Ralph Scully

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint BRCA1 and BRCA2 in hereditary breast cancer
    Ralph Scully
    Department of Hematology Oncology, Cancer Biology Program, Beth Israel Deaconess Medical Center and Harvard Medical School, 77 Avenue Louis Pasteur, HIM 925, Boston, MA 02215, USA
    Biochimie 84:95-102. 2002
  2. ncbi request reprint Molecular functions of BRCA1 in the DNA damage response
    Ralph Scully
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Biol Ther 3:521-7. 2004
  3. pmc XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids
    Ganesh Nagaraju
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Mol Cell Biol 29:4283-94. 2009
  4. pmc Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair
    Anyong Xie
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Mol Cell 28:1045-57. 2007
  5. pmc Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks
    Ganesh Nagaraju
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    DNA Repair (Amst) 6:1018-31. 2007
  6. pmc Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C
    Ganesh Nagaraju
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Cell Biol 26:8075-86. 2006
  7. pmc Role of mammalian Mre11 in classical and alternative nonhomologous end joining
    Anyong Xie
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Struct Mol Biol 16:814-8. 2009
  8. pmc H2AX post-translational modifications in the ionizing radiation response and homologous recombination
    Anyong Xie
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Cell Cycle 9:3602-10. 2010
  9. ncbi request reprint BRCA1 and BRCA2 in breast cancer predisposition and recombination control
    Ralph Scully
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Mammary Gland Biol Neoplasia 9:237-46. 2004
  10. pmc Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks
    Andrea J Hartlerode
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA
    PLoS ONE 7:e49211. 2012

Collaborators

  • Anyong Xie
  • Gerburg M Wulf
  • Judith Balmana
  • Jose Baselga
  • John M Asara
  • Gunnar Schotta
  • Hong Yang
  • Manuel Stucki
  • Wael M ElShamy
  • Bijan Sobhian
  • Stephen P Jackson
  • Sarah M Wright
  • Raul Mostoslavsky
  • David A Sinclair
  • Shridar Ganesan
  • Leping Li
  • Cindy A Wilson
  • Gurushankar Chandramouly
  • Ganesh Nagaraju
  • Andrea J Hartlerode
  • David M Livingston
  • Christine L Nguyen
  • Anbazhagan Rajendran
  • Ashish Juvekar
  • Nicholas A Willis
  • Shailja Pathania
  • Amy Kwok
  • Yiduo Hu
  • Andrea Hartlerode
  • Philipp Oberdoerffer
  • Frederick W Alt
  • Nadine Puget
  • P LouAnn Cable
  • Dror Avni
  • Craig H Bassing
  • Bin Huang
  • Antonella Papa
  • Erica L Bauerlein
  • Laura N Burga
  • William C Hahn
  • Jagesh V Shah
  • Caterina Nardella
  • Costas A Lyssiotis
  • Richard Possemato
  • Hai Hu
  • Elaine P Lunsford
  • Katherine Spencer
  • Yinghua Guan
  • Yasir H Ibrahim
  • Kiyoe Ura
  • Pier Paolo Pandolfi
  • Lewis C Cantley
  • Guillaume O Adelmant
  • Jean Feunteun
  • Sarah J Hill
  • Elena Shestakova
  • Jarrod A Marto
  • Jenna Nguyen
  • Patrick Loerch
  • Azad Bonni
  • Judith Stegmuller
  • Shaday Michan
  • Angela Hafner
  • Michael McVay
  • Tomas A Prolla
  • James Vann
  • Bruce A Yankner
  • Sang Kyu Park
  • Kevin D Mills
  • Shobu Odate
  • Melodie Knowlton
  • Frank J Rauscher
  • Fabio Martelli
  • P Andrew Futreal
  • Francesco Hofmann
  • Courtney B Blackwell
  • Frank J Calzone
  • Cynthia A Afshari
  • JoAnn Sekiguchi
  • Heikyung Suh
  • Katrin F Chua
  • Catherine Yan
  • James C Fleming
  • David O Ferguson
  • Katerina Vlasakova
  • David N Ciccone
  • Brianna C Monroe
  • Scott R Whitlow

Detail Information

Publications27

  1. ncbi request reprint BRCA1 and BRCA2 in hereditary breast cancer
    Ralph Scully
    Department of Hematology Oncology, Cancer Biology Program, Beth Israel Deaconess Medical Center and Harvard Medical School, 77 Avenue Louis Pasteur, HIM 925, Boston, MA 02215, USA
    Biochimie 84:95-102. 2002
    ..Recent work has produced valuable insights into the mechanisms of action of the gene products. This review summarizes some of these advances, and attempts to place them in the context of known functions of the genes...
  2. ncbi request reprint Molecular functions of BRCA1 in the DNA damage response
    Ralph Scully
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Biol Ther 3:521-7. 2004
    ..In particular, BRCA1 functions in concert with Rad51, BRCA2 and other genes to control double strand break repair (DSBR) and homologous recombination. Here, we reassess the role of BRCA1 and its associated proteins in this process...
  3. pmc XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids
    Ganesh Nagaraju
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Mol Cell Biol 29:4283-94. 2009
    ..These results reveal an unexpectedly general role for Rad51 paralogs in the control of the termination of gene conversion between sister chromatids...
  4. pmc Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair
    Anyong Xie
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Mol Cell 28:1045-57. 2007
    ..These results suggest a specialized adaptation of the "histone code" in which distinct histone tail-protein interactions promote engagement of distinct DSBR pathways...
  5. pmc Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks
    Ganesh Nagaraju
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    DNA Repair (Amst) 6:1018-31. 2007
    ....
  6. pmc Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C
    Ganesh Nagaraju
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Cell Biol 26:8075-86. 2006
    ..2 kb in length. These results indicate that Rad51C plays a pivotal role in determining the "choice" between short- and long-tract gene conversion and in suppressing gene amplifications associated with sister chromatid recombination...
  7. pmc Role of mammalian Mre11 in classical and alternative nonhomologous end joining
    Anyong Xie
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Struct Mol Biol 16:814-8. 2009
    ..The NHEJ function of Mre11 is independent of H2A.X. We propose a model in which both enzymatic and scaffolding functions of Mre11 cooperate to support mammalian NHEJ...
  8. pmc H2AX post-translational modifications in the ionizing radiation response and homologous recombination
    Anyong Xie
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Cell Cycle 9:3602-10. 2010
    ..The results suggest that the HR and IR-resistance functions of H2AX are controlled in large part by specific MDC1-interacting residues of H2AX, but that additional H2AX residues modulate these core functions of H2AX...
  9. ncbi request reprint BRCA1 and BRCA2 in breast cancer predisposition and recombination control
    Ralph Scully
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Mammary Gland Biol Neoplasia 9:237-46. 2004
    ..Our aim here is to highlight new advances in the study of BRCA1 and BRCA2 , and to place these advances in the context of existing knowledge...
  10. pmc Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks
    Andrea J Hartlerode
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA
    PLoS ONE 7:e49211. 2012
    ..We found that WHSC1 homozygous mutant MEFs reveal an alteration in balance of H4K20 methylation patterns; however, 53BP1 DSB responses in these cells appear normal...
  11. pmc A protective role for BRCA2 at stalled replication forks
    Gurushankar Chandramouly
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Breast Cancer Res 13:314. 2011
    ..A recent paper describes a new replication fork protective function of BRCA2, which appears to collaborate with its HR function to suppress genomic instability...
  12. pmc BRCA1 is required for postreplication repair after UV-induced DNA damage
    Shailja Pathania
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 44:235-51. 2011
    ..The last function, in turn, triggers post-UV checkpoint activation and postreplicative repair. These BRCA1 functions differ from those required for DSBR...
  13. pmc Double strand break repair functions of histone H2AX
    Ralph Scully
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, United States Electronic address
    Mutat Res 750:5-14. 2013
    ..Here, we review progress in research aimed at understanding how γH2AX contributes to double strand break repair in mammalian cells. ..
  14. pmc Control of sister chromatid recombination by histone H2AX
    Anyong Xie
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    Mol Cell 16:1017-25. 2004
    ..H2AX phosphorylation may help set up a favorable disposition between sister chromatids...
  15. pmc Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
    Craig H Bassing
    Howard Hughes Medical Institute, Department of Genetics, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:8173-8. 2002
    ..However, H2AX(Delta)/Delta ES cells exhibit altered IR-induced BRCA1 focus formation. Our findings indicate that H2AX function is essential for mammalian DNA repair and genomic stability...
  16. pmc BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids
    Gurushankar Chandramouly
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Nat Commun 4:2404. 2013
    ..This suggests that BRCA1/CtIP-mediated processing of the second end of the break controls the annealing step that normally terminates SDSA, thereby suppressing the error-prone LTGC outcome. ..
  17. pmc Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts
    Christine L Nguyen
    Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA, USA
    Mol Cell Biol 32:3963-77. 2012
    ..Together, these observations implicate Nek4 as a novel regulator of replicative senescence and the response to double-stranded DNA damage...
  18. pmc RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci
    Yiduo Hu
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 25:685-700. 2011
    ..Since chromosomal instability emerges when BRCA1 HR function is either unbridled or absent, active tuning of BRCA1 activity, executed in nuclear foci, is important to genome integrity maintenance...
  19. pmc SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
    Philipp Oberdoerffer
    Department of Pathology and Glenn Labs for Aging Research, Harvard Medical School, Boston, MA 02115, USA
    Cell 135:907-18. 2008
    ..Thus, DNA damage-induced redistribution of SIRT1 and other chromatin-modifying proteins may be a conserved mechanism of aging in eukaryotes...
  20. pmc Hijacking the DNA damage response to enhance viral replication: gamma-herpesvirus 68 orf36 phosphorylates histone H2AX
    Anyong Xie
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Cell 27:178-9. 2007
    ..2007) characterized a gamma-herpesvirus protein, which phosphorylates histone H2AX during infection, suggesting that the virus actively initiates and benefits from the host DNA damage response...
  21. pmc Molecular analysis of sister chromatid recombination in mammalian cells
    Nadine Puget
    Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, HIM 923, Boston, MA 02215, USA
    DNA Repair (Amst) 4:149-61. 2005
    ..Dysregulated sister chromatid recombination may contribute to cancer progression, in part, by promoting gene amplification...
  22. pmc In my end is my beginning: control of end resection and DSBR pathway 'choice' by cyclin-dependent kinases
    Ralph Scully
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    Oncogene 24:2871-6. 2005
    ..Recent evidence in yeast of a role for cyclin-dependent kinases in DNA end resection suggests a possible solution to the long-standing puzzle of how DSBR pathway 'choice' is regulated through the cell cycle...
  23. pmc Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer
    Ashish Juvekar
    Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cancer Discov 2:1048-63. 2012
    ....
  24. pmc Mechanisms of double-strand break repair in somatic mammalian cells
    Andrea J Hartlerode
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Biochem J 423:157-68. 2009
    ..We also review evidence for both co-operation and competition between the two pathways...
  25. ncbi request reprint Hereditary breast and ovarian cancer genes
    Ralph Scully
    Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 222:41-57. 2003
  26. ncbi request reprint Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage
    Dror Avni
    Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 12:735-46. 2003
    ..Thus, PP2A normally licenses the recruitment of Rb to chromatin sites in S phase from which, after DNA damage, it relocalizes to selected replication control sites and suppresses abnormal, postdamage rereplicative activity...
  27. ncbi request reprint Novel consensus DNA-binding sequence for BRCA1 protein complexes
    P LouAnn Cable
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Mol Carcinog 38:85-96. 2003
    ....