspectives related to the potential use of vaginal microbicides among drug-involved women: focus groups in three cities in the United States and Puerto RicoTheresa H Mason
Abt Associates Inc, Cambridge, Massachusetts, USA
AIDS Behav 7:339-51. 2003..Focus groups also provided insight into how aspects of different women's sexual lives, including partner type, might influence the issues that would concern them if and when they tried out new microbicidal products in the future... - Routine human immunodeficiency virus testing: an economic evaluation of current guidelinesRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, and the Partners AIDS Research Center, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med 118:292-300. 2005..Our objective was to evaluate the clinical effect and cost-effectiveness of current guidelines and of alternate HIV prevalence thresholds... - Sexual behavior, psychosocial and knowledge differences between consistent, inconsistent and non-users of condoms: a study of female bar and hotel workers in Moshi, TanzaniaKatherine K Tassiopoulos
Department of Epidemiology, Harvard School of Public Health, Kresge Building, Room 816, 677 Huntington Avenue, Boston, MA 02115, USA
AIDS Behav 10:405-13. 2006..There are important differences between women by level of condom use. These findings can help inform interventions to increase condom use... - The reliability of passively collected AIDS surveillance data in MassachusettsKathleen M Gallagher
Massachusetts Department of Public Health, AIDS Surveillance Program, Boston, USA
Ann Epidemiol 13:100-4. 2003..To determine the reliability of demographic, clinical, and treatment information collected during routine AIDS surveillance... - Acceptability of formulations and application methods for vaginal microbicides among drug-involved women: results of product trials in three citiesT M Hammett
Abt Associates Inc, Cambridge, Massachusetts 02138 1168, USA
Sex Transm Dis 27:119-26. 2000..Female-controlled methods of HIV prevention, such as vaginal microbicides, are urgently needed, particularly among drug-involved women. Acceptability research is critical to product development... - Violence victimisation, sexual risk and sexually transmitted infection symptoms among female sex workers in ThailandMichele R Decker
Department of Society, Human Development and Health, Harvard School of Public Health, Boston, Massachusetts, USA
Sex Transm Infect 86:236-40. 2010..This study sought to compare sexual risk and STI symptoms among FSW based on recent violence exposure... - Estimating the lost benefits of antiretroviral drug use in South AfricaPride Chigwedere
Department of Immunology and Infectious Diseases, Harvard School of Public Health AIDS Initiative, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 49:410-5. 2008..6 million person-years lost by not implementing a mother-to-child transmission prophylaxis program using nevirapine. The total lost benefits of ARVs are at least 3.8 million person-years for the period 2000-2005... - Expanded screening for HIV in the United States--an analysis of cost-effectivenessA David Paltiel
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Conn 06520 8034, USA
N Engl J Med 352:586-95. 2005..The effect of expanded screening for HIV is unknown in the era of effective antiretroviral therapy... - Malignancy in perinatally human immunodeficiency virus-infected children in the United StatesHelen Kest
Division of Infectious Disease, St. Joseph Regional Medical Center of New Jersey, Paterson, NJ, USA
Pediatr Infect Dis J 24:237-42. 2005..Cancer incidence was highest in children who were severely immunosuppressed and in children who received HAART for < or =2 years... - Randomized, controlled evaluation of a prototype informed consent process for HIV vaccine efficacy trialsAnne S Coletti
Family Health International, Research Triangle Park, North Carolina, USA
J Acquir Immune Defic Syndr 32:161-9. 2003..It is recommended that the prototype informed consent process be adopted for future HIV vaccine efficacy trials as well as for clinical trials in other research areas... - Sexual risk, nitrite inhalant use, and lack of circumcision associated with HIV seroconversion in men who have sex with men in the United StatesSusan P Buchbinder
AIDS Office, San Francisco Department of Public Health, San Francisco, CA, USA
J Acquir Immune Defic Syndr 39:82-9. 2005..8, PAR = 7%). Having a large number of male sex partners, nitrite inhalant use, and engaging in receptive anal sex explained the majority of infections in this cohort and should be targeted in prevention strategies for MSM... - Lifetime cost of HIV care in France during the era of highly active antiretroviral therapyYazdan Yazdanpanah
Service Universitaire des Maladies Infectieuses et du Voyageur, Centre Hospitalier de Tourcoing, Faculte de Medecine de Lille, France
Antivir Ther 7:257-66. 2002..To estimate the treatment and health care costs of HIV infection or AIDS in France during the era of highly active antiretroviral therapy (HAART)... - The lifetime cost of current human immunodeficiency virus care in the United StatesBruce R Schackman
Department of Public Health, Weill Medical College of Cornell University, New York, New York 10021, USA
Med Care 44:990-7. 2006..We sought to project the lifetime cost of medical care for human immunodefiency virus (HIV)-infected adults using current antiretroviral therapy (ART) standards... - Expanded HIV screening in the United States: effect on clinical outcomes, HIV transmission, and costsA David Paltiel
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut 06520 8034, USA
Ann Intern Med 145:797-806. 2006..An extensive literature supports expanded HIV screening in the United States. However, the question of whom to test and how frequently remains controversial... - In utero nucleoside reverse transcriptase inhibitor exposure and cancer in HIV-uninfected children: an update from the pediatric AIDS clinical trials group 219 and 219C cohortsSusan Brogly
J Acquir Immune Defic Syndr 41:535-6. 2006
Research Grants
- Alcohol use and the risk of HIV-1 infection in BotswanaGeorge Seage; Fiscal Year: 2005..If alcohol plays an important role in the sexual transmission of HIV in Botswana, this proposal will be essential in design and conduct of future HIV risk reduction interventions in Sub-Saharan Africa. ..
- Epidemiology of Infectious Diseases and BiodefenseGeorge Seage; Fiscal Year: 2007..abstract_text> ..
- PHACS - Data and Operations CenterGeorge Seage; Fiscal Year: 2007..Given their prior and current professional experience, the PIs expect to be uniquely positioned to provide the scientific and epidemiologic leadership to successfully conduct the PHACS. ..
- Modeling the Impact of HIV Prevention InterventionsGeorge R Seage; Fiscal Year: 2010....